Occupational Specialty Codes

Serves as the Security Specialist and Special Security Representative responsible for executing Information Security (INFOSEC), Personnel Security (PERSEC), and Industrial Security (INDUSEC) programs and functions for the Defense Health Agency Research and Development (DHA R&D) and United States Army Medical Research and Development Command (USAMRDC) G-2 / Deputy Chief of Staff for Intelligence and Security (DCSSEC). Initiates and tracks background investigations to adjudication; prepares reports of investigation, including expedited requests and Statement of Reasons responses to derogatory findings; interprets, analyzes, and adapts security related regulations, precedents, and instructions; makes and implements recommendations on revisions to internal standing operating procedures and methodology to ensure optimal security programs in activities with overlapping and conflicting requirements; and provides security management and inspection oversight of security programs. Develops training program for headquarters and subordinate organization personnel on a wide range of security program matters. Personally conducts training sessions as appropriate.
SERIES: 0080

Work involves designing and implementing a basic and applied research program to investigate the physiological mechanisms regulating metabolism during rest, exercise, exposure to environmental stress, and/or dietary manipulation, especially restriction of energy intake. Work requires skill in establishing new or using existing human, animal or in vitro experimental models and physiological laboratory technologies appropriate to study metabolic responses in humans and/or animals to include measurement of metabolic energy expenditure, nervous and endocrine responses, tissue sampling and quantitative assay of metabolite concentrations.
SERIES: 0413

Designs and manages research experiments. Submits research associated products for U. S. Patent (as applicable). Is the subject matter expert and team player in support of the research conducted within the work element. Submits articles for publication in peer reviewed journals and/or presents research at national conferences (abstract, short topic, poster, or presentation). Prepares research proposal package(s) that support the research needs of the Army and the Department of Defense (DOD) and submits them for extramural funding.
SERIES: 0401, 0403, 0405, 0410, 0413, 0414, 0415, 1301, 1320

Incumbent works in containment suites with highly hazardous infectious agents and toxins and is required to participate in the Special Immunizations Program (SIP), a program that monitors worker health and provides vaccinations aimed at additional protection above personal protective devices. The SIP administers both licensed and investigational vaccines. Licensed vaccines are approved for use by the FDA because data support the conclusion that they are both safe and effective. These vaccines are administered according to the manufacturers' product labels. Investigational New Drug (IND) vaccines may be administered voluntarily according to specific protocols which are written following FDA, International Conference on Harmonization/Good Clinical Practices guidelines, DOD and Army regulations which protect the rights and welfare of research subjects. Prior to each IND vaccine protocol enrollment, incumbent will be given a separate, detailed informed consent describing that specific protocol. If the incumbent agrees to receive the vaccine his/her signature is required before the initial administration of the investigational vaccine. The SIP Clinic Staff will monitor incumbent's general health to ensure working with dangerous agents will not put incumbent at additional or unnecessary risk. In order to safely carry out the agency research mission, certain Food and Drug Administration approved vaccines will be required to be taken as a condition to participation, placement, and retention in this SIP position. Individuals who have a medical condition that precludes receipt of a SIP FDA approved vaccine or who otherwise decline to receive said vaccine will not meet the conditions of employment for this position.
SERIES: 0080, 0401, 0404, 0403, 0415, 0601, 0602, 0610, 0801, 0802, 1310, 1320, 2001

Maintains and disseminates scientific awareness of emerging and enabling mobile technologies use cases, technical specifications and standards, as well as interoperability requirements for telemedicine and eHealth efforts. Provides subject matter expertise and guidance in clinical and scientific domains to support research initiatives related to, but not limited to, mobile health, health data standards, and healthcare technologies. Routinely conducts scientific and multi-disciplinary literature reviews. Conceives of value-added, military health information technology research topics. Serves as a principal investigator and/or lead manager for mobile health research projects. Develops and executes strategic scientific research and development plans for the integration and application of mobile technologies with other technology areas, including, but not limited to electronic health records. Develops contract statements of work/performance work statements, and monitors contract performance for mobile health projects. Collaborates with other Investigators and technologists from a broad range of organizations such as government, non-profit, medical centers, hospitals, corporations, companies, private entities. Communicates with Service Flag Officers and senior MHS staff to align research with requirements and capability gaps.
SERIES: 1550

Provides leadership, establishes vision, and directs the oversight of regulatory activities of USAMRDC and, per agreement, other customers developing the FDA-regulated medical products. In coordination with FDA Sponsor's Representative, provides oversight and consultation for regulatory, clinical, non-clinical, manufacturing, data management, and biostatistics support for FDA regulated drug, vaccine, biologic, medical device, in vitro diagnostic, and combination products. Demonstrates extensive knowledge and application of FDA regulated clinical research, laboratory practice, and manufacturing regulations and guidelines, as well as comprehensive knowledge and application of Title 21 Code of Federal Regulations (CFR) and International Conference on Harmonization (ICH) guidelines. Provides executive leadership to formulate, interpret, and apply policies and principles for FDA-regulated medical product development and regulated clinical research matters. Functions as the USAMRDC Director of the Office of Regulated Activities (ORA). Supervises employees and ensures the ORA provides consistent, competent and timely management and oversight of the regulatory aspects of USAMRDC's development of FDA regulated products, from developing an initial regulatory strategy and throughout advanced development of medical products. Establishes and maintains learning initiatives and training programs to promote regulatory and clinical support competencies as well as to facilitate understanding of regulatory requirements across the USAMRDC enterprise. Establishes and implements standard operating procedures and policies to achieve compliance and efficiency within the regulatory affairs and clinical support teams. Coordinates funding, priorities, and decisions with senior leaders for regulatory affairs and regulated clinical service. Prepares and presents command-level briefings to senior regulatory staff, Commanders, General Officers and Senior Executive Service civilian managers. Establishes strong working relationships and efficient processes within USAMRDC, including interfacing with the FDA Sponsor's Representative, Science Directors, Project Management Offices and other stakeholders to ensure quality regulatory compliance in a timely fashion. Establishes partnerships with other organizations developing regulated medical products within the DoD, non-DoD agencies, industry and non-governmental organizations that are involved in the development of FDA regulated medical products. Provides guidance and support to USAMRDC and partners regarding: development and execution of FDA regulatory strategies that include risk assessments to inform the USAMRDC Commanding General and other decision makers; consultative support for non-Army product development activities funded with DoD resources; and regulatory guidance to product development governance decision makers and committees.
SERIES: 0601

Work involves functioning as primary investigator through designing, conducting, and analyzing applied human research and evaluation studies in one or more of the following fields of study: psychology, kinesiology, physiology or physical performance. Skills and knowledge are required in one or more of the following specialty areas: biomechanics, statistics, human factors, scientific methods and investigation techniques, experimental design, instrumentation, project management, and the research, development, testing and evaluation process.
SERIES: 0180, 0601, 0801

Administers the PERSEC Program in accordance with current laws, regulations, and policies. Ensures personnel are properly cleared to handle information as required by their duties. Provides guidance for the issuance of personnel security clearances for organizational and contractor personnel. Resolves security clearance issues and determines the appropriate course of action based on regulatory guidance and precedent-setting cases; seeks guidance from supervisor where no clear course of action is apparent. Processes requests for position sensitivity designations (military and civilian) and recommends approval/disapproval to the G-2. Provides assistance on security matters in connection with visits conducted by organizational personnel. Processes and coordinates visit requests from organizations outside the HQ DHA R&D - USAMRDC and certifies clearances of official visitors. Coordinates with Special Security Officer (SSO) on SCI related visit requests. Sends outgoing security clearance certifications. Issues courier cards and authorization letters for transporting classified information both within CONUS and OCONUS. Assists in coordination of matters pertaining to SCI. Performs security functions and produces administrative instructions for collateral secure areas and Sensitive Compartmented Information Facilities (SCIF). Supports annual inspections and investigations of security infractions and prepares associated reports. Supports Security Education Training and Awareness (SETA) Program for all personnel. Provides foreign travel briefings and debriefs as appropriate for collateral security personnel and for all SCI program personnel. Schedules and performs SCI Indoctrinations. Supports the command security manager responsible for managing all security aspects of collateral and SCI programs.
SERIES: 0080

Assists in planning, developing, and implementing security policies and procedures to ensure classified material is received, transmitted, handled, stored, and accounted for from the time of receipt until dispatch, return, or destruction. Conducts security training, briefings, and inspections. Frequently reviews classified holdings for currentness, properly downgrades the classification of information as appropriate, and destroys or coordinates for the destruction of all unneeded classified documents and electronic media in accordance with appropriate regulations and directives. Supports various information security related tasks to include assisting in carrying out security violation/compromise investigations, reviewing and analyzing associated reports of findings, and determining and directing necessary remedial action. Provides recommendations on the need for the issuance of classified information courier orders. Provides guidance to the staff and contractor personnel concerning information security program safeguards. Analyzes classification guides and is responsible for all administrative processes concerned with the classification, downgrading, and declassification of information. Conducts inspections of all classified information handling areas. Provides advice, instruction, and direction relative to the proper identification, marking, sorting, transporting, and destruction of classified material.
SERIES: 0080

Serves as the point of contact for Industrial Security Program matters pertaining to DoD contractors visiting and/or contracted to perform work for the organization. Verifies proof of need-to-know and degree of clearance required of industry visitors. Ensures security requirements are adhered to by contractor personnel. Reviews DD Form 254s for completeness and accuracy and verifies identified security requirements are included in contracts. Verifies and revalidates in-house and visiting contractor personnel security clearances. Provides contractor personnel guidance on proper storage of classified information and applicable guidelines.
SERIES: 0080

Responsible for the development and maintenance of the inventories of Hazardous Material (HAZMAT) and Hazardous Waste (HAZWASTE) generated, used, stored and disposed of by all activities. Incumbent independently reviews, summarizes, and provides information such as type of materials or wastes, rates of production, and proper handling/storage. Ensures that wastes collected are managed IAW applicable laws, acts, regulations, statutes, etc. such as segregating incompatible wastes, waste containers are properly labeled, differing wastes remain sorted, wastes are removed IAW regulations. Arranges for analysis of unknown wastes and their disposal. Prepares appropriate documentation or enters into automated Hazardous Waste Tracking System to turn-in HAZMAT/HAZWASTE to the installation's hazardous waste facility or other disposal activity, monitors resources expended disposing of wastes. Maintains records and waste manifests as required. In assigned areas, interviews persons to obtain factual information and reviews files/records in compliance with applicable laws, statutes, regulations, etc. regarding HAZMAT/waste management and advises activity environmental coordinator of potential problems and provides detailed summaries of findings. Attends inspections conducted by external regulating agencies of HAZMAT/waste operations and facilities. Incumbent is familiar with standardized techniques and processes performed on post which utilize HAZMAT or create HAZWASTE and conducts periodic inspections to assure process is functioning as designed. Works with Directorate of Public Works to ensure minimum amounts of HAZMAT and waste are kept in the workplace and IAW Safety Data Sheets (SDS). Independently manages electronic updating and reporting in the Hazardous Waste Tracking System (HWTS). Performs reviews of chemical inventories.
SERIES: 0029

Cleans and sterilizes a wide variety of laboratory glassware. Loads, unloads and operates steam autoclave in decontaminating glassware. Loads machines, selects type of glassware best handled by each loading device and visually inspects items, rejecting those showing cracks, chips or permanent stains. Makes record of discarded glassware so that replacement items can be ordered. Washes soiled laboratory ware using semi-automated dishwashing equipment under required specifications of the washing equipment and the cleanliness required. Removes clean, dry glassware from drying ovens, sorting and placing sorted glassware in its proper place in the issue room. Strict compliance with procedures is critical, since improperly cleaned or sterilized items can cause erroneous results and require repetition of experimental procedures and failure to detect cracked glassware can endanger others through possible release of toxic chemicals or pathogens. Administers the issue of glassware as appropriate to the organizational unit and/or individual research/researchers. Keeps records of items received and issued. Checks stock levels and notifies supervisor of shortages. Controls the issue of special category glassware to known users. Receives bulk deliveries of glassware, plus items that have shortages in use an stores other items until processing is necessary.
SERIES: 0029

Serves as the Staff Specialist and Principal Technical Consultant responsible for planning, directing, managing, implementing, and maintaining the Institute's environmental program to ensure compliance with federal, state, DoW, and local regulations. Acts as the Activity Environmental Coordinator (AEC), overseeing all environmental functions related to research activities. Develops, implements, and manages programs such as Hazardous Waste, Hazardous Materials, Medical Waste, NEPA, EPCRA, Pollution Prevention, TSCA, Air and Water Quality, and Environmental Management Systems. Provides subject matter expertise to support evolving research projects and ensures ongoing compliance with policies and procedures. Independently plans and accomplishes objectives, establishes standards, and modifies methods to achieve program goals efficiently. Manages and coordinates environmental projects, investigations, assessments, and studies, resolving complex issues by interpreting relevant laws and regulations. Reviews research protocols to identify and address potential environmental impacts, recommending modifications to ensure compliance. Collaborates with Principal Investigators to prepare required environmental documentation. Prepares and updates SOPs, policies, and memorandums as needed, manages the environmental program budget, and oversees the scheduling and delivery of environmental training for laboratory personnel.
SERIES: 0028

Reviews, updates, and implements environmental regulations and procedures to ensure USAMRICD's compliance with DOD, USAMRDC, APG, and other requirements. Oversees laboratory and facility operations to maintain regulatory compliance, and develops a comprehensive inspection program (i.e. waste management, air, and water quality). Coordinates with Departments to minimize environmental impacts from infrastructure and equipment. Reviews SOPs, policies, and protocols for environmental compliance and health impacts, identifying and initiating corrective actions as needed. Evaluates facility operations, maintenance, and new construction requests for environmental impact, documenting findings and conducting assessments in accordance with NEPA. Monitors hazardous materials usage, promotes safer alternatives, and prepares annual EPCRA reports. Participates in contractor facility surveys to provide technical guidance and assess adequacy for handling hazardous compounds. Conducts studies to resolve complex issues and recommends improvements for agent-related work areas and practices within USAMRDC and its contractors.
SERIES: 0028

Plans, organizes, executes, and analyzes comprehensive surveys and Job Hazard Analyses (JHAs) across all assigned areas at frequencies dictated by designated hazard levels, concurrently developing or improving safety standards and procedures for complex work operations and problem areas. Investigates hazardous conditions, equipment, mishaps, and property damage to determine root causes, severity, and contributing elements, subsequently preparing reports with actionable recommendations for elimination, correction, or protection. To mitigate these risks, consults with subject matter specialists and supervisors to modify work processes, while providing follow-up guidance to commanders, directors, managers, supervisors, workers, and unions. Works closely with unit leadership to assure proper mishap reporting and monitors the overall Safety and Occupational Health (SOH) program to ensure strict regulatory compliance, evaluating the severity of encountered problems, keeping supervisors informed of major obstacles, and following up on corrective actions. Implements tailored mishap prevention measures applicable to staff, contractors, and visiting researchers engaged in chemical research and development. Maintains active liaisons with industrial hygienists to resolve occupational health hazards and with other specialists to integrate the latest safety techniques and protective devices. Furthermore, establishes and oversees the SOH education and training program by developing, evaluating, and revising formal courses, curricula, media, and promotional materials. Serves as an expert instructor conducting site briefings and training employees on a wide variety of subjects, including chemical, biological, and physical safety, laboratory needs, ventilation requirements, and safe work methods. Finally, provides expert interpretation of SOH regulations and standards, participating in all applicable planning conferences and In-Progress Reviews (IPRs) to develop comprehensive safety support action plans, initiatives, and milestones for exercises and real-world missions.
SERIES: 0018

The Deputy Director works under the general supervision of the Director of the Risk Management Office. The incumbent is expected to operate with a high degree of independence and professional judgment, providing advice and recommendations to the Director and other senior leaders. The incumbent will play a critical role in identifying, assessing, mitigating, and monitoring risks across the full spectrum of the command's activities, with a focus on safety, occupational health, and environmental compliance. The work is reviewed for effectiveness in meeting program objectives and for its impact on the command's mission. The incumbent will act on behalf of the Director in their absence.
SERIES: 0018

Work involves conducting studies to develop dipstick-based enzyme linked immunosorbent assays and latex microparticle-based assays for the detection of viral and parasitic diseases of military importance in arthropods; prepares sera, specific globulins and purified antigens required for these tests; optimizes these assays and determines sensitivity and specificity of the test once developed; and uses these assays to determine infection rates in laboratory-infected arthropods. Conducts field studies at overseas sites to validate assays developed to detect arthropod-borne pathogens. Performs a wide variety of immunological evaluations under containment conditions of infected invertebrate and vertebrate hosts by employing tests such as plaque neutralization, complement fixation, hemagglutination inhibition, enzyme linked immunosorbent assay and radioimmunoassay; prepares all sera, specific globulins and purified antigens required for these tests, such preparation requires the use of centrifuges and ultracentrifuges. Immunizations Required.
SERIES: 0404, 0646, 0403, 0645, 0414, 0602, 0701

Work involves skill, knowledge, and ability to provide effective scientific leadership, personnel management, and acquisition and allocation of human and material resources for a bacterial diseases research program. Position includes ensuring that mission objectives are met and a safe, healthy work environment is maintained. Functioning as the science and technology objective/ science and technology plan (STO/STEP) coordinator and principal investigator for one STO as well as coordinating work done under other STOs/STEPs is required.
SERIES: 0401, 0403, 0440, 0602, 1320

Work involves the skill, knowledge and ability to analyze, clone and modify the DNA of bacteria using modern methods of molecular biology in order to engineer strains with a specific desired phenotype. Determining DNA sequences, producing recombinant molecules in appropriate expression systems, elucidating gene structure and function, and studying the mechanisms of bacterial pathogenesis are also required skills. Functional tasks include DNA sequencing, DNA purification and characterization, cloning, doing PCR reactions, working with DNA sequence databases, preparing novel DNA constructs and plasmids, transformation, transduction, blotting, hybridization, gel electrophoresis, and other DNA-related procedures.
SERIES: 0401, 0403, 0440

Work involves the skill, knowledge and ability to establish and carry out a research program to elucidate the host immune response to bacterial infections and to test immunization with candidate bacterial vaccines. Specific tasks and approaches include preparation and characterization of monoclonal antibodies, development and use of assays for measurement and characterization of antibodies and cell mediated immunity, animal and human studies of vaccine immunogenicity, studies of adjuvants, and development of models for measuring vaccine potency and efficacy.
SERIES: 0401, 0403, 0601, 0602, 0644, 1320

Work involves the skill, knowledge, and ability to isolate, purify, and characterize bacterial surface antigens such as proteins, lipopolysaccharides, and capsular polysaccharides, and to test candidate vaccine antigens for safety and immunogenicity in animals and humans. Functional tasks include growing and processing bacteria, performing chemical and physical analytical tests on purified antigens, immunizing animals, performing serologic assays, analyzing data, and preparing reports.
SERIES: 0401, 0403, 0644, 1320, 0404

Work involves a research program designed to evaluate the immune response to a variety of pathogenic bacteria. Identifies bacterial antigens as virulence factors, isolates and evaluates antigenic fractions as potential vaccine components, rates bacterial fractions as potential biological response modifiers in stimulating non-specific immunity.
SERIES: 1320, 0401, 0403, 0413, 0440, 0602, 0701

Work involves basic and applied research to identify bacteria and their metabolic products involved in bacterial diseases, evaluate the influence of chromosomal and extrachromosomal elements on bacterial virulence and develop and test prophylactic and therapeutic products for bacterial diseases. Develops and evaluates highly specific and sensitive immunological, biochemical or physical techniques for detecting, identifying and quantitating bacteria and their components. Extensive knowledge of bacteriology, immunology and biochemistry is required to select, apply and modify existing methods and to develop innovative approaches or techniques for the identification of both common and esoteric bacteria and their products.
SERIES: 1320, 0401, 0403, 0413, 0440, 0602, 0701

Work involves research on infectious agents, or their virulence factors, of military relevance. Research emphasizes the field of immunology, cell/molecular biology and protein chemistry. Goal is the understanding of the immune response and the development of new and improved vaccines against bacteria and other agents. Performs research on the immunology and pathogenesis of infectious agents and toxins with specific emphasis on the development of an effective immune response. This involves measuring the cellular and humoral immune response to infectious agents; determining in vitro correlates of immunity; developing new live, killed and synthetic vaccines using both traditional and novel routes and carriers; evaluating the nature of antigen processing and adjuvanticity; and optimizing vaccine preparations and immunization schedules to enhance the safety and efficacy of new vaccines.
SERIES: 1320, 0401, 0403, 0413, 0440, 0602, 0701

Work involves a comprehensive research program to discover the mechanism of action of various bacterial virulence factors and their contributions to pathogenesis. Directs a multidiscipline program that requires extensive current knowledge of concepts in biochemistry, cell biology, microbiology and immunology. Studies the biosynthesis, structures and mechanism of action of bacterial virulence factors, i.e., toxins, antigens, enzymes, at the molecular, cellular and organismic level.
SERIES: 1320, 0401, 0403, 0413, 0440, 0602, 0701

Work involves possessing the knowledge and ability to keep up with cutting edge issues. Essential duties include planning, identifying resources, executing, analyzing, interpreting, and presenting experiments on cell- and tissue-specific and non-specific stimulus-initiated biochemical processes that lead to cell survival or death. Work activity should be focused on identifying modalities that can control the stimulus-initiated cell process.
SERIES: 0401, 0405, 0410, 0413, 0415, 0701, 1310, 1320

Work involves conducting research pertaining to the biology of a variety of viral agents. Emphasis is placed on the application of biochemical procedures to study the basic interactions of viruses with the cells they infect. Plans, directs, and conducts research designed to study the relationship between cellular and viral components responsible for attachment and/or penetration and the observed movement of virus through vertebrate and invertebrate hosts. Participates responsibly in the development, production, and testing of molecular tools for studying the basic interactions of viruses with cells. Plays a proactive role in the production and characterization of chemical reagents to be used in the development of viral vaccines. Specifically, the incumbent will follow conventional approaches for the production of viral antigen for use in microencapsulated vaccines. Trains investigators and technicians in specialized biochemical techniques involved in separation, purification, identification, and characterization of cell and virus proteins. Immunizations Required.
SERIES: 1320, 0602, 0701, 0644

Work involves serving as Head of Purification Section for Walter Reed Army Institute of Research's Pilot Bioproduction Facility. Position requires extensive theoretical and practical knowledge of all types of purification, process development, and full-scale production. Employing creative and inventive strategies for solving difficult production problems of various procaryotic and eucaryotic cells is essential. The ability to conceptualize, design, start up, validate, and execute complex and sometimes novel purification procedures is necessary. Additional responsibilities include writing Standard Operating Procedures, Batch Production Records, and any other documents that are required to maintain documentation and compliance with current Good Manufacturing Practices. Supervising professional and technical staff is also required.
SERIES: 0401, 0403, 0440, 1320

Work involves skill, knowledge, and ability to provide effective scientific leadership, personnel management, and the acquisition and allocation of human and material resources for a department that is involved in the development, production, and testing of vaccines and biological products for use in humans. Establishing and ensuring that mission objectives are met and a safe, healthy work environment is maintained are essential, as is completing projects in compliance with current Good Manufacturing Practices and Good Laboratory Practices regulations. Tasks include developing program content, marketing/reporting, establishing Cooperative Research and Development Agreements with business collaborators, and representing/defending programs at agency, national and international levels for Walter Reed Army Institute of Research's Pilot Bioproduction Facility. Position also entails functioning as a scientific advisor for all Army Science and Technology Objectives and vaccine steering committees. Acting as a consultant for DOD on vaccine development and production is also required.
SERIES: 0401, 0403, 0440, 0801, 1320, 0340, 0510, 1083, 1152

Work involves serving as cellular immunologist expert responsible for all aspects of cell mediated immunity as it relates to discovery and implementation of malaria vaccine program. Theoretical and practical experience with human cellular immunology, especially as it relates to B and T function, antigen recognition, memory responses, and markers of activation is essential. The ability to conceptualize, design, and execute complex and sometimes novel methods of assessing human cellular immune responses to malaria antigens is required. Additional responsibilities include supervising professional and technical staff, writing technical reports for internal use and publications, and interacting with intramural and extramural scientists on multidisciplinary level.
SERIES: 0403, 0401, 0602, 0701

Work involves direct supervisory responsibility for conducting basic and applied studies of the immune response to malaria antigens in support of malaria vaccine development. Tasks include conducting of basic and applied research requiring expert knowledge and command of concepts and techniques in immunology, cell biology, microbiology and biochemistry. Tasks include investigations focusing on cellular responses that correlate with antimalaria protective immunity, cellular and antibody effector functions, memory responses, peripheral and tissue-specific regulatory T cell subsets and lymphokine production. Skills include planning of experiments, compilation of data, interpretation of results, preparation of summary reports, oral and written presentations to local and international collaborators and to local and international scientific meetings, and recruitment and supervision of scientific personnel, i.e., junior scientists, postdoctoral fellows, technicians and students.
SERIES: 0401, 0403

Work involves support of Army's malaria vaccine program. Position is responsible for all aspects of cell mediated immunity as it relates to discovery and implementation of malaria vaccine program. Theoretical and practical experience with human cellular immunology, especially as it relates to B and T function, antigen recognition, memory responses, and markers of activation is required. The ability to conceptualize, design, and execute complex and sometimes novel methods of assessing human cellular immune responses to malaria antigens is essential. Responsibilities include supervising professional and technical staff, writing technical reports for internal use and publications, and interacting with intramural and extramural scientists on multidisciplinary level.
SERIES: 0403, 0401, 0440

Work involves serving as the command technical authority in medicinal chemistry, information systems, and pharmaceutical analyses. Must manage the information system for the USAMRMC's drug discovery and development missions?one of the world's largest chemical inventory and biological data collections. Plans and executes structure/function analyses to predict optimal chemical structures for development as clinical candidates. Serves as consultant to USAMRMC and government agencies in medicinal and analytical chemistry. Manages research material transfer and cooperative research and development agreements.
SERIES: 1320, 0405, 1301, 0601

Work involves conducting experiments that require specialized knowledge and experience in current immunology, virology, and arbovirology. Performs daily laboratory research independently and also functions as a team member of a biomedical research program aimed at generating novel scientific knowledge required to combat highly pathogenic human viral diseases. Most of the work is performed under P3 level containment. Coordinates and executes a wide variety of technical procedures as required to achieve overall goals and objectives. Techniques will include state-of-the-art techniques to measure virus, viral antigen, and antibodies against viruses and virus subunits (e.g., enzyme-linked immunosorbent assays, virus neutralization, and immunofluorescence). Techniques in immunochemistry, biochemistry and molecular biology will be utilized as necessary to address immunological problems. Maintains and manipulates (including microinoculation) arthropod (e.g., mosquito, sand fly, and tick) colonies as needed to conduct research on their ability to transmit a variety of pathogens. Executes studies on the immunobiology and pathogenesis of viral diseases in experimental animals. Immunizations Required.
SERIES: 0403, 0401, 0602, 1320, 0701

Work involves serving as the senior or head technician in a medical research serology laboratory providing direct serological support to the Institute's Special Immunization Program (SIP), in-house efficacy studies of Investigational New Drugs (IND), in seroepidemiological studies to determine disease threat assessments or quantify immunological responses, incidence and prevalence of diseases in geographic areas of military interest and in the maintenance of the Institute's human serum bank. Performs a wide variety of serological and immunological procedures including, but not limited to the following: plaque assay neutralization, hemagglutination, agglutination, and inhibitions of such systems, complement fixation, radioimmunoassay, enzyme immunoassay, and immunofluorescent assays. Employs theoretical, as well as practical knowledge, of the nature of antigens to be employed in various serological tests. Prepares, maintains, and assays antigen seed stocks and reference antisera to a wide variety of antigens utilized in vaccine and seroepidemiological studies. Immunizations Required.
SERIES: 0404, 0646, 0403, 0645, 0644

Work involves planning and conducting basic and applied research on liposomes as carriers of vaccines, adjuvants, or drugs, and on the immunology of liposomes, lipids and lipid mediators. Ability to perform investigation of safety, immunogenicity and physiological effects of liposomes in small and large animal models, develop new methodologies, analyze and interpret results, and prepare reports and scientific research papers pertaining to studies conducted. Ability to develop new and refined technology for current Good Manufacturing Practices manufacture of liposomal vaccines as well as manufacturing liposomal vaccines for clinical trials.
SERIES: 0401, 0403, 0405, 0415, 0601, 0701, 1320, 0301, 0332, 0343, 0560, 1083, 1910

Work involves conducting a pharmacological research program to develop effective therapeutic agents against infectious disease, and biological and chemical warfare agents. Tasks include developing analytical techniques for analyzing drug and drug metabolite concentrations from in vitro and in vivo studies to support drug development program including stereospecific/chiral assays for drugs and drug metabolites. Work involves performing x-ray crystallography to determine conformations of molecules. The ability to use advanced quantum chemical techniques and state-of-the-art computational software to identify stereoelectronic attributes of candidate drug molecules that confer potent biological activity (toxicity as well as efficacy) is essential. Using molecular modeling to provide predictions of new compounds for chemical synthesis and biological pharmacological testing is also required. Expertise for evaluation of clinical and preclinical protocols and drug development contractor reports, and for selecting and advancing drugs through the decision network process is required.
SERIES: 0401, 0405, 0413, 1301, 1320

Work involves knowledge and application of epidemiological methods and principles independently as a principal investigator on a variety of research projects focused on the role of infectious diseases in the development of chronic diseases. Work also involves direct consultative support to other investigators, organizations, and agencies regarding appropriate design and interpretation of research as well as providing estimates of the meaning and practical operational significance of trends in data obtained from military databases and other sources. Requires a Ph.D. in epidemiology, with specific knowledge in cancer epidemiology, infectious disease epidemiology, biostatistics, immunology, biology, and public health to accomplish research.
SERIES: 0601, 0602, 0610

Work involves efficiently managing, directing, and administering departmental budget, personnel, and resources to achieve research program objectives. Formulating, directing, planning, and executing research programs with the aims of understanding immune and pathologic mechanisms and developing effective vaccines and drugs for diseases caused by infectious agents and biological toxins are required. Providing scientific expertise to review scientific manuscripts, research contracts, grant applications, and research programs for Federal, Army, and civilian scientific and medical organizations is essential.
SERIES: 0401, 0403, 0405, 0415, 0440, 0602, 1320

Work involves designing and implementing molecular biology experiments required to clone, express and analyze genes. Tasks include immunization of animals with expressed products and analysis of the antibodies produced by immunofluorescence assay, ELISA, and Western blot. Skills include oligonucleotide synthesis; DNA sequencing; construction of expression plasmids; transfection, cloning, expression and purification of recombinant proteins; isolation, purification and quantitation of DNA; SDA-PAGE and immunoblotting; chemiluminesence, PCR, and Northern blotting.
SERIES: 0401, 0403, 0701, 0644, 0602, 0440

Work involves performing research on the comparative evaluation of gene expression systems related to the expression of important viral immunogens of potential prophylactic value in man. Conducts research designed to qualitatively and quantitatively evaluate the immunogenic potential of expressed products with specific reference to the purity, adjuvanting, and recombinant release regulations governing human vaccine development. Examines a variety of recombinant viruses as efficient vectors of immunogenic determinants and evaluates their application to the USAMRIID vaccine development program. Performs basic research relevant to the generation of new recombinant viruses that will be safe and efficient as human vaccines. Investigates new expression methods and vehicles for specific application to vaccine development and modifies existing procedures and reagents for direct utility under the GLP and GMP conditions required for human vaccine research. Characterizes individual virus constituents as potential immunogens for vaccine development. Evaluates synthetic peptide immunogens, anti-idiotype antibodies and virtually any new and innovative approach to human vaccine development. Immunizations Required.
SERIES: 0401, 0403, 0415, 0440, 0602, 0701, 0644

Work involves carrying out research to further characterize both cellular and humoral murine and human immune responses to malaria antigens in support of malaria vaccine development. Tasks include separation and cryopreservation of human peripheral blood mononuclear cells, isolation of murine splenic and liver lymphocytes, evaluation of antigen-specific lymphocyte activation by measuring parameters such as lymphocyte proliferation, cytokine production, and expression of cell-surface activation markers. Tasks also include a study of the interaction of malaria sporozoites with human monocytes and a characterization of malaria antigen-specific antibodies in human immune serum. Skills and knowledge required include cell culture techniques, ELISA assays, flow cytometry, isolation of sporozoites from infected mosquitoes, handling laboratory animals, and analysis of results.
SERIES: 0403, 0401

Work involves basic and applied research related to the development of the Rapid Diagnosis Section's program to adapt nucleic acid hybridization as an alternate method of rapid, sensitive, and reliable detection of virus in clinical and environmental specimens. Directs, plans, conducts, coordinates, evaluates, and actively participates in basic and applied research to adapt polymerase chain reaction (PCR) technology to the nucleic acid hybridization detection program. Plans, conducts, coordinates, evaluates, and actively participates in both basic and applied research to develop, adapt, and standardize sensitive and specific immunodiagnostic tests for the detection of virus particles, antigenic components and antibodies in clinical and environmental specimens. Serves as an Institute representative for hybridization-based diagnostic assays. Immunizations Required.
SERIES: 0644, 0401, 0403, 1320, 0415, 0440, 0602, 0701

Work involves utilizing the skill, knowledge, and ability to design and perform experimental research, construct conjugate vaccines, chemically modify antigens, improve immunogenicity and/or safety, analyze the structure-function relationships of antigens and antibodies, epitope map antigens with monoclonal antibodies, prepare synthetic peptides and peptide derivatives, purify and quantify antigens and antibodies, and define the chemical structure of antigens. Functional tasks include development and use of synthetic procedures and equipment; development and use of analytical procedures, chemical assays, and immunologic assays; development of novel vaccines; purification of candidate vaccine antigens; and compositional analysis of candidate vaccines.
SERIES: 0401, 0403, 0440, 0602, 1320

Work involves conducting research on the development and use of reagents and methodologies for identification and localization of antigens in cells and tissues. Plans and conducts research in the field of immunocytochemistry to develop highly specific reagents and procedures for detecting antigens in cells and tissues by light and electron microscopy. Requires a thorough knowledge of chemistry and biochemistry to be able to use chemical and physical methods to bond various materials or compounds to antibodies or physiologically active proteins, to isolate and purify the reaction product, and to evaluate its purity. Duties include, but are not limited to, (a) studies to assess and enhance the purity and specificity of immune sera and monoclonal antibodies used in immunocytochemical and molecular procedures studies; (b) studies to evaluate various types of probes for detection of antigens in immunologic and molecular hybridization techniques, i.e., chromogenic morphological, isotopic, and/or enzymatic; (c) studies to develop and evaluate methods for identifying antigens in cells and tissues; (d) studies to determine optimal methods for preparing reagents for detection of antigens in tissues; and (e) studies to develop efficient systems to evaluate efficacy of reagents used to detect antigens in tissues. Immunizations Required.
SERIES: 1320, 0601, 0602, 0701, 0644

Work involves both basic and applied research to develop, adapt and standardize sensitive and specific immunodiagnostic tests for the detection of virus particles, toxins, bacterial proteins, antigenic components, and antibodies in clinical specimens. Provides rapid diagnostic support to Institute investigators and other Department of Defense agencies as necessity dictates. Produces, purifies, and characterizes recombinant antigens for use in diagnostic assays, determines their usefulness as diagnostic reagents and develops standard procedures for their production and storage. Immunizations Required.
SERIES: 0403, 0644, 0404, 0645, 0646

Work involves performing complex and uncommon immunological and cytological studies as well as developing, adapting, or revising procedures to improve and expand services. The position requires broad knowledge of immunology, biology, biochemistry, cytology, hematology and serology principles, theories, practices and methodologies sufficient to develop new procedures in support of immunologic and cytologic studies. Thorough knowledge of light physics (i.e., optics and filters for both lasers and sample fluorescence) and fluid dynamics is necessary in order to perform the full range of duties connected with the development of new fluid dynamics. Such knowledge is required in performing the full range of duties connected with the development of new flow cytometry procedures as well as development of techniques in support of clinical and research immunology program. Required skills in operating flow cytometry equipment include set-up, operation, troubleshooting, and computer networking.
SERIES: 0401, 0403, 0644

Work involves research on the comparative immunological expression of candidate human vaccines to provide scientific estimates of potential prophylactic value in man. Conducts research designed to qualitatively and quantitatively evaluate immune responses with specific reference to improving sub-optimal or marginal protective immune responses while conforming to all pertinent guidelines and regulatory compliance. Develops experimental animal models for evaluating vaccines and immunogenic compounds. Evaluates synthetic peptide immunogens with vaccine potential to include definition and testing of specific B cell and T cell epitopes required to optimize the immune response. Develops methodology to monitor immunologic responsiveness to include both humoral and cellular responses to candidate vaccines. Investigate and develop the in-house capability for serologically monitoring the immune responses of human volunteers receiving vaccines. Immunizations Required.
SERIES: 0403, 0602, 0701

Work involves serving as a principal investigator planning, conducting, supervising and evaluating the results and progress of an independent research program on the immunology of infectious disease and the role of immunology in both the pathogenesis of and protection against hazardous pathogens of interest to the military. Initiates and conducts original and independent research on basic immunological mechanisms related to the expression of foreign genes in viruses selected as potential vaccines candidates. Such studies will include, but are by no means restricted to, the expression of foreign genes in vaccinia virus. Designs research directed toward the elucidation of the humoral and cellular response to both the vector virus and the foreign gene product. Investigates sub-virion components, synthetic peptides, and monoclonal and anti-idiotypic antibodies as specific and/or sensitive reagents for antigen and antibody detection. Evaluates the application of the most recent techniques of biotechnology and immunology to the research mission of USAMRIID. Immunizations Required.
SERIES: 0401, 0403, 0440, 0602, 0701, 0644

Work involves planning, executing and reporting research on biochemical and immunological mechanisms of presentation of protein, lipid, and liposome-associated antigens by antigen presenting cells. Tasks include preparing protocols, carrying out day-to-day operations, and coordinating overall progress of research. Maintaining different cell lines and T cell clones in culture is required. Additional tasks include analyzing, interpreting, and reporting results of ongoing research, reviewing pertinent literature, consulting with colleagues, and attending scientific seminars to keep informed of recent advances. Training technical personnel and collaborators in special areas of expertise and participating in scientific meetings and publishing research results in scientific journals are also responsibilities associated with this position.
SERIES: 0401, 0403, 0413, 0601, 1320

Work involves planning and conducting basic and applied biochemical research on development of liposomes as carriers of drugs, adjuvants and vaccines. Developing new methods and analyzing, interpreting, and publishing results obtained in scientific literature are essential. Work involves studying safety, immunogenicity, and physiological effects of liposome in vivo. Additional requirements include manufacturing under cGMP liposomal vaccines for clinical trials and conducting preclinical testing.
SERIES: 0401, 0403, 0405, 0415, 0601, 1320

Work involves molecular parasitological studies in support of the development of a malaria vaccine. Tasks include identification and characterization of malaria antigens, testing malaria antigens in malaria model systems (murine, simian and in vitro), and providing hybridoma support. Expertise in malaria slide reading in support of human vaccine trials, and the compilation, analysis, and reporting of data are essential. Skills include the application of theories and techniques of immunology, biochemistry, parasitology and tissue culture; knowledge of standard immunological techniques such as antibody and antigen purification, ELISA, IFA, PAGE, all aspects of malaria and hybridoma technology, use of animal models (murine and simian), and skilled interpretation of malaria smears.
SERIES: 0401, 0403, 1320

Work involves supervisory responsibility for designing and implementing a research program in support of the department's efforts to develop malaria vaccines. Responsibilities include integrating the program into interdisciplinary departmental efforts; training subordinates and assigning appropriate tasks; ensuring that research is carried to completion, findings are presented accurately, and manuscripts are written and published; ensuring that job performances are reviewed and evaluated accurately and on time; and ensuring that all aspects of the laboratory environment are safe and operate according to applicable regulations. Required skills and knowledge include a detailed professional command of protein chemistry, molecular biology, immunology, animal use, laboratory safety, and technical writing. The ability to motivate others to perform their assignments professionally and to comply with standard safe operating procedures is crucial.
SERIES: 0401, 0403, 1320

Work involves supervisory responsibility for designing and implementing a research program involving molecular engineering techniques required to construct expression vectors capable of producing recombinant malaria proteins in support of the department's malaria vaccine program. Tasks include the use of heterologous expression systems such as bacteria, yeast, insect, or mammalian cell lines to produce antigens for use as vaccines, skin test antigens, or immunological reagents. Expertise in nucleic acid engineering using a variety of methodologies is required. Additional required skills and tasks include protein purification techniques such as gel analysis and chromatography, writing of batch records for current Good Manufacturing Practice (cGMP) production, compilation of data, preparation of reports, writing papers for publication, and task management of technical, medical, and scientific staff. Necessary skills involve detailed understanding of nucleic acid genetic engineering, protein biochemistry, purification methodologies, immunological techniques, and familiarity with cGMP production of materials regulated by the U.S. Food and Drug Administration.
SERIES: 0401, 0403, 1320

Work involves molecular parasitological studies in support of the department's efforts toward the development of a malaria vaccine. Tasks include testing malaria antigens in malaria model systems (murine, simian, and in vitro), providing departmental hybridoma support, providing expertise in malaria slide reading in support of human vaccine trials, and compiling, analyzing, and reporting of data. Required skills include the application of theories and techniques of immunology, parasitology and tissue culture; knowledge of standard immunological techniques such as antibody and antigen purification, ELISA, IFA, PAGE; hybridoma technology; use of animal models (murine and simian); and skilled interpretation of malaria smears.
SERIES: 0401, 0403, 0410

Work involves serving as a senior zoologist for the Army's malaria vaccine program. Extensive in-depth experience with nonhuman primate models of Plasmodium falciparum malaria is required. Tasks include designing and conducting experiments to test safety, immunogenicity, and efficacy of candidate malaria vaccines. Expertise in standard and novel methods of parasite detection, quantitation, and speciation is also required.
SERIES: 0403, 0410

Work involves serving as a principal investigator planning, conducting and evaluating research on molecular mechanisms of action of antiviral agents. Resident expert in antiviral research, utilizing modern methods of biotechnology and genetic engineering. Actively directs a virus research program that is capable of evaluating basic virus research data available, obtaining additional critical information. Develops in vitro systems for study of viral replication mechanisms and means for disruption of replication processes. Develops functional assays for viral polymerase activity. Examines nucleotide sequences of relevant viral genes and generates synthetic antisense nucleic acids to potential gene regions suspected to be essential for viral replication. Utilizes recombinant DNA technology to produce cDNAs representative of viral genes. Identifies polymerase binding sites on nucleic acids. Identifies cell surface receptors for viruses. Determines characteristics of viral assembly and identifies potential targets for disruption of viral morphogenesis. Immunizations Required.
SERIES: 0401, 0403, 0602, 0701

Work involves extensive theoretical and practical knowledge of discovery, cloning, and expression of malaria genes. Experience with overexpression of recombinant proteins at the 10L scale and solid understanding of approach to purification of recombinant proteins is required. Essential expression expertise includes E. coli, Pichia, Sacchromyces, and baculovirus systems. Employing creative and inventive strategies for solving difficult expression systems, and supervising professional and technical staff are responsibilities of this position. Other tasks include writing reports for intramural and extramural sources and managing collaborations with industrial partners.
SERIES: 0403, 0401, 0440

Requires a senior medical technologist proficient in execution of FDA-approved assays for the quantitation of HIV-1 viral load in clinical specimens. Can establish chain of custody for incoming specimens and report the results of testing using electronic databases. Can assist in the design and implementation of the Roche Amplicor Assay and the Chiron Branched Chain assay in a laboratory approved by the College of American Pathologists. Experienced in ensuring compliance with all appropriate proficiency standards and quality assurance testing.
SERIES: 0644

Work involves demonstrated experience in conducting, directing, and overseeing of serological and molecular biological research on diagnosis of HIV infection. The position requires the capability to provide state-of-the-art HIV-1 resistance genotyping for DOD clinical facilities throughout DOD. A proven ability to conceptualize and implement collaborative clinical research addressing issues of HIV infection management is required. Monitoring and evaluating research goals and milestones and redirecting efforts and resources as appropriate to accomplish objectives are essential.
SERIES: 0401, 0403, 0410, 0440, 0601

Work involves serving as team leader with knowledge of biochemistry, physiology, and drug-resistance/sensitivity of designated military important parasites that infect people. Knowledge is used in molecular design of candidate parasitic drugs having maximum efficacy and minimal toxicity. Some techniques used are (1) biochemical tracer studies to elucidate unique parasite/human attributes; (2) in vitro/in vivo drug assay of drugs to determine (therapeutic indexes); (3) chemical assay of drug resistance/and drug sensitivity; and (4) computer modeling in development of hypotheses regarding mechanisms of drug action and drug resistance. Knowledge required consists of biochemistry, physiology, analytical chemical, molecular biology, and medicinal chemistry. Thorough knowledge of epidemiology, taxonomy, diagnosis, clinical presentation, and treatment of human and animal parasites. Knowledge of statistical methods and computer-assisted data analysis is also required.
SERIES: 0410, 1320, 1530, 0413, 0701, 1301

Work involves pathogenesis and the genetics of pathogens and the interactions of bacterial agents with the immune system to establish a technological base for the assessment of militarily important pathogens. Executes research leading to an increase in the defensive capability of identifying and treating novel pathogens. Develops methods and appropriate research to establish a technological base for the genetic analysis of pathogens of military importance with an emphasis on determining the presence and nature of extrachromosomal genetic elements.
SERIES: 0440, 0602, 0701, 0403

Work involves serving in the Army's malaria vaccine program. Extensive theoretical and practical knowledge of molecular parasitology of malaria parasites is required, as is the ability to conceptualize and design experimental strategies to identify, purify, characterize, resolve, and express parasite antigens in native form to optimize immune responses to them. Additional tasks include interpretation of data, preparation of reports for internal and external publication, and management of extramural collaborations with industry.
SERIES: 0403, 1320, 0440

Work involves research to investigate biotechnology problems in molecular virology and the development of human virus vaccines. Investigations are required as a result of the most recent developments in molecular biology and attempts to apply this technology to the initial phases of development of virus vaccines. Directs, modifies and performs recombinant DNA cloning procedures to include cDNA cloning of viral RNA segments, subcloning of specific genes into sequencing and/or expression plasmids, modification of plasmids and inserts utilizing restriction enzyme cleavages to affect desired modifications and site-directed mutagenesis. Maintains a working library of plasmid, bacteriophage, cosmid, and both plant and animal virus vectors, together with associated host cells and appropriate technologies for their optimal use. Immunizations Required.
SERIES: 0401, 0403, 0440, 0602, 0644, 0701

Work involves the skill, knowledge and ability to design and perform experimental research to construct peptide-based vaccines, chemically modify peptides to improve immunogenicity and/or safety, analyze the structure-function relationships of peptide antigens, prepare synthetic peptides and peptide derivatives, and purify.
SERIES: 0403, 1320, 0401

Work involves responsibility for applying combination of skills and knowledge of programming, systems, design, and epidemiology to solve problems in disease research and analysis. Expert in available military databases, accessing data appropriately, aware of limitations of databases, and informing researchers of the limits of these data. Expertise is required in utilizing existing computer software packages to establish new databases and perform analyses (e.g., SAS, EPI-INFO, STATA).
SERIES: 0181, 0404, 1521, 1531

Work involves the study of cellular immune responses induced by recombinant malaria vaccines and the investigation of the potential role of T cell subsets specific for parasite antigens. Major tasks include isolation and cryopreservation of human peripheral lymphocytes, evaluation of T cell responses involving lymphocyte proliferation, CTL reactivity and cytokine production to a variety of malaria protein antigens, and characterization of the antigen and cytokine requirements for the activation of T cell subsets. Required skills and knowledge include cell culture technology, application of routine immunological assays (lymphocyte proliferation assay, CTL and flow cytometry), and development of cytokine assays (ELISPOT and intracellular staining).
SERIES: 0401, 0403, 1320

Incumbent will design, develop and execute research projects involving HIV-1 vaccine and therapeutics clinical trials and HIV-1 infection cohorts, as well as other emerging pathogens. In this capacity, the incumbent will integrate cutting edge immunological techniques and assays, using state of the art, high-throughput technologies, and applying scientific principles and concepts to assess immune responses to vaccines and infection. Focus will be on development of research and core capacities to explore aspects of B cell responses associated with disease progression and vaccination. In addition, the incumbent is responsible for independently developing and supervising research projects and investigating the feasibility of applying a wide variety of scientific principles and concepts to potential inventions, products and problems while establishing and fostering collaborations within and outside of the program. Responsibilities include oversight of a B Cell Biology core laboratory, which will provide antigens to investigators at for analyzing binding antibody responses and antigen-specific B cell expression profiles in samples from vaccinated and infected individuals. In addition to protein expression and purification, the incumbent will work to isolate monoclonal antibodies using molecular techniques and identify the characteristics of B cell ontogeny that elicit neutralizing antibodies. The incumbent will utilize high throughput technique to assess the biophysical aspects of binding antibodies by assessing the Fc and Fab portions in parallel using antibody profiling. The successful candidate will work to further our understanding of vaccine-induced immune responses and investigate acute and chronic infection immune factors.
SERIES: 0403

Work involves conducting basic and applied research toward developing candidate malaria vaccines. Tasks include cloning, expression and purification of P. falciparum antigens using bacterial, viral, and eukaryotic systems as well as analyzing these antigens using various in vitro and in vivo methods. Skills in support of job tasks include PCR, site-directed mutagenesis, protein purification, immunization protocols using various adjuvant formulations, analysis of responses using solid phase receptor-ligand binding assays, ELISA, IFA, immunoblot, immunoprecipitation and others. The position requires data collection, analysis, and compilation for publication.
SERIES: 0401, 0403, 0440

Work involves supporting and facilitating the development of recombinantly expressed malaria antigens for use as vaccines. Tasks include the development of recombinant DNA clones for expression, optimization of expression, protein purification, and production at laboratory and large fermentation scales. Skills and knowledge required to implement tasks include molecular cloning technologies, column chromatography and protein biochemistry, the development of appropriate scale-up fermentation and purification processes, and analysis of products for conformation using various immunodetection assays such as immunoblotting, ELISA, IFA.
SERIES: 0401, 0403, 1320, 0440

Position entails design, organization, execution, and report of laboratory studies related to HIV-1 infection/HIV-related diseases, other prevalent, and emerging infectious diseases of military importance. Investigations generate knowledge products to inform risk assessment, Force Health protection countermeasures, new/novel applications of diagnostic countermeasures, Service component and/or DoD Policy, and meet requirements of the geographic and functional Combatant Command in the areas of HIV/HIV-related infectious diseases and prevalent and emerging pathogens of U.S. Military and/or National interest. Subject matter expertise in design, execution, direction of complex laboratory studies which can be applied to assessing Service-specific military populations, Force accession, retention, and deployment Health policy, and Force Health Protection diagnostic countermeasures. Identifies novel threats and gaps in existing diagnostic countermeasures and/or existing knowledge products and Force Protection policy. Position entails interaction with diagnostic industry, specialty Providers, U.S. Military operational leaders, U.S. Military Public Health officials, other DoD components, and interagency partners. Ability to lead/serve on multidisciplinary teams conducting diagnostic countermeasure and prevention/intervention research efforts.
SERIES: 0403

Position directs the execution of U.S. government funds for activities with DoD, interagency, and/or national and/or international partner intended to improve and/or expand capacity, quality, and/or delivery of laboratory services for those at risk for and infected with HIV/HIV-related infectious diseases and other infectious pathogens of military and civilian public health importance. Activities entail engagement in multi-disciplinary international collaborative efforts, non-governmental organizations, and U.S. government partners to execute military to military, military to civilian public health activities. Essential skills include ability to assess requirements, gaps in services, and policies that threaten successful laboratory service delivery. Leads research efforts in support of public health investigations, evaluations, and/or research initiatives that inform and close gaps in existing laboratory capacity, knowledge, and services. Tasks include identifying opportunities to advance U.S. government objectives and improve Global Public Health in the area of infectious diseases.
SERIES: 0403

Work involves knowledge of vaccine development and molecular biology enabling identification of new areas of research that need to be developed to meet changing demands of the military service or research opportunities that become available.
SERIES: 0403, 0602

Work involves serving as principal investigator who plans, conducts, supervises and evaluates the results and progress of an independent research program on the immunology of infectious disease and the role of immunology in both the pathogenesis of and protection against hazardous pathogens of interest to the military. Initiates and conducts research on the basic immunological and immunopathological properties of viruses and potential vaccine candidates. Such studies will include but are not limited to investigation of immune responses to select viruses such as Bunyaviridae (hemorrhagic fever with renal syndrome) or Arenaviridae in humans and non-human primates. Designs research directed toward the elucidation of the humoral and cellular responses to viruses and to candidate vaccines. Evaluates human vaccine potential of candidate vaccines including detailed investigation of the ultimate safety of such vaccines, as well as factors contributing to efficacy. Investigates animal models of pathogenesis and assesses the contribution of the immune response to the disease process. Immunizations Required.
SERIES: 0401, 0403, 0413, 0602, 0701

Reports results through publications, presentations, and technical records and reports in the areas of molecular biology, microbiology, vector biology, immunology, epidemiology, and biostatistics. Developing new methodologies is required, as is analyzing/interpreting results. Coordinates extramural research projects and manages/directs in-house independent research projects. Broad technical and theoretical knowledge or hands-on experience in the above listed disciplines in support of multiple projects of public health and military importance. Work involves both the management of projects, but also the familiarity and technical ability to perform and evaluate/troubleshoot laboratory procedures and tests required for successful execution of such projects. Will serve as the subject matter expert in studies on investigative vaccines for diseases of military importance. Work also involves supporting, sustaining and improving molecular laboratory capabilities using high-throughput technologies utilized for pathogen analysis. Oversees cell culture laboratory capabilities to support ongoing vector-borne disease research.
SERIES: 0401

Work involves developing liposomes as carriers of vaccines, adjuvants, or drugs. Ability to plan and execute basic and applied research on the immunology of liposomes, lipids and adjuvants, develop new methodologies, analyze and interpret results, and prepare reports and scientific research papers pertaining to studies conducted. Ability to develop new liposomal vaccine formulations and investigate chemical identity, safety, and immunogenicity of these formulations, develop new refined technology for current Good Manufacturing Practices manufacture of liposomal vaccines, prepare manufacturing documentation for clinical vaccine trials, manufacture liposomal vaccines for clinical trials, and perform quality control testing on clinical vaccines
SERIES: 0403, 0405, 0601, 0701, 1320, 0301, 0332, 0510, 0560, 1083, 1910

Work involves serving as a principal investigator to plan, conduct, and report the results and progress of an independent research program on identification and prevention of human diseases due to viral agents. Contributes to long-range program planning. Initiates and conducts research on the basic properties of virus and host responses to them. Develops diagnostic tests and vaccine candidates. Research areas include methods to identify virus agents and their heterogeneity, structure and function of virus proteins, immune responses elicited in animal and human hosts, and mechanisms of pathophysiology. Evaluates vaccine candidates in animal models and supports evaluations in volunteers. Establishes and coordinates extramural collaborations and contracts to augment the research program he or she directs. Immunizations required.
SERIES: 0401, 0602, 0701

Assists where necessary with maintaining a pathogen-free environment conducive to rearing non-infected insects (i.e. mosquitoes, ticks, sand flies). Assists in the production of infected insects (i.e. ticks, mosquitoes and or sand flies containing pathogens). Assists in the production of Plasmodium falciparum and Plasmodium berghei- infected mosquitoes when needed, specifically where new protocols and SOPs are adopted for vector parasite culturing in order to facilitate optimal training of personnel.
SERIES: 0401

Work involves technical laboratory support of a research program investigating the epidemiology of arthropod (mosquito, tick, and sand fly)-borne pathogens. Most husbandry roles will be supervisory. Assists in oversight of daily operation of an insectary that rears mosquitoes, sandflies, and ticks for a variety of projects focused on vaccine development, vector competence, vector control and diagnostics, and other studies that directly or indirectly correlate with the DoD?s mission to protect the warfighter from vector-borne disease. Communicates regularly with insectary technician staff for production of insects/vectors specific to ongoing/proposed studies.
SERIES: 0401

Plans, designs, and executes laboratory and field studies on the transmission of leishmaniasis by sand fly vectors. Supervises the establishment and maintenance of the most diverse colonies of sand flies in the U.S., cultures several species of Leishmania parasites, and conducts studies on laboratory infected sand flies. Organizes support for the development of new diagnostic techniques, drugs, and vaccines. Serves as the USAMRMC primary consultant on epidemiology of leishmaniasis.
SERIES: 0414, 0403, 0401

Expert at the collection, preservation, and identification of arthropods of medical importance. Curates the National Mosquito Collection housed at the Smithsonian Institution. Provides rapid on-site identification of vectors to troops deployed abroad. Aids in the molecular study of mosquito systematics and in the development of a computerized key to mosquito fauna. Qualified to work in BL-3 facilities identifying potential vectors of arboviruses.
SERIES: 0414

Expert at the taxonomic identification and systematic classification of mosquitoes and other biting flies that transmit human diseases. Plans and conducts detailed analysis of large groups of methodically collected specimens from the wild, does statistical analyses, determines phylogenetic relationships, estimates geographic disease risk to troops, and aids in development and testing of an expert system for threat assessment. Participates in the curation of the National Mosquito Collection and acts as consultant to the Smithsonian Institution and foreign governments.
SERIES: 0414

Conducts and analyzes tests of innovative vector suppression methods in the laboratory and field. Studies the ecology of ticks and mites as vectors of typhus, Lyme disease, and other human pathogens. Expert at collecting, identifying, and rearing arthropods from the field. Familiar with techniques of wildlife biology.
SERIES: 0401, 0408, 0410, 0414

Plans and conducts research on the infectivity of human pathogens - especially malaria parasites - to arthropod vectors. Develops and tests improved methods for parasite culture. Supervises the selection and in vitro culture of Plasmodium falciparum and Plasmodium vivax parasite isolates for use in vaccine and drug development and in genetic studies. Supervises laboratory infection of mosquitoes with cultured parasites and their use in the human challenge phases of malaria vaccine trials, according to GLP practices. Primarily responsible in the Army for collection and maintenance of cryopreserved malaria isolates for culture.
SERIES: 0401, 0413, 0414

Devises innovative, economical, and practical methods for the control by troops of disease vectors, such as those of malaria, dengue, leishmaniasis, and typhus. Conducts laboratory and field tests, prepares devices and strategics for advanced development, and oversees patent applications when applicable. Coordinates with foreign institutions and commercial partners. Supervises military and civilian scientists and technicians.
SERIES: 0414

Work involves studying the immunologic response of animals to vaccination with virus vaccines and viral antigens. Conducts, develops and improves methods for serological assays including virus isolation, serum neutralization, and enzyme-linked assays. Studies require a proficiency in the processing, storage, accounting, and retrieval of serum samples from a variety of animal species. In addition, incumbent must be proficient in cell culture techniques, including husbandry, cryopreservation, and passage procedures. Conducts, develops and improves on procedures for large scale production, purification, stabilization, and storage of viruses and viral antigens. Requires proficiency in biocontainment and biosafety procedures, handling and storage of vertebrate and invertebrate viruses, and large scale cell cultures techniques. Incumbent must be familiar with baculovirus expression systems and be capable of assisting with development and use of such viruses. Familiarity with associated basic gene cloning techniques to include manipulation of plasmids, screening for gene inserts, preparation of plasmid DNA, restriction enzyme digests, and agarose gel electrophoresis is required. Immunizations required.
SERIES: 0401, 0403, 1320

Work involves planning, organizing and conducting experimental research involving human subjects to determine the safety and efficacy of vaccines and drugs against a variety of infectious disease or biologic toxin agents of military importance. Ability to assist in Phase I & II (safety, dose finding) and Phase III (field) testing of these products and conduct research on the epidemiology of the disease in question in order to define the appropriate target population and the bases for measuring efficiacy. Ability to plan, organize and conduct research on the pharmacokinetics and pharmacodynamics of selected drugs in human subjects. Skill in writing and revising clinical protocols for studies involving human subjects and providing expert consultation and treatment of infectious diseases of military importance. Plays a role in preclinical development of experimental vaccines and drugs, particularly advanced testing of these products in small animal and nonhuman primates. These studies are designed to answer specific questions about safety, immunogenicity, or efficacy of vaccines or drugs. Immunizations required.
SERIES: 0602

Work involves cloning and expression of human antibody genes to viral pathogens of military importance. Ability to conducts research to generate and characterize phage display libraries of human antibody gene fragments (Fabs) from blood cells of immune donors. Characterizes Fabs with respect to gene sequence, protein specificity, virus neutralization, and other biologically relevant properties. Evaluates expressed Fabs for diagnostic applications. Skill and ability to genetically engineer selected Fabs to generate complete human antibodies. Ability to evaluate therapeutic potential of the antibodies using appropriate animal models. Skill andKnowledge to design novel expression systems for human antibodies. Investigates new methods for purifying expressed antibodies. Immunizations Required.
SERIES: 0401, 0403, 1320, 0440

Work involves designing and managing research programs and support services to evaluate host immunological responses to infectious disease threats. Investigates humoral and cellular constituents of protection against viral disease agents and defines key immunological determinants or correlates of protection. Suggests improvements to vaccine design or immunological therapies via investigation of humoral and cellular immune responses. Manages an in-house program and supervises personnel to develop monoclonal antibodies for use by the scientific community. Manages an in-house program to provide cell culture, reagents and media for propagation of viral and bacterial infectious organisms. Serves as a principal immunology consultant to the Command regarding issues of advanced development of viral vaccines.
SERIES: 0403, 0401

Work involves directing a multidisciplinary research program of intramural and extramural projects that perform the various functions required to develop antiviral therapeutics for the prophylaxis and/or treatment of viral infections caused by diseases of military or bioterrorist importance. Program responsibility involves two or more major and substantially different development efforts such as a requirement to develop antiviral therapeutics against two distinct classes of viruses. Work typically involves areas where little or not precedence exists to guide research. Ability to serve as senior expert advisor in antiviral research, utilizing classical virological techniques, modern methods of biotechnology and genetic engineering, animal model development and utilization for the evaluation of antiviral therapeutics and clinical trials. Serves on expert committees and scientific journal editorial boards in the area of antiviral research.
SERIES: 0401, 0403, 1320

Work involves skill, knowledge, and ability to provide effective scientific leadership, personnel management, and the acquisition and allocation of human and material resources for a department that is involved in the virology, viral pathogenesis, vaccine concept exploration, immunology, nonclinical testing, and transition to human testing of viral vaccines. Ability to assure that vaccine research and vaccine approaches are of high quality, appropriate in direction, and of proper emphasis in accordance with mission requirements. Skill in developing program content, marketing/reporting, establishing research and development agreements with business or academic collaborators, and representing/defending programs at agency, national and international levels. Ability to function as a coordinator or scientific advisor for strategic plans, technology objectives, and vaccine steering committees.
SERIES: 0401, 0403, 1320

Work requires experience in the areas of cytokine biology and chronic inflammatory disease related to oral infections. Ability to assist and interact with the primary investigators for studying interactions between host and dental pathogens. Work involves the investigation of intracellular trafficking of dental pathogens in host cells, signaling transduction events, cytokine induction, and bacteria-cytokine interactions in oral diseases.
SERIES: 0401, 0403

Work involves serving as a principal investigator planning, conducting and evaluating research on the pathobiology of viral pathogens of interest to the military. Most of the work is performed under BSL (BioSafety Level)-4 containment, but a signification proportion may involve BSL-3 containment; experience working in BSL-3 and BSL-4 is required. Initiates and conducts research utilizing animals and cell cultures, light and electron microscopy, and immunological techniques including flow cytometry, in situ hybridization and polymerase chain reaction. Investigates animal models of human disease and assesses the protective and deleterious effects of the immune response to the disease process. Extensive in-depth experience with nonhuman primate models of viral hemorrhagic fevers is essential. Expertise in cell and tissue injury caused by proinflammatory cytokines, inflammatory leukocytes, and toxic oxygen and nitrogen radicals is necessary. Determines characteristics of viral assembly and identifies potential targets for disruption of viral functions. Prepares reports and scientific research papers pertaining to studies. Immunizations required.
SERIES: 0403, 0401

Work involves conducting research on the systematics of arthropod vectors of disease organisms. This includes study of evolutionary relationships, classification, identification, population genetics, and comparative biology and ecology. Skill in employing morphological, statistical, molecular and biochemical techniques. Ability to determine vector attributes that may influence disease transmission or aid in predicting risk to troops. Ability to select and prepare field sites for testing innovative control and diagnostic methods. Skill in coordinating activities with outside agencies, including foreign governments, military or US government agencies, and civilian institutions.
SERIES: 0414

Work involves the skill, knowledge and ability to establish and carry out a research program to clone, express and analyze Brucella genes and use these gene products to elucidate the host immune response to bacterial infections and to test immunization with candidate vaccines. Some studies are carried out in biosafety level 3 laboratories. Specific tasks and approaches include immunization of animals with expressed products and analysis of the antibodies produced by immunofluorescence assay, ELISA, and Western blot and assessment of the cellular immune response by lymphocyte proliferation assays and measurement of cytokine production. Skills include oligonucleotide synthesis; DNA sequencing; construction of expression plasmids; transfection, cloning, expression and purification of recombinant proteins; isolation, purification and quantitation of DNA; SDS-PAGE and immunoblotting; chemiluminesence, PCR, and Northern blotting. development and use of assays for measurement and characterization of antibodies and cell mediated immunity, animal and human studies of vaccine immunogenicity, studies of adjuvants, and development of models for measuring vaccine potency and efficacy.
SERIES: 0401, 0403, 0601, 0602, 0644, 1320

Work involves coordination of clinical research efforts supporting malaria vaccine development. This includes the management of regulatory files, coordination of the interactions of military clinical investigators and various institutional review boards, assuring timely dissemination to all concerned parties of relevant communications, assist with clinical protocol management, interact with study sponsors and CRDA partners, assist with the management of product development plans, help manage and distribute documentation, plan, coordinate, and facilitate periodic review sessions, and oversee selected logistics aspects as needed in support of individual clinical studies.
SERIES: 0601

Work involves serving as the Program Manager for anthrax vaccine-related clinical research under the Army Vaccine Immunization Program (AVIP), Office of the Surgeon General (OTSG) developing and recommending strategies for clinical research pertaining to medical countermeasures for biological defense, particularly as related to defense against the anthrax threat. Direct a team of health care professionals and technicians to execute approved clinical research stategies for improving force protection against anthrax. Serve as consultant/member pertaining to the clinical research and use of anthrax vaccine.
SERIES: 0602

Performs research on the immunology and pathogenesis of infectious agents with specific emphasis on the development of human innate and adaptive immunity. Measuring the cellular and humoral immune responses; determining in vitro correlates of immunity; evaluating the nature of antigen processing; and optimizing vaccine preparations or immunization schedules to enhance the safety and efficacy of human vaccines. Specialization in molecular biology/molecular genetics: ability to perform sophisticated analyses on specimens from human volunteers or appropriate animal models to quantify gene expression through nucleic acid and protein analysis. Experience and expertise are required to conduct polymerase chain reaction, automated DNA sequencing, oligonucleotide synthesis and flow cytometry to isolate, identify and quantify cytokines, biochemical markers and other indicators/surrogates of immunity.
SERIES: 0403, 0404, 0440

Work involves providing veterinary anatomic pathology support to animal-use research and will include the following: 1) conducting comprehensive postmortem examinations of various species of small and large research animals, and all other related procedures and operations, under the stringent conditions of biocontainment (Biosafety Levels (BSL) -2, -3 and -4); 2) proficiency in all aspects of bright field and electron microscopic examination; 3) proficiency at interpreting morphologic changes in animal tissues and producing accurate yet concise pathology reports for both single-case and study requirements, often on a stringent time line; 4) execution of some protocols in compliance with Good Laboratory Practices; 5) a working knowledge of molecular and nucleic acid-based diagnostic assays, such as immunohistochemistry, in situ hybridization, or polymerase chain reaction, and proficiency at examining and interpreting findings. The candidate will have an American Veterinary Medical Association-recognized degree in veterinary medicine, and have diplomate status in the American College of Veterinary Pathologists in the specialty of anatomic veterinary pathology.
SERIES: 0410

The position requires capacity to serve as consultant and scientific advisor for DoD in De Novo gene expression technologies. Work involves establishing, directing basic and applied functional genomics De Novo microarray research program supporting priority missions within Walter Reed Army Institute of Research, USA Medical Research and Materiel Command, and sister agencies. The position requires subject matter expertise, and ability to provide scientific leadership in the acquisition and allocation of human, bioinformatic, and material resources for application of gene expression technologies for development and evaluation of putative anti-viral and antimalarial vaccines, development and evaluation of novel anti-viral and antimalarial therapeutics, identification of host correlates of infection to pathogens of military importance, and antimalarial drug discovery and development efforts. Additional responsibilities include reporting results in scientific literature, presentations at nation and international meetings, and preparation of command and agency briefings as requested.
SERIES: 0403

The position involves directing, planning, executing a multidisciplinary research program on host pathogen interactions of HIV and malaria using state-of-art gene expression technologies, and functional assays. Research emphasizes the fields of parasitology, virology, cytology, molecular biology and functional genomics to develop novel in vitro co-infection systems for study of pathogenesis of host/parasite interactions, and for application of gene expression technologies to identify genetic changes in both host and parasite transcriptome following HIV/malaria co-infection in humans. Research is directed at identification of important immunodeterminants of disease (HIV, malaria) to expedite development of strategies for early monitoring of infection, rapid diagnosis, vaccine development, or therapeutic intervention. Monitoring and evaluating research goals and milestones, and redirecting efforts and resources as appropriate to accomplish objectives are essential.
SERIES: 0403

Work involves a research program to investigate all aspects of pathogenesis, immunology, and prophylaxis of bacterial infections of military relevance. Work requires proficiency in the performance of and theoretical understanding of concepts and techniques of standard microbiology, biochemistry, and immunology. Performs research including, but not limited to, the following: (a) evaluate the immunological response(s) of various animal models after immunization using established serological and cell-based antibody assays and to include development of such assays (b) the safe culturing of pathogenic bacteria, (c) handling of laboratory animals to include injections and blood collection, (d) biochemical procedures to purify, characterize, and modify proteins from antisera and bacteriological cultures, and (e) maintain and propagate tissue culture cell lines.
SERIES: 0401

Work involves designing and conducting research regarding environmental physiology and temperature regulation. Person examines body temperatures, thermoregulatory control, heat loss and conservation responses with regard to environmental exposure and physical exercise. Person assesses effects of heat stress and cold stress on exercise performance capabilities as well as environmental injury. Person studies integrated responses to environmental perturbations including skin blood flow, thermoregulatory sweating, blood pressure control, vascular and baroreflex responses and sympathetic nerve activity. Responsibilities include conducting environmental chamber and field studies on human volunteers to develop military doctrine, acclimatization / training programs, pharmacological / nutritional interventions and specialized clothing / equipment to minimize thermal strain, optimize performance and minimize injury during military operations.
SERIES: 0413

Work involves designing and conducting research regarding environmental (heat, cold, altitude) exposure, physical exercise effects on fluid / electrolyte regulation. Person accesses thirst, satiation, body water volumes and exchanges and fluid /electrolyte losses in humans. Person studies associated integrated renal, endocrine, blood pressure and vascular responses supporting homeostasis with environmental / exercise perturbations. Responsibilities include conducting environmental chamber and field studies on human volunteers to develop military doctrine regarding fluid / electrolyte requirements and replacement strategies to minimizing the adverse consequences (performance and health) from fluid / electrolyte imbalances during military operations.
SERIES: 0413

Work involves designing and conducting research regarding environmental (heat, cold, altitude) exposure, physical exercise effects on blood pressure regulation and orthostatic tolerance. Person accesses sympathetic nervous activity, blood pressure, blood flow, and baroreflex control in humans. Person studies associated integrated cardiovascular, neural, endocrine responses supporting homeostasis with environmental / exercise perturbations. Responsibilities include conducting environmental chamber and field studies on human volunteers to develop military doctrine regarding blood pressure regulation to minimize the adverse consequences of hypotension during military operations.
SERIES: 0413

Work involves serving as assistant to a principal investigator, performing independent research in a program involving development of vaccines against viral agents and analysis of immune responses elicited by these vaccines. Experimentation requires highly specialized knowledge and proficiency in numerous different laboratory techniques and procedures for performing both routing and complex molecular biological and immunological analyses. Performs polymerase chain reaction, restriction enzyme analysis, automated DNA sequencing, oligonucleotide synthesis, and other molecular techniques in the development of DNA and recombinant viral vaccine candidates. Analyzes protein expression in cell culture by transient tranfection, polyacrylamide gel electrophoresis, immunoblot and immunoprecipitation. Vaccinates animals with vaccine preparations. Measures cellular and humoral immune responses by ELISA, ELISPOT, intracellular cytokine staining, flow cytometry and other immunological techniques. Performs cell culture procedures required to support viral assays and production of virus in BSL 3 or BSL 4 containment laboratories. Immunizations Required.
SERIES: 0403

Work involves planning, development, establishment, management and execution of complex medical research and development projects conducted to determine mechanisms affecting the development of Leishmania parasites in vertebrate hosts and invertebrate vectors. Exploits cutting edge technology and classical parasitological and biochemical methods to design and test innovative methods for controlling Leishmania parasites in the host and vector. Broad theoretical knowledge or hands-on experience in such disciplines as microbiology, ichemistry, Immunology, epidemiology and biostatistics in performing different aspects of research projects, and extensive knowledge and experience in directing and executing scientific biomedical research from the most basic to applied, product-oriented efforts are critical.
SERIES: 0410

Develops innovative, economical, and practical molecular assays for surveillance of militarily significant vector-borne pathogens such as dengue, leishmaniasis, and malaria. Conducts assay validation in laboratory and field tests, prepares diagnostic assays for advanced development, and oversees patent applications when applicable. Provides support for FDA validation studies. Coordinates with foreign institutions and commercial partners.
SERIES: 0401, 0414

Oversees epidemiological surveillance of bacterial isolates from burn unit patients and maintain unit's repository of historical isolates. Provides microbiology consultation/support to investigators, researchers and staff. Serves as team lead for development of assays for the rapid identification of pathogenic bacteria in wounded Soldiers, primarily PCR-based. Provides clinical laboratory services to medical researchers in the areas of microbiology, hematology, clinical chemistry, coagulation, immunology, and flow cytometry. Plans and conduct experiments and procedures to provide solutions to testing problems and to evaluate published methods and techniques for incorporation into the laboratory. Research, test, and evaluate new clinical laboratory procedures, equipment, and supplies. Reviews and implements standing operating procedures, including the definition of reference values and acceptable ranges, and interprets quality control results. Ensures that laboratory performs in accordance with College of American Pathologists (CAP) and other applicable standards, ensuring maintenance of all required logs and records. Establishes and maintains the budget for the laboratory with approval authority for order of supplies, equipment contracts, etc. Recommends use/purchase of new equipment based on such factors as efficiency, cost effectiveness, reliability, performance and overall suitability.
SERIES: 0403

This position requires the incumbent to administer and manage human subjects' protection and animal care oversight operations and policy for all Army medical research activities. The incumbent must have extensive knowledge of law, regulations and ethics governing the use of humans and animals in basic research, development and clinical research. The incumbent serves as the senior advisor on use of humans and animals in research to the CG, USAMRMC as well as all echelons of management within the Army medical research community and as a senior expert interfacing within the Department of Defense and with the Food and Drug Administration and other Federal agencies on research protection operations and policy. Ability to manage a large staff of highly qualified specialists in research protections activities.
SERIES: 0601

Work involves conceiving, planning, directing, and execution of basic and applied biochemical and immunological research programs. These would include executive involvement in missions and programs for developing liposomes as carriers of adjuvants and vaccines; for developing novel methodologies for delivery of antigens and vaccines, including needle-free technologies; for investigation of interactions of liposomal protein and lipid antigens and viruses with cells; for elucidating the role of proteasomes in antigen processing; for studying interactions of multi-specific monoclonal and polyclonal antibodies with cells and viruses; and for conducting preclinical testing of vaccines; and for other relevant missions as they are identified. Also required is direction of the analysis, interpretion, and publication of results in scientific literature and preparation of essential reports. Responsibilities include supporting priority missions such as infectious diseases, managing changes to the structure and content of research programs, exercising discretionary and executive authority to approve allocation and distribution of Army approved budget and extramural funds to the degree that is authorized in the assigned organization. Works independently, exhibits knowledge and experience in directing scientific research, and is proficient in cell culture techniques, and immunological assays.
SERIES: 0401, 0403, 0413, 0601, 1320

Performs research on the immunology and pathogenesis of infectious agents and protein toxins with specific emphasis on the development of therapeutics and vaccines. Work involves studying cell signaling mechanism for all aspects of innate and adaptive immunity as it relates to drug discovery. Measures the cellular and humoral immune responses; determines in vitro correlates of immunity; and evaluates efficacy of the experimental compound for identifying intracellular drug target for therapeutic intervention against exposure to toxins or bio-threat agents. Specialization in immunology and molecular biology. Ability to perform sophisticated analyses on immune cells from human blood or appropriate animal models to measure functional activation and quantify gene expression through nucleic acid and protein analysis. Experience and expertise are required to conduct real time polymerase chain reaction, automated DNA sequencing, oligonucleotide synthesis, RNA interference technique, cytotoxicity assay and flow cytometry to isolate, identify and quantify cytokines, biochemical markers and other indicators/surrogates of immunity.
SERIES: 0403

Conducts physical exams, sedates and anesthetizes animals, monitors anesthetized patients, performs humane euthanasia when required, provids guidance to supporting veterinary technicians, assures security of controlled drugs, reviews daily rounds records, properly documents actions in medical records, conductsanimal rounds when needed, and serves in on-call duty status on a rotational basis. Duties require knowledge of a wide range of veterinary medical concepts, techniques, principles and practices, such as: anatomy, bacteriology, chemistry, epidemiology, immunology, microbiology, parasitology, pathology, pharmacology, physiology, serology, toxicology, virology, and other basic clinical sciences applicable to diagnosis, treatment, prevention, surveillance, control, and eradication of animal diseases; detection, diagnosis, disposition, transmission, and epidemiology of animal conditions, including those that are zoonotic, foreign, or emerging, and those that may be transmitted by importing animals, animal products and by-products, and related materials; routine husbandry practices and the use of various drugs, biologics, and pesticides; routine veterinary surgical procedures, patient sedation/anesthesia, preparation, monitoring, and recovery; standards for Accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care,International and requirements established by the Animal Welfare Act and recommendations by the Guide for Care and Use of Laboratory Animals.
SERIES: 0701

Work involves planning, organizing and conducting experimental research involving human subjects to determine the safety and efficacy of vaccines and drugs against a variety of infectious disease or biologic toxin agents of military importance. Ability to assist in Phase I & II (safety, dose finding) and Phase III (field) testing of these products and conduct research on the epidemiology of the disease in question in order to define the appropriate target population and the bases for measuring efficiacy. Ability to plan, organize and conduct research on the pharmacokinetics and pharmacodynamics of selected drugs in human subjects. Skill in writing and revising clinical protocols for studies involving human subjects and providing expert consultation and treatment of infectious diseases of military importance. Plays a role in preclinical development of experimental vaccines and drugs, particularly advanced testing of these products in small animal and nonhuman primates. These studies are designed to answer specific questions about safety, immunogenicity, or efficacy of vaccines or drugs.
SERIES: 0602

The incumbent will focus on the development of medical countermeasures against orthopoxviruses and other biodefense-associated viruses. Individual will plan and direct/conduct studies aimed at the development of molecular vaccines. Studies will involve designing and testing molecular adjuvants and other strategies to enhance and optimize the immunogenicity of gene-based molecular vaccines. Incumbent's responsibility will include working with molecular vaccine delivery technology (e.g. gene gun, electroporation), working with vaccinia virus mouse challenge models, and with the optimization of orthopoxvirus animal models and their use to test novel antiviral drugs and biologics.
SERIES: 0403

Serves as a Research Scientist and manages the day-to-day operation of the computational biology efforts in the systems biology lab. Leads the development and execution of multiple research projects, formulates experimental hypotheses, develops innovative approaches, and designs and implements experimental protocols related to computational and mathematical models. Uses the scientific literature to examine cross-disciplinary research areas for developing new projects and programs. Develops necessary new software, technologies and protocols, assesses the strengths and weaknesses of the projects and their progress. Collects, processes, and interprets experimental data and model outputs. Advises and guides other research scientists. Initiates, develops, and maintains collaborations with scientists, computational staff, and external research groups for research projects and development of new approaches to existing research problems. Prepares programmatic reviews, research proposals, progress reports, and manuscripts for submission to scientific journals. Actively participates in appropriate scientific conferences. Serves as a Principal Investigator and executes research within his/her areas of expertise. Performs Contract Officer's Representative duties on specific contracts or grants within his/her areas of expertise. Presents the Institute's research in abstracts, posters, and presentations at national and international science meetings. Position requires demonstrated ability to guide and execute interdisciplinary research bridging computational work and an established record of cross-disciplinary publications in top-tier, peer-reviewed scientific journals.
SERIES: 1520

Work involves serving as subject matter expert in noise hazards, noise induced hearing loss, speech intelligibility, and hearing protection devices. Requires participation as a member of aeromedical multidisciplinary teams to identify health hazard risks that affect Army aviation. Works with other agencies to develop innovative solutions to minimize hazards in the Army aviation environment. Serves as subject matter expert for the Army to ensure full and safe product integration.
SERIES: 1310, 0180, 0413, 0602

Work involves using advanced statistical techniques to examine physiological, cognitive, psychomotor, and psychological response in the context of simulator and actual in-flight performance. Necessary analytical skills include effect factoring of performance as influenced by stressors such as sleep deprivation, and sustained flight requirements. Additionally, the position examines the effectiveness of use in sustained flight operations of various pharmacological interventions (e.g., stimulants) as compared to non-pharmacological interventions (e.g., exercise). Position requires exercising responsibility for the process of original research protocol development, initiation, data collection, analysis, and publication of government technical reports and refereed open literature publications. Supervising and directing technical personnel in the assignment of work and setting of suspenses is required. Responsibilities include additional implementation, sustainment, and reporting on internal management controls in area of operation.
SERIES: 0180

Acts for the Command General, U.S. Army Medical Command (USAMEDCOM), and serves as the senior advisor to and spokesperson for The Surgeon General, Department of the Army (TSG) on regulatory affairs and related policy and human subjects research matters within the Office of the Assistant Secretary of the Army for Acquisition, Logistics, and Technology and Office of the Assistant Secretary of the Army for Manpower and Reserve Affairs. Participates in executive-level organization's and tri-service medical materiel development program, policy setting, and management decision-making processes to establish and maintain required materiel manufacturing competencies, and keep the medical materiel development program viable and responsive to warfighter needs with regards to regulatory issues. Ensures that the Organization and its staff provide the leadership for the Army's lead and executive agent for regulated research and development responsibilities and enables broad participation by the Services in all phases of the medical materiel development and acquisition process where Joint Service requirements exist. As the key regulatory spokesperson for the USAMEDCOM and the Organization, interfaces and coordinates directly with officials in the Office of the Secretary of Defense; other federal departments and agencies; Office of the Joint Chiefs of Staff; Office of the Secretary of the Army; the Army Acquisition Executive; Office of the Chief of Staff, Army; Headquarters, Department of the Army staff and its agencies; congressional staffers and members of Congress; and the private sector (academia and private industry) on regulatory matters critical to the Organization's assigned Army programs and to stay abreast of changing program requirements and policies.
SERIES: 0601

Work involves functioning as primary investigator with skills and knowledge in mechanics, biomechanics, physics, statistics, human safety engineering, scientific methods and investigation techniques, experimental design, instrumentation, program management, and the research, development, testing and evaluation process. Preparing documentation and justification for both monetary and supportive manpower resourcing is required. As a team leader, supervising and directing scientific and engineering technical personnel in assignment of work, setting of suspense, and evaluation of performance is essential. Authoring and co-authoring technical reports, technical memos, and open literature publications are also required. Additionally, implementing, sustaining, and reporting on internal management controls in area of operation are required.
SERIES: 0601, 0858, 1310, 0830

Work involves functioning as primary investigator with skills and knowledge in mechanics, biomechanics, physics, statistics, human safety engineering, scientific methods and investigation techniques, experimental design, instrumentation, program management, and the research, development, testing and evaluation process. Preparing documentation and justification for both monetary and supportive manpower resourcing is required. As a team leader, supervising and directing scientific and engineering technical personnel in assignment of work, setting of suspense, and evaluation of performance are essential. Additionally, implementing, sustaining, and reporting on internal management controls in area of operation are required. Authoring and co-authoring technical reports, technical memos, and open literature publications are required.
SERIES: 0018

Work involves coordinating, planning, and executing biomedical scientific research programs. Develop scientific strategy as well as coordinating research and early development efforts. Recommend scientific priorities to senior leaders; recommend the prioritization of trauma and combat casualty care research portfolio. Support the development of scientific strategy and investment for combat casualty, trauma, hemorrhage, and burn biomedical research. Plan for future research investments to align with agency scientific strategy. Scan the combat casualty care and trauma field for promising technology; incorporate and further develop promising enabling technology and products.
SERIES: 0601

Work includes providing consultation and advice to the laboratory's primary investigators and research assistants on instrumentation capabilities and techniques, engineering principles, and design tradeoffs. Requires an in-depth knowledge of electronic engineering, instrumentation techniques, and standard practices. Requires the ability to recommend, specify and procure equipment needed for research.
SERIES: 0855, 0858

Work involves functioning as primary investigator with skills and knowledge in mechanics, biomechanics, physics, statistics, human safety engineering, scientific methods and investigation techniques, experimental design, instrumentation, program management, and the research, development, testing and evaluation process. Preparing documentation and justification for both monetary and supportive manpower resourcing is required. As a team leader, supervising and directing scientific and engineering technical personnel in assignment of work, setting of suspense, and evaluation of performance are essential. Authoring and co-authoring technical reports, technical memos, and open literature publications are also required. Additionally, implementing, sustaining, and reporting on internal management controls in area of operation are required.
SERIES: 0018

Work involves formulating, conducting, and directing original applied research to issues of human tolerance and mechanical insult resulting from aircraft mishaps. Additional tasks include participation in tri-service effort on efficacy of medical equipment for use aboard military rotary-wing MEDEVAC aircraft. Knowledge of system safety engineering, human factors engineering, accident investigation techniques, aviation life support equipment design, and survival is essential, as is extensive experience in military rotary-wing operations to accomplish research.
SERIES: 0018, 0801, 0856

Work involves research directed toward examining the impact of fatigue, workload, and environmental stressors as they relate to aviation flight performance. Tasks include identifying and defining aviation-related stressors, proposing methods to reduce these stressors, and developing scientific techniques to test these hypotheses. The ability to design simulator and in-flight helicopter experiments to measure and predict military flight performance under conditions likely to degrade mission effectiveness is essential. Directing and conducting studies employing objective, computerized flight performance measures, objective and subjective mental alertness evaluations, computerized cognitive function evaluations, and physiological indices to identify biomedical mechanisms which may impact aviator effectiveness in operationally relevant scenarios are required. This position requires exercising full responsibility for the process of original research protocol development, initiation, data gathering, analysis, and eventual publication in both government technical reports and refereed civilian journal formats. Ability to author and co-author technical reports, technical memos, letter reports, and open literature publications containing heretofore unknown scientific findings thereby expanding the science base of knowledge in the relevant areas of expertise.
SERIES: 0180

Execute GLP studies as Study Director in support of medical countermeasures development under the FDA Animal Rule at biosafety levels BSL-3 and BSL-4. Incumbent will have complete control over execution of regulated laboratory studies to ensure compliance with the FDA Good Laboratory Practices (GLP) regulation. Requires knowledge, skills and application of current FDA non-clinical, and pivotal animal study research. Additional tasks include preparing and reviewing SOP's, protocols, study plans, data, final reports, educating research scientists and study coordinators regarding regulatory practices and requirements, and developing local procedures and policy for FDA-regulated activities.
SERIES: 0403, 0601, 0401

Work involves development of standard operating procedures for analytical techniques utilized in the laboratory and maintaining a safe laboratory operating environment. Incumbent will ensure proper handling of hazardous and biological wastes (including blood, urine, human and animal tissues and cell culture systems), and the training/oversight of staff working in the laboratory. In addition, incumbent will serve as a subject matter expert in the proper handling/preparation of biological specimens and analytical procedures performed in the laboratory. Requires proficiency in a wide variety of laboratory skills including RNA, microRNA, and protein isolation and quantification using techniques such as RT-qPCR, gel electrophoresis, and Western blot, chemiluminescence-fluorometric enzyme activity assays, ELISA and multiplex assays, fatty acid and muscle glycogen analyses.
SERIES: 0413

Work involves formulating, conducting, and directing original basic and applied military acoustical research. Developing novel approaches and new methods for determining the efficacy of hearing protection is required. Additional tasks include collecting acoustical signature data on systems such as artillery, rocketry, tracked vehicles, and aircraft for database from which processed information can be used to improve system design, voice communications, and hearing protection standards.
SERIES: 1310, 1301, 0858

Work involves formulating, conducting, and directing original, basic, and applied research efforts on topics related to head impact protection, personnel seating and restraint systems, crash survivability design of aviation systems, personnel life support equipment and armor, human tolerance to acceleration and vibration, and design of in-flight emergency escape systems. Developing and validating test and evaluation procedures to determine the protective capability and acceptability of Army protective helmets and equipment are required. Determining injury mechanisms and developing effective means of preventing or mitigating injury through investigations and analysis of equipment recovered from helicopter accidents are also essential.
SERIES: 0830, 0018

Work involves formulating, conducting and directing original basic and applied biomechanics research efforts on topics related to musculoskeletal tissue and viscera response to mechanical stimulation or insult. Establishing criteria for safe levels of short and sustained exposure to mechanical stimulation or insult, determining injury mechanisms related to mechanical insult, and developing effective means of preventing or mitigating injury are all essential tasks. Developing theories and models of complex injury mechanisms associated with both acute and chronic exposure to mechanical insult is also required.
SERIES: 0858

Provides support in the execution of research protocols and subsequent analysis of data. Specific responsibilities include (but are not limited to) study preparation and supporting study logistical requirements, data collection in accordance with established protocols, biological sample collection and pre-analytical processing, use of statistical software such as SPSS to collect and process data, performance of dual energy x-ray absorptiometry (DEXA) and peripheral quantitative computed tomography (pQCT) scans, and administration of survey/questionnaires. The incumbent must have demonstrated experience collecting research data from test volunteers operating in complex environments.
SERIES: 0413

Work involves formulating, conducting, and directing original applied research efforts on topics related to aviation life support equipment (ALSE) and systems. Establishing design criteria and validating ALSE for the human-aircraft interface, utility, and injury risk reduction are required. The position requires knowledge in system safety engineering, human factors engineering, accident investigation techniques, ALSE design, and survival. Extensive experience in military rotary-wing operations to accomplish research is also necessary.
SERIES: 0018, 0801, 0856

Serves as associate Department Chief in the Division of Experimental Therapeutics. Plans, manages, directs and supervises department staff under the direction or in the absence of Department Chief. Advises and works with department chief to lead a staff of 30 + personnel who are engaged in the accomplishment of research efforts critical to the mission and success of the Division. Work involves knowledge of Army policies and regulations, administrative and financial functions pertaining to personnel and research support needs to include: military and civilian personnel; resource management; logistics; information management; facilities management; central laboratory support; safety; veterinary services; marketing, technical transfer and public affairs; DoD acquisitions, and research quality assurance for the laboratory.
SERIES: 0403, 1320

Work involves managing and executing an infectious disease research and development program directed at the discovery and transition to advanced development of drugs, vaccines and diagnostic assays for the treatment and prevention of naturally occurring infectious diseases. Supervise a staff of scientists and technicians, mentoring and developing others. Prepare budgets, annual reports, and other taskers. Exhibit knowledge and experience in directing scientific research and developing strategic plans for the organization. Provide expert consultation to USAMRMC in areas of expertise. Serve as CORs, reviewer of proposals as requested. Report scientific work in published reports and presentations and briefings.
SERIES: 0403, 1320

Work involves serving as subject matter expert in ALSE design criteria and validation for the human-aircraft interface, utility, and injury risk reduction. Participating as a member of aeromedical multidisciplinary teams to identify hazards and safety risks that impact Army aviation is required. Working with other agencies to develop innovative solutions to minimize the safety hazards in the Army aviation environment and serving as subject matter expert for the Army to ensure full and safe product integration are also required.
SERIES: 0018, 0602, 0858, 0180

Work involves the scientific expertise needed to support a drug development program with an in vitro and in vivo testing strategy designed to combat the anti-parasitic and anti-bacterial diseases that could affect the warfighter. Experience with design, optimization, and execution of various in vitro and in vivo test systems for malaria, leishmania, and multi-drug resistant bacteria is required. The ability to manage the acquisitions strategy to support these test systems is also needed. Responsibilities would include serving as a COR on supply and service contracts, reporting to the Division on research activities, preparing related FDA documents to support IND submission, and periodic reporting to funding sources.
SERIES: 0403

Work involves designing and conducting research directed toward characterizing the forces placed on specific body parts (bones, muscles, joints) during exercise and/or military tasks and performing biomechanical analysis through kinematic techniques to assess mechanical and physiological responses and medical or performance readiness outcomes to physically demanding occupational and operational requirements (e.g., load carriage performance). Experience in quantifying muscle activity by electromyography and other technologies is recommended. Ability to generate hypothesis driven protocols and conduct biomechanical research studies independently on human subjects is required. Applying and elucidating knowledge on complex biomechanical and physiological mechanisms of muscle contraction and/or power development during intense physical exertion (such as during exercise or military performance tasks) is essential.
SERIES: 0413, 0602, 0858

Work involves serving as subject matter expert in health hazards of vibration and repeated impact environments, lethality assessment of blunt impacts, injury assessment of whole body acceleration, and adverse effects of head supported devices. Duties include participating as a member of aeromedical multidisciplinary teams to identify health hazard risks that affect Army aviation. In addition, working with other agencies to develop innovative solutions to minimize health hazards in the Army aviation environment is essential. Serving as subject matter expert for the Army to ensure full and safe product integration is also required.
SERIES: 0858, 0601, 0602, 0018

Work involves designing and conducting research and model development/verification in the interface area of biophysics and engineering related to human physiological responses to environmental extremes. Designing novel methods for incorporating physical factors and biomedical engineering coefficients to discover ways in which environmental hazards can be curtailed in humans is also required.
SERIES: 0180, 0401, 0413, 0858, 1310, 1520, 1529, 0602

Responsible for the full scope of library operations, administration, and program management of the USA USAMRMC Library System. Work involves serving as the primary advisor to the MRMC Commanding General and staff, on matters relating to Library management. Ability to interpret Army Regulations, write Command policy, and provide guidance to other MRMC Libraries. Responsible for providing technical guidance and consultation, and training for the staff of 5 USAMRMC full-service libraries. Conducts staff assistance and site visits to USA MRMC libraries, analyzing activities, programs, and personnel. Provides evaluations, recommendations, and solutions to commanders related to biomedical library policy and functions. Consolidates reports and data from USAMRMC libraries for submission to higher headquarters. Initiates and coordinates contract support on MRMC contracts for library products and services (e.g., integrated online library system software; online resources). Responsibilities include development of contract specifications, provision of technical advice to the contract officer, and the performance of Contracting Officer Technical Representative (COTR) functions. Develops short and long range library plans, policy, and programs for the USAMRMC Library System. Plans, reviews, analyzes and implements technological applications for command-wide implementation to improve user access and promote efficient operations. Assesses the effectiveness of the USA MRMC Library System through systematic studies and analysis of management reports submitted annually by the libraries, reviewing the professional literature, and closely monitoring leading university and private sector medical library systems to keep abreast of the latest and most efficient practices, trends, and technological innovations.
SERIES: 1410

Serves as liaison with user groups, establishes cooperative linking with other libraries and/or information centers, and maintains contact with professional organizations. Maintains currency in library profession. Functions as the organization's library representative and liaison with DA, DoD or other Federal agency library or information management committees and workgroups. Serves as backup representative to the Department of Army Library Program Army Library Steering Committee.
SERIES: 1410

Work involves designing and conducting research using animal models to evaluate the effects of environmental extremes and pharmacologically active compounds (antidotes, therapies, vaccines, medications), alone and in combination, on mammalian physiological responses.
SERIES: 0180, 0401, 0405, 0413, 0701, 0403, 0602

Work involves planning and developing methods for establishing the validity of heat stress and cold stress prediction models. Tasks include developing and analyzing modeling algorithms defining physiological responses to thermal environments or the wearing of protective clothing. Additional requirements include using statistical methods to derive biophysical transfer coefficients needed in model analysis, and developing global biomedical models, such as MERCURY, for human biophysical studies (e.g., insulative or heat transfer determinations) on the effects of environmental extremes.
SERIES: 0401, 0413, 0858, 1520, 0602

Work involves designing and conducting research involving the fields of environmental physiology and clinical medicine as applicable to the laboratory and field study of human physiological responses attributable to heat, cold, and high terrestrial elevations. Assessing physiological responses in the field in response to actual climatic extremes and assessing the physiologic limitations on work performance and susceptibility to climatic injury are required tasks. Assessing the effects of heat and cold stress levels on humans as affected by the introduction of drugs, hydration levels, workloads, and protective clothing/equipment is also required. Additional responsibilities include conducting physiological chamber trials to validate predictions of heat transfer or work capacity and assessing environmental heat or cold problems and synthesizing results into models to predict mission performance capabilities and/or limitation of troops in hot, cold, and high terrestrial environments.
SERIES: 0180, 0401, 0405, 0413, 0602

Serves as the USAMRMC Command Librarian and as head of US Army Medical Research Institute of Infectious Diseases library. Responsible for library policies, objectives, vision, and direction. Ensures the library is effectively supporting the mission of USAMRIID and that all USAMRMC libraries are supporting the mission of the USAMRMC Command. Oversees the public and technical library functions performed by the library. Develops and implements new public and technical services to ensure the library is best supporting the needs of USMRIID staff. Evaluates and acquires computer hardware and software to improve clients' access to resources. Ensures clients' access to resources. Plans and executes the budget. Markets library services and products to current and potential clientele. Ensures USMRIID staff have access to needed information resources to perform their mission. Evaluates vendor services in terms of cost-effective service. Monitors interlibrary loan services to ensure the library borrowing complies with CONTU Guidelines or copyright law.
SERIES: 1410

Work involves designing and conducting research in the fields of occupational physical task performance, manual materials handling, and exercise physiology. Assessing and detailing the physical demands of individual soldier tasks so as to enhance the efficiency and capacity of physical task performance and avoid injury related to such tasks are required. Developing tests and procedures to evaluate physical task performance and developing training programs or alternative procedures to enhance task performance is critical. Additional responsibility involves creating strategies to establish physical standards for military jobs.
SERIES: 0180, 0413, 0601

Responsible for directing the identification, development, establishment, management and execution of complex, basic and applied research to support mission priorities. Also responsible for managing the structure and content of research programs; coordinating the supervision and mentoring of doctoral level researchers and junior and early-career staff. Further managerial responsibilities include planning and establishing objectives for complex task areas and helping the Division Chief with the establishment of guidelines for subordinates; determination of resource allocations and direction of overall accomplishment of program areas by making necessary adjustments, modifications, and revisions to meet program objectives.
SERIES: 0413

Work involves knowledge and application of epidemiological methods and principles independently as a principal investigator on a variety of research projects focused on the role of nutrition or malnutrition as risk factors in the development of illness and injuries of military relevance, and contribution to military readiness. Work involves original research and direct consultative support to other investigators, organizations, and agencies regarding appropriate design and interpretation of research as well as providing estimates of the meaning and practical operational significance of trends in data obtained from military databases and other sources. Participates in manuscript and oral/poster presentation development from research findings. Requires specific knowledge in epidemiology and public health and research experience including knowledge of human subjects protection regulations.
SERIES: 0630

As a senior scientist at the Department level, incumbent is responsible for the development and oversight of chemical and biological (CB) security policy for the nation's CB defense program. Employee is responsible for planning and directing program efforts to develop, maintain, and enhance the security and safety of material and personnel involved in the nation's CB defense research program. Evaluates technological trends and establishes developmental projects to explore promising approaches for achieving cost effective advancements in state-of-the-art security and safety technology. Conducts special studies involving assessment of known hazards commonly found at chemical and biological research facilities. Work requires extensive knowledge of DoD chemical and biological security policies, precedents, goals, and objectives as well as technical knowledge of the scientific protocols in use and being developed at DoD chemical and biological research laboratories. Maintains a detailed and complete working knowledge of all DoD and US government security and safety rules and regulations. Provides professional and technical analysis and policy development, implementation, and oversight support for CB agent security, personnel reliability, transfer and inventory control, and consequence management. Provides technical analysis which leads to the development of policy and implementation actions for CB agent physical security, information security, safety, transportation, inventory, and accident response; to include writes and updates DoD Instructions, Directives and manuals. Maintains liaison with executives of Military Services, and other Government Agencies and Departments, industry, professional and technical associations and academia responsible for CB security and safety policy development and execution.
SERIES: 0401

Work involves planning, initiating, conducting, and completing original research on human behavior in the military both independently as principal investigator and collaboratively as associate investigator. The position requires specifying, coordinating, conducting, and reporting on data analysis for hypothesis testing and descriptive research using field generated questionnaires, individual and small group interviews, and observational data. The application of administrative data systems to the scientific assessment and evaluation of soldier behavior issues in this research is also required.
SERIES: 0101, 0180, 0601, 1520

Duties include designing and implementing an experimental human physiology research program to attenuate bone stress injury rate and optimize performance by investigating bone biochemical and microarchitectural adaptations to military-relevant occupational stress, exercise, and environmental extremes. Requires knowledge of bone biology, exercise and environmental physiology, and use of state-of-the art imaging technologies, biochemical and applied exercise science laboratory techniques, and body composition assessments to identify candidate mechanisms suitable for exploitation by targeted physical training interventions and materiel solutions to enhance optimal musculoskeletal health, function, and performance. Requires experience in writing research proposals and grant applications, publishing research findings in peer-reviewed scientific publications, and presenting research at national and international scientific conferences, academic seminars and symposia. Additional requirements include experience and capability of coordinating and collaborating with industrial, military, academic, and clinical partners in the disciplines of applied and clinical bone and exercise physiology research.
SERIES: 0413

Work involves planning and performing a research program in neurobiology to identify neurobiological mechanisms of action of military threats. These threats include exposure to biological and chemical agents, blast overpressure, operational stress, hemorrhage, and brain trauma. The ability to utilize whole animals, brain slices, synaptosomes, and neuronal cell cultures for identifying markers of injury and for screening potential neuroprotectants is required. Measuring ion channel traffic using neuronal cultures and sophisticated imaging equipment and localizing neurotransmitter receptors affected by injury/exposure to specific brain regions is also required. Additional responsibilities include reporting results in scientific manuscripts, technical reports, and presentations at scientific meetings.
SERIES: 0401, 0405, 0413, 1320

Work involves planning and performing a research program in neurochemistry and neuroendocrinology in support of military mission needs. Determining brain neurochemical mechanisms affected by head injury, infectious disease, operational stress, ischemia, trauma, hemorrhage, blast overpressure, and chemical and biological threats is required. An additional requirement is elucidating biochemical mechanisms that underlie pathophysiological changes in brain following injury/exposure in order to design rational therapeutics targeted to intervention points suggested by knowledge of the mechanisms involved. Designing and performing assays for neurotransmitters, receptors, hormones, and neuromodulators are also required. The ability to utilize animal models, brain slices, synaptosomes, and neuronal cell cultures as appropriate is essential.
SERIES: 0401, 0405, 0413, 1320

Work involves designing, conducting, and directing basic and applied research in nutrition and physical and psychological performance. Defining nutritional standards/requirements for operational rations in terms of health and performance indicators is required. Evaluating effectiveness of rations, field feeding systems and garrison dining facility feeding on indicators of nutritional status, health and physical/cognitive performance is also required. Developing nutritional strategies to support and enhance military performance is essential.
SERIES: 0180, 0401, 0405, 0413, 0630

Work involves functioning as researcher in the design, conduct, and analysis of human kinesiology and biomechanics to examine forces impacting muscle and bone function relevant to military performance research questions. Technical skills and knowledge in biomechanics include the collection and analysis of movement patterns through motion capture, force platform and electromyography metrics, as well as statistical software for data analysis and mathematical modeling (e.g. MATLAB, finite element analyses) that relate to assessment of musculoskeletal injury risk. In addition, work responsibilities include measurement and data analyses of bone microarchitecture via bone imaging technologies (tibia bone scans) and other bone/muscle/whole body composition metrics. Applying and elucidating knowledge on the physiological and biomechanical mechanisms associated with optimal bone and muscle as well as musculoskeletal injury risk is critical.
SERIES: 0858, 0413

Responsible for planning, coordinating and executing division resources in consultation with the division's Chief and principal investigators, and the institute's Resource Manager, to include the research program spend plans and funding allocations to support the advancement of the division's research fellowship program. Further managerial responsibilities include helping the Chief with complex tasks assigned by institute Command, senior leaders, and stakeholders. Finally, will serve as liaison between the Chief and principal investigators to manage the accountability of overall research milestones and deliverables to meet approved program objectives.
SERIES: 0413

Duties include designing and implementing an experimental human kinesiology and biomechanics research program to examine forces affecting muscle, bone, joint, and tendon/ligament function in an effort to mitigate musculoskeletal injury risk and optimize occupational and physical performance during military training and operations. Requires technical skills and knowledge in the collection and analysis of movement patterns using motion capture, force platform and electromyography metrics, and statistical software for data analysis and mathematical modeling that relate to the assessment of musculoskeletal injury risk and performance. Requires experience with wearable sensors and other field-expedient approaches to assess motion analysis. The ability to apply physiological and biomechanical knowledge base of the mechanisms associated with musculoskeletal loading and injury risk for military personnel is critical. Finally, requires experience in writing research proposals and grant applications, publishing research findings in peer-reviewed scientific publications, and presenting research at national and international scientific conferences, academic seminars and symposia.
SERIES: 0413, 0858

Work involves formulating, designing, and executing research programs on human performance effects (including EEG, endocrine, immune, neurochemical, psychomotor, memory, and mood effects) of sleep loss. Tasks include determining the physiological substrate underlying sleep/arousal states. Developing interventions and strategies to counteract sleep loss effects during military operations (e.g., pharmacological and behavioral interventions) is essential. Reporting results in the scientific literature, through presentations at scientific meetings and in technical reports is required, as is providing briefings as requested.
SERIES: 0180

Work involves planning, designing, and performing a neuroscience research program to develop improved therapeutics for neuroprotection of soldiers. Military threats that affect the central nervous system include trauma, ischemia, infectious disease, operational stress, blast overpressure, and biological and chemical threats. The position involves developing and utilizing whole animal models of injury and threat exposure to test potential neuroprotectants. Additional requirements include the ability to utilize neuronal cell cultures to screen potential therapeutics and to assist in elucidating pathophysiological mechanisms of injury/insult. Essential responsibilities include reporting results through publications in the scientific literature, presenting at scientific meetings, providing technical reports, and providing briefings as requested.
SERIES: 0401, 0405, 0413

Work involves coordinating with Principal Investigators (PIs) and Lead Scientists in managing and executing in vitro and in vivo infectious disease research projects directed at the discovery, and transition to advanced development, of therapeutics for the treatment and prevention of infectious diseases of pandemic potential. Support a staff of scientists and technicians, mentoring and developing in the execution of experimental and BSL-2, BSL-3, and BSL-4 lab related work. Help in preparing budgets, technical, monthly, and annual reports, and other requirements as directed. Exhibit knowledge and experience in the execution of scientific research and help develop strategic plans for the Branch. Provide expert consultation to Branch, Division and/or Institute staff in research areas related to the Therapeutics Discovery Branch (TDB). Report scientific work in published reports, presentations, and briefings.
SERIES: 0403

Work involves designing and conducting research in the field of nutrition science to determine the effects of new rations and feeding systems on health and performance. Determining the effects of nutrition education programs on nutritional status, health, performance, and nutritional knowledge is also required.
SERIES: 0180, 0630, 0413, 0601

Work involves planning and conducting military medical research designed to identify factors that have an impact on soldier health and unit cohesion. Additional tasks include designing surveys, conducting interviews, and analyzing and evaluating results using advanced statistical techniques and computer software. Providing key leaders and policymakers with information to maintain soldier readiness and performance and prevent loss of soldiers as psychiatric casualties is essential.
SERIES: 0180

Work involves development and implementation of research programs to study operational and deployment stress issues. Planning, organizing, and executing research programs with deployed forces, including preparing and training teams for deployment, leading teams in operational theaters, analyzing and reporting results of the data obtained, and making recommendations to theater commanders and senior Army leaders are required. Supervising doctoral level Research Psychologist and enlisted and civilian support staff as assigned is also required. Additional tasks include supervising administration and budget, and execution of the Department, and ensuring members' work is published in Army professional publications and in scientific literature.
SERIES: 0101, 0180, 0601, 1301, 1306, 1310, 1530, 0018, 0201, 0205, 0332, 0340, 0343, 0346, 0391, 0505, 1035, 1082, 1083, 2001

Duties include designing and implementing an experimental basic science and applied human physiology research program centered on optimizing the molecular regulation of muscle mass, regeneration, remodeling and repair in response to injury, disuse, exercise, and military-relevant occupational stressors (e.g., load carriage, under nutrition, mechanical strain). Requires core understanding of exercise physiology and the application of basic science techniques, to include (but not limited to) executing experiments using cell culture and small rodent models, stable isotope modeling of metabolism, and molecular biology, with an emphasis on the analyses of intracellular microRNA, RNA, and cell signaling pathways. Additional requirements include experience with exercise testing, prescription, and analyses of tissue samples (e.g., blood, urine, and muscle) collected from human research participants. Capability to mentor junior scientific and technical staff and foster an intra and extramural collaborative program is required. Finally, requires experience in writing research proposals and grant applications, publishing research findings in peer-reviewed scientific publications, and presenting research at national and international scientific conferences, academic seminars and symposia.
SERIES: 0413

Responsible for providing leadership and management in planning, coordinating, programming, and executing scientific research, analytical, educational and programmatic activities of a large research division in direct support of the Institute Commander. Exercise full responsibility for daily oversight of the programmatic and administrative activities of the Division. Demonstrate the ability to make decisions with wide latitude and independent judgment, largely operating on a day-to-day basis in an independent manner. Exercise skill in directing and effectively managing the work of a complex organizational division. Establish guidelines for subordinates (including multiple levels of subordinate supervisors and team leaders). Serve as a Rater for civilian and military personnel within the Division. Serve as liaison between the principal investigators and Institute Commander to manage the accountability of overall research milestones and deliverables to meet approved program objectives. Provides guidance and oversight to division personnel on all division-related research activities to include technical and professional publications and symposia; and military related publications and reports. Knowledge and experience in directing scientific medical toxicology research from the most basic to applied, product-oriented efforts are critical.
SERIES: 0413

Subject Matter Expert (SME) and Program Manager (PM) responsible for the implementation of DOD Risk Management Internal Control Program. Reviews, establishes, and monitors Internal Control standards at the Headquarters level and provides oversight and expert guidance for all subordinate unit's Assessable Unit Managers and Internal Control Administrators. Documents any material weaknesses and tracks the progress of corrective actions through to completion. Interprets Higher HQ Risk Management Internal Control policies and regulations, authors, and edits HQ regulatory guidance, tracks subordinate unit's RMIC progress and status, analyzes the RMIC unit status and prepares the annual statement of assurance reports for HQ for submission to Higher Headquarters upon the approval of the DTCG Commander. Ensures the accurate and timely execution of the Command-wide program for the Commander, including required training and role assignments are met.
SERIES: 0501

Work involves designing, conducting, and directing research aimed at establishing basic mechanisms, physical and biophysical principles, thermal modeling techniques, and indices of heat and energy exchanges between humans and extreme environments for clothing systems and equipment.
SERIES: 0413, 0858, 1310, 1520, 1529

Work involves formulating, developing, and conducting tests to assess predictive modeling systems for determining the limits for normal human exposure to environmental extremes and workloads. Formulating and developing computer prediction modeling systems by selecting, adapting, and deriving mathematical models and translating into software to predict soldier performance capabilities are essential.
SERIES: 0413, 0858, 1310, 1520, 1529

Work involves performing duties as an aviator for research flight protocols.
SERIES: 2181

Work involves development and implementation of basic and applied research programs to sustain performance and effectiveness during continuous military operations (i.e., when there is little or no opportunity for sleep). Supervising multidisciplinary doctoral level researchers including psychologists, neurologists, psychiatrists, and physiologists as well as technical support and administrative staff as assigned is required. Additional responsibilities include supervising administration and budget, and overall execution of the program.
SERIES: 0101, 0180, 0401, 0405, 0413, 0601, 0602, 0858, 1530

Work involves leadership and research oversight of Soldier and Family Studies. Supervising doctoral level staff members and support staff as assigned, and overseeing departmental administration and budget execution are necessary. Research efforts should focus on individual, group and environmental variables affecting the physical, mental, and social health of soldiers and their families. Research results should be published in the professional literature and are briefed to senior Army leaders to maximize combat readiness and soldier/family quality of life.
SERIES: 0101, 0180, 0601, 1301, 1306, 1530, 0018, 0332, 0340, 0391, 0505, 1035, 1082, 1105

Work involves acting as principal investigator and program manager. This position entails planning, budget execution, development of research protocols, human subjects protection and monitoring, data gathering, analyzing data, and publishing. Research is conducted on areas that affect soldier combat readiness and military family functioning. Soliciting funding support from other DOD agencies and research end users is required. Synthesizing research findings into reports for end users and sponsoring organizations is essential. Preparing research reports for publication in scientific journals is also required.
SERIES: 0101, 0180, 0601, 1530, 0340, 0391, 1083

Work involves conducting military research to provide information that enhances operational readiness. Tasks include developing surveys and analyzing data collected. Responsibilities include preparing and presenting initial briefings focusing on soldier readiness to field commanders and senior Army leaders, as well as making recommendations for reducing operational stress and maximizing soldier motivation and performance.
SERIES: 0180

Designs and conducts applied research projects in the field of human physiology. Performs thermoregulation studies in order to determine heat, cold and hypoxia stress levels on humans as affected by introduction of biomedical products and protective clothing/equipment. Conducts physiological chamber and field tests to assess health hazard assessment problems. Synthesizes empirical physiological results into models to predict mission performance capabilities and/or limitations of troops in hot, cold, and high terrestrial environments.
SERIES: 0401, 0413

Work involves research in lasers, electro-optics and biophysics designed to describe acute retinal/ocular response to visible and near IR laser irradiation and to determine and model the interaction mechanisms. Serves as subject matter expert on acute laser bioeffects and project team leader in areas of lasers and optics, dosimetry, retinal alteration, and optical evaluation. Interacts with other research scientists and meets interdisciplinary objectives in efforts to determine laser effects on vision and performance and treatment of laser eye injury. Serves as consultant to other DoD or civilian activities on laser bioeffects/safety and eye protection issues. Requires specialized knowledge in physics, biophysics, optical design and engineering, experimental design, statistical methods, ophthalmology, vision, ocular anatomy and physiology, electromagnetic radiation interactions with tissue, dosimetry and medical imaging.
SERIES: 1310, 0413, 0662, 0858, 1306, 1520, 1529

Work involves designing and implementing a basic and applied research program to investigate the systems-level physiological, cellular and/or molecular basis for the regulation of structural and functional protein, peptide, and amino acid metabolism in liver, skeletal muscle and/or brain during exercise and exposure to stressors including malnutrition and environmental extremes. Work requires skill in establishing new or existing animal, human or in vitro experimental models appropriate to elucidate candidate metabolic mechanisms suitable for exploitation by novel nutritional interventions to sustain and enhance physical and mental performance and optimize biological function. Experience is required using and adapting existing research technologies and developing new procedures to study cellular, tissue and organ system responses to exercise and environmental stress and nutritional manipulation. This research will involve the use of experimental procedures and laboratory equipment required for muscle and organ perfusion studies, tissue sampling and quantitative assay of metabolite concentrations, metabolic flux analysis, and protein turnover.
SERIES: 0413

Work involves research into the biophysical, and biomechanical responses of warfighters. The ability to integrate physiologic systems from sensors that predict performance, locomotion, hydration, & exercise limits is a requirement. Work requires ability in transforming empirical biophysical data such as energetic cost, physical forces, terrain slope coefficients into model algorithms applicable to the Warfighter Physiological Status Monitoring (WPSM) hardware/software items. Candidate has used of a variety of biophysical and physiological Work requires ability to plan, develop, implement, and or conduct research to define mechanisms of response relevant to WPSM. Research will include skill in investigating the effects of environmental and operational stressors and personal status limits on the mechanisms of physiologic response. Ability to review contract proposals in area of expertise and serve as Contracting Officer's Representative when required.
SERIES: 1320, 0413

Work involves regulatory affairs and quality assurance support for advanced and early 'tech base' medical product Development efforts involving Food and Drug Administration (FDA) Phase II and III human trials conducted according to current Good Clinical Practices (cGCP) to demonstrate safety and efficacy of candidate biologicalinvestigational new products. Responsibilities include support for current Good Clinical Practice (cGCP) regulation compliance. Skills required include knowledge and application of FDA clinical research, regulations and guidelines; ability to store and access a vast archive of patient medical records for human protocols and oversee the data entry staff for this essential patient data; ability to serve as point of contact with civilian and military participants in the special immunization program; ability to writes MOAs and Cooperative Research and Development Agreements (CRDA) to support services provided to other institutions; and ability to prepare Investigational New Drug (IND) annual reports in support of vaccines used within the institution and at other institutions. IND annual reports are mandated by federal regulations and are forwarded to the FDA.
SERIES: 1520, 1910, 0301

Work involves functioning as a principal or associate scientific investigator conducting research on directional hearing, binaural and three-dimensional auditory displays, and other issues relevant to hearing and military air operations. Position requires skills and knowledge of scientific methods and investigation techniques, experimental design, instrumentation, statistics, acoustics, and hearing science, especially relating to research on directional hearing. Ability to set up and conduct hearing research from which information can be gained relevant to the use of auditory displays on voice communication and auditory performance in noisy environments in normal and hearing-impaired listeners is required. Work involves eventually becoming a subject matter expert for the Army for aeromedical hearing research and development.
SERIES: 0180

Work involves planning and performing a research program to identify the effects of military threats on gene expression using non-mammalian and in vitro models. Threats include primarily toxic industrial chemicals or materials (TICs/TIMs), and military relevant chemicals (MRCs). Elucidating the genes involved in the toxic mechanisms that underlie the progressive pathophysiology of injury/exposure in order to rationally design new bioassay and biomonitoring methods. The ability to utilize non-mammalian models as well as complementary cell culture techniques to discern mechanisms and test potential outcomes is required. An extension of the gene expression includes research involving proteins or proteomic approaches. An additional responsibility is reporting results in the scientific literature, at presentations at scientific meetings, through technical reports, and at briefings as requested.
SERIES: 0403, 0401

Conducts physical examinations and routine outpatient medical care of aircrew IAW ARs 40-501, 40-3, 95-1, and 95-20. Conducts aeromedical education programs for military and Department of the Army civilian flight crews and pilots; programs include aviation physiology, global survival, and aviation human factors. Conducts medical and survival aspects of aircraft accident investigations. Participates in aerial flight in military aircraft as crewmember. Engages in policy development, planning, evaluating and administering aeromedical publications (aviation safety brochures, research technical reports, Army aeromedical policy letters (APL) and other didactic materials (training manuals, multimedia products, presentation materials, etc.) used to disseminate aeromedical information to promote aviation safety.
SERIES: 0602

Work requires inputting flight time into the Automated Flight Record Systems and maintaining monthly flight time for assigned aviators, flight surgeons and non-crewmembers. Must have flight operations experience in maintaining records and files, accessing and updating records to include generating weekly, monthly, and quarterly flying hour reports. Responsible for maintaining the unit's aviation reading file and the DoD FLIP account.
SERIES: 2181

Work involves designing and conducting research involving the fields of environmental physiology and clinical medicine as applicable to the laboratory and field study of the human visual system. Assessing physiological responses in the field in response to changes in visual stimuli and assessing the physiologic limitation on work performance and susceptibility as related to these changes are required tasks. Additional responsibilities include the conduction of physiological trials to validate predictions and assumptions concerning visual performance under varied environmental and visual circumstances.
SERIES: 0413

Work involves serving as Pilot-in-Command/Instructor Pilot of units assigned aircraft/flight simulator for the process of original research from flight protocol development, flight profile initiation, in-flight data gathering and analysis, and contribution to preparation and publication in government technical reports and scientific journals. Work requires knowledge and skillful application of aviation experience, aviation operations, risk evaluation and reduction, research methods and practices on a variety of research projects focused on the protection, safety, risk, reduction and improved performance of the Army aviator or aircrew. Requires ability to coordinate with investigators of other government research facilities, provide assistance in determining flight profile modes, maneuvers and equipment necessary to facilitate data gathering. Ability to conduct research flights designed to qualitatively and quantitatively evaluate the efficacy and potential of data collection for approved research protocols, or of expressed products with specific relevance to pilot performance, pilot workload, mission compatibility, simulation and/or data collection techniques, and regulations governing air movement, aircraft modifications/operations, and pilot responsibilities. Ability to conduct aviation risk evaluation procedures, prepare risk matrixes and recommend and evaluation risk reduction measures. Ability to provide skillful ground and flight instruction to subject aviators, data collectors, and aircrew members in accordance with the approved research plan and aviation regulations and directives. Responsible for the safe and effective conduct of flight profiles in the aircraft and/or flight simulator. Requires specific knowledge of and experience in the unit's UH-60 Synthetic Flight Research Simulator, and the ability to collect data via the data acquisition system, as well as certification as an Army pilot in the UH-60 and HH-60 aircraft.
SERIES: 2181

Work involves planning and performing neuropsychological research to determine effects of military threats on brain physiology as it relates to the visual system. Assessing the effects of injury, blast overpressure, operational stress, neurotoxicants and infectious disease upon the visual system. Reporting results in the scientific literature through presentations at scientific meetings, in technical reports and in briefings as requested is required.
SERIES: 0413

Responsibilities include but are not limited to administrative and regulatory support for completeness and submission to the FDA of all Pharmaceutical regulatory documents and reports of INDs, IDEs, MFs, NDAs, PLAs, and ELAs. Monitor due dates, initiate processes and assist in preparation of OTSG-sponsored IND annual reports for FDA-regulated products with the point-of-contact personnel as well as ability to maintain the current status of all OTSG-sponsored IND products and protocols and official Department of the Army files for such documents. Ability to coordinate the preparation and maintenance of the automated document management system (DMS) and entry of required data into the information management system (IMS). Candidate must possess the knowledge and skill to administratively revise the input and present the input for review and approval.
SERIES: 0301

Responsibilities include, but are not limited to, administrative and regulatory support for advanced and early "tech base" medical product development efforts involving FDA human trials conducted according to current Good Clinical Practices (cGCP) to demonstrate safety and efficacy of candidate pharmaceutical, biological and medical device investigational new products. Candidate must possess the knowledge and skill to administratively review and revise data received and present the revised data for review and approval. Skills required include comprehensive knowledge and application of FDA Title 21 Code of Federal Regulations (21.CFR), clinical research, regulatory compliance and quality review of submissions to FDA relating to product approval; regulatory affairs guidance and policy document development, regulations and guidelines to ensure FDA clinical research compliance, highly developed communication and negotiating capability. Assists in the tracking of OTSG-sponsored IND products; As well as annual Report due dates and maintenance of the electronic document and information management systems. Regulatory duties include completion of FDA forms (e.g. 1571, 1572, 2252) per 21.CFR and/or USAMMDA policy and/or regulations. Individual must possess excellent written and oral communication skills.
SERIES: 0301

Work involves planning and conducting research in the area of hemorrhage, circulatory shock, and trauma as they relate to both military and civilian issues. The ability to elucidate the biomedical and molecular mechanisms underlying the pathophysiological changes following hemorrhage and trauma and devise means to ameliorate them is essential. Additional tasks include developing new methods and adapting existing methods to solve research problems directed at understanding the cell and molecular biology of cell injury and repair. Overseeing and conducting research utilizing animals and cell cultures, light and electron microscopy, immunological techniques, in situ hybridization and polymerase chain reaction are also required, as is preparing reports and scientific research papers pertaining to studies.
SERIES: 0401, 0403, 0405, 0601, 0602, 0701

Work involves serving as an independent investigator. Tasks include planning and conducting research in the area of nursing care of the burn patient. Studies may be independent or be segments of related investigations. Collecting, interpreting, analyzing, and evaluating data, as well as reporting research findings, are requirements. Developing techniques and mechanisms to implement and monitor the clinical data collection requirements for nursing staff of all unit protocols is also required. Advanced training in clinical experiments in critical burn care along with knowledge of pathophysiology of burns and associated injuries involving all major body systems is essential. An additional skill requirement is the ability to adapt human critical care nursing skills to the animal laboratory environment.
SERIES: 0610

Work involves independently planning, developing, implementing, supervising, and/or conducting critical research in cellular mechanisms of injury. Such topics are primarily involved in the research mission areas of Blast Overpressure/Blunt Trauma and Inhalation Injury. Expertise in cell and tissue injury caused by proinflammatory cytokines, inflammatory leukocytes, and toxic oxygen and nitrogen radicals is required. Extensive experience in neutrophilic injury, cellular signal transduction mechanisms, cell biology of inflammation and bacterial infection/sepsis is essential. Additional duties include advising/consulting Uniformed Services University of the Health Sciences, Department of Veterans Affairs, National Science Foundation, National Institutes of Health in specialty areas.
SERIES: 0401, 0413, 0415, 0403, 0602, 0701

Work involves and requires a thorough knowledge of normal ultrastructure of all tissues in the body as viewed with both transmission (TEM) and scanning (SEM) electron microscopes. Additional requirements include experience and knowledge in handling and viewing thermally injured tissues and all other experimentally altered tissues utilizing both TEM and SEM. The position also requires the incumbent to perform all duties in the electron microscopy lab. These duties entail receiving, logging, processing, cutting, staining, examining, and diagnosing all specimens. Additional requirements include some administrative work such as maintaining supplies, keeping current with professional journals, evaluating new technology for implementation, doing dark room procedures, and preparing material for publication in professional journals and at meetings.
SERIES: 0401

Work involves designing and conducting research by studying the effects of pharmacological agents on human thermoregulation. Conducting epidemiological surveys and field studies to determine predisposing factors for thermal injuries and illnesses is required. Additional tasks include determining physiological mechanisms responsible for, and the most efficacious treatment of, thermal injuries and illnesses.
SERIES: 0401, 0405, 0413, 0602

Work includes the skill, knowledge and ability to design and implement animal studies for the study of platelet function and storage issues, fibrin sealants and plasma. Requires knowledge and certification in the use of rodents and rabbits. Functional tasks include sample analysis using flow cytometry, isotope procedures, cell culture techniques, protein purification, electrophoresis, spectroscopy, cytokine assays (particularly ELISA), intracellular second message assays, coagulation assays and aggregation assays. Reviews grant/contract proposals in areas of expertise as requested. Serves as COR as requested.
SERIES: 0401, 0403, 0405, 0410, 0413, 0415, 0701

Work involves serving as principal investigator. Duties include independent planning, developing, implementing, supervising, and/or conducting of critical research in cellular mechanisms of injury primarily involved in the research mission areas of Blast Overpressure/Blunt Trauma and Inhalation Injury. Additional responsibilities include serving as a subject expert in cell and tissue injury caused by pro-inflammatory cytokines, inflammatory leukocytes, toxic oxygen, and nitrogen radicals. Possessing extensive experience in neutrophilic injury, cellular signal transduction mechanisms, cell biology of inflammation and bacterial infection/sepsis is critical. An additional duty is serving as an advisor/consultant to scientists within Walter Reed Army Institute of Research and other organizations Uniformed Services University of the Health Sciences, Department of Veterans Affairs, National Science Foundation, National Institutes of Health in the specialty areas.
SERIES: 0190, 0401, 0405, 0410, 0413, 0415, 0701

Work involves planning and conducting basic and applied cell and molecular research studies, with a special emphasis on cellular injury. Developing new methods or adapting existing procedures as needed to solve research problems directed at understanding the molecular biology of cell injury and repair is required. This position involves overseeing and conducting research utilizing electron microscopy, cell culture, electrophoresis, antigen detection, and the production of antibodies to antigens for identification of cellular responses to injury.
SERIES: 0401, 0403, 0413, 0602

Work involves planning and implementing basic and applied research studies related to trauma, hemorrhage, and resuscitation. Research concentrates on major research problems relevant to military and civilian trauma. Tasks include reviewing and or conducting experiments pertaining to burn and blunt trauma, hemorrhagic shock, ischemia/reperfusion injury, tissue salvage, and resuscitation. Additional tasks include developing new methodologies and analyzing and interpreting results.
SERIES: 0405, 0413

Work involves planning and implementing basic and applied research studies related to trauma, hemorrhage, and resuscitation. Research concentrates on problems relevant to trauma management. Additional responsibilities include reviewing and/or conducting experiments pertaining to blood storage, hemorrhagic shock, resuscitation, and ischemia/reperfusion injury with special attention to the fields of protein chemistry and cell, organ, and integrative physiology. Developing new methodologies is required, as is analyzing/interpreting results.
SERIES: 0401, 0413, 0602, 1320

Work involves conducting animal modeling of infections related to burn injury, to include the standard scald wound surface models and the scald injury-associated susceptibility to pneumonia model. Required tasks include conducting epidemiological surveillance of P. aeruginosa isolates from the burn unit's patients and wards, collecting and maintaining stocks of significantly important bacteria for use in studies of bacteria causing infections in burn patients, and maintaining stocks of an experimental topical agent used on burn patients. Additional requirements include maintaining extensive computer databases on the microbiology of burns for use in presentations and publications.
SERIES: 0403, 0401, 0701, 0644

Work involves knowledge of and ability to carry out studies of intestinal transport under normal and pathologic conditions. Ability to define pathogenesis and therapy of diarrheal conditions, particularly bacterial toxin-induced diarrheas is required.
SERIES: 0413

Work involves serving as principal investigator. Tasks include independently developing and writing scientific proposals, conducting and publishing original research in the areas of blast overpressure, blunt trauma, and inhalation injury as they relate to weapon effects. This position requires expertise in oxidative injury products and anti-oxidants. Additional duties include operating equipment and interpreting results from electron spin resonance analysis. Responsibilities encompass serving as a national and international subject matter expert as manifested by appointments as member, editor, and reviewer to multiple committees and boards.
SERIES: 0401, 0405, 0410, 0413, 0415, 0701

Work involves conducting original research and overseeing all contract and intramural investigations into the pathophysiologic mechanisms and injury exposure thresholds of airborne toxins. Research emphasis is placed on development of medical risk criteria which is immediately applicable to Live Fire Test (crew casualty) and Soldier Survivability (MANPRINT) assessments. Work also includes examining potential pharmacologic interventions and biochemical markers of injury. Work focus is placed on structural and functional changes of major organ systems that may cause decreased performance of the battlefield soldier. Research focus and tools range in biologic complexity from chemical and macromolecule interactions to use of cell culture, isolated organ systems, and whole animal testing. Animal testing includes a unique large animal exercise stress test model. Current scope of research includes developing a predictive model for incapacitation after exposure to a combination of fire gases, understanding the toxicology of new crew-space fire suppressants and their pyrolysis by-products, and examining the effects of mechanical insult (blast or blunt trauma) alone or combined with chemical insult. Additional responsibilities include reviewing grant/contract proposals in areas of expertise as requested, and serving as contracting officer's representative as requested.
SERIES: 0190, 0401, 0405, 0410, 0413, 0415, 0701, 1310, 1320, 1520, 1529

Work involves research into the normal and inappropriate hemo-dynamic responses of intact organisms, and isolated organs and tissue damage due to hemorrhage, environmental exposure, electromagnetic radiation and heat, and other forms of injury. Work requires ability to plan, develop, implement, and or conduct research to define mechanisms of injury. Research will include skill in investigating the effects of environmental and operational stressors and chemical agent therapies on the mechanisms of tissue injury. Ability to reviewing contract proposals in area of expertise and serve as Contracting Officer's Representative when required.
SERIES: 1320, 0413

Work involves planning, designing, and performing a neuroscience research program to study the molecular, cellular and functional dynamics of central nervous system injury as it relates to brain trauma and neuroprotection for the soldier. Military threats that affect the central nervous system include: penetrating wounds, trauma, ischemia/hemorrhage, infectious disease and biological and chemical threats. The position involves developing and applying in vivo animal (i.e. rodent) models of brain injury to study the mechanisms of acute and delayed neuronal cell death and dysfunction, and test potential pharmacological drug therapies as neuroprotectants. Specific requirements include demonstration of excellent small animal surgical skills and experience in brain trauma modeling, utilizing pharmacological treatment protocols to evaluate neuroprotection in recovery animals, and applying state-of the-art histological, neurological and functional behavior assays to assist in defining injury and recovery dynamics. Essential responsibilities include reporting results through publications on the scientific literature, presenting at scientific meetings, providing technical reports and briefings as requested.
SERIES: 0401, 0405, 0413

Research, develop and implement systems that will allow future combat medics to diagnose and triage wounded soldiers through the use of real time vital sign measurements in support of the Army's combat casualty care programs. Research and develop new approaches that provide an earlier and clearer depiction of patient status and their eventual outcome based on physiological models of trauma injuries in the civilian and battlefield environment. Implement new algorithms for prehospital patient classification and sorting through the use of real time and post capture analysis of acquired vital signs obtained through invasive and non-invasive patient sensors. Provide statistical analysis and modeling of both animal and human data for algorithm design and implementation. Provides support for data warehousing and data access of the USAISR trauma patient database. Manage data collection software and procedures from multiple data collection and processing sites. Maintain the trauma data collection server and associated software. Develop new approaches for data capture across the pre-hospital and hospital phases of care. Develop new data mining approaches for innovative processing of physiological signals in real time. Perform system design and integration of medical information technologies used for medical diagnosis and treatment. Research new approaches for closed loop and automated control of patient care during the prehospital and hospital care phases.
SERIES: 1550

Work involves serving as Laboratory Coordinator for the engineering assessment of Soldier protective equipment. Ensures laboratory test schedules are coordinated between multiple ongoing and new research initiatives. Interacts with customers in defining their test needs, estimating resource requirements, resolving scheduling conflicts and communicating program status and results. Assists in defining laboratory test equipment and data acquisition needs, facilitate system designs, modifications, and installations, and ensures that laboratory test systems are maintained, calibrated, and inventoried. Modify and create standard test procedures and data reporting procedures which may include the interpretation of Department of Defense, national, international, industrial, and commercial standards and procurement documents. Assist in defining instrumentation, data acquisition, and data archival requirements are identified and implemented. Performs preliminary data reduction and assists in preparing presentations on test methodologies, results, and findings. Requires the ability to recommend, specify and procure equipment needed for research.
SERIES: 0801

Work involves assessing the operational and laboratory performance of protective equipment used by the Soldier. Protective equipment assessed includes full systems, and their components, such as: aviation and infantry helmets, eyewear, seats, passive and active occupant restraint systems, inflatable occupant restraints, seat cushions, body armor, crash sensors, inertia reels, and protective mask. This equipment could be individual equipment or mounted on Army ground and aviation vehicle platforms. The position requires knowledge in system safety engineering, human factors engineering, accident investigation techniques, and crash survival.
SERIES: 0801

Work involves the planning and conduct of research studies on health hazards. The position requires knowledge of critical test equipment and instrumentation systems and the ability to independently design, prepare, and conduct tests and assessments. The test equipment includes helmet impact towers, mass properties instruments, inertia reel testers, instrumented test manikins, high-speed video recorders and motion analyzers, three-dimensional digitizers, quasi-static and dynamic universal test machines, horizontal test sleds, vibration table, and various smaller pieces of equipment. Instrumentation systems include computer-controlled data acquisition systems, signal conditioners, strain gauges, accelerometers, load cells, multimeters, oscilloscopes, linear and rotary potentiometers, and timing devices. The position requires the ability to program personal computers and data acquisition systems to facilitate data collection and the ability to design unique and original test fixtures.
SERIES: 0801

Work requires knowledge of injury biomechanics and engineering. For injury biomechanics, this includes knowledge of musculoskeletal injury, anthropometry, human tolerance to blunt impacts to the torso, spine, and head, and human factors. For engineering, this includes knowledge in statics, dynamics, engineering mechanics, material properties, electronics and instrumentation, and physics. The position requires application of this knowledge to the Soldier environment to identify health hazards, injury risk, and performance decrements as related to Soldier protective equipment.
SERIES: 0801

Work involves conducting original research and overseeing all contract and intramural investigations into the pathophysiologic mechanisms and injury exposure thresholds of chemical/biological warfare agents. Work also includes examining potential pharmacologic interventions and biochemical markers of injury. Work focus is placed on structural and functional changes of major organ systems that may cause decreased performance of the battlefield soldier. Research focus and tools range in biologic complexity from chemical and macromolecule interactions to use of cell culture, isolated organ systems, and whole animal testing. Animal testing includes rodents and non-human primates. Current scope of research includes developing a predictive model for incapacitation after exposure to chemical/biological agents, understanding the toxicology of new candidate antidotes and examining the effects of chemical agents alone or in combination with antidotes. Additional responsibilities include reviewing grant/contract proposals in areas of expertise as requested, and serving as contracting officer's representative as requested.
SERIES: 1320

Assesses patient's physiological, psychosocial status to formulate a base (nursing care plan) to include preparing goals based upon nursing diagnosis, and develop patient outcomes. Provides information on disease process and surgical procedure, teaches pre- and post-operative care, health maintenance and illness prevention to patient and significant other. Refers patient/family to allied health care providers such as social worker, chaplain, etc. Manages care of patients for a wide range of procedures of an advanced nature and difficulty, where there is high susceptibility to infection and bodily functions are mechanically assisted by life support equipment. Performs duty as circulator and, if required, those of a scrub person during surgical procedures. Takes counts (needles, sponges, etc.) labels, handles and assures proper disposition of surgical specimens. Completes perioperative documentation. Monitors numerous and complex equipment such as lasers, computerized monitoring stereotaxic device, cardiac monitor, ultra sonic tumor aspirator, etc. Monitors all ongoing processes anesthesia, surgery, aseptic technique, equipment functions, patient response and initiates/intervenes with immediate corrective action. Responsible for quality assurance/risk management; notes and responds to breaches of standard procedures which compromise the patient or staff members. Implements individualized nursing plans to include safety precautions, correct positioning, infection control precautions, aseptic practices, qualified personnel assignments, medications, supplies, equipment, etc. Assesses progress of surgical procedures and patient responses through sophisticated clinical observations and detailed data analysis. Makes independent perioperative nursing judgments and appropriate revisions in the care plan based on moment-to-moment changes in the patient's condition and responses. Implements crisis intervention techniques to provide support to the family. Assists surgeons with complex or potentially life-threatening procedures and assists anesthesiologists with insertion of invasive lines. Maintains lines and dressings in accordance with infection control practices. Plans the integrated continuity of care, working in collaboration with other health care providers (surgeon, anesthesiologist, radiologist, pathologist, etc.) to determine and meet patient needs. Independently establishes surgical nursing protocols and coordinates activities of all team members. Briefs post anesthesia/SICU nursing staff on perioperative nursing orders and other pertinent data such as surgical procedure(s) performed, patient problems, nursing diagnosis and actions, patient response, specialized care and equipment required to support the patient, etc. Conducts postoperative nursing assessment immediately following and within 48 hours after surgery to determine validity of nursing care plan, outcomes and long-range patient goals.
SERIES: 0610

Provides specialized perioperative care to patients undergoing procedures ranging from highly complex, high acuity (cardio thoracic, orthopedic, neuro-surgical) or trauma (knife wounds, gunshots) surgery to routine (appendectomy, hysterectomy) procedures. Cases often involve referrals of patients from Air Force, Navy and Army medical facilities not equipped to perform complicated surgery such as re-do of coronary by-pass graft procedures, complicated open heart procedures, and craniotomy procedures for unusual tumors. The employee regularly encounters patients classed as the "sickest of the sick;" i.e., those not expected to survive 24 hours with or without surgery. The duties encompass preoperative, intraoperative and postoperative phases.
SERIES: 0610

Serves as project officer/unit coordinator for 1-2 surgical specialties. Serves as unit coordinator for selected committees such as Quality Assurance, Infection Control, In service, etc. Serves as Charge Nurse in absence of Head Nurse, overseeing 4-35 personnel. Rotates as Charge Nurse on evening, night, weekend and holiday tour of duty. May serve as Floor Coordinator, responsible for the entire operative suite, assignment of personnel, surgery changes for that day and the preparation of next day's surgery schedule.Serves as preceptor/instructor for newly assigned graduate nurses, BSN students from local colleges, nurses from the Army's Operating Room Nurse Reserve Course, reservists, etc. Teaches medical students, interns, and residents principles of scrubbing, gowning, gloving, surgical site prepping, the use of multidisciplanary high tech equipment, etc. Provides guidance, orientation, on-the-job training and leadership to other professional perioperative nurses and to paraprofessional personnel. Training is provided while incumbent is performing critical perioperative duties. Responsible for ensuring all nurses and technicians in the section are thoroughly familiar in scrubbing and circulating on all types of surgery performed. Includes teaching the reason for use, and function of simple as well as highly complex and potentially dangerous instruments and equipment. Instructs pre- and postoperative patient classes. Develops lesson plans and presents continuing education classes for staff members. Develops and presents formal classes for the post graduate Operating Room Nurse Resident Course in the specialty assigned. Counsels students and submits performance reports to course directors.
SERIES: 0610

Isolates RNA, DNA and protein from cultured cells or frozen tissues in preparation for analysis of the genetic response to injury. Performs quality control on isolated material to evaluate and ensure integrity. Reverse transcribes RNA into cDNA, identifies and quantifies mRNA synthesis in a variety of tissues by polymerase chain reaction methods. Identification and quantification are performed by agarose gel electrophoresis and fluorescent staining and densitometry or with the Applied Biosystems ABS 7700 and Taqman® technology. Performs polyacrylamide gel electrophoresis on protein samples and transfers gels to PVDF or nitrocellulose membrane prior to probing with antibody and quanfification. Performs enzyme-linked immunoassays to identify and quantify cytokines synthesized and released into media or from serum or plasma samples. Prepares oligonucleotides for spotting with a GeneMachines Accent Arrayer and utilizes this instrument to prepare microarrays. Operates this instrument and prepares files for analysis or microarrays with GenePix scanner and software. Performs labeling of very small samples of RNA by reverse transcription followed by the Eberwine synthesis to produce antisense RNA that is hybridized to Agilent microarrays. Operates GenePix laser scanner for acquisition of images from microarrays prior to analysis with the GenePix 6.0 software and performs preliminary analysis of data generated from the software.
SERIES: 0401

Maintains human and animal cells in vitro as required. Practices sterile technique and understands requirements for handling both animal and human pathological material. Prepares media, buffers and reagents for cell culture and reverse transcriptase polymerase chain reaction as required. Understands the requirements of exclusion for RNAses and DNAses from these preparations, and utilizes proper disposal of liquid wastes. Stores, retrieves and processes data from spreadsheets and image analysis programs. Accesses the National Center for Biotechnology Information database and determines PCR primer pairs for cytokine analysis by RT-PCR. Maintains current knowledge of developments in the field of gene expression analysis for trauma and hemorrhagic shock research, as well as participation in producing scientific reports to be published in open literature. Ability to train other personnel, as necessary, in molecular biology techniques.
SERIES: 0401

Leads a team of technicians in research designed to apply cell culture techniques to understand extremity trauma pathophysiology and apply cellular approaches to the treatment of military injuries. Possesses technical expertise in the isolation, propagation, differentiation, and analysis of adipose cell cultures. Specific analysis techniques include ELISA, immunohistochemistry, protein chromatography and mass spectrometry. Has experience and training in the conduct of research in accordance with applicable laws, rules and regulations within a government facility. Is able to interface with other research teams to apply cell culture and protein analysis techniques to animal models of traumatic injury. Extensive knowledge of the technical methods and procedures, management practices, agency policies and programs, and an extensive familiarity with the methods and practices of biochemistry, cell biology, and molecular biology to design, coordinate, and execute complete conventional research projects when the projects are well described in the scientific literature.
SERIES: 0413

Work involves planning and conducting research in the area of hemorrhage, circulatory shock, and trauma as they relate to hemostasis and inflammation in both military and civilian populations. Ability to elucidate the biomedical and molecular mechanisms underlying the pathophysiological changes following hemorrhage and trauma and devise means to ameliorate them is essential. Additional tasks include developing new methods and adapting existing methods to solve research problems directed at understanding the cell and molecular biology of inflammation, cell injury and repair. Oversees and conducts research utilizing animals and cell cultures, light and electron microscopy, immunological techniques, in situ hybridization and polymerase chain reaction. Prepares reports and scientific research papers pertaining to studies.
SERIES: 0401

Provides clinical laboratory services to medical researchers in the areas of microbiology, hematology, clinical chemistry, coagulation, immunology, and flow cytometry. Plans and conducts experiments and procedures to provide solutions to testing problems and to evaluate published methods and techniques for incorporation into the laboratory. Researches, tests, and evaluates new clinical laboratory procedures, equipment, and supplies. Responsibilities require coordination within the unit to ensure that timeliness, form, procedure, accuracy, quality, and quantity standards are met. Reviews and implements standing operating procedures, including the definition of reference values and acceptable ranges, and interprets quality control results. Ensures that laboratory performs in accordance with College of American Pathologists (CAP) and other applicable standards, ensuring maintenance of all required logs and records. Establishes and maintains the budget for the laboratory with approval authority for order of supplies, equipment contracts, etc. Recommends use/purchase of new equipment based on such factors as efficiency, cost effectiveness, reliability, performance and overall suitability.
SERIES: 0401, 0403, 1320

Work involves conducting biomechanics research to fully characterize whole body and joint torques and forces associated with military task motions to provide injury prevention and mitigation solutions; this work includes biomechanical analyses, such as inverse dynamics kinematic analyses as well as working with computer software programs (e.g., MATLAB). Experience with motion capture systems (i.e., Qualysis track manager (QTM) or similar), Statistical Analysis software (SAS) or other statistical software for data analysis and mathematical modeling to relate the biomechanics to injury potential is recommended. Ability to generate hypothesis driven protocols and conduct biomechanical research studies independently on human subjects is required. Applying and elucidating knowledge of physiological and biomechanical mechanisms associated with bone and muscle injury is critical.
SERIES: 0413, 0858

Reports results through publications in the scientific literature, presents at scientific meetings, provides technical reports, and provides briefings as requested. Develops new methodologies is required, as is analyzing/interpreting results. Coordinates extramural research projects and directing in-house independent research projects. Broad theoretical knowledge or hands-on experience in such disciplines as microbiology, immunology, molecular biology, epidemiology and biostatistics in performing different aspects of research projects. Work involves monitoring the annual validation, linearity, and semi annual accuracy and precision for various laboratory procedures and tests. Determines standard curves, runs samples, validate laboratory methods and maintains/troubleshoots a variety of laboratory instrumentation.
SERIES: 401

Serve as principal investigator and scientific leader for research in regenerative medicine in soft tissue and bone. Demonstrated track record of research and understanding of traumatic craniomaxillofacial injuries. Coordinates with industrial, academic, and clinical partners in the disciplines of basic, translational, and clinical research. Provides scientific leadership, acquisition and allocation of human and material resources for the conduct of research. Skilled in establishing a research program in regeneration of bone and soft tissue. Provides fiscal and scientific oversight, reporting and direction to the research projects in craniomaxillofacial regeneration research programs. Manages extramural medical research programs and serves as a mentor to clinical researchers, scientists in training, and technicians.
SERIES: 0413

Work involves ability to coordinate and/or perform in vitro and/or in vivo research in the area of blast induced closed-head brain injury, including studies of pathophysiology, histopathology, cellular metabolism, biochemical mediators and markers, inflammatory pathways, molecular recognition and functional outcomes. The required skills include experience in the shock-tube method of generating blast overpressure, experience in whole animal experimentation and/or cell culture models, experience and expertise in establishing animal and in vitro models to test hypotheses relating to the mechanisms of pathologic responses of the brain to blast overpressure induced injury and to evaluate the effectiveness of therapeutic interventions. Work additionally requires experience with models of systemic hemorrhage and/or trauma, and experience in the analytical techniques and equipment required to accomplish research in the above areas.
SERIES: 0413, 1320, 0415

Work involves research into the normal and inappropriate hemodynamic responses to hemorrhage, with the focus on identification of novel vital sign measurements designed to provide improved decision support for the need of life saving intervention(s) and triage prioritization during the compensatory, pre-shock stages of hemorrhage. Work requires ability to plan, develop, implement, and or conduct research to define mechanisms of compensation to blood loss. Research includes skill in investigating the effects of environmental, operational and or genetic factors on the mechanisms of compensation to blood loss. Requires expertise with using telemetry to continuously measure cardiovascular parameters in the study of blood pressure regulation, with a preference on experience with human experimentation. Proven ability to write successful grant proposals and publish scientific papers in peer-reviewed journals. Ability to review contract proposals in area of expertise and serve as Contracting Officers Representative when required.
SERIES: 0413

Work involves research into the normal and pathologic cardiopulmonary responses of intact organisms, and isolated organs and tissue damage due to hemorrhage, environmental exposure, electromagnetic radiation and heat, and other forms of injury. Work requires ability to plan, develop, implement, and or conduct research to define mechanisms of injury in large animals and human trauma patients. Research includes skill in applying novel methods of physiologic monitoring, biosignal analysis, and closed-loop control of therapy in these models. Ability to review contract proposals in area of expertise and serve as Contracting Officers Representative when required.
SERIES: 0413

Serve as principal investigator and scientific leader for research in tissue engineering and regenerative medicine for soft tissue and bone. Demonstrated a track record of being able to obtain funding for research. Demonstrated research and understanding of traumatic extremity and craniomaxillofacial injuries. Demonstrated a track record of understanding and managing intellectual property and obtaining patents. Coordinates with industrial, academic, and clinical partners in the disciplines of basic, translational, and clinical research. Provides scientific leadership, acquisition, allocation of human and material resources, and organizational management for the conduct of research. Skilled in establishing a research program in regeneration of bone and soft tissue and prevention of infection. Provides fiscal and scientific oversight, reporting and direction to the research projects in regeneration research programs. Manages extramural medical research programs and serves as a mentor to clinical researchers, scientists in training, and technicians. Serves as the source matter expert for a wide range of natural and synthetic biomaterials and their application for tissue engineering.
SERIES: 0413

Provides comprehensive services related to clinical pathology, to include but not limited to, post mortem anatomic pathology examinations, histological analysis of fresh and frozen tissue specimens submitted from the operating room or wards, and consultative services related to diagnosis and treatment of complex diseases treated at the Burn Center. Provides expert advice to the Director and staff regarding acute and chronic illnesses to include: severe burns, necrotizing soft tissue infections, inhalation injury and complications associated with same. Provides timely analysis and reporting of bacterial and fungal infections diagnosed through a variety of methods selected by the physician. Provides expert post mortem analysis using techniques and procedures outlined by the institution and the Armed Forces Medical Examiner for military casualties. Assists in reviewing abstracts and manuscripts which include data gathered from work at the Institute and serve as a subject matter expert with respect to severe burns and inhalation injury.
SERIES: 0601

Work involves application of tools from complexity science and cell biology to understanding the normal and pathologic cardiopulmonary responses of intact organisms, isolated organs, and cells to various stressors. These stressors include hemorrhagic shock, environmental exposure, electromagnetic radiation, heat, and other forms of injury. Work requires ability to plan, develop, implement, and/or conduct research to define mechanisms of injury in multiple species. Research requires skill with novel methods of physiologic monitoring and biosignal analysis, to include expertise in application of nonlinear dynamics software to the analysis of variability in the heart rate and other physiologic waveforms. Hands-on care of animals in an intensive care unit (ICU) setting will be performed, including mechanical ventilation, sedation, fluid management, and digital data acquisition during multi-day studies. Advanced cell biology techniques to include isolation of cells from lung tissue and other organs, and flow cytometry, will be performed. Ability to review contract proposals in area of expertise and serve as Contracting Officers Representative when required.
SERIES: 0413

Responsible for coordinating a multi-disciplinary team approach to acute and chronic wound care management in the burn and trauma patient population. Functions in an advanced clinical capacity providing direct patient care to include assessing, diagnosing, planning, and prescribing pharmacologic and non-pharmacologic treatments to inpatient and outpatient burn or trauma victims with acute or chronic wounds. Primarily responsible for implementing, documenting, continuing and coordinating the individual patients wound management care plan in a multidisciplinary team effort as directed by the primary burn surgeon to achieve optimal patient outcomes. Assesses all patients for preventative management of alterations in skin integrity. Plans and prescribes pharmacologic and non-pharmacologic treatments to prevent skin breakdown.
SERIES: 0610

Maintains current subject matter expertise and serves as a clinical resource in wound care management to the multidisciplinary health care team, our patients and their family members. Provides consultation in developing and implementing standards of clinical practice and institutional protocols for wound care management. Provides clinical subject matter expertise and consultation guidance on the selection and purchase of wound care products (pharmacological and non-pharmacological). Primarily responsible for clinical education regarding wound care management to members of the multidisciplinary team. Clinical education will consist of formal new employee orientation classes as well as experiential training in wound care management of the burn / trauma patient. Provides wound care education and training to patients and family members. Provides Wound Care subject matter expertise and instruction in a variety of informal and formal educational venues (ABLS, pre-deployment training, Critical Care Course, ABA national conference, etc.).
SERIES: 0610

Serves as a principal clinical nursing leader reporting to the Chief Nurse and Medical Director of the ISR. Records and documents the process of burn wound healing. Plans and conducts clinical research in the topic of burn wound management. Disseminates wound management research and evidence based practice in a variety of manners to include oral presentation, poster presentation, and manuscript preparation. Supports and participates in a variety of approved clinical research protocols at the USAISR. Develops, reviews, evaluates and revises policies and procedures regarding wound care management. Collaborates with members and leaders of the multidisciplinary team at the USAISR. Responsible for ensuring 24/7 scheduled availability of wound care staff. Participates in the development, implementation, and evaluation of an annual budget. Maintains demographic and information statistics on acute and chronic wounds in our patient population. Serves on a variety of unit and hospital based committees. Authorizes rental and manages therapeutic support / specialty bed program (develops guidelines and protocols, acts as liaison with various POCs from manufacturers, oversees expenditures, etc).
SERIES: 0610

Responsible for the design and implementation of comprehensive patient safety, performance improvement and risk management programs that require an advanced level of competence as gained from professional nursing knowledge, advanced educational preparation and extensive experience. Performs comprehensive and intensive reviews of clinical data, patient and provider information in comparison with multiple program elements in areas of quality assurance, risk management, patient safety, performance improvement, licensure, certification programs, peer review processes and compliance with regulatory guidance to include standards of The Joint Commission (TJC), the American College of Surgeons, and the American Burn Association. Establishes short and long-range goals and objectives in support of the USAISR and BAMC Performance Improvement, Patient Safety and Risk Management Programs. Interprets and analyzes current legislation, directives, and literature to include all TJC standards. Ensures goals and objectives incorporate the MRMC, USAISR and GPRMC mission, vision and strategic plans in addition to attaining an optimal level of performance for all program elements within available resources. Reviews, evaluates and modifies plans based on medical/clinical operating requirements. Leads and serves as a member of multiple interdisciplinary teams/committees (internally and externally) in the conduct of performance improvement, patient safety, risk management, and accreditation activities. Ensures goals prescribed by USAISR, MRMC, BAMC, GPRMC, Departments of the Army and Defense, and other agencies are addressed and implemented in daily operating procedures. Conducts and attends meetings of a formal and informal nature, leading or acting in the capacity of consultant for clinical, medical-legal, and medical administrative issues, cases, ideas, processes, methods, etc.
SERIES: 0610

Reviews information contained in various medical documents, e.g., patient medical records, surgical reports, administrative records/reports, clinical/medical inspections/reports, contracts and similar documents reflecting health care services in areas such as nursing, pharmacy, laboratory, surgery, medicine, psychiatry, family practice, radiology and other services provided to patients. Conducts intensive technical reviews to identify or detect situations of compliance/non-compliance with standards of care prescribed by internal and external organizations or agencies having jurisdiction over health care functions carried out in medical treatment facilities. Information reviewed frequently contains details of clinical and/or medical procedures performed by practitioners and support personnel which typically describe results of diagnostic, medical, surgical, and other clinical services rendered to patients. Information reviews involve the recognition of very subtle clinical details that may go undetected by other than professionally qualified personnel. Investigates incidents where information may evolve into any of the areas such as risk management, quality assurance, credentials, etc. Coordinates with legal personnel assigned to USAISR, MRMC, BAMC and GPRMC in areas where events may require command attention and/or a case having potential for compensation. Sets standards for areas such as performance improvement, patient safety, case management and utilization management in support of high levels of quality in health care services, resource management, efficiency of services, and other areas associated with the delivery of health care. Understands the relationships of health care services provided by the military medical center, contracted health care, TRICARE and other types of health care services in order to detect problem areas and recommend improvements. Performs analytical functions (e.g., statistical analysis, information collection, subjective and objective evaluation, etc.) to determine levels of compliance, provide trend analysis, chart and graph data, and compile information for conclusions of recurring or special studies. Keeps abreast of health care trends to support positive results in quality care such as risk reduction, shorter hospital stays, better treatment procedures, faster and less costly service with better products, and numerous other elements associated with quality services. Writes a variety of materials in narrative and/or statistical formats to provide written documentation of reportable information, provide responses to information requests, elicits information, and/or presents written information for other situations. Gives verbal presentations to individuals or groups of individuals in meetings, conferences, briefings, surveys, orientations or other settings. Communications may be subject to short notice with little time for preparation or established completion dates. Responsible for all clinical areas of the USAISR Burn Center to include the Burn Clinic, the Burn Operating Room, the Burn Intensive Care Unit and the Burn Progressive Care Unit.
SERIES: 0610

Work involves planning, leading and executing basic applied and clinical research studies in a research program investigating pain management to identify mechanisms of pain as well as therapeutic interventions and outcomes. Conduct experiments to determine physiological outcomes associated with anesthetic usage including effects on inflammatory parameters, transcriptional changes and resuscitation fluids. Conduct experiments on neuronal remodeling and psychological outcomes associated with pain and anesthetic usage. Utilizes knowledge of pain research and/or clinical experience with pain management in the conduct of duties. Additional responsibilities include reporting results in scientific manuscripts, technical reports, and presentations at scientific meetings.
SERIES: 0413

Provides direct care to patients and families. Educates patients and families in the prevention or resolution of illness, treatment of disease, injury and disability. Conducts comprehensive, holistic wellness and illness assessments using established or innovative evidence-based techniques, tools and methods. Collaborates with the multidisciplinary team to plan, implement, evaluate patient care and resolve issues related to patient care, communication, policies and resources. Schedules and coordinates procedures, tests, new referrals, admissions, and appointments. Helps assess, develop, and coordinate, educational programs for the medical staff. Provides formal and informal instruction for nursing staff. Evaluates patient outcomes and cost-effectiveness of care. Designs, implements, and evaluates nursing practices. Serves as a consultant to other nurses and health-care professionals. Influences care outcomes by providing expert consultation to nursing and medical staff and by identifying and implementing improvements in the health care delivery systems. Initiates emergency treatment when necessary (e.g. CPR, ACLS). Responsible for handling the most complex cases and resolving critical problems. The result of the tasks completed affect other nursing experts within the department and physicians decision on patient care. Leads and serves as a member of multiple interdisciplinary teams/committees (internally and externally) in the conduct of performance improvement, patient safety, risk management, and accreditation activities. Ensures goals prescribed by Departments of the Army and Defense, and other agencies are addressed and implemented in daily operating procedures. Conducts and attends meetings of a formal and informal nature, leading or acting in the capacity of consultant for clinical, medical-legal, and medical administrative issues, cases, ideas, processes, methods, etc. Support and facilitates the implementation and compliance to standards established for performance improvement, patient safety, case management, utilization management, and credentialing. Provides feedback and recommends alternatives to ensure the delivery of quality health care services, resource management, and access to care, customer satisfaction and overall efficiency of services provided throughout the organization. Understands the relationships of health care services provided by the military medical center, contracted health care, TRICARE and other types of health care services in order to detect problem areas and recommend improvements. Performs analytical functions (e.g., statistical analysis, information collection, subjective and objective evaluation, etc.) to determine levels of compliance, provide trend analysis, chart and graph data, and compile information for conclusions of recurring trends. Keeps abreast of current medical research and trends that result in the delivery of quality care, risk reduction, shorter hospital stays, current treatment procedures, while ensuring fiscal accountability. Evaluates the impact of nursing interventions on fiscal and human resources.
SERIES: 0610

Designs and evaluates innovative educational programs for patients, families and groups. Administers direct nursing care to burn patients as identified through nursing or medical referrals (verbal or written) and/or via personal assessment. Initiates and plans care conferences or programs for individual burn patients or populations. Identifies, collects and analyzes data that serve as a basis for program design and outcome measurement. Systematically collects data through interviews, observation, physical assessment and review of medical records. Evaluates information and makes professional assessment of the burn patient's physical, developmental, social, spiritual, emotional and mental status. Collects demographic and other data. Documents health assessment in the medical records. Interprets and reports abnormal diagnostic data and changes in signs and symptoms; coordinates with the multidisciplinary staff to modify the plan of care accordingly. Identifies situations in which the physician should be notified immediately. Ensures continued health care delivery to the discharged patient via telephone service and return clinic visits as appropriate. Maintains written nursing notes, progress notes or consultation forms for the purpose of documentation, assessment and mutual patient-family multi-disciplinary plan of care. Coordinates activities with the Nurse Managers of 4E and the Burn Clinic, the Multi-Disciplinary team members of both areas, the Chief Nurse and the Burn Center Director.
SERIES: 0610

Performs data collection, compiles data, creates, accesses, updates, and maintains security of computer databases concerning care delivered to facilitate patient outcomes. Generates statistical reports regarding access to and outcome of care provided for the purposes of process improvement and ensuring optimal patient outcomes and appropriate resource utilization. This involves computation, analysis, tracing/trending, graphing and preparation of summary management reports. Participates in, utilizes and disseminates research to enhance practice. Researches and develops patient care procedures, policies, algorithms, and treatments. Identifies researchable nursing problems. Initiates literature reviews and makes recommendations. Utilizes methods to share findings of research with nursing colleagues and others. In light of research findings develops evidence-based policies and procedures. Performs independent nursing assessments, including physical examination as required and interpretation of laboratory reports to assess the impact of the surgical procedure upon the patient. Performs a postoperative assessment and develops a plan of care with the interdisciplinary team. Provides comfort measures and psychological support to the patient and family members. Operates and monitors highly sophisticated equipment. Participates in the need identification, selection and evaluation of products and equipment. Assists in procedural pain and sedation management. Administers a variety of rapid-acting, potent medications by direct intravenous and other routes, according to unit policies, procedures and protocols. Utilizes broad knowledge of drugs and intravenous therapy, including properties, indications, dosages/rates and side effects. Closely monitors and documents patient response, and adjusts therapy accordingly. Responds decisively to life threatening changes in patient conditions, providing immediate and appropriate emergency measures according to ACLS protocols. Assesses the appropriateness of patient education materials to include websites, teaching materials, and general media to stay current with recent developments in burn nursing research.. Develops, obtains, reviews and updates appropriate teaching tools for patient/families and staff which help explain injury, disease, treatment, side effects, and expected outcomes, and which involves the patient in his own care. Educates and counsels patients and family members regarding procedures to be performed and treatment provided. Instructs family members in the home care of burn patients before discharge. Promotes harmonious, positive interpersonal relationships with patients, families and other health care personnel. Directs particular attention to supporting emotional needs in a demanding and stressful environment.
SERIES: 0610

Functions as a consultant and assists the burn patient and family to cope with an existing problem or situation. Consultation consists of problem solving with an individual, group, agency or colleagues. Problems usually concern, but are not limited to standards of care, equipment, facilities, and delivery systems/processes. Provides highly specialized nursing care to burn patient's that have undergone acute surgeries or have acute/chronic medical conditions. Coordinates the nursing plan of care with the medical surgical plan of care. Utilizes advanced assessment skills to identify burn patient care problems, formulate patient care plans and continually revise plans to adjust to changes in complex and unstable patients under routine and emergent conditions. Maintains a follow-up procedure on a select group of patients who have major problems on discharge such as wound management or other unusual complications. Is a core member of the ISR Wound Care Team. Works in collaboration with the physician in the management of complex medical problems. Serves in the teaching capacity for graduate students obtaining clinical experience in population specific nursing. Promotes established nursing standards by increasing staff awareness of skills pertaining to data collection, diagnosis, approaches to care, assessing outcomes and revising plans related to burn medical surgical problems. Teaches highly specialized burn nursing concepts, as well as difficult and complex nursing procedures. Assists nursing personnel to achieve greater effectiveness in the nursing process by means of scheduled ward in-services, patient care conferences, and assisting in the development of nursing care plans. Serves as a preceptor for new and less-experienced professional staff. Assesses their learning needs and in conjunction with the unit manager develops individualized orientation plans to meet these needs. Reviews information contained in various medical documents, e.g., patient medical records, surgical reports, administrative records/reports, clinical/medical inspections/reports, contracts and similar documents reflecting health care services in areas such as nursing, pharmacy, laboratory, surgery, medicine, psychiatry, family practice, radiology, OB/GYN, and other services provided to patients. Conducts intensive technical reviews to identify or detect situations of compliance/non-compliance with standards of care prescribed by internal and external organizations or agencies having jurisdiction over health care functions carried out in medical treatment facilities. Information reviewed frequently contains details of clinical and/or medical procedures performed by practitioners and support personnel which typically describe results of diagnostic, medical, surgical, and other clinical services rendered to patients. Information reviews involve the recognition of very subtle clinical details that may go undetected by other than professionally qualified personnel. Serves as the subject matter expert in Root Cause Analysis related to incidents where information may evolve into any of the areas such as risk management, quality assurance, credentials, etc. Assists in monitoring the competency of assigned nursing staff. Corrects deficiencies by developing and conducting informal and formal training. Provides input to the Nurse Managers regarding performance standards, performance evaluations, awards, promotions, training and disciplinary needs. Arbitrates and resolves personnel or staff conflicts.
SERIES: 0610

Provides an advanced level of specialized burn nursing care to burn patients, using knowledge of an extensive range of professional burn nursing theories, principles, and procedures; knowledge of interrelation of body systems and disease process; knowledge of emergency and resuscitative measures; knowledge of pathologic conditions associated with a variety of medical conditions; and skill to interact with patients and family members. Independently determines and implements proper emergency measures. Initiates advanced cardiovascular life support measures. Mixes and administers special, potent, and lethal drugs. Performs defibrillation and maintains invasive lines. Assists physicians with complex or life-threatening procedures. Assesses patient responses and performs continuous respiratory ventilation.
SERIES: 0610

Conducts continuous patient assessment, using knowledge of an extensive range of professional burn nursing theories, principles, and procedures; knowledge of interrelations of body systems and disease process; knowledge of emergency and resuscitative measures; knowledge of pathologic conditions associated with a variety of medical and surgical conditions; knowledge of burn wounds and procedures; and skill to interact with patients and family members. Monitors patient's condition by continuous observation and precise calculation of fluid levels and vital signs. Determines, prescribes, and implements nursing orders. Evaluates and documents nursing interventions and revises plans accordingly. Collaborates with physicians and other health care team members to assure the delivery of optimal level of overall care to burn patients. Provides constant support to patient and family members through counseling and manages the most difficult advocacy problems that occur in a burn setting, using knowledge of an extensive range of professional nursing theories, principles, and procedures; knowledge of interrelations of body systems and disease processes; knowledge of pathologic conditions associated with a variety of medical conditions; and skill to interact with patients and family members. Develops meaningful goals to assist patient and family members in attaining optimal balance within limitations of illness. Provides information on disease process, pre and post operative care, diagnostic procedures, use of equipment related to disease/care, health maintenance, etc. Performs difficult and demanding advocacy tasks that involve patient's options and actions or activities of physicians, other health care providers, family members, and significant others.
SERIES: 0610

As an expert in the nursing care of burn patients, serves as a role model and resource person to experienced burn nurses as well as those who are not fully trained, using knowledge of an extensive range of professional nursing theories, principles, and procedures; knowledge of interrelations of body systems and disease process; knowledge of emergency and resuscitative measures; knowledge of pathologic conditions associated with a variety of medical conditions; and skill to interact with patients and family members. Provides guidance and leadership to other nurses. Provides orientation and on job training (OJT) to nurses and other paraprofessionals. Teaches patient care to other burn nurses at all levels of development. Leads patient care conferences. As charge nurse provides guidance and leadership to other professional nurses. Conducts classes as part of continuing in-service training in critical and burn care.
SERIES: 0610

Provides an advanced level of specialized nursing care to complex, critically ill patients having numerous complicating conditions. High levels of acuity resulting from the hospital's designation as a Level I Trauma Center, require specialized nursing care with patients presenting real or potential life-threatening health problems. The nurse provides continuous observation and monitoring and must intervene to prevent complications and attempt to restore health. In the absence of a physician, independently makes decisions and implements proper emergency measures after identifying and interpreting life-threatening conditions. Initiates life-saving measures which include, but are not limited to advanced cardiopulmonary resuscitation; calculating dosages and mixing potent and potentially lethal drugs prior to arrival of a physician and administering these drugs upon the physician's directives; and performing arterial punctures for assessment of blood gases and making various ventilator adjustments, in accordance with unit policy, based on blood gas interpretations. Assists in the performance of endotracheal intubation.
SERIES: 0610

Assists the physician with complex and potentially life-threatening procedures such as insertion of arterial and venous catheters, chest tubes, and endotracheal tubes. Inserts intravenous catheters and performs venipunctures to collect blood samples. Monitors intake and output and notifies physician when caloric or fluid needs change. Assesses patient's response regarding cardiac output, vital signs, peripheral perfusion, and level of consciousness. Performs continuous respiratory ventilation assessments, evaluating blood gas results from both arterial and mixed venous sources. Obtains patient and environmental cultures; uses crash cart appropriately in emergencies; suctions endotracheal tubes and other airways and assists with tissue biopsies. Continually observes, monitors and assesses patient's condition. Interprets signs and symptoms of deterioration in condition and takes corrective action. Independently orders lab tests and X-rays to better assess patient. Consults with physician regarding medical and nursing management. Starts intravenous line if none is available and if the critical condition of the patient makes access to circulatory system mandatory for administration of resuscitative medications. Knows and ensures infection control standards are applied in accordance with unit and department operating instructions. Collaborates with physicians and other health care team members to assure the delivery of the optimal level of overall care to critical care patients.
SERIES: 0610

Administers and monitors the use of therapeutic agents (medications) in accordance with Department of Nursing and unit operating instructions, the Lippincott Manual of Nursing Practice, and initial orientation and/or certification, to include: chemotherapy drugs; pain-relieving drugs including narcotics; antibiotics including experimental agents; and specific agents used in the care of oncology patients such as Antithymocyte Globulin (ATC), Amphotericin B, Cyclosporin, Acyclovir and intravenous Immunoglobulin. Mixes and administers prescribed emergency medications (Isuprel, Dopamine, Nipride, Nitroglycerine), and is familiar with correct dosages and potential side affects. Must monitor drugs which alter the affects of another drug if administered concurrently. Administers and regulates intravenous fluids such as lipids and blood volume expanders. Administers and regulates vasoactive drugs. Uses specialized patient equipment such as respiratory equipment, including oxygen masks, ambu bags and ventilators, intravenous infusion pumps, gomcos and wall suction, Emerson pumps and pleurovacs, cardiovascular monitors used for measuring cardiac output, defibrillators, invasive thermodilutional catheters, arterial and central venous catheters and EKG machines; equipment used for paritoneal dialysis and exchange transfusion, intraaortic balloon pumps and others as required. Uses ICP monitors and CO2 monitors. Transports critically ill patients outside of the hospital for various diagnostic procedures.
SERIES: 0610

Assesses patient and family to include physical and psychosocial needs by preparing a detailed history. Provides care in accordance with patient-specific nursing care plans, either developed by incumbent or another critical care nurse. Continuously reevaluates patient's care plans as patient's needs or conditions change. Provides an anticipatory, sound discharge plan that includes rehabilitation and health teaching both for patient and family. Performs difficult and demanding patient advocacy tasks and effectively manages the most difficult advocacy problems that occur in a critical care setting. Advocacy matters involve patient's options, and actions or activities of physicians, other health care providers, family members and significant others.
SERIES: 0610

As an expert in the nursing care of critically ill patients, serves as a resource person with whom other experienced nurses and other health care providers consult when particularly difficult problems in the care of critically ill patients arise. Serves as a role model to experienced critical care nurses as well as those who are not fully trained. Provides guidance and leadership to other professional nurses, and oversees the work of paraprofessional personnel. Provides orientation and on-the-job training for such personnel. Is a preceptor for newly assigned nurses. Conducts in-service lectures and provides formal and informal ICU training. Leads patient care conferences. Participates in the development of standards of care and in the establishment of quality assurance goals for the critical care unit. Serves as a charge nurse on night or evening shifts. As charge nurse, provides guidance and leadership to other professional nurses. Floats to other special care units as required.
SERIES: 0610

Responsible for the quality of nursing care provided to inpatients and outpatients undergoing treatment and procedures in both inpatient and outpatient settings. Plans, organizes, directs and evaluates nursing activities and services that relate to Enterostomal therapy. Serves as a consultant to professional and paraprofessional personnel. Coordinates nursing services and patient care activities with hospital ancillary and administrative services and members of the health care team to ensure comprehensive patient care and efficient integration of services in support of quality patient care. Maintains appropriate records and reports. Supports the goals and mission of the Department of Nursing and the organization. Preoperatively interviews all ostomy surgical patients. Discusses expectations of patients prior to surgery, identifies the site of the ostomy per physician order, and discusses, explains and teaches the function of the ostomy. Visits ostomy patients postoperatively for delivery and monitoring of ostomy care based on biological and psychosocial assessments. Initiates patient/family teaching to encourage responsibility for self-care as appropriate. Determines appropriate equipment and appliances for stomas, fistulas, and draining wounds. Provides selected written patient literature regarding ostomy care and equipment. Initiates ostomy nursing care plan (critical pathway). Regularly consults with patient's physician to discuss progress and plan of care. Participates in discharge planning of ostomy client in conjunction with multi-disciplinary team. Collaborates with home health nurse referral as appropriate. Arranges for follow-up outpatient Enterostomal nurse clinic visit. Works collaboratively with other members of the health care team to provide comprehensive, holistic, quality health care.
SERIES: 0610

Identifies educational needs of clients, nursing and physician staff. Assists professional staff in planning in-service programs and continuing education activities as it relates to enterostomal therapy and wound care prevention and management. Conducts classes and staff development programs i.e., Department of Nursing Orientation (formal and informal) regarding: (a) Role of Enterostomal Therapy Nurse; (b) Ostomy care management; (c) Wound/fistula/pressure ulcer prevention and care; (d) Client care plans (critical pathways); (e) Research findings and application to Enterostomal Therapy. Formulates, revises, and/or reviews written teaching materials involving client/staff education. Coordinates client care conferences involving interesting and/or complicated ostomy client cases. Includes other members of the health care team. Provides direct client/family teaching to include appropriate psychomotor "hands on" experiences. Encourages, supports, and guides staff in client education activities. Utilizes evaluation tools to measure client/staff learning and relevance to outcomes management. Participates in community activities as they relate to ostomy client care and education, i.e., consultative services, lectures, demonstrations and consumer programs. Identifies self-educational needs to promote professional growth and development.
SERIES: 0610

Serves as clinical and administrative nurse manager in the development, implementation and evaluation of standards of nursing practice in Wound, Ostomy, Continence Nursing in a 450 bed teaching hospital and regional medical center. Case manages ostomy clients, providing direct and/or indirect case management. The purpose of the work is to manage the Wound, Ostomy, Continence Program. This includes pre- and post-operative care through outpatient and inpatient areas across the continuum of care (from prevention to treatment). Maintains outcomes management database for those clients managed. Clients include those with stomas, fistulas, draining wounds, incontinence, pressure ulcers, and skin problems. Manages accurate client records. Demonstrates outcomes management through length of stay, cost/benefits, third party reimbursement, etc. (Records to provide quarterly summary of activities for local headquarters and higher headquarters as required). Participates on Quality Assurance, Infection Control and Research Committees and select nursing and hospital committees. Chairs the Department of Nursing Skin Care Team. Develops written duty objectives to include short and long-term goals. Reviews/approves all standard supplies and equipment available for ostomy care in conjunction with Department of Surgery physician consultant. Serves as the gatekeeper to ensure appropriate pressure-reduction and pressure-relief therapies are used. Assesses all patients in need of pressure-reduction or pressure-relief therapies and recommends appropriate care and treatment. Maintains liaison with hospital-supply companies and local ostomy associations to stay abreast with latest appliance products and techniques. Acts as a consultant in Enterostomal Therapy to military communities and networks with appropriate Enterostomal Therapy organizations and/or agencies. Insures mandatory meetings and obligations are met. May supervise other enterostomal therapy nurses and/or technicians.
SERIES: 0610

As the assigned charge nurse on the shift, independently makes nursing care assignments to various skill levels of professional and paraprofessional personnel. Allocates and assigns staff based on personal assessment of patient acuity conditions and expertise of individual staff members. Monitors, evaluates and oversees staff performance to assure work is accomplished on a timely and effective basis. Ensures staff sakes legible, accurate and complete nursing entries in patient charts. Ensures appropriate patient education occurs during the shift and appropriate responses to patient emergencies are made. Verifies and annotates all physicians orders written during the shift. Assesses patient status reviews and independently revises nursing care plans as needed. Advises attending physicians of significant changes in patients conditions in a timely manner. Coordinates and assures timely arrival of patients to schedule appointments within various hospital activities. Monitors, oversees, and documents staff performance during orientation/preceptorship periods to verify appropriate training is provided. Assists in development of the evening/night orientation plan. Reports and documents performance and/or problems to the supervisor as requested. Approves short term emergency or sick leave requested during the shift. Initiates call back of off duty nurses/other personnel as required due to unexpected emergencies or absences. As requested by the supervisor, submits written input for employee performance evaluations or disciplinary actions, etc. As the recognized charge nurse on the shift, provides advice and assistance to experienced as well as: inexperienced professional and paraprofessional staff members (the staff includes approximately 4-6 members, both professional and paraprofessional). Prioritizes care requirements for best use of assigned personnel. Completes documentation for quality assurance problems, unusual occurrences, on-the-job injuries, or performance problems. Develops written response to shift quality assurance inquiries and provides analysis of unusual shift occurrences. May brief distinguished visitors from all levels of the military and educational community.
SERIES: 0610

Assesses patient care needs on a continuing basis. This includes reviewing records/reports from prior shifts, interpreting signs and symptoms of patients changing status and taking corrective action. Facilitates obtaining timely lab tests and X-rays as needed. Provides comprehensive nursing care to patients based on nursing assessments and diagnoses, physician's medical care plan as well as the physical, mental, social, and emotional needs of the patient. Institutes CPR as needed, and reacts to emergencies occurring on the shift. Advises physicians of actions taken and ensures proper documentation of nursing care provided on standardized nursing forms. Sets up, operates and monitors specialized medical equipment such as cardiac monitors, defibrillators, suction devices, etc. Manages nasal-pharyngeal and gastric suction as well as a variety of other drainage tubes. Consults with physician regarding medical and nursing management of patient care needs. Ensures infection control standards are applied in accordance with unit and department operating policy.
SERIES: 0610

Provide image and analysis of biofilm infected wound samples by scanning electron microscopy. Quantitate bacterial load present in experimental infected wounds. Produce biofilms consisting of war wound pathogens to determine their susceptibility to anti-biofilm agents.
SERIES: 0403

Serves as a resource with whom the Joint Theater Trauma System (JTTS) Director and Deputy Director(s) can consult on difficult problems related to the training of Trauma Nurse Coordinators who are deployed in support of designated military operations i.e., Operation Iraqi Freedom and Operation Enduring Freedom. Identifies educational needs of the Joint Theatre Trauma Registry (JTTR) Trauma Nurse Coordinators (TNCs), JTTR abstractor/coders and physician staff in the systematic collection, aggregation, coding, entry, storage, retrieval, and reporting of demographic, incident, treatment, and outcome data for casualties. Designs and evaluates innovative educational programs for TNCs and JTTS staff. Assists professional staff in planning in-service programs and continuing education activities as it relates to JTTS and Performance Improvement. Conducts classes and staff development programs i.e., JTTR Orientation (formal and informal) regarding: (a) Role of Abstractor/Coder; (b) Trauma Nurse Coordinators; Formulates, revises, and/or reviews written teaching materials involving TNCs/JTTS staff education. Includes other members of the JTTS team. Encourages, supports, and guides staff in TNC/JTTS education activities. Utilizes evaluation tools to measure TNC/JTTS staff learning and relevance to outcomes management. Participates in activities as they relate to JTTS education, i.e., consultative services, lectures, and demonstrations. Is a preceptor for new Abstractor/Coders to the Joint Theatre Trauma System/Registry. Conducts in-service lectures and provides formal and informal JTTR training. Conducts an After Action Review of each course taught to identify strengths and weaknesses. Implements approved changes to training. In coordination with the JTTS Director and Deputy Directors(s) develops, implements, and continually evaluates policies and procedures for the systematic collection, aggregation, coding, storage, retrieval, and reporting of demographic, incident, treatment, and outcome data for casualties and patients during designated military operations. Identifies self-educational needs to promote professional growth and development.
SERIES: 0610

Work involves planning, designing, and performing a neuroscience research program to study the molecular, cellular and functional dynamics of central nervous system injury as it relates to brain trauma. The position involves conducting proteomic and genomic analysis inclusive of high-throughput immunoblotting, 2D gel electrophoresis, Western and immuno-blotting, and Typhoon Scanning, as well as use of Spot Picker Systems, BD PowerPlot Analysis, quantitative RT/PCR gene expression techniques, genomic microarrays and proteomic/genomic design and testing and general molecular biology applications for brain tissue analysis. Additional requirements include neural stem cell dissection, culture, and neurotransplantation techniques, identifying/measuring growth factors in biological tissues, immunocytochemistry and quantitation by image analysis and/or stereology, and performance of required surgery on small animals (i.e., rodents), design and implement proteomics and genomic technologies for studies in rat brain tissue, CSF and blood following brain injury. Identifying biomarkers of brain injury by characterizing the profile of specific changes in functional proteins relative to injury severity and functional recovery measures. Essential responsibilities include reporting results through publication in scientific literature, presenting at scientific conferences and meetings, providing technical reports, and providing briefings as requested.
SERIES: 0401, 0403, 0405, 0413

Work involves hands-on care of large animals (swine) in an ICU setting to include monitoring and assessment of critically ill animals; intravenous administration of fluids; planning, set-up, and monitoring of total intravenous anesthesia; set up and monitoring of mechanical ventilation; perform video bronchoscope in injured swine (acute respiratory distress syndrome); perform emergency surgical procedures; collect vital sign waveforms using Dynamic Research Evaluation Workstation. The work solicits application of tools from complexity science and cell biology in order to understand the normal and pathologic cardiopulmonary responses of intact organisms, isolated organs, and cells to various stressors. These stressors include hemorrhagic shock, environmental exposure, electromagnetic radiation, heat, and other forms of injury. Research requires skills with novel methods of physiologic monitoring and biosignal analysis, performance of non-linear and complexity analysis of ECG and other wave forms collected from multiple human and animal subjects using WINCPRS software. The incumbent is expected to be proficient with advanced cell biology techniques to include isolation of cells from lung tissue and other organs, collection and determination of cell populations and application of flow cytometry to assess changes due to injury.
SERIES: 0413

Serves as a board certified physician responsible for the examination, diagnosis and treatment of patients who are admitted to the burn services in the outpatient setting and on the wards on a consultation basis. Exercises independent judgment in selection and performance of a full range of diagnostic procedures for patients. On the inpatient units and in the outpatient clinic performs a wide range of medical duties covering rehabilitation medicine and care of patients with functional deficit. Examines and assesses patients, develops and manages a comprehensive rehabilitation program evaluates radiolographic and laboratory tests, performs electro diagnostic studies and prescribes appropriate treatment to include therapeutic services and modalities, prostheses and orthotics, medications, radiographic studies, durable medical equipment, and dispositions and direct pain management procedures to include soft tissue injects, botox and has an understanding of alternative treatment strategies. Refers to appropriate specialty clinic when required for evaluation and/or treatment. Provides prescription renewal and telephone consultative services. Provides episodic care to acute and chronic patients. Evaluates recommends, and coordinates appropriate rehabilitation regimens for inpatients with multiple complicated problems who were referred by various inpatient services. Participates in research in the development and implementation of prospective and retrospective studies with the goal of presenting the results in appropriate forums. Reviews articles and contributes to publication at the request of or with the approval of staff members. Advises, teaches and provides consultation to other heal care providers (nurse practitioners, physician's assistants, therapists, medical students and interns). Serves as a member of a health care team comprised of other physicians, non-physician providers, and ancillary staff. Provides medical consultative services and chart review for quality assurance purposes. Attends other meetings such as Multidisciplinary Conference at CFI, regional and national meetings as directed.
SERIES: 0602

Work involves specialized knowledge and experience to conduct regulatory laboratory studies in the field of combat casualty care. Laboratory activities usually require compliance with and a working knowledge of Food and Drug Administration (FDA) requirements for Good Laboratory Practices, Good Manufacturing Practices, or Good Clinical Practices. Laboratory work will support Phase1, Phase 2, Phase 3, or FDA Animal Rule studies, as well as characterization of medical products manufactured for clinical research. Investigational new products could be drugs or medical devices. Responsibilities include coordination, interaction, and communication with regulatory affairs, quality assurance support, and pharmaceutical sponsor personnel. Skills and knowledge include knowledge and application of current FDA non-clinical, clinical, and pivotal animal study research. Knowledge and experience in analytical method optimization and validation is highly desirable. Additional tasks include preparing and reviewing SOP's, protocols, research reports, educating research scientists regarding regulatory practices and requirements, and developing local procedures and policy for FDA-regulated activities.
SERIES: 0620

Work involves research into the normal and inappropriate hemodynamic responses to hemorrhage, with the focus on identification of novel physiological measurements and knowledge products designed to provide improved decision support for the need of life saving intervention(s) and triage prioritization during the compensatory, pre-shock stages of hemorrhage. Work requires ability to plan, develop, implement, and or conduct research to define mechanisms of compensation to blood loss. Research will include skill in investigating the effects of environmental, operational and or genetic factors on the mechanisms of compensation to blood loss. Expertise with using telemetry to continuously measure cardiovascular parameters in the study of blood pressure regulation, with a preference on experience with human experimentation. Proven ability to write successful grant proposals and publish scientific papers in peer-reviewed journals. Ability to review contract proposals in area of expertise and serve as Contracting Officers Representative when required.
SERIES: 0413

Work involves knowledge of, and experience with DoD accession policy for enlisted and commissioned officer. This position with serve to assist the Director of Statistics and Epidemiology in the supervision of several data analysts and epidemiologists who work on the AMSARA projects. AMSARA is chartered by the Deputy Undersecretary of Defense for Personnel and Readiness, and serve as a consultant to the Medical-Personnel Steering Committee, and the Accessions Medical Standards Working Group (AMSWG). Requires specific knowledge in epidemiology and public health and research experience including knowledge of human subjects protection regulations.
SERIES: 0601

Work involves specialized knowledge and technical experience with telemetry hardware and software used for physiological data acquisition, analysis and presentation, coupled with extensive knowledge of chronically implanted biomedical instrumentation, electromagnetic signal transmission, signal filtering and processing, A/D conversion, and signal analysis. Assemble, calibrate and test telemetry systems; troubleshoot electronic and software communication issues, and independently perform telemetry support for animal studies in Biosafety Level (BSL)-2, BSL-3, and BSL-4 biocontainment laboratory environments. Write and execute telemetry system validation protocols, perform maintenance and maintain systems in validated state for use in Good Laboratory Practices (GLP) animal studies. Work requires ability to assist with telemetry implantable device and equipment selection, author telemetry methods for animal protocol design, and provide engineering/technical consultations. Responsible for the establishment of telemetry protocol support to include hardware and software installation, assembly of study materials, collection and analysis of study data, preparation of collaborating scientist technical report. Publish scientific papers in peer-reviewed journals, review contract proposals in area of expertise and serve as Contracting Officers Representative when required.
SERIES: 0855

As an expert in the nursing care of burn patients, serves as a role model and resource person to experienced burn nurses as well as those who are not fully trained, using knowledge of an extensive range of professional nursing theories, principles, and procedures; knowledge of interrelations of body systems and disease process; knowledge of emergency and resuscitative measures; knowledge of pathologic conditions associated with a variety of medical conditions; and skill to interact with patients and family members. Provides guidance and leadership to other nurses. Provides orientation and on job training (OJT) to nurses and other paraprofessionals. Coaches and mentors staff in the orientation process with a goal of those staff successfully completing wound care knowledge and skills validation prior to completion of the orientation/preceptorship period. Monitors, oversees, and documents staff performance during orientation/preceptorship periods to verify appropriate training is provided. Teaches patient care to other burn nurses at all levels of development. Leads patient care conferences, and conducts classes as part of continuing in-service training in intermediate and burn care.
SERIES: 0610

Provides comprehensive nursing care from admission to discharge for patients suffering from extensive burns and or complications and associated injuries. The work includes continual assessment, planning and evaluation of care, the development of a comprehensive plan of care, the recognition of physiological and behavioral changes and their significance to patient welfare, and extensive wound care. Wound care may include but is not limited to wound cleansing, debridement, application of topical agents and special dressings to include negative pressure wound therapy devices. Care also involves administering medications to include research drugs, and operating special equipment such as cardiac monitors and air fluidized beds. Requirements include knowledge in pathophysiology of burns and associated injuries; clinical experience and training in critical burn care; knowledge of psychosocial therapy and techniques to support and motivate burn patient and family; ability to interpret deviation in selected laboratory tests and procedures; and Advanced Cardiac Life Support.
SERIES: 0610

Provides long-term patient care from admission to discharge for patients suffering from extensive burns and or complications and associated injuries. Observe, reports, and documents all pertinent data affecting patient status. Performs a wide range of procedures to include but not limited to foley catherization, nasogastric tube insertions, bladder irrigations, tracheostomy care and suctioning, pre- and post-operative care, central line dressing changes and other procedures as established within the scope of practice. Delivers meticulous wound care using principles of aseptic technique. Provides daily wound care including cleansing, debridement, application of topical agents and special dressings to include negative pressure wound therapy devices. Administers prescribed medications within licensure and established scope of practice. Initiates infusion therapy and manages infusion of IV fluids, hyperalimentation fluids, blood, and blood products. Care also includes operating specialized equipment to include but not limited to bedside cardiac monitoring, remote telemetry, and air fluidized beds.
SERIES: 0620

Assesses patient care needs on a continuing basis. This includes reviewing records/reports from prior shifts, interpreting signs and symptoms of patients changing status and taking corrective action. Facilitates obtaining timely lab tests and X-rays as needed. Provides comprehensive nursing care to patients based on nursing assessments and diagnoses, physician's medical care plan as well as the physical, mental, social, and emotional needs of the patient. Documents legible, accurate and complete nursing entries in patient charts. Provides ongoing and appropriate patient education throughout stay and at discharge. Advises attending physicians of significant changes in patient's conditions in a timely manner. Institutes CPR as needed, and reacts to emergencies occurring on the shift. Advises physicians of actions taken and ensures proper documentation of nursing care provided on standardized nursing forms. Sets up, operates and monitors specialized medical equipment such as cardiac monitors, defibrillators, suction devices, etc. Manages nasal-pharyngeal and gastric suction as well as a variety of other drainage tubes. Consults with physician regarding medical and nursing management of patient care needs. Ensures infection control standards are applied in accordance with unit and department operating policy.
SERIES: 0610

Supports the Chief of Staff with managing the entire portfolio of organizational support services for the activity. Functional areas of oversight include: Resource Management, Military and Civilian Personnel, Logistics and Facilities Management, Information Management and Technology, Acquisition Management, Operations, Security, Safety, and Training. Develops, implements, communicates and oversees goals, objectives, processes, and policies to ensure support functions efficiently and effectively achieve the activity's mission. Ensures support services goals, objectives, and operations are aligned with organizational goals and objectives. Establishes baseline strategic planning initiatives and provides annual strategic plan updates. Coordinates and prioritizes resources across support services to manage links between the functional areas and the overall costs and risks to the organization. Exercises discretionary oversight and management of support services budget. Reviews and interprets new and established directives, policies, and procedures to assess their impact on support services and the overall operation of the activity. Provides reports, briefings, and recommendations to the activity for all functional areas.
SERIES: 0343

Manages and serves as a Senior Rating Official for Center level Management and Program Analysts Program and Support Directorate level Administrative Officers assigned to the institute; advises on staffing/reshape, position classification/organization design, personnel management, and human resource development/career program management. Assignments typically involve planning extensive, complex and critical initiatives that affect the quality and efficiency administrative management systems and programs. Gathers administrative information and requirements from higher headquarters, other command and elements, senior level management officials, and other affected personnel and activities; identifies critical issues and goals for the organization; and develops implementation plans that consider personnel, budget, manpower and other management requirements. Analyzes mission, management objectives and organizational goals, projecting personnel needs and potential problems.
SERIES: 0343

Provides an advanced level of specialized nursing care to complex, critically ill patients having numerous complicating conditions. As Level I Trauma Center, high level of specialized nurses are required for the management of patient presenting with current or potential life-threatening health problems. The nurse provides continuous observation, monitoring and must intervene to prevent complications and attempt to preserve health and promote optimized patient outcomes. Must independently make decisions and implement proper emergency measures after identifying and interpreting life-threatening conditions. Initiates life-saving measures which include but are not limited to advanced cardiopulmonary resuscitation; calculating dosages and mixing potent and potentially lethal drugs prior to arrival of a physician and administering these drugs upon the physician's directives; and performing arterial punctures for assessment of blood gases and making various ventilator adjustments, in accordance with unit policy, based on blood gas interpretations. Assists in the performance of endotracheal intubation and other life interventions as an integral member of the emergency response team in the burn patient population.
SERIES: 0602

Assists the physician with complex and potentially life-threatening procedures to include but not limited to, insertion of arterial and venous catheters, chest tubes, and endotracheal tubes. Inserts intravenous catheters and performs venipunctures to collect blood samples. Monitors intake and output and notifies physician when caloric or fluid needs change. Assesses, monitors and cardiovascular, pulmonary, neurological, gastrointestinal, integumentary, and genitourinary systems to include cardiac output, vital signs, peripheral perfusion, and level of consciousness. Performs continuous respiratory and ventilatory assessments, evaluating blood gas results from both arterial and mixed venous sources. Obtains patient and environmental cultures; uses crash cart appropriately in emergencies; suctions endotracheal tubes and other airways and assists with tissue biopsies. Continually observes, monitors, and assesses patient's condition. Interprets signs and symptoms of deterioration in condition and takes corrective action. Consults with physician and multidisciplinary team regarding medical and nursing management. Initiates, monitors and starts intravenous access, including US Guided IV or Intraosseous (IO) for administration of resuscitative medications. Knows and ensures infection control standards are applied in accordance with unit and department operating instructions. Collaborates with physicians and the multidisciplinary team to assure the delivery of the optimized clinical care standards are in adherence with the Joint Commission, the Society of Critical Care Medicine, the American Burn Association, and other governing agencies.
SERIES: 0602

Administers and monitors the use of therapeutic agents (medications) and manages advance diagnostic equipment treatment modalities in compliance with American Association for Critical-Care Nurses, (AACN), the Department of Health Affairs (DHA) regulations and directives, hospital and unit policies/guidelines for clinical nursing practice. , Initial orientation and/or certification will validate the use of medication, included but not limited to; sedation medication given intravenously, anxiolytics, Schedule II through Schedule V drugs, antimicrobials, experimental agents, anticoagulants and immunomodulators. Mixes and administers prescribed emergency medications to include vasoactive drugs) and is familiar with correct dosages potential side effects and antidotes. Must ensure IV compatibility with all medications administered intravenously and be knowledgeable of drug-drug interactions and proper administration. Administers and regulates intravenous fluids such as lipids, Total Parental Nutrition (TPN), blood volume expanders and blood products. Will titrate and administer medication as prescribed. Obtain ordered labs for medication monitoring as prescribed. Will notify providers with critical values and document per hospital policy. Uses specialized patient equipment to include but not limited to: ventilators, continuous renal replacement therapy machines (CRRT), intravenous infusion pumps, monitors extracorporeal membrane oxygenation (ECMO) circuits and pleurovacs, cardiovascular monitors used for measuring cardiac output, defibrillators, invasive pulmonary artery catheters, arterial and central venous catheters and EKG machines; equipment used for peritoneal dialysis and exchange transfusion, intra-aortic balloon pumps and others as required. Uses ICP monitors and CO2 monitors. Transports critically ill patients within and outside of the hospital for various diagnostic procedures, will support mission critical transports as a direct asset or in a supportive role at the unit level.
SERIES: 0602

Assesses patient and family to include physical and psychosocial needs by obtaining a detailed medical and surgical history. Provides care in accordance with patient-specific nursing care plans, either developed by incumbent or another critical care nurse. Continuously reassess and reevaluates care plans as the needs or conditions change for the patient. Provides an anticipatory, sound discharge plan that includes rehabilitation and health teaching both for patient and family in conjunction with the multidisciplinary team. Performs difficult and demanding patient advocacy tasks and effectively manages the most difficult advocacy problems that occur in a critical care setting. Advocates for patient rights to self-determination and autonomy, in conjunction with plans of the multidisciplinary team, family members to promote a holistic approach to patient wellness and health.
SERIES: 0602

Demonstrates expertise in in the management of complex cases critically injured patients. Serves as a role model to experienced critical care nurses in the management and care of burn patients in the critical care arena. Provides guidance and leadership to other professional nurses and oversees the work of paraprofessional personnel assigned to the Burn Center. Provides orientation and on-the-job training for such personnel. Will precept organic nursing personnel, promote operational readiness for military and civilian personnel across the Tri-Services through direct instruction, simulation and assigned nurses. Conducts clinically relevant in-services, lectures and provides formal and informal critical acer training. Leads patient care discussions with family and the multidisciplinary team for a collaborative approach to clinical care with an emphasis of evidenced base practice Participates in the development of standards of practice/evidenced based practice and in the establishment of quality assurance goals for the critical care unit. Serves as unit charge nurse or nursing clinical care coordinator if assigned as an additional duty. . As charge nurse or nursing clinical care coordinator for the Burn Center, will provide mentorship, education, and support to other professional nurses across the organization. Will floats to other critical care units care units as required. Maintains Advanced Life Support (ALS) credentialing according to hospital guidelines as a critical care nurse in the Burn Intensive Care Unit.
SERIES: 0602

Provides comprehensive nursing care from admission to discharge for patients suffering from extensive burns and or complications and associated injuries. The work includes continual assessment, planning and evaluation of care, the development of a comprehensive plan of care, the recognition of physiological and behavioral changes and their significance to patient welfare, and extensive wound care. Wound care may include but is not limited to wound cleansing, debridement, application of topical agents and special dressings to include negative pressure wound therapy devices. Demonstrates knowledge in pathophysiology of burns and associated injuries; clinical experience and training in critical burn care; knowledge of psychosocial therapy and techniques to support and motivate burn patient and family; ability to interpret deviation in selected laboratory tests and procedures; and Advanced Life Support (ALS).
SERIES: 0602

Work involves research on theoretical models of respiratory infectivity research on theoretical models of respiratory infectivity properties of microorganisms and their products, aerosol deposition within the respiratory system, effects of respiratory infections on pulmonary physiology, and interrelation of physics and pathogenesis of disease induced by aerosol exposure to infectious agents. Principal objectives of investigations are to develop knowledge of basic properties and physical interactions that occur between aerosol particles and the pulmonary system, and subsequent biological and physiological reactions (with collaboration and assistance from specialists in microbiology, physiology, immunology, and pathology) between inhaled microorganisms and the host. Serves as an expert consultant in the field of aerobiology. Immunizations Required.
SERIES: 0401, 0403, 0413, 0415, 0602, 0701

Work involves utilizing the skill and knowledge to conduct laboratory investigations on the aerosol toxicity of infectious agents and biological toxins (to include generation, characterization, and sampling of bioaerosols; evaluation of retention and deposition of aerosols; and determining the efficacy of vaccines/therapies against an aerosol challenge).
SERIES: 0401, 0403, 0415, 0404

Work involves participation in both basic and applied research to develop, adapt and standardize aerosol generating and sampling equipment for exposure of appropriate animal models to microbiological agents. Investigates and develops new and novel methodology for determining aerosol deposition and retention of microorganisms and biological toxins. Generates, characterizes and samples biological aerosols. Develops animal models for studying the pathogenesis of aerosolized biological agents of mission relevance and for vaccine efficacy studies. Carries out microbiological assays to determine aerosol concentrations and inhaled distribution of biological agents. Investigates independently and in collaboration with others events in the acute and early convalescent phases of infection in representative laboratory animals following aerosol exposure. Immunizations Required.
SERIES: 0440, 0403, 0401, 0602, 0701, 0644, 0413

Work involves investigations in which the nature, scope, and emphasis of problems may vary due to the viruses or toxins under study, such as the development and application of assays for histologic localization of antigens/proteins, cellular populations, agent/host nucleic acid sequences, and host mediator constituents; development and application of assays for quantitation of antigens/proteins or specific nucleic acid sequences; and correlation of data with the clinicopathologic characteristics of the model being utilized. This involves biochemical techniques for demonstrating proteins (i.e. immunohistochemistry, immunoelectron-microscopy, analytical chemistry, Western blots, radioimmunoassay) and nucleic acid sequences (i.e., in situ hybridization, analytical slot blots, Northern and Southern gels and blots, filter hybridization) in fresh, fixed, and frozen tissue or specimens. Immunizations Required.
SERIES: 1320, 0601, 0602, 0701, 0644

Work involves a research program to characterize the macromolecular components of pathogenic bacteria of military relevance to determine their roles in pathogenesis, expression during disease and their use in methods for rapid pathogen detection, diagnosis and identification. Work requires extensive current knowledge of concepts and techniques in microbiology, immunology, and biochemistry. Plans and performs research including but not limited to the following: (a) isolates and chemically characterizes cellular components of bacterial biological warfare (BW) agents; subjects purified components to various biochemical and immunological assays to determine chemical and antigenic composition; (b) establishes and maintains expertise, reagents, and equipment for bacterial identification; develops new approaches to bacterial identification and implements them for rapid detection of BW agents; (c) studies use of and sensitivity of various detection methodologies and diagnostic assays; and (d) supports other government agencies in dealing with BW agents, in special investigations and in analyzing clinical and environmental samples. Immunizations Required.
SERIES: 0403, 0401, 1320, 0415, 0602, 0701, 0644

Work involves designing, planning, and performing biochemical research on the development of native and genetically engineered enzymes as pretreatment and treatment drugs for counteracting the toxicity of chemical agents. Devising and carrying out methods for large-scale purification of enzymes and for genetic engineering of enzyme molecules are required. Additional responsibilities include preparing and implementing protocols for elucidating the inhibition of enzymes by organophosphate and other related toxins. The ability to characterize recombinant and native enzymes for definition of structure-function relationships and for efficacy as bioscavengers against nerve agent toxicity is essential.
SERIES: 0401, 0405, 0415, 0440, 1320, 1083

Work involves participating in the planning, coordinating, evaluation of, administration of, and reporting on various aspects of a complex biomedical research program. Duties include responsibility for managing the technology transfer program that includes patents and intellectual property. Developing, coordinating, and managing an extramural research program, an in-house independent research program, and an Army Research Office program for the activity is required. Knowledge of biomedical research programs is critical.
SERIES: 0401, 0403, 0601, 0701, 0440

Work involves formulating and evaluating both basic and applied research pertaining to development of vaccines/therapies. Expertise is required in microbiology, immunology, and pathophysiology to perform laboratory investigations to develop immunoprophylaxis and therapeutic measures for treatment of botulinum neurotoxin intoxication.
SERIES: 0403, 0413, 0401, 0701

Work involves applied chemical, biochemical and biophysical research pertaining to development of medical defensive measures against biological agents. Serves as principal investigator for biochemical and related research to resolve structural properties of bacterial toxins and viral proteins. Studies are concerned primarily with the elucidation of the amino acid sequence of bacterial toxins. Methods will be developed to fragment the proteins and to isolate and purify the resulting peptides. Applies and modifies when necessary standard methods for the determination of the amino acid sequence of the peptides; (b) serves as collaborative investigator for the identification of viral proteins. Conducts studies to determine partial amino acid sequence of these proteins; (c) conducts studies to determine the site of biological action of bacterial toxins. Modifies the toxins by means of chemical and enzymatic reagents and measures the effects upon their toxicity and immunological reactivity. Immunizations Required.
SERIES: 1320

Work involves planning and developing research projects according to the Army's biomedical mission (medical defense against chemical and biological weapons). Performing research as a principal investigator or collaborator, working independently, and supervising technical personnel are all associated duties of this position. Duties require knowledge of mechanistic enzymology, chemistry, biochemistry, neurochemistry, neurobiology, chemistry, and cell biology. Work demands experience in methodology required for protein and small ligand characterization, in biological toxin inhibitor studies, in intricate experimentation in cell culture model systems.
SERIES: 0401, 0403, 0415, 0440, 1320

Work involves planning and developing research projects related to Army's mission of development of biotechnology-related defense against chemical and biological agents. This position requires thorough knowledge of biochemistry, analytical chemistry, immunology, and tissue culture. Required tasks include performing research as a principal investigator or collaborator in projects related to the development of models for organophosphate toxicity, use of enzymes and other macromolecules as pretreatment drugs for chemical and biological toxicity, and use of computer methods in biological research. Serving as assistant department chief and handling administrative activities and personnel management tasks for the Dept. of Biological Chemistry are additional responsibilities.
SERIES: 0401, 0403, 0405, 0415, 1320

Work involves planning and developing biochemical research projects related to the Army's mission of medical defense against chemical and biological weapons. Working independently and as a supervisor of technical personnel is required. Using skills and knowledge of pharmacology, neurochemistry, neurobiology, chemistry, cell biology, organic synthesis, analytical chemistry, and the methodologies required in conducting experiments in animal and cell culture model systems is essential. This position requires experience in biochemical probes and ligands synthesized and used to study structure-activity relationships within receptor systems.
SERIES: 0401, 0403, 0405, 0413, 0415, 1320

Work involves designing, planning, and performing research on the Army's mission of defense against chemical and biological weapons. Tasks include serving as an independent investigator performing research studies in neurophysiology, neurochemistry, pharmacology, and biochemistry. Work requires extensive knowledge and experience in tissue culture. Developing protocols to study the effects of organophosphates and other toxic compounds on the central nervous system is also required.
SERIES: 0401, 0403, 0405, 0413, 0415, 1320, 0332, 1083

Work involves serving as a research protein biologist performing tasks related to Army mission of development of pretreatment and treatment drugs for chemical and biological agent toxicity. Utilizing expertise in methodologies of enzymology and protein chemistry to study the structure and function of cholinesterases and the effects of organophosphates on these enzymes is essential. This position requires a thorough knowledge of protein sequencing, protein synthesis, biochemistry, and a working knowledge of immunology.
SERIES: 0401, 0403, 0415, 0440, 1320

Work involves planning and executing basic and applied research directed at the discovery and transition to advanced development of drugs for the treatment and prevention of naturally occurring infectious diseases or chemical and biological warfare agents. Expertise is required in mechanisms of drug action, the design and synthesis of novel organic compounds, structural confirmation using chemical spectroscopic techniques (mass spectrometry, infrared spectroscopy, NMR spectrometry, etc.), design of medicinal agents, development of methods for the analysis of drugs in complex biological milieus, isolation and structure elucidation of natural products and synthetic medicinals, biotransformation of drugs, molecular modeling, structure determination of target biological molecules, molecular biology, and drug-biomolecule interactions.
SERIES: 0401, 0403, 1320, 0405, 0413, 0601, 0602

Work involves serving as a principal investigator in virology providing electron microscopic support for a variety of arbovirus research problems being investigated to include the basic characterization of "new" or unidentified viral agents as they are submitted for identification or become a research problem. Must have sufficient experience in arbovirus electron microscopy. Supports existing research programs investigating the etiologic agents of Hemorrhagic Fever with renal syndrome and tick-borne encephalitides by providing basic biochemical and biophysical characterization of the viruses. Immunizations Required.
SERIES: 0403, 0401, 0602, 1320, 0701, 0601, 0644

Work involves conducting experiments that require specialized knowledge and experience in current immunology and virology aimed at generating novel scientific knowledge required to combat highly pathogenic human viral diseases. Most of the work is performed under P3 level containment, but a signification proportion may involve P4 level containment. Coordinates and executes a wide variety of technical procedures as required to achieve overall goals and objectives. Techniques will include not only standard immunoassays to measure antibodies against viruses and virus subunits (e.g., enzyme-linked immunosorbent assays, virus neutralization, and immunofluorescence) but also assays of antigen-specific cytolysis and lymphoproliferation. Executes studies on the immunobiology and pathogenesis of viral diseases in experimental animals. Inoculates, bleeds, and removes selected organs from animals. Performs standard assays to measure immune responses in serum and/or lymphoid cells, and to quantify virus or viral antigen in blood and tissues. Applies appropriate sterile microbiological techniques to cell culture for virus propagation (or assay), and for production and maintenance of lymphocyte hybridomas and other continuous cell lines. Immunizations Required.
SERIES: 1320, 0401, 0403, 0602, 0701, 0644

Work involves drug design and development. Position involves study of mode of action of bioactive lipid metabolism in lethal shock, and carcinogenesis. The identification of genes differentially expressed in response to toxins or other agonists is required.
SERIES: 0401, 0403, 0415, 1320, 0440

Work involves various procedures in protein and nucleic acid biochemistry, serology, and molecular virology involving several successive, sophisticated phases for completion. Requires a current and extensive knowledge of the methodologies utilized in biochemistry, molecular virology, cell culture, and immunology/serology. Studies are with high-hazard viral agents. Performs biochemical analysis of viral proteins and antigens. Adopts or modifies available methods or develops new procedures as required for the identification and characterization of viral proteins and glycoproteins and for the separation and purification of individual components from complex mixtures. Performs intrinsic/extrinsic-radiolabeling procedures resulting in preparations of high specific activities. Uses such techniques as affinity, ion exchange, and exclusion chromatography, one and two dimensional polyacrylamide gel electrophoresis, analytical and preparative isoelectric focusing, immunoprecipitation, and preparative elution electrophoresis. Conducts peptide analysis and separation by gel, thin layer, ion exchange, and reverse phase chromatography. Immunizations Required.
SERIES: 1320, 0401, 0403, 0602, 0701, 0644

Work involves formulating and evaluating both basic and applied research pertaining to development of therapies. Expertise is required in microbiology, molecular biology, and pathophysiology to perform laboratory investigations developing therapeutic measures for treatment of botulinum neurotoxin intoxication.
SERIES: 0403, 0405, 0413, 1320, 0401, 0602, 0701

Work involves a comprehensive research program to investigate all aspects of pathogenesis, immunology, and prophylaxis of bacterial infections. Proficient in the performance and theoretical understanding of standard microbiology, molecular biology and biochemistry techniques. Involved in studies requiring the safe culturing of pathogenic bacteria, handling of laboratory animals, isolation and purification of nucleic acids, cloning and subcloning of DNA fragments, restriction enzyme analysis of DNA, polymerase chain reaction, DNA sequencing, transformation/electroporation of bacteria, and agarose/polyacrylamide gel electrophoresis will be performed routinely.
SERIES: 0401, 0403, 0415, 0602, 0701, 0644, 1320

Work involves conducting an independent research program on analysis and detection of marine, aquatic, and terrestrial toxins of military importance. Serves as senior resident investigator in the areas of chemistry, analytical chemistry, analytical instrumentation, analytical toxinology, and analytical methodology. Directs a multi-disciplinary research program to investigate chemistry and analytical chemistry of toxins. Develops new analytical strategies utilizing electrophoretic, chromatographic, and spectroscopic analytical instrumentation for identification, detection, and quantification of toxin and/or metabolites at trace and ultratrace levels. Immunizations Required.
SERIES: 1320

Work involves conducting research studies designed to develop anti-toxin products for protection against or treatment of toxin exposure. Conducts research where the problems vary over a period of time. Conducts investigations into the effects of antitoxin substances on the pathogenesis of toxin exposure to utilize appropriate animal models for the evaluation of anti-toxin substances in rodents and primates. Initiates studies involving a number of specialized and technically difficult procedures, with protein toxins highly lethal for humans, that require special considerations imposed by biological containment facilities for biological samples and infected animals under BL-3 microbiological containment conditions. Evaluates potential anti-toxin substances including the formulation and administration of treatment regimens as required, evaluation of the treatment on the disease course including the collection and analysis of specimens that describe alterations in the pathogenesis. Immunizations Required.
SERIES: 0401, 0403, 0413, 0415, 0405, 0602, 0701, 0644

Work involves research on protein toxins. Research emphasizes the field of cellular immunology, cell/molecular biology and protein chemistry. Develops new and improved vaccines against protein toxins. Performs research on the immunology and pathogenesis of toxins with specific emphasis on the development of an effective immune response. This involves measuring the cellular and humoral immune response to toxins; determining in vitro correlates of immunity; developing new CRM or synthetic vaccines using both traditional and novel routes and carriers; evaluating the nature of antigen processing and adjuvanticity; and optimizing vaccine preparations and immunizations schedules to enhance the safety and efficacy of new vaccines. Immunizations Required.
SERIES: 0401, 1320, 0403, 0440, 0602, 0701

Work involves serving as a principal investigator responsible for planning, directing and conducting basic research to investigate, with computer-aided molecular modeling systems, the molecular structures of biological warfare (BW) threats (e.g., toxins, toxic substances from viruses, infectious microorganisms), and their naturally occurring target molecules (substrates). Conducts basic research to develop potentially effective prophylactic and chemotherapeutic countermeasures (vaccines, antibodies, and drugs) to eliminate the effects of BW threats (e.g., botulinum toxin, ricin, various toxins in snake venoms, infectious disease vectors). Investigates structural and chemical features of the toxin and substrate molecules under study by using strategies that involve the calculation of free energies, electrostatic properties, and that use algorithms based on molecular dynamic, quantum mechanics, statistical mechanics, simulated annealing, and Monte Carlo techniques. Immunizations Required.
SERIES: 0701, 0413, 0602, 1320, 0401, 1310, 1520

Work involves designing research plans and directing assigned personnel and selecting and developing means of basic or applied research methods to determine the effects of toxins of military importance utilizing aerobiology approaches. Develops new techniques, methodologies, and instrumentation to aerosolize toxins of biological origin. Develops procedures and instrumentation to expose animals in the most appropriate manner to solve the research goals. Once a responsive model has been developed, incumbent determines appropriate end points and develops methodologies to measure, quantify, and validate the toxic response. This involves principally in vivo studies but in vitro studies may also be required as ancillary measure in expanding the aerosol studies. Immunizations Required.
SERIES: 1320, 0401, 0413, 0415, 0602, 0701

Work involves serving as assistant investigator involving the biochemical and biophysical characterization of protein toxins. Studies the synthesis, processing, and function of nucleic acids using existing methodology. Requires proficiency in the extraction of undegraded RNA from tissues or cell cultures, and characterization by agarose gel electrophoresis, density-gradient centrifugation and hybridization assays. Requires experience in the in vitro translation of messenger RNA to determine coding specificities and relationships. Purifies messenger RNA by affinity chromatography or by the preparation of solid phase matrices using RNA or recombinant DNA clones. Performs basic gene cloning techniques to include manipulations of plasmids, screening for gene inserts, preparation of plasmid DNA, restriction enzyme digests and the entire methodology associated with DNA sequencing. Immunizations Required.
SERIES: 0440, 0403, 0401, 0602, 0701, 0644

Work involves studies of the synthesis, processing, and functions of nucleic acids using existing methodology. Develops and improves methods for gene synthesis using synthetic oligonucleotides. Such studies require proficiency in the extraction of undegraded RNA from tissues or cell cultures, and characterization by agarose gel electrophoresis, density-gradient centrifugation and hybridization assays. Experience in the in vitro translation of messenger RNA to determine coding specificities and relationships. Purifies messenger RNA by affinity chromatography or by the preparation of solid phase matrices using of recombinant DNA clones. Performs basic gene cloning techniques to include manipulations of plasmids, screening for gene inserts, preparation of plasmid DNA, restriction enzyme digests and the entire methodology associated with DNA sequencing. Immunizations Required.
SERIES: 1320, 0401, 0403, 0602, 0701

Work involves participation in research pertaining to the development of antiviral drugs. The incumbent carries out laboratory investigations to assess the efficacy, toxicity and pharmacology of antiviral drugs in compliance with the Good Laboratory Practices Act. Conducts and executes a research program of intramural and extramural research projects for the development of immunoenhancing drugs. The research is inherently complex and requires an intimate knowledge of immunology, toxicology and virology. Plans and performs experiments to evaluate the potential of selected compounds as vaccine adjuvants and evaluate new drug delivery technologies for a slow timed release of such compounds. Immunizations Required.
SERIES: 0401, 0403, 0602, 0701, 0405

Work involves independently, or as a team member, investigating assigned research problems pertaining to the immunological and immunochemical relationships of toxins to pathogenesis in experimental animals, and in the development of techniques and assays for the early detection of toxin exposure in man. Requires a current and extensive knowledge of the methodologies utilized in immunochemistry, biochemistry, and immunology. Performs a variety of biochemical and immunochemical procedures to purify antibodies, conjugate antigens to carriers, separate serum components, and isolate factors such as interleukins, prostaglandins, or others associated with immune function studies. These include but are not limited to column chromatography, agar gel and acrylamide gel electrophoresis, high pressure liquid chromatography, fast protein liquid chromatography, thin layer chromatography, iso-electric focusing, and gas-liquid chromatography. Directs and participates in immunological assays such as radioimmunoassays and enzyme linked assays, where required, and assists in the development of new and innovative rapid diagnostic techniques. Immunizations Required.
SERIES: 1320, 0404, 0602, 0701

Work involves conducting research on protein toxins. Research emphasizes the fields of immunology, cell, and molecular biology. Develops a research plan and performs research on the immunology and pathogenesis of protein toxins, with special emphasis on developing vaccines or therapeutic moieties effective in preventing pathogenesis. This involves applying the appropriate techniques of immunology, cell and molecular biology to measure the immune response to toxins and toxin vaccines; develop in vitro correlates of immunity; develop or improve upon vaccines using existing or novel routes; optimize vaccine preparations and immunization schedules to enhance the safety and efficacy of new vaccines. Immunizations Required.
SERIES: 1320, 0403, 0401, 0644

Work involves participation in animal experimentation involving the handling and surgical manipulation of a variety of infected, non-infected, and toxin-treated laboratory animals including, but not exclusive of mice, rats, rabbits, and guinea pigs. Coordinates and executes investigations in which the nature, scope and emphasis of problems may vary due to the toxins under study. Depending on the toxin-host interaction, this may include measuring pulmonary function such as pulmonary-blood gas exchange, pulmonary mechanics (i.e., respiratory frequency, respiratory tidal volume, respiratory resistance and compliance), oxygen consumption and carbon dioxide production, cardiorespiratory homeostasis and other physiological parameters as indicated by the biological reactions of the intoxicated host. Conduct in vivo investigations to determine direct and indirect effects of inhaled toxins and products on host metabolism, pulmonary clearance, and pulmonary extraction ratios of inhaled substances, alterations in host defense mechanism and survival time. Immunizations Required.
SERIES: 0401, 0413, 0701

Work involves responsibility for conducting in vivo toxicological studies and analytical chemistry evaluation of toxins of importance in the biological defense program. Conducts in vivo toxicological evaluation of all toxins utilized in the division by parenteral, oral, dermal, and ocular routes of exposure. Develops animal models to assess various routes of exposure. Utilizes an in vivo bioassay system to evaluate procedures for inactivation of toxins. Utilizes chemical procedures to evaluate the purity, composition, stability and physical characteristics of various toxins. This involves the use of various chromatographic procedures, such as high pressure liquid chromatography (HPLC) and ion exchange chromatography for amino acid analysis. Serves as division safety officer for handling of toxin materials. Implements requirement set forth in the DOD guidelines for safe handling of toxic material and regulatory guidance for handling, using, storage, and disposal of hazardous chemicals. Immunizations Required.
SERIES: 0701, 0413, 0602, 1320, 0401

Work involves serving as associate investigator on a research team that plans, coordinates, and executes multiple projects in microbiology, immunology, and pathophysiology, with special emphasis on the development, prevention, and treatment from poisoning by protein toxins. This includes the development and use of measures of toxin lethality, antigenemia and specific humoral or cellular immune responses. Adapts or develops techniques for successful characterization and use of the animal or cell models. Obtains all experimental materials and assumes responsibility for performing the required assays or coordinating specialized tasks with appropriate investigators. Immunizations Required.
SERIES: 0401, 0403, 0644, 0405, 0413, 0414, 0415, 0701

Work involves research on plant, animal or microbial toxins of military relevance. Research spans the field of toxin research from synthesis and production of toxins to their action on target cells or organs. Special emphasis is placed on the use of molecular genetic approaches to solve various problems. Serves as principal investigator and Institute advisor in the area of molecular genetics. Employs the technology of molecular genetics to investigate and solve problems of toxin synthesis including its regulation, toxin production and purification, and toxin mechanism of action. Directs research toward novel approaches to protection from toxins such as Cross Reacting Materials (CRMs) or site-specific mutagenesis products. Conducts biochemical studies as required to define the binding, internalization, activation, enzymatic activity and subcellular distribution of toxins. Immunizations Required.
SERIES: 1320, 0440, 0602, 0701

Work involves investigations in which the nature, scope, and emphasis of problems may vary due to the peptides and physiologically active compounds under study, such as the development of techniques for quantitative and qualitative evaluation of host-agent interaction. Performs biochemical techniques for the isolation and purification of peptide and non-peptide compounds using HPLC and gel electrophoresis. Develops chemical and radioimmunologic assays for the specific detection and quantitation of protein and non-protein compounds; prepares radiolabel peptides; develops radioreceptor assays using whole cells or isolated membranes. Studies receptor-coupled cyclic nucleotide metabolism, and membrane transport of small molecules and ions. Studies the mechanism of action and pathogenesis of physiologically active compounds. Develops methods for their quantitation in biological samples. Immunizations Required.
SERIES: 1320, 0413, 0602, 0701

Work involves research on plant, animal or microbial toxins of military relevance. Research emphasizes the field of immunology, protein chemistry and toxin/protein purification. Serves as principal investigator and Institute advisor in the area of immunology, toxin production/purification and vaccine development. Directs research to develop new vaccines by both traditional and novel routes. Optimizes toxoiding and immunization schedules for toxin-derived vaccines. Studies toxin structures and obtains peptides for testing and development as synthetic vaccines. Tests genetically produced altered toxins (CRMs) for their potential as vaccines. Conducts research necessary to prove safety and efficacy of new vaccines. Immunizations Required.
SERIES: 0401, 0403, 0440, 0644, 0602, 0701

Work involves research on plant, animal or microbial toxins of military relevance. Research emphasizes the fields of microbiology, fermentation and toxin/protein purification. Serves as principal investigator and Institute advisor in the areas of microbiology, fermentation, toxin production/purification and toxoiding. Directs research to improve present vaccines to include such subjects as developing high toxin-producing strains, optimizing toxin yields in fermentation, improving purification schemes and optimizing toxoiding schedules. Directs research to develop new vaccines by such means as production and purification of cross-reacting materials (CRMs) or synthetic peptide-based vaccines. Conducts research necessary to prove safety and efficacy of the new vaccines. Immunizations Required.
SERIES: 0401, 0403, 0602, 0701

Work involves serving as a senior primary investigator in the Pathology Division, USAMRIID. Plans an independent research program and utilizes a wide variety of electron microscopic techniques to elucidate the subcellular pathogenesis of potential BW infectious agents and intoxicants. This includes application and interpretation of techniques such as morphologic interpretation of subcellular changes, immunoelectron microscopy, freeze fracture and freeze substitution methodology, scanning electron microscopy, and scanning immunoelectron microscopy. Conducts searches of recent scientific literature to develop background data and define problem areas. Plans and executes independent and collaborative research with particular emphasis on the ultrastructural technology and morphologic interpretation of subcellular lesions associated with pathogenesis studies. This entails defining the research problem, developing approaches and experimental protocols for tasks, coordinating research efforts with other professionals, overcoming technical difficulties, and interpreting the significance of results to plan further research or to recommend termination of unfruitful tasks to pursue problems of higher priority. Plans, directs, and participates in the development and application of technology and assays for ultrastructural research. These include (a) defining and developing reproducible reliable identification systems such as immunoelectron-microscopy, immunohistochemistry, and in situ hybridization techniques for viruses, toxins, bacteria, and mediators of disease at the subcellular level; (b) developing fixative methods for retention of antigens and nucleic acids in animal tissues and cell cultures; (c) utilizing and applying image analysis systems to quantitatively evaluate ultrastructural pathology; and (d) exploring the application of methodology such as elemental analysis, freeze fracture and freeze substitution, cytoultramicrotomy to elucidate pathogenesis of microbial infections and intoxications. Immunizations Required.
SERIES: 0401, 0403, 0602, 0701, 0415

Work involves providing research support for independent research programs consistent with Institute and Command objectives. Utilizes a variety of electron microscopic techniques to identify and define ultrastructural changes and the pathogenesis of injury to cells and tissues exposed to chemical, biochemical and non-kinetic battlefield threats. Plans, develops and executes collaborative research efforts with particular emphasis on the ultrastructural interpretation of subcellular lesions associated with exposure to chemical and biochemical agents and non-kinetic battlefield threats Serves as a technical expert in ultrastructural microscopy and performs all duties in the electron microscopy laboratory. These duties entail receiving, logging, processing, cutting, staining, examining, and diagnosing all specimens. Reviews proposed and existing research proposals and protocols for the applicability of electron microscopy and assurance that ultrastructural aspects are fully explored. Reviews technical reports and manuscripts to assure scientific and technical accuracy as pertains to electron microscopy. Additional requirements include keeping current with professional journals, evaluating new technology for implementation, digital imaging and image processing, and preparing material for publication in professional journals and at meetings.
SERIES: 0401, 0403, 0602, 0701, 0644, 1310, 0415

Work involves studies of the biological properties of viruses to include synthesis, processing, and function of viral nucleic acids and viral proteins. Uses existing methodologies or modification of published techniques. Knowledge and implementation of advanced eucaryotic vector systems to express viral proteins or nucleic acids will be required. Such studies require proficiency in the extraction of undegraded RNA from virus particles or infected cell cultures, and characterization by gel electrophoresis, density-gradient centrifugation and hybridization assays. Performs biochemical analysis of viral proteins and antigens. Uses techniques such as affinity, ion exchange and exclusion chromatography including HPLC, polyacrylamide gel electrophoresis, immunoprecipitation and preparative elution in electrophoresis. Performs radiolabeling procedures resulting in preparations of high specific activities. Conducts peptide analysis and separation. Prepares recombinant DNA clones using viral templates. Propagates, purifies, concentrates, and analyzes hazardous viruses under BL-3 or BL-4 containment conditions. Immunizations Required.
SERIES: 0401, 0403, 0602, 0701

Work involves investigating respiratory and systemic toxicity and pathogenesis of disease/toxicity induced by aerosol exposure to infectious agents or biological toxins. Principal objectives of investigation are to develop knowledge of the initial interactions that occur between aerosol particles and the respiratory system, and subsequent biological, physiological and immunological responses between the inhaled organisms/toxins and the host. Research conducted is inherently complex and necessitates knowledge of immunology, cell biology, microbiology, and molecular biology. Directs and coordinates laboratory investigations in the area of analysis of respiratory immune responses to inhaled microorganisms and/or biological toxins that are of importance to USAMRIID's mission. Emphasis is on the development of immunogens for respiratory protectin and analyses of mechanisms of cellular commitment to immune responses, including effects of cytokines on immunoglobulin production and expression of surface phenotypes that result in selective lodging of immunoreactive effector cells in respiratory tissue. Immunizations Required.
SERIES: 0401, 0403, 1320

Work involves the elucidation and manipulation of critical molecular determinants of pathogenicity of potential viral and bacterial biological warfare (BW) agents. These studies require the application of a wide range of molecular biology and genetic engineering methods to construct multiple-attenuated virus strains to gain a better understanding of genetic determinants that govern pathogenesis. Technical skills include the ability to construct full-length cDNA clones, subclone and modify segments of genome, sequence DNA, transform and maintain bacterial cultures, extract and purify DNA from plasmid preparations, perform site-directed mutagenesis, PCR amplification, and express protein from cloned sequences in replicon or baculovirus vectors. Pathogenesis studies involve infection of appropriate animal models with selected virus clones to support vaccine research efforts and to study the molecular determinants of pathogenesis in vivo. Ability to perform or direct standard virologic assays which involve cell culture techniques, growth and preservation of virus stocks, virus titrations, and the development and application of in situ hybridization and immunohistochemical assays at microscopic and ultrastructural levels in order to elucidate the pathogenesis of selected infectious diseases. Work is performed frequently under BSL3 and BSL4 conditions. Immunizations required.
SERIES: 0403, 0401, 1320

Work involves planning, development, establishment, management and execution of complex medical research and development projects conducted to support priority missions such as biological defense, infectious disease or public health surveillance. Responsibilities include coordinating extramural research projects and directing in-house independent research projects to develop medical devices. Broad theoretical knowledge or hands-on experience in such disciplines as microbiology, immunology, molecular biology, epidemiology and biostatistics in performing different aspects of research projects, and extensive knowledge and experience in directing and executing scientific biomedical research from the most basic to applied, product-oriented efforts are critical.
SERIES: 0101, 0180, 0190, 0401, 0403, 0405, 0408, 0410, 0413, 0414, 0415, 0440, 0601, 0602, 0610, 0630, 0644, 0662, 0701, 0801, 0830, 0855, 0858, 1301, 1306, 1310, 1320, 1520

Work involves ability to develop, plan and coordinate research in the areas of pharmacology/pharmacokinetics, functional characterization of blood and plasma components to include coagulation and clotting cascades, cellular metabolism, pathophysiology, molecular recognition and functional characterizations. Skill in identifying areas in the biochemistry specialty arena that require study and when necessary, skill in establishing in vitro and animal models to test hypothesis relating to mechanisms of normal and pathologic responses of tissues and organs to trauma . Work requires experience with analytical techniques and equipment necessary to accomplish research in the above areas.
SERIES: 1320, 0413

Work involves supervisory responsibility for designing and implementing a research program that is integrated into institutional efforts to develop vaccines and therapeutic molecules for control of infectious and other biological threats. Responsibilities include physical measurements of protein stability, folding pathways, thermodynamic and kinetic parameters of ligand binding, molecular cloning, expression and purification of polypeptides. Goals are to improve the performance of vaccines and other proteins of mission-relevance. Required skills and knowledge include a detailed professional command of protein chemistry and molecular modeling, microalorimetry, biosensors and related biophysical instrumentation, molecular biology, laboratory safety, and technical writing.
SERIES: 0401, 0403, 1310, 1320

Work involves the performance of necropsies and the microscopic evaluation of the pathology and pathogenesis of viruses, bacteria and toxins in multiple species of animal models. Work also involves gross and microscopic evaluations to determine safety and efficacy of candidate prophylactic and therapeutic countermeasures to biological warfare threat agents. Ability to perform necropsies at biosafety levels 2,3, and 4. Microscopic evaluations include light and electron microscopic identification and interpretation of lesions, pathogenic mechanisms, and animal model characterizations through the use of routine and special histologic stained sides as well as slides prepared using immunohistochemical and in situ hybridization methodologies. Skill in documenting all significant findings in detailed pathology reports, which may require collaboration/consultation with principal investigators concerning their interpretation as well as the presentation of these findings at scientific meetings and in peer reviewed scientific journals. Ability to develop approaches and experimental protocols for research efforts, coordinating these research efforts with other professionals, overcoming technical difficulties, and interpreting the significance of results to plan further research, or to recommend termination of unfruitful tasks to pursue problems of higher priority. Immunizations are required.
SERIES: 0403, 1320, 0401

Work involves the skill knowledge and ability to establish and carry out a research program to evaluate the efficacy of antibiotics for protection against and treatment of bacterial biological warfare threat agents. Ability to perform the screening of activity by in vitro methods and evaluation of antibiotic activity in vivo in experimental models of infection, to include the application of pharmackinetic and pharmacodynamic principles to study design. Scope of research products includes both FDA-licensed and investigational compounds.
SERIES: 0401, 0403, 1320

Work involves the development of transgenic plants for the delivery of vaccines against biowarfare threat agents. Expertise is required in microbiology, molecular biology, transgenic plant construction, plant genetics, botany, immunology, and protein biochemistry.
SERIES: 1320, 0401, 0403, 0434

Work involves managing the planning, coordinating, evaluation of, administration of, and reporting of all aspects of a complex biomedical research program. Duties include responsibility for managing the stategic research planning, programming, budgeting and reporting activities as well as managing the technology transfer program that includes patents and intellectual property. Develping, coordinating, and managing an extramural research program, an in-house independent research program, and an Army Research Office program for the activity is required. Knowledge of biomedical research programs is critical.
SERIES: 0401, 0403, 0601, 0701, 0440

Work involves serving as a research protein chemist performing tasks related to Army mission of development of pretreatment and treatment drugs for chemical and biological agent toxicity. Utilizing expertise in methodologies of biochemistry, and protein chemistry to study the structure and function of cholinesterases and the effects of organophosphates on these enzymes and/or the effect of toxins on cellular processes. Thorough knowledge of enzymology, protein purification and assay, data acquisition and analysis, and protein sequencing.
SERIES: 0401, 0403, 0415, 0440, 1320

Work involves serving as a team leader for the discovery and development of new drugs against infectious disease or biological and chemical warfare agents. Ability to design the overall development program, provide program plans to the Command, and coordinate the discovery, candidate selection, chemical characterization, chemical purity and stability, pre-clinical efficacy, pre-clinical toxicology, and formulation efforts towards the successful development of new therapies. Work also involves x-ray crystallography, computational chemistry, and analytical chemistry in support of the drug discovery and synthesis program of the medicinal chemists. Expertise required in single crystal x-ray crystallography, in advanced quantum chemical computational methods and state-of-the-art computational software, and in chrial chromatographic methods.
SERIES: 1320

Work involves serving in multiple capacities, principal investigator, team leader, supervisor, and program manager for establishing the mechanisms of action of identified chemical and biological threat agents and for developing medical protection against these agents. The incumbent manages two separate and highly complex major program elements in the Army's chemical and biological defense program, the vesicant and botulism threats, respectively. Work represents outstanding scope and complexities being responsible for conceiving, planning, organizing the efforts to include procurement of funding, and program execution through supervisory and managerial roles. Serves as an expert advisor on the two designated program elements for peers, the command group and outside academia and industries. Expertise in state-of-the-art cell and molecular biology, toxicology, biochemistry, and protein chemistry and functions is essential.
SERIES: 1320, 0403, 0415

Coordinate basic and applied research, patient diagnosis and clinical trials in a multidisciplinary program to develop new therapies for the prevention and treatment of tropical, emerging diseases with special emphasis in malaria. Integrates and coordinate all aspects of research and development including management of technology, process, budget, personnel, product development teams and interface with Human Use and Institutional Review Boards, Food and Drug Administration, collaborating agencies and global pharmaceutical co-development partners. Write and implement strategic plans to balance drug portfolios with global marketing analysis and unmet medical needs.
SERIES: 0403

Work involves serving as principal investigator, planning, conducting and evaluating research on soft tissue wound pathophysiology, infection and healing. Position includes conduct of basic and applied research in wound healing and wound treatments in order to meet mission requirements by combining molecular, morphometric, biochemical and mechanical measurements of wounds and wound healing. Must co-ordinate with industry and academic partners in the conduct of research, and provide effective scientific leadership, personnel management, acquisition and allocation of human and material resources for the conduct of research. In addition, as a Task Area Manager, must provide fiscal and scientific oversight, reporting and direction to the STO/STEP research programs in both hard and soft tissue research programs. Additional duties include regulatory oversight of animal research to ensure regulatory compliance and animal welfare.
SERIES: 0413, 1320

Work involves planning and executing basic and applied research directed at the discovery and transition to advanced development of drugs for the treatment and prevention of naturally occurring infectious diseases . Expertise is required in mechanisms of drug action, the design and synthesis of novel organic compounds, structural confirmation, design of medicinal agents, development of methods for the analysis of drugs in complex biological milieus, isolation and structure elucidation of natural products and synthetic medicinals, biotransformation of drugs, molecular modeling, structure determination of target biological molecules, molecular biology, and drug-biomolecule interactions.
SERIES: 0401, 0403, 0410, 1320, 0405, 0413, 0601, 0602

Work involves designing, planning, and performing research on the Army's mission of defense against chemical and biological weapons. This position requires thorough knowledge of biochemistry, molecular biology, basic immunology, and tissue culture. Required tasks include performing research as a principal investigator or collaborator in projects related to the development of therapies for chemical and biological toxicity via the delivery of genes for macromolecules or recombinant macromolecules themselves. Skills include cloning and screening of cDNA and genomic libraries; sub cloning of genes; large scale purification of viruses; DNA purification and sequencing; transfection, and production of recombinant proteins in E. Coli and adenoviral expression systems; purification and characterization of recombinant proteins; chemiluminesence, PCR, RT-PCR, gel electrophoresis, Northern and Southern blotting; SDS PAGE and Western blotting. Additional responsibilities include: (1) reporting results in scientific literature, at presentations at scientific meetings, through technical reports, and at briefings as requested; serve as a (2) Chemical Hygiene Officer for the Division of Biochemistry, and (3) member of the scientific review committee for vesicant agent countermeasures.
SERIES: 0401, 0403, 0405, 0415, 1320

Work involves serving as a research protein chemist performing tasks related to Army mission of development of pretreatment and treatment drugs for chemical and biological agent toxicity. This position requires a thorough knowledge of biochemistry, protein purification and characterization, enzymology, and a working knowledge of molecular biology. Required tasks include purification of native and recombinant cholinesterases from plasma or tissue culture media, respectively, utilizing expertise in methodologies of enzymology and protein chemistry to study the structure and function of cholinesterases and the effects of organophosphates on these enzymes. Skills include column chromatography; protein, DNA, RNA, and plasmid purification; gel electrophoresis; purification and characterization of native and recombinant proteins; SDS PAGE and Western blotting. Additional responsibilities include: (1) ordering laboratory supplies, chemicals, and equipment for the department of Molecular Pharmacology using WMIS and CARE systems; (2) taking care of the monitoring of refrigerators and freezers through the Datatron system for the department of Molecular Pharmacology.
SERIES: 0401, 0403, 0415, 0440, 1320

Work involves planning and performing biochemical research on the Army's mission of development of biotechnology-related defense against chemical and biological agents. This position requires thorough knowledge of molecular biology experiments required to clone, express, and analyze genes. Required tasks include performing research as a principal investigator or collaborator in projects related to the development of enzymes and other macromolecules as pretreatment drugs for chemical and biological toxicity. Skills include oligonucleotide synthesis; cloning and screening of cDNA and genomic libraries; DNA sequencing; construction of expression plasmids; transfection, and production of recombinant proteins in mammalian and baculovirus expression systems; isolation of recombinant proteins; isolation, purification and quantitation of DNA; chemiluminesence, PCR, RT-PCR, gel electrophoresis, Northern and Southern blotting; site-directed mutagenesis. An additional responsibility is reporting results in the scientific literature, at presentations at scientific meetings, through technical reports, and at briefings as requested.
SERIES: 0401, 0403, 0405, 0415, 1320

Work involves serving as a team leader, coordinating, planning, and executing basic and applied research directed at the discovery and transition to advanced development of drug products for the treatment and prevention of naturally occurring infectious diseases or chemical and biological warfare agents. Ability to design the overall development program, provide program plans to the Command, and coordinate the discovery, candidate selection, chemical characterization, chemical purity and stability, pre-clinical efficacy, pre-clinical toxicology, and formulation efforts towards the successful development of new therapies.
SERIES: 1320

Responsible for maintaining registry of biological agents and for select agent transactions, including updating of the select agent program documents. May serve as Responsible Offical or Alternate Responsible Offical (42 CFR 73). Assesses risk of exposure for biological agents and provides advice on engineering controls and personal protective equipment (PPE). Provides guidance for, and approves shipping of infectious materials. Provides training for lab safety, and use of positive pressure suits for Biosafety Level 4 (BSL4) laboratories. Reviews research protocols and conducts risk assessments. Serves as the Biosafety Officer on the Institutional Biosafety Committee and Laboratory Animal Care and Use Committee. Sets policy and provides written guidance (regulations, SOPs, etc.) that incorporate DoD, Army and consensus standards into biosafety programs. Oversees decontamination operations for rooms, airlocks, and equipment. Inspects and advises on design and modifications of BSL1 through BSL4 laboratories. Coordinates with researchers to determine empirical guidelines for safe research with biological agents. Participate in other safety programs as required: respiratory protection, decontamination, bloodborne pathogens, accident or exposure investigations, environmental sampling, etc. Additional skill in industrial hygiene or general safety, or certification as a biosafety professional, safety professional, industrial hygienist, or sanitarian are desirable. IND vaccines may be recommended, some licensed vaccines may be required. Individual may serve as alternate for Director of Safety.
SERIES: 0403

Work Involves the directing, planning and execution of a Laboratory scientific research program. The Scientific Director will act as a focal point for scientific activities at USAMRIID, developing scientific strategy as well as directing research and early development efforts. The incumbent will manage USAMRIID's functional science departments to ensure business processes are being followed and that the departments are effective in delivering value to the Institute. The director will translate the scientific goals of the Commander into research activities by overseeing the execution of USAMRIID's project portfolio; reviewing proposed project plans; ensuring the transition of technology and candidate products to advanced developers; recommend scientific priorities to the Commander; recommend the prioritization of USAMRIID project portfolio; support the development of USAMRIID's scientific strategy ; develop and execute an annual research plan inline with the Institute's scientific strategy ; ensure USAMRID's scientific expertise through the incorporation of state-of-the-art technologies and the recruitment of a premier workforce; scan the biodefense field for promising technology ; incorporate and further develop promising enabling technology and products; ensure USAMRIID attracts, trains, and retains a workforce with the necessary scientific skills; coordinate the activities of USAMRIID's science functions to establish seamless workflow; Identify and resolve cross-functional and cross-disciplinary conflicts and develop and implements policies and procedures for the management of USAMRIID's research programs.
SERIES: 0401, 0403, 0440, 0601, 0602, 1320

Supervises the quality and execution of the scientific research programs in DoD's largest, most comprehensive biomedical research institute, comprised of a central laboratory, two CONUS detachments, and three OCONUS subordinate laboratories in Africa, Asia, and Europe, staffed by 1800 scientists, physicians, and support personnel. Oversees military-relevant research and development for infectious diseases, biological defense, chemical defense, military operational medicine, and combat casualty care, funded by the Institute's annual budget of approximately $120M. Coordinates the Institute's research execution with USAMRMC's Planning, Programming, Budgeting, and Execution System (PPBES) process. Directs research studies.
SERIES: 0101, 0180, 0190, 0401, 0403, 0405, 0408, 0410, 0413, 0414, 0415, 0440, 0601, 0602, 0610, 0630, 0644, 0662, 0701, 0801, 0830, 0855, 0858, 1301, 1306, 1310, 1320, 1520

Work involves the skill, knowledge, and ability to develop and manage research projects with both intramural and extramural components. Developing and applying new analytical chemistry techniques or methods for the evaluation of militarily relevant chemicals or complex chemical mixtures are required. Functional tasks include the planning, execution, documentation, and management of independent research projects in analytical chemistry; and providing expertise in high performance liquid chromatography (HPLC), inductively coupled plasma mass spectrometry (ICP-MS) and proteomics mass spectrometry techniques and instrumentation.
SERIES: 1320

Duties are to support research and development efforts in an aquatic biomonitoring program, to include operating automated aquatic biomonitoring systems and water quality monitors, conducting toxicity assays using automated diluters, caring for aquatic organisms, writing standard operating procedures (SOP's) and research protocols, performing field work in support of automated biomonitor deployments, and presenting results of laboratory and field tests. Additional duties include ancillary tasks associated with verification testing of new, state-of-the art environmental sentinel biomonitor systems (culturing of biological systems, cleaning, set-up, operation, and breakdown of equipment), conducting literature searches, and maintaining databases as required.
SERIES: 0401

Work involves planning and performing cell and molecular biological experiments, including pilot and range-finding studies, for elucidating molecular responses to exposure to toxic industrial materials and chemicals of military interest. This position requires a facility with basic molecular biology techniques, including gel electrophoresis, PCR, extraction, purification, manipulation and modification of nucleic acids from cells, tissues, and/or multicellular organisms. Expertise in specialized techniques for preparing RNA for microarray, especially Affymetrix GeneChip, analysis is essential. A strong capability in sterile culture methods is also necessary, particularly in methods for culturing and propagation of Caenorhabditis elegans in liquid medium. Experience with Xenopus genus frogs as an experimental model is also important. The development of new methods and/or adaptation of existing procedures to solve experimental problems is a critical component of this position. Computer literacy is essential: The majority of instrumentation employed in the laboratory is computer-operated, and all data are analyzed with scientific and statistical software tools. The position requires experience with software used in analyzing large microarray datasets. The position requires working with hazardous materials and animals.
SERIES: 0401

Work involves providing electron microscopic support to principle investigators for a wide variety of toxic and infectious agents. Utilizes a variety of ultrastructural microscopy techniques to identify toxic and infectious biological warfare (BW) agents in biological systems and to identify and define ultrastructural changes elicited by BW agents. Develops technical advances in ultrastructural methodologies to be utilized in ongoing and future research. Provides collaborative research and diagnostic support with particular emphasis on the ultrastructural interpretation of subcellular lesions associated with BW agents. Serves a technical expert in ultrastructural microscopy for both research and diagnostic cases and to the technicial electron microscopy staff. Responsible for training the technical staff in ultrastructural methodologies and monitoring their development. Reviews proposed and existing research protocols for the applicability of electron microscopy and assurance that ultrastructural aspects are fully explored. Reviews technical reports and manuscripts to assure scientific and technical accuracy, as it pertains to electron microscopy.
SERIES: 0403

Work involves research into the genetics and pathogenesis of category A and B biological threat agents. Research focuses on all aspects of pathogenesis of bacterial infections of military relevance. Work requires proficiency in concepts and techniques in the area of microbiology and immunology. The incumbent will perform independent experiments involving but not limited to, the following: (a) DNA amplification, DNA cloning, RNA purification, (b) protein expression and purification, (c) handling of laboratory animals to include injections, immunizations, and blood collection, (d) the safe culturing of BSL3 pathogenic bacteria including Francisella tularensis, Yersinia pestis, Burkholderia mallei, and Burkholderia pseudomallei, (e) maintain and propagate tissue culture cell lines. Various bacterial and viral immunizations are required for this position.
SERIES: 0401

Serve as principal investigator and scientific leader for research in regenerative medicine in soft tissue and bone. Demonstrated track record of research and understanding of traumatic extremity injuries. Coordinates with industrial, academic, and clinical partners in the conduct of basic, translational, and applied research. Provides scientific leadership, acquisition and allocation of human and material resources for the conduct of research. Skilled in establishing a research program in regeneration of one or more of the following: skin; muscle; bone; or tendon. Provides fiscal and scientific oversight, reporting and direction to the research programs in extremity regeneration research programs. Manages extramural medical research programs and serves as a mentor to clinical researchers.
SERIES: 0413

Work involves serving as a senior primary investigator. Plans an independent research program and utilizes a wide variety of electron microscopic techniques to elucidate the sub cellular pathogenesis of potential BW infectious agents and intoxicants. This includes application and interpretation of techniques such as morphologic interpretation of sub cellular changes, immunoelectron microscopy, freeze fracture and freeze substitution methodology, scanning electron microscopy, and scanning immunoelectron microscopy. Conducts searches of recent scientific literature to develop background data and define problem areas. Plans and executes independent and collaborative research with particular emphasis on the ultra structural technology and morphologic interpretation of sub cellular lesions associated with pathogenesis studies. This entails defining the research problem, developing approaches and experimental protocols for tasks, coordinating research efforts with other professionals, overcoming technical difficulties, and interpreting the significance of results to plan further research or to recommend termination of unfruitful tasks to pursue problems of higher priority. Plans, directs, and participates in the development and application of technology and assays for ultrastructural research. These include (a) defining and developing reproducible reliable identification systems such as immunoelectron-microscopy, immunohistochemistry, and in situ hybridization techniques for viruses, toxins, bacteria, and mediators of disease at the subcellular level; (b) developing fixative methods for retention of antigens and nucleic acids in animal tissues and cell cultures; (c) utilizing and applying image analysis systems to quantitatively evaluate ultrastructural pathology; and (d) exploring the application of methodology such as elemental analysis, freeze fracture and freeze substitution, cytoultramicrotomy to elucidate pathogenesis of microbial infections and intoxications.
SERIES: 0401, 0403, 0602, 0701, 0415

The position requires skill, demonstrated expertise (by publications), and ability to provide scientific leadership in each of the individual aspects of systems biology. Work involves contributing to and development of new research programs to investigate all aspects of systems biology including pathogenesis, immune responses, and therapeutic strategies for infections/exposures of military relevance. The complexity of the work requires extensive collaboration with world-class experts and the candidate will have evidence of such collaborations among co-authors on their publications. Additional aspects of the work include (a) evaluation of the cellular and immunological response(s) of various animal models after infection (or immunizations) using state of the art technologies; (b) microscopic procedures (fluorescence, phase confocal) and use of in vivo imaging of live animals with luciferase transfected pathogens of military interest, (c) analyses of host-pathogen interactions and host responses in general upon exposure to pathogenic agents. This position requires a facility with basic molecular biology techniques, demonstrated expertise in specialized techniques for preparing RNA for many different types of microarray analysis; experience with multiple platforms is essential. A strong capability in protein-protein interactions and experience in sterile culture methods is required. The position requires extensive experience and demonstrated capability (publications) in analyzing large datasets, such as from microarrays and extracting key features, regulatory networks and integrating them with clinical aspects and identification of host correlates of infection to pathogens of military importance. The position may require working with hazardous materials and animals. Duties requires appropriate clearance status for use of select agents in BioSafety Level 2 (BSL-2) containment and CDC approval/ required training for BSL-3 containment. Has knowledge and skills for implementation of a completely electronic format of planning, collecting, and storage of laboratory data using Laboratory Information Management System (LIMS). Additional responsibilities include reporting results in scientific literature, presentations at nation and international meetings, and preparation of command and agency briefings as requested.
SERIES: 0403, 1320

Incumbent will have skills in interfacing electronic data capture, data storage and data management systems. Work entails using computer programming (e.g., C++, C# MATLAB, JAVA, Python) and analysis software (e.g., R, SPSS) to create solutions that improve Soldier health readiness and performance.
SERIES: 0401

Incumbent performs specialized biochemical laboratory techniques for the analyses human blood samples collected during thermal and altitude research experiments, to include ELISA, multiplex, and protein quantitation assays. Work also involves management and analysis of laboratory data using spreadsheet software, statistical packages and database management software, if applicable. Other duties include collection of human performance data using computerized tests, physiological exposures in testing chambers and collection of biological fluids for biochemistry analyses using techniques such as ELISA.
SERIES: 0401

Work involves managing and executing an infectious disease research and development program to advance the discovery and transition to advanced development of drugs, vaccines and diagnostic assays for the treatment and prevention of naturally occurring infectious diseases under the direction or absence of the director. Supervise a staff of scientists and technicians, mentoring and developing others. Prepare budgets, annual reports, and other taskers. Exhibit knowledge and experience in directing scientific research and developing strategic plans for the organization. Serve as CORs, reviewer of proposals as requested. Report scientific work in published reports and presentations and briefings.
SERIES: 0403

Serves as Senior Project Leader, Neuroepidemiology, a key research group of the Cognitive Performance Team for the USARIEM Military Performance Division, leading an interdisciplinary team of research epidemiologists, psychologists, physiologists, statisticians, behavioral scientists, and lab technicians. Utilizing an interdisciplinary approach, conducts scientifically sound retrospective and prospective epidiologic studies, and conducts rigorous scientifically sound research towards improving warfighter performance. Publishs findings in peer-reviewed journals, and briefs findings of Team at distinguished military and scientific forums. Serves as lead Institute Epidemiologist expert, advising the Team Leader, Cognitive Performance, Chief, Military Performance Division and Institute Commander regarding trends and directions towards addressing and improving warfighter performance through epidemiologic and neuroepidemiologic studies. Work involves knowledge and application of epidemiological methods and principles. Works independently as a principal investigator on a variety of research projects focused on the role of cognitive performance and neurological health issues. Work also involves direct consultative support to other investigators, organizations, and agencies regarding appropriate design and interpretation of research as well as providing estimates of the meaning and practical operational significance of trends in data obtained from military databases and other sources.
SERIES: 0601

Work involves designing and implementing an experimental biomedical research program employing molecular biology, and biochemistry to determine the nutritional needs of the modern warfighter, by defining organ system, tissue, cellular and molecular physiological responses to exercise, nutritional manipulation and environmental extremes. Work requires use biochemical and nutritional knowledge to plan and conduct animal or in vitro experiments to elucidate candidate metabolic mechanisms suitable for exploitation by nutritional interventions to sustain and enhance optimal biological function, health and performance. The position requires experience writing and publishing research findings in peer-reviewed scientific publications, and presenting research findings at international scientific conferences, academic seminars and symposia. This position requires skill using experimental animal models in research, design of animal diets, small animal husbandry (rats and mice), and experimental biochemical and molecular biological laboratory technologies and procedures for tissue sampling, quantitative assay of metabolite concentrations, and molecular regulation of protein synthesis, especially use Western-blotting, protein analysis and ELISA. Requires documented biochemical research experience and skills elucidating metabolic and cellular roles of essential micronutrients (e.g., zinc and selenium) in rodent and cell culture models. Ability to detect metabolic function of micronutrients using Western-blotting and ELISA for proteins involved in cell signaling, including mTOR and insulin, is required.
SERIES: 0401

Work involves development and use of animal models of potential biothreat agents to generate tissue specimens that will serve as a resource for the development, evaluation and comparison of current and future diagnostic platforms. These studies require proficiency in performance and understanding of standard microbiology, molecular biology, immunology and biochemistry techniques. Work involves interacting with biological select agents in BSL-3 laboratories with emphasis on detection and identification of these agents and maintaining reference stocks and specimens. Performs standard molecular biological techniques including isolation of nucleic acids from various clinical matrices, and reverse transcription real time polymerase chain reaction (PCR). Ability to perform and evaluate standard microbiological and immunological diagnostic assays including microbial culture and ECL/ELISA. In vivo studies involve aerosol exposure experiments with select agents. Collection of samples involves development and maintenance of database for inventory and archiving. Immunizations required.
SERIES: 0403, 0401, 0415, 0704

Work involves performing research in a program aimed at the development of medical countermeasures to viral diseases of military importance. The position requires highly specialized knowledge and proficiency in numerous different laboratory techniques and procedures including molecular biology (e.g. cloning viral genes into expression plasmids), virology (e.g., quantitation of viral stocks), and antibody-based immunology (e.g., plaque reduction neutralization tests, ELISA). The position requires experience in the preparation of vaccines in the form of particle-mediated epidermal delivery (gene gun) cartridges and experience working with viruses in a BSL-3 laboratory environment. Immunizations are required.
SERIES: 0403

Serves as an ultrastructural pathologist and possesses advanced knowledge of electron microscopy (EM) methodology and tissue and cellular ultrastructure as well as extensive experience in ultrastructural pathology and interpretation of normal and abnormal ultrastructure of a variety of pathogenic agents. Plans, conducts, and participates in investigations utilizing ultrastructural techniques to detect morphological and immunopathological changes in a variety of in vivo and in vitro models exposed to biological and chemical threat agents. Accomplishes these research tasks by utilizing the disciplines of transmission electron microscopy, scanning electron microscopy, immunoelectron microscopy, cytochemistry, and photomicroscopy. Provides professional scientific support in developing or assisting in the development of collaborative studies with in-house Principal Investigators from other disciplines and participates fully in the investigative management of all biological specimens submitted for collaborative analysis. Examines and studies referred specimens of human pathological tissues. Diagnoses and provides information on basic biology of diseases. Provides professional scientific support in developing or assisting in the development of new techniques in the electron microscopy sciences when standardized methods are not adequate for any given task within the research mission. Generates peer-approved finalized manuscripts for open literature publication in appropriate journal format. It is anticipated that such publications be generated at a cadence that is commensurate with timely dissemination of scientific information.
SERIES: 0401, 0403, 0602

Provides a full range of veterinary microbiological diagnostic services in the fields of bacteriology, serology and mycology which require a high level of technical competence due to the wide range of specialty areas and the complexity of veterinary microbiology performed in support of research projects. Isolates pathogenic microorganisms (bacterial and fungal) for identification and reports findings so it can be determined whether an animal died as a result of an experiment or an unrelated disease. Provides a full range of clinical chemistry analysis in support of research studies conducted. Such tests cover analysis of various blood, fluid and tissue samples of a variety of laboratory experiments; to determine cause and nature of mortalities; and to determine if the laboratory animals have any unusual biochemical characteristics which would influence the outcome of research studies. Examples of tests/analyses are cytology, endpoint chemistry, hematology and urinalysis for specific research studies. Establishes, maintains and updates a database which contains selected clinical chemistry data on the research animals used.
SERIES: 0401, 0403, 1320, 0701

Tests the microbiological content of water, feces and bedding from the breeding colony of animals to determine the natural flora and incidence rate of pathogenic microorganisms in the colony. Determines source and mode of pathogenic transmission and recommends the most effective chemotherapeutic treatment or method of control. Monitors the bacteriological purity of specific pathogen free strains of animals. Performs bacteriological surveys designed for the purpose of verifying the effectiveness of equipment washing, decontamination, and sanitizing procedures. Performs quality control bacteriological examinations of newly purchased animals to ensure that they are disease free. Performs quality control bacteriological examinations of present laboratory animals to insure the issuance of healthy animals to investigators. Performs routine blood chemistries on blood and serum from laboratory animals. Performs antibiotic sensitivity testing on bacterial isolates. This requires not only a knowledge of microbiological techniques and the characteristics of various bacteria but also a knowledge of the antibiotics being tested and the animals for which the sensitivity is being conducted. Orders all supplies and arranges for maintenance of lab equipment. Is responsible for updating laboratory techniques and procedures and develops or adapts new procedures to fit particular needs of activity. Trains and directs the work of technicians assuring that all microbiology work is technically correct. Develops, writes and updates guidelines (SOPs) used in the laboratory, ensuring that these guidelines are technically correct and meet the needs of the organization.
SERIES: 0401, 0403

Work involves a research program to investigate all aspects of pathogenesis, immunology, and prophylaxis of bacterial infections of military relevance. Work requires proficiency in the performance of and theoretical understanding of concepts and techniques of standard microbiology, biochemistry, and immunology. Performs research including, but not limited to, the following: (a) evaluation of the cellular and immunological response(s) of various animal models after immunization or infection using established and newly developed serological and cell-based antibody assays and to include quantitative assays of cellular apoptosis and cytotoxicity; (b) microscopic procedures (fluorescence, phase confocal) and use of digital cameras and associated software to enable image capture; (c) the safe culturing of pathogenic bacteria to include bacterial biological warfare (BW) agents, (d) analyses of bacterial-host protein interactions involving techniques of gradient fractionation, electrophoresis-immunoblotting, immunoprecipitation, flow cytometry (FACS), and molecular cloning; (e) biochemical procedures to purify, characterize, and modify proteins from antisera and bacteriological cultures, and (f) maintain and propagate tissue culture cell lines. Knowledge of mass spectrometry (MS), bioinformatics, and in vitro binding procedures is desirable. Immunizations required.
SERIES: 0401

Work involves planning, organizing and conducting experimental research involving human subjects to determine the safety and efficacy of vaccines and drugs against a variety of infectious disease or biologic toxin agents of military importance. Ability to assist in Phase I & II (safety, dose finding) and Phase III (field) testing of these products and conduct research on the epidemiology of the disease in question in order to define the appropriate target population and the bases for measuring efficiacy. Ability to plan, organize and conduct research on the pharmacokinetics and pharmacodynamics of selected drugs in human subjects. Skill in writing and revising clinical protocols for studies involving human subjects and providing expert consultation and treatment of infectious diseases of military importance. Plays a role in preclinical development of experimental vaccines and drugs, particularly advanced testing of these products in small animal and nonhuman primates. These studies are designed to answer specific questions about safety, immunogenicity, or efficacy of vaccines or drugs.
SERIES: 0602

Serves as a recognized authority on the use of animals in DOD animal use research, testing, and training with special emphasis on infectious disease animal research in biocontainment. Chairs the Institutional Animal Care and Use Committee (IACUC) and ensures compliance with all applicable state, federal, and military regulations guiding animal use in research. Advises Commander on reportable animal welfare incidents and communicates with Office of Laboratory Animal Welfare (OLAW), Association for Assessment and Accreditation of Laboratory Animal Care International (AAALACi), USAMRMC, and the USDA as required. Investigates these incidents, indentifies cause, and recommends solutions to the Commander. Schedules and conducts semiannual facility inspection and programmatic reviews. Oversees preparation of all IACUC related mandatory reports to the Commander, USAMRMC, DOD and outside agencies. Recommends IACUC membership for appointment by Commander and ensures Committee composition meets legal requirements. Assists database and website developers in preparation of documentation databases and informational website for the IACUC. Counsels investigators and staff on noncompliance issues. Oversees and conducts post approval compliance monitoring for approved animal protocols. Mentors investigative staff in on a variety of research disciplines as they relate to animal research. Mentors and provides educational development to IACUC membership. Trains IACUC members on performance of Committee functions as required by AR40-33.
SERIES: 0701

Serves as recognized authority and primary senior level expert advisor to the Commander in the fields of animal welfare, laboratory animal medicine, regulatory compliance in animal research, and research ethics in animal research. Serves as a representative to the Armed Forces Biomedical Research Evaluation and Management (ASBREM) Joint Technical Working Group for Animal Use in the DOD. Administers the advanced level animal research program which is a broad, coordinated national and international program of regulatory compliance that deals with critical scientific, regulatory, and ethical issues. Assures that all animal research is conducted ethically and legally. Responsible for maintaining Association for Assessment and Accreditation of Laboratory Animal Care International (AAALACi) accreditation and PHS assurance. Identifies and develops the policies of the research institute in this and related fields such as research integrity in animal research. Resolves major problems in gaining approval for a wide range of animal research initiatives from safety, scientific review, and institutional animal care and use committee to the US Army Medical Research and Materiel Command and other domestic and international regulatory bodies. Is intimately familiar with literature of laboratory animal medicine and the governance of animal use in research. Incumbent has the responsibility for mitigating risks for the institute on ethical missteps in animal research, since much of the guidance is ambiguous and possibly conflicting. Assists the Commander in developing new policies for laboratories to keep in line with the latest regulatory requirements in animal use research. Develops memorandum of agreements and similar documents with other institutions to clarify responsibilities and provide for mutual benefits in the case of collaborative research. Reviews grants involving animal research for appropriateness to ensure compliance with Office for Laboratory Animal Welfare policies. Assists in the preparation and review of scientific manuscripts, publications, and presentations involving animal use in research. Prepares and manages budget for the Institute Animal Care and Use Committee (IACUC) office. Provides input for updating Army regulations, and USAMRMC and research institute policies and guidelines in the field of expertise. Develops and implements necessary investigator training programs to ensure compliance with applicable regulations, policies, and guidelines. Provides input into software development for required documentation of animal research. Is a recognized expert in the fields of biocontainment animal research with infectious diseases, animal research regulatory compliance, animal welfare, and laboratory animal medicine. Represents the institute and the animal research program at national conferences. Maintains current knowledge through membership in national organizations such as American Association for Laboratory Animal Science (AALAS), AAALACi Council, American College of Laboratory Animal Medicine (ACLAM) and American Veterinary Medical Association (AVMA). Performs supervisory responsibilities for IACUC staff.
SERIES: 0701

Work involves knowledge and application of epidemiological methods and principles independently as a principal investigator on a variety of research projects focused on the role of risk factors in the development of illness and injuries of military relevance. Work involves direct consultative support to other investigators, organizations, and agencies regarding appropriate design and interpretation of research as well as providing estimates of the meaning and practical operational significance of trends in data obtained from military databases and other sources. Participates in manuscript and oral/poster presentation development from research findings. Requires specific knowledge in epidemiology and public health and research experience including knowledge of human subjects protection regulations.
SERIES: 0601

Work involves the funding and management of basic and applied research to isolate, sequence, and analyze nucleic acid sequences derived from prokaryotic pathogenic organisms. Requires understanding of the principals and methods for nucleic acid (RNA and DNA) isolation procedures from prokaryotic pathogens as well as from a variety of eukaryotic host cells and tissues infected by these pathogens. Works collaboratively with peers to establish direction and supervision of work conducted by technical and postdoctoral level staff. Involves the production, isolation, and analysis of nucleic acids derived from prokaryotic organisms and eukaryotic cells. Maintains a state-of-the-art prokaryotic sequencing and bioinformatics capability. Manages work conducted under BioSafety Level 2 (BSL-2) containment as well as any work required to be conducted in BSL-3 or BSL-4 containment. Manages the establishment of a completely electronic format of planning, collecting, and storage of laboratory data. Establishes and conducts all operations under a Laboratory Information Management System (LIMS). Reports on progress, problems, and corrective actions to management. Assures subordinate staff training and compliance with normal laboratory operations including the hazards and safeguards related to work involving infectious agents, toxic chemicals, carcinogens, safe handling of animal as well as human tissues/fluids, highly flammable materials and radiation hazards. Manages a budget and overseas the timely acquisition of laboratory equipment and supplies. Maintains knowledge of and instructs others in current and relevant scientific literature. Prepares oral presentations, poster presentations, and manuscripts that communicate the scientific work being conducted.
SERIES: 0403

Devises innovative, economical, and practical methods for the control of arthropod vectors of diseases such as malaria, dengue, and leishmaniasis. Plans, conducts, andanalyzes laboratory and field tests of innovative vector suppression methods, prepares devices and strategies for advanced development and oversees patent applications when applicable. Studies the ecology of sand flies and mosquitoes as vectors of leishmaniasis, malaria, and other human pathogens; plans, designs, and executes laboratory and field studies on the transmission of these diseases by their vectors. Selects and prepares field sites for testing innovative control methods and diagnostic devices. Work involves management and/or execution of a medical research, development, testing and evaluation program or a subpart of a program to include technical content and/or cost, schedule, and performance. Required skills include the application of theories and techniques in parasitology. Coordinates activities with DOD and other federal agencies, foreign institutions and governments, and commercial partners. Oversees the research work performed by military, civilian, and contractor personnel.
SERIES: 0401

The position requires capacity to serve as consultant and scientific advisor for MEDCOM phylogenetic characterization of multi-drug resistant bacteria. Work involves establishing, directing basic and applied functional genomics to the MEDCOM Multi-Drug Resistant Organism Repository and Surveillance Network (MRSN). The position requires subject matter expertise and ability to provide scientific leadership in the genotypic and clonal characterization of clinical isolates from within the Military Healthcare System (MHS). Translational support to clinically approved protocols using clinical database management and epidemiology; proteome, genome and metabolome bioinformatics; antimicrobial and biofilm assay; novel drug discovery and application; identification of host correlates of infection; and animal modeling. Additional responsibilities include reporting results in scientific literature, presentations at national and international meetings, and preparation of command and agency briefings as requested.
SERIES: 0403

Oversees epidemiological surveillance of bacterial isolates from infected patients and maintains repository of isolates. Provides microbiology consultation and support to investigators, researchers and staff. Serves as team leader for development of assays in support of molecular epidemiology and characterization of these organisms. Evaluates new clinical laboratory procedures, equipment, and supplies. Reviews and implements standing operating procedures, including the definition of reference values and acceptable ranges, and interprets quality control results. Ensures that laboratory performs in accordance with required regulatory guidelines and other applicable standards, ensuring maintenance of all required logs and records. Establishes and maintains the budget for the laboratory with approval authority for order of supplies, equipment contracts, etc. Recommends use/purchase of new equipment based on such factors as efficiency, cost effectiveness, reliability, performance and overall suitability.
SERIES: 0143

Work involves serving as the primary investigator who designs and implements studies to develop, optimize, validate and test molecular diagnostic systems. These molecular diagnostic systems are for the identification of infectious disease agents in human samples and take place on rapid real-time amplification platforms, such as LightCyclers, R.A.P.I.D.s, JBAIDS, and Smart Cyclers. Responsible for developing and identifying the appropriate methods for the isolation of RNA/DNA from infectious disease agents in clinical matrices and performing the real-time PCR/RT PCR assays on the nucleic acids extracted from those infectious disease agents. Serves as the subject matter expert in performing molecular biological techniques such as, isolation of nucleic acids from various organisms, reverse transcription (RT), polymerase chain reaction (PCR), labeling of nucleic acids with non-isotopic substrates, and nucleic acid hybridization for DNA/RNA analysis. Applies broad theoretical knowledge or hands-on experience in such disciplines as microbiology, immunology, molecular biology, epidemiology and biostatistics to effectively manage different aspects of research projects. Develops and executes the appropriate regulated studies to produce data for the submission of a 510k application to the FDA. Serves as the subject matter expert and liaison between commercial partners and regulatory agencies in the FDA clearance of In Vitro Diagnostic Devices.
SERIES: 0401

Serves as subject matter expert and regulatory liaison to directing clinician for labs which provide clinical laboratory services to medical professionals in the areas of microbiology, hematology, clinical chemistry, coagulation, immunology, or molecular diagnostics. Develops and identifies candidate research grade assays for validation to be used for clinical diagnosis in a College of American Pathologists (CAP) accredited laboratory. Develops and executes the required studies to ensure candidate assays results can legally be used to base patient treatment on by the requesting clinician. Ensures these studies and the work of the laboratory will stand up to the scrutiny of annual inspections which include quality assurance groups and CAP. Responsibilities require coordination within the unit, laboratory director, and quality assurance to ensure that timeliness, form, procedure, accuracy, quality, and quantity standards are met. Reviews, approves, and implements standing operating procedures, including the definition of reference values and acceptable ranges, and interprets quality control results. As the subject matter expert, serves as the final approval for all testing results released to directing clinician and medical professionals. Ensures that laboratory performs in accordance with CAP and other applicable standards, ensuring maintenance of all required logs and records. Is responsible for the maintenance of accreditation for the clinical laboratory.
SERIES: 0401

Work involves serving as a principal investigator responsible for planning, directing and conducting basic research to investigate protein structures of important biological targets and their molecular interactions by the application of computational chemistry methods. Targets include protein toxins, viruses and intracellular pathogens. Conducts basic research to develop therapeutics and vaccines to mitigate the effects of current and emerging toxins and diseases. Computational methods include in silico screening of drug-like compound libraries, molecular dynamics simulations, absolute protein-ligand binding predictions, protein engineering and protein structure bioinformatics. Develops new molecular modeling software and maintains computer clusters for computational chemistry research.
SERIES: 1320

Work involves design and conduct of clinical research studies in the area of infectious diseases of military medical relevance. Work involves protocol development, management of regulatory affairs, and quality assurance support for product development efforts involving Phase I and II human trials conducted according to current Good Clinical Practices to demonstrate safety and efficacy of candidate investigational medical countermeasures or retrospective clinical studies. Serves as subject matter expert in support of the research conducted within the work element. Knowledge and skills include both theoretical and practical knowledge of clinical trial design, Food and Drug Administration (FDA) clinical research regulations, laboratory practice, and manufacturing regulations and guidelines. Tasks include the following: (1) developing and reviewing clinical research protocols (i.e., experimental design, managing responses to scientific review committees/institutional review boards/ FDA, data management, and data analysis); (2) reviewing case report form and informed consent compliance; (3) reviewing submissions to the FDA for regulatory compliance and quality; (4) serving as liaison between satellite trial sites and the Institute; and (5) educating other investigators regarding regulatory requirements. Submits articles for publication in peer reviewed journals and/or presents research at national conferences (abstract, short topic, poster, or presentation). Prepares research proposal package(s) that support the research needs of the Army and the Department of Defense (DOD) and submits them for Army, DOD, or extramural funding. Provides medical advice and input to research efforts as requested, advising the Institute leadership and investigators regarding medical risks to HRV in the development and execution of research.
SERIES: 0602

Serves as Institutional Review Board (IRB) coordinator for the ethics committee. Assists in the administration of the human subjects protection program, a broad, coordinated national and international program of regulatory compliance that deals with critical scientific and ethical issues. Supports the Administrative Director, the IRB Chair, and other staff members in meeting preparation. Assists, organizes, and liaises to set up IRB pre-review meetings, scientific review committee liaison, and IRB meeting materials, interactions, and finalization of minutes and monthly expedited review listing. Educates, updates, and maintains communications with Principal Investigators (PIs), IRB Chair, IRB members, administrators, staff, and other interested persons concerning the functions of the IRB. Updates membership rosters, assurance documentation and renewals, as well as, membership records. Coordinates with outside IRBs to ensure complete protocol package submission. Develops memoranda of agreement with other institutions for mutual benefit to their human subjects protections programs in the case of collaborative research. Provides input updating research institute policies, procedures, and guidelines in the application of human subjects research management. Performs administrative reviews of protocols/projects that are determined to be exempt (per 32 CFR 219) and research not involving human subjects. Assists in the administration of the human subjects protection program, a broad, coordinated national and international program of regulatory compliance that deals with critical scientific and ethical issues. Updates and maintains the database with regard to protocols. Advises investigators on appropriateness and completeness of the submission and communicates other avenues of approach if necessary. Coordinates preparation of letters of approval/determination with the IRB Administrative Director (or designee). Triages publication clearances on behalf of the IRB Administrative Director.
SERIES: 0601

Work involves a research program to test and evaluate biological warfare (BW) agents, including work in biocontainment laboratories to develop new laboratory procedures and reagents to provide laboratory services to researchers in the area of diagnostic microbiology. Responsibilities require coordination within the unit to ensure that timeliness, accuracy, and quality are met. Reviews and implements standing operating procedures (SOPs), including support for accreditation processes are met. Plans and performs research including but not limited to the following: (a) isolates and characterizes biological warfare (BW) agents; (b) establishes and maintains expertise, reagents, and equipment for BW agent identification including reagents from other government programs (such as CDC LRN); develops new approaches to bacterial identification and implements them for rapid detection of BW agents; (c) studies use of and sensitivity of various detection methodologies and diagnostic assays; and (d) supports other government agencies in dealing with BW agents, in special investigations and in analyzing clinical and environmental samples. This position requires thorough knowledge of molecular and immunoassay methods required to identify BW agents according to developed and ad hoc protocols. Entry into a biosurety program and immunizations are required. Will be required to use computer software and input data for complex data reporting.
SERIES: 0401, 0403, 0404

Work includes serving as an instructor in training programs for biological warfare (BW) agents diagnostics and detection methods. Duties include work in biocontainment laboratories to develop or evaluate new laboratory procedures and reagents to support training program requirements. Responsibilities require coordination within the unit to ensure program responsibilities are met and often between other government agencies to insure requests for training are scheduled and coordinated appropriately. Reviews and implements standing operating procedures (SOPs), including support for accreditation processes are met. This position requires thorough knowledge of molecular and immunoassay methods required to identify BW agents according to developed and ad hoc protocols. This position requires thorough knowledge of Department of Defense concepts of BW agent diagnostic and detection programs as well as the integration of the programs across other federal government agencies or Departments. Entry into a biosurety program and immunizations are required.
SERIES: 0401, 0403, 0404

Performs clinical investigation of malaria vaccines, serving as principal investigator and assistant investigator in Phase I, II and III clinical trials. Duties include developing, writing and defending research protocols, grants, scientific papers and scientific posters/presentations at national and international meetings, as well as ensuring studies are conducted within regulatory guidelines. Maintains communication between study partners, Sponsors, the Food and Drug Administration (FDA), and Institutional Review Boards (IRBs) as needed for proper conduct of said trials. Serves as advisor/participant in safety monitoring and/or IRB committees for clinical studies both within and outside the activity.
SERIES: 0602

Execute primary sporozoite malaria challenge model for evaluation of malaria vaccine efficacy including management of acutely ill volunteers with malaria infection, safe conduct and execution of actual challenge by mosquito bite as well as clinical follow-up of such volunteers and familiarity with anti-malarial medications/contraindications/adverse effects.
SERIES: 0602

Performs immunology studies in support of malaria vaccine research, to include but not restricted to: 1) ELISPOT- cellular generation of IFN-gamma or other cytokines, 2) Luminex and immunofluorescence analysis, and 3) malaria diagnostics (PCR, rapid tests, blood smears).
SERIES: 0602

Work involves skill, knowledge, and abilities to lead a group that will develop assays and methods for characterization of viral and other vaccines intended for human use. Assays may require validation to meet Good Laboratory and Good Manufacturing Practices as defined in federal regulations for human, experimental vaccines. Has knowledge of microbiology, molecular biology, virology, immunology, and cell culture techniques. Conducts monoclonal antibody production and purification, viral antigen production and purification, viral inactivation procedures, enzyme-linked immunosorbent assays, and viral neutralization and infectivity assays. When required devises new and unique assays for measuring vaccine antigen potency and specificity. Receives, catalogs, and processes blood from human clinical trials for testing of antibodies and other measures of immune response to experimental vaccines. Compiles and analyses data from studies for presentation to colleagues and collaborators. Provides data and summarized reports for regulatory submissions and publication in the scientific literature.
SERIES: 0403

Work involves planning and developing research projects according to the Army's biomedical mission. Performs research as a collaborator, working independently, and oversees technical personnel. Duties require knowledge of mechanistic enzymology, chemistry, biochemistry, neurochemistry, neurobiology, chemistry, and cell biology. Work requires experience in the methodology required for protein studies and enzymatic assays.
SERIES: 0401, 1320

Critical work includes planning, organizing, conducting, and reporting epidemiologic research studies related to HIV-1 infection/HIV-related conditions and other infectious diseases of military importance. These studies are designed and executed to generate knowledge products to inform risk assessment, force health protection measures, and Service and DOD Policy and to meet the specific interests of the geographic and functional combatant commands in the area of HIV/HIV-related infectious diseases. Subject matter expertise in DOD and Service-specific military population health and force accession, retention, and deployment health policy and force health protection countermeasures is essential. Ability to identify novel threats and gaps in existing knowledge products and force protection policy is essential. Active and on-going communication with military public health, specialty provider, and operational leaders (e.g. Combatant Commands) is required in order to define and update current needs and to communicate study results through appropriate military communication (e.g. Technical Report, Threat Brief, White Paper, peer reviewed scientific publication). Essential tasks include leading multidisciplinary teams of military public health and specialty providers, laboratory staff, and epidemiologists assembled to execute complex studies in settings that range from garrison to combat zone.
SERIES: 0602

Conducts, directs, and oversees high complexity molecular diagnostics and therapeutic monitoring of HIV and related diseases of Soldiers, Sailors, Marines, Airmen, and beneficiaries in a College of American Pathology (CAP) accredited laboratory. Position requires expertise in the identification, assessment, verification/validation of all FDA cleared assays related to state-of-the-art molecular diagnostics, certification in FDA cleared quantitative and qualitative clinical monitoring assays for HIV/related diseases, and HIV Resistance Genotype testing. Position requires expertise in the design and implementation of clinical research projects in support of epidemiological studies and evaluation of therapeutics and vaccines. Leads a team in the development, and evaluation of clinical and research goals/milestones to meet the challenges of the AIDS epidemic and related diseases relevant to the DOD and its collaborators.
SERIES: 0403

Directs research efforts in the design, development, and implementation of molecular diagnostic and research assays for clinical diagnostic applications for research protocols studying HIV/AIDS and related infectious diseases. Directs modification, development, and verification/validation of mission relevant molecular diagnostic assays in support of clinical diagnosis/monitoring in lieu of FDA cleared assays in studies of HIV or other related disease pathogenesis. Requires knowledge and expertise in real-time PCR assays, transcription-mediated amplification (TMA), and state-of-art nucleic acid quantification/qualification methodologies/technologies. Applies a broad theoretical knowledge in microbiology, immunology, molecular biology, and biostatistics in the design and performance of extramural/intramural research projects supporting Army and Department of Defense requirements. Submits articles for publication in peer reviewed journals and/or presents research national/international conferences. Serves as Contracting Officer Representative (COR) administering DOD research grants/contracts. Serves as Subject Matter Expert (SME) on Selection Boards and International Committees.
SERIES: 0403

Work involves the assessment of the immunopathogenesis of human retroviruses with a focus on human immunodeficiency virus type 1 (HIV-1); requires handling infectious HIV-1 and supervision of several staff in the handling of live, high titer HIV. Leads a research section in the characterization of the humoral immune responses to retroviruses in infected and vaccinated humans, in vaccinated small animals and in non-human primates. Develops, applies and qualifies or validates novel test methods, including but not limited to methods for measuring HIV permissivity, neutralization, binding antibody titers and epitope-specific responses using assembled panels of viral isolates and antibodies. Serves as an expert HIV humoral immunologist on international committees for laboratory standardization and technology transfer; obtains and manages independent research funding from outside organizations such as the Bill and Melinda Gates Foundation and the NIH Division of AIDS. Trains graduate students and early career investigators; presents novel research findings at internal and external meetings and publishes findings in peer-reviewed journals.
SERIES: 0403

Manage the Host Genetics Laboratory. Study the relative importance of specific signaling pathways including MAPKp38, JNK, and ERK; various kinases; protein tyrosine and serine/threonine phosphatases and their roles in mediating dexamethasone effects on chemokine receptors CXCR4 and CCR5. Elucidate the 'relative' RNA expression levels (using quantitative RT-PCR) of transcription factors under different experimental conditions and their indirect effects on expression of putative target gene RNA levels (CCR5 and CXCR4) in primary human lymphocytes. Employ nucleofection and RNAi (RNA interference) technologies to study roles of transcription factors including GR, MR, and c-Jun both at the level of RNA and protein in regulating expression of chemokine receptors. Perform Infra-Red emissions-based Western Blot technologies with lysates from cell cultures and primary human lymphocytes exposed to various treatments for various times to detect and monitor changes in the amount and activity of various transcription factors and MAPK signaling pathway mediators putatively involved in CXCR4 and CCR5 expression; and monitor their intracellular levels. Purify primary human lymphocytes from whole blood leukopaks employing negative enrichment magnetic bead technologies. Collaborate with the FACS laboratory to study the effects on surface expression of CXCR4 and CCR5 at the levels of fraction of expression positive and absolute densities in primary lymphocytes in the presence or absence of steroids and pathway inhibitors. Perform statistical analyses on normalized qRT-PCR (quantitative reverse transcribed - polymerase chain reaction), Western blot, and surface expression data. Design and optimize numerous primer/probe sets for use in qRT-PCR experiments.
SERIES: 0403

Work involves conceiving, planning, directing, and execution of basic and applied biochemical and immunological research programs. These would include involvement in missions and programs for developing liposomes as carriers of adjuvants and vaccines, for developing novel vaccine strategies, adjuvants and delivery platforms, including needle-free routes of immunization for infectious diseases and other substances that are risk factors for the spread of infectious diseases, for designing vaccine formulas that generate unique antibody specificities such as antibody binding to both protein and lipid epitopes, for the development of monoclonal antibodies that inhibit or prevent disease both in vitro and in vivo, for conducting preclinical testing of vaccines in animal models and in vitro; for developing peptide based vaccines and conjugating haptens to peptides or proteins for the generation of vaccines against haptens, and for other relevant missions as they are identified. Additional work includes generating monoclonal antibodies to lipids and investing the role of these antibodies in pathogenesis of infectious diseases, ability to inhibit infection and normal body functions both in animals and humans; investigating pathogenesis of infectious diseases; and the role of antibody control or prevention of infection. Also required is direction of the analysis, interpretation, and publication of results in scientific literature and preparation of essential reports, generation of human use and animal protocols, preparation of documentation leading to CRADA, MTA, contracts, and patents applications. Responsibilities include supporting priority missions such as infectious diseases, managing and approving allocation and distribution of Army approved budget and extramural funds to the degree that is authorized in the assigned organization. Works independently, exhibits knowledge and experience in directing scientific research, and is proficient in cell culture techniques, and immunological assays.
SERIES: 1320

Work involves conceiving, planning, directing, and execution of basic and applied biochemical and immunological (humoral, mucosal, and cellular) research studies pertaining to human immunodeficiency virus (HIV). Studies include executive involvement in basic and preclinical animal studies for developing HIV vaccines. This would include developing liposomes as carriers of adjuvants and vaccines, developing novel methodologies for delivery of HIV antigens and vaccines to include transcutaneous needle-free technology and use of bacteriophage T4 nanoparticles, analysis of HIV-protein and peptide specific antibodies in the pre-clinical and clinical samples by enzyme-linked immunosorbent and surface plasmon resonance assays, development of novel in vitro assays for evaluating HIV neutralizing and blocking antibodies, study of immunological mechanisms of adjuvants such as lipid A, presentation of protein, lipid, and lipid associated antigens by antigen presenting cells (APC), intracellular trafficking of antigens, interactions of liposomal protein and lipid antigens and HIV with APC, in vitro studies of early entry events in HIV infection, elucidating the role of proteasomes in antigen processing and presentation to T cells, analysis of samples for cellular responses such as intracellular and cell-associated cytokines, cytotoxic T cell responses, study of interactions of multi-specific monoclonal and polyclonal antibodies with APC and HIV, and other relevant missions as they are identified. Also required is direction of the analysis, interpretation, and publication of results in scientific literature, presentation of research work at meetings and conferences, preparation of essential reports, initiation of collaborations, assisting employees in career planning and developing work performance standards and objectives, guiding and supervising junior staff. Responsibilities include supporting priority missions such as HIV, managing changes to the structure and content of research programs, exercising discretionary and executive authority to approve allocation and distribution of Army approved budget and extramural funds to the degree that is authorized in the assigned organization. Works independently, exhibits knowledge and experience in directing scientific research, is the subject matter expert on liposomes, adjuvants, and delivery systems and has expertise in flow cytometry, biacore, cell culture techniques, and immunological assays.
SERIES: 1320

Work involves the skill, knowledge, and ability to purify and characterize bacterial antigens, including proteins and lipopolysaccharides and to test candidate vaccine antigen formulations for safety and immunogenicity in animals and humans. Extensive knowledge of bacteriology, immunology and biochemistry is required to work independently to select, apply and modify existing methods or develop innovative approaches for the identification of bacteria and their products while managing a team of research associates focused on antigen production for vaccine evaluation, reporting directly to the Chief of the Department of Enteric Vaccines & Immunology. Mastery of skills including the operation and calibration of various laboratory equipment, including but not limited to, a spectrophotometer (UV and Visible), bacterial fermentation systems, liquid chromatography (FPLC and HPLC), SDS-PAGE, aseptic processing and other analytical and preparative equipment as necessary as well as the treatment and handling of research animals. Functional tasks include growing and processing bacteria, performing chemical and physical analytical tests on purified antigens, immunizing animals, performing serologic assays, analyzing data, and preparing reports. The incumbent assists in writing Standard Operating Procedures (SOPs), cGMP Batch Production Records, annual reports, manuscripts, manufacturing [Chemistry, Manufacturing, and Control (CMC)] sections of FDA IND submissions, product quality control (QC) reports, and summary reports for both in-house and extramural collaborations. Required expertise includes the ability to follow and provide detailed instruction and coordinating efforts with other investigators to evaluate mission progress as part of a complex research effort. Theory and practice of both Good Laboratory Practices (cGLP) and Good Manufacturing Practice (cGMP) is required.
SERIES: 0401, 0403, 1320

Work involves comprehensive research program devoted to the development of vaccines to prevent infection with military relevant pathogens. The position requires leadership and expertise in the fields of mucosal immunology, cell biology, microbiology, and protein chemistry. Tasks include leading a research team focused on elucidating host immune response in both peripheral and mucosal compartments after infection or immunization, specifically cellular and antibody effector functions using novel or established methods such as ELISA, lymphocyte proliferation assays, cytokine profiles, memory responses and immunophenotype. The position serves as a team leader of a research effort focused on the evaluation of live, non-live, and DNA vaccine candidates along with appropriate vaccine adjuvants in pre-clinical and clinical trials. Manage and direct the immunological characterization of samples collected in the course of experiments involving clinical trials, cGMP product performance, and stability studies. Existing animal models or new in vitro or in vivo model development will be used to clearly define immunological correlates of immunity. Tasks will also include developing novel immunological assays, adapting existing protocols to meet research goals, maintenance, archiving, and distribution of existing monoclonal antibody collection and the development of new monoclonal antibodies as needed. The position requires managing and planning of experiments, compilation of data, interpretation of results and preparation of seminars, technical reports or manuscripts for local and international collaborators. Provide mentorship and training to junior scientists, postdoctoral fellows, technicians, and students.
SERIES: 0401, 0403, 1320

Work involves support of Army's malaria vaccine program. Task includes conducting basic and applied research towards identification of novel liver-stage antigens as potential vaccine candidate to be used in future clinical trials, either alone or in combination with other vaccines. These activities require expert knowledge and command of tissue culture of human and murine hepatocytes, molecular biology using qRT-PCR, DNA vaccine delivery by Gene Gun, electroporation and as viral vectored vaccines. This task also includes supervisory responsibilities for the preparation and delivery of liver stage antigens as DNA and or protein components, timely vaccination regimen of small laboratory rodents, and the performance of immunologic and molecular biology tests to assess the effectiveness of the putative novel liver-stage vaccines. Skills include planning of experiments, compilation and interpretation of result, preparation of reports for presentation to a consortium of collaborators. Other responsibilities include supervising scientific and technical staff and meeting regularly with collaborators on multidisciplinary level.
SERIES: 0403

Performs independent research in a program involving development of multiplexed diagnostic assays for a variety of pathogens. Develops procedures, protocols and appropriate test materials for novel diagnostic tests. In particular, assays will include magnetic or non-magnetic bead-based, multi-analyte panels and instrumentation such as the MagPix or FlexMap systems. Tests are evaluated using materials from infected animals or humans to determine their sensitivities and specificities.
SERIES: 0403

Work involves support of Army's malaria vaccine program. Skills include developing assays to map B and T cell epitopes of malaria vaccine candidates. Epitope display technologies, in vitro assays to determine correlates of protection, including but not limited to, Surface Plasmon resonance, parasite growth and invasion inhibition assays, simulation of molecular structure and rational design of immunogens. Devise strategies to refocus host immunity to defined epitopes and to study of immune responses induced by the vaccines. In vivo challenge models of malaria including the mosquito induced and blood stage induced challenge of rodents and non-human primates. Development of novel particle based technologies and adjuvant systems to augment immune responses induced by malaria vaccine candidates.
SERIES: 0403

Position encompasses a multidisciplinary approach to the construction and evaluation of live Shigella vaccine candidates for use in clinical trials. The scope of scientific activities include: microbial pathogenesis, molecular biology, biochemistry, genetic engineering of attenuated vaccines and of recombinant vaccines expressing heterologous protein antigens, immunological evaluation of genetically engineered vaccines in animals, cGMP manufacture and release of candidate vaccines for human use, and preparation of documents for Investigational New Drug applications. Required skills include a detailed professional knowledge of pathogenesis, molecular biology, protein chemistry, immunology, and animal use.
SERIES: 0403

Work involves roles and responsibilities that define a Product Manager for the manufacture and preclinical characterization of live Shigella vaccine candidates that are developed at WRAIR and manufactured under cGMP conditions. The position is a leadership role and will require thorough knowledge of microbial physiology, microbial pathogenesis, and overview of live Shigella vaccine development. The incumbent will lead and provide guidance to junior colleagues in evaluating the behavior of live Shigella vaccines grown and harvested under fermentation conditions, and lyophilization and storage of live bacterial vaccine products. Various analyses specifically tailored to each product will be completed including immunological, microbiological, and biochemical analyses. The skills required will include evaluating the viability and stability of the vaccine candidates using Shigella-specific assays, molecular and genetic characterization of attenuation features to include genome sequencing, evaluation of the safety, immunogenicity and efficacy of the cGMP products in animal models and evaluation of microbial bioburden in lyophilized vaccines. These analyses will be documented for use in reports to FDA, MIDRP status reports, or in support of Cooperative Research And Development Agreements (CRADAs) with industry partners. The position will require knowledge of SOP development including writing new SOPs for specific products and new assays. The position will require a knowledge of general safety tests and potency tests that will be documented for each vaccine candidate. The goal of the Product Manager is to lead a group to manage and plan experiments to compile data on live vaccine candidates that are sufficient to advance and sustain the products through the clinical development phase and eventually FDA licensure. The position will entail recruitment, supervision, mentorship, and training for managing Shigella vaccine products to junior colleagues and students.
SERIES: 1320

As Department Chief provides effective scientific, programmatic, and administrative leadership of a research Department developing vaccines for enteric bacterial pathogens and other infectious diseases threats targeted by the Command. Research emphasis is on the development of a subunit vaccine for bacterial enteric pathogens such as Shigella and ETEC. Extensive knowledge and experience in directing and coordinating complex biomedical research and development from the most basic to applied, product-oriented efforts are critical. The scientific activities under management range include basic bacterial pathogenesis, antigen discovery and purification, invasion complex vaccines, process development, immunology, cGMP manufacture, surveillance for diarrheal pathogens, and regulatory affairs (protocol and IND preparation) pertaining to development and evaluation of vaccines for human use. Responsibilities also include defending program to upper management and investors, supervising professional and technical staff, writing technical reports and publications, submitting patents, and establishing effective collaborations that advance the MIDRP mission. Administrative responsibilities entail the acquisition, management and allocation of human and material resources ensuring that proposed research is completed and documented in an effective, safe and timely manner and in compliance with applicable regulations.
SERIES: 0403

Provides management expertise for genomics and proteomics research initiatives to include chronic and infectious disease focus. Provides management expertise for suicide prevention programs and post traumatic stress disorder research initiatives. Ensures protocols meet ethical, statistical power, and human subject regulatory requirements, projects are clinically valid, militarily relevant and all milestones and deliverables are attainable and achieved. Initiates and tracks required approvals for proposal and panel reviews, developing the statements of work and validating personnel, facility and budget requirements. Directs the management and execution of military relevant genomic, proteomics, suicide prevention, and post traumatic stress disorder focused research programs conducted in educational, research, government, industry, and other institutions. Review and manage projects which intersect telehealth and psychological health research efforts. Serve as a panel reviewer for militarily-relevant research initiatives in which technology can be leveraged to improve the quality of health and the life of veterans, active duty, and military dependents. Serve as the domain analyst for military genomics and proteomics research, suicide prevention programs, and post traumatic stress disorder. Coordinates the efforts of a multidisciplinary team of researchers, clinicians, academic experts, and consumers in order to execute and manage research that fills a significant gap in these research areas. Serve as a Contracting Officers Representative or Grant Officers Representative on relevant projects. Author, co-author, and manage Small Business Innovative Research topics to promote research that fulfills a significant need within the portfolio. Specific knowledge and experience in epidemiology, biological sciences, biotechnology, laboratory sciences, human subject protection and regulatory requirements in human use research is required.
SERIES: 0601

Incumbent will serve as a data manager for the Select Agent Program and Biological Personnel Reliability Program (BPRP). Incumbent will input/retrieve data as needed to support specimen databases to include transferring records, registration, inspections, and managing inspection findings/observations. Monitor Centers for Disease Control and Prevention registration, permits, and all required training records. Incumbent will manage user accounts for all Program data bases. Troubleshoot specimen label printers and provides training as appropriate. They will develop procedures and train staff on how to integrate simple and complex experiments on individual specimens contained in the BSAT databases. Develop and assist in the generation and use of uniform labels that include bar coding and human readable information for all biological specimens in/out of biocontainment. Develop and generate reports based on requests from principal investigators, senior leadership, and external organizations. Prepares and updates documentation applicable to all Program databases.
SERIES: 0403, 0404, 0401

Work involves the funding and management of basic and applied research to isolate, sequence, and analyze nucleic acid sequences derived from viral organisms. Requires understanding of the principals and methods for nucleic acid (Ribonucleic Acid (RNA) and Deoxyribonucleic Acid (DNA)) isolation procedures from viral pathogens as well as from a variety of eukaryotic host cells and tissues infected by these pathogens. Works collaboratively with peers to establish direction and supervision of work conducted by technical and postdoctoral level staff. Involves the production, isolation, and analysis of nucleic acids derived from viral organisms and eukaryotic cells. Maintains a state-of-the-art viral sequencing (Next Generation and conventional) capability and bioinformatics knowledge can capability. Manages work conducted under BioSafety Level 2 (BSL-2) containment as well as any work required to be conducted in BSL-3. Reports on progress, problems, and corrective actions to management. Assures subordinate staff training and compliance with normal laboratory operations including the hazards and safeguards related to work involving infectious agents, toxic chemicals, carcinogens, safe handling of animal as well as human tissues/fluids, highly flammable materials and radiation hazards. Manages a budget and overseas the timely acquisition of laboratory equipment and supplies. Maintains knowledge of and instructs others in current and relevant scientific literature. Prepares oral presentations, poster presentations, and manuscripts that communicate the scientific work being conducted.
SERIES: 0403

The Director of Science position involves the directing, planning, and execution of world-class scientific research programs. The Director will act as a focal point for scientific activities at USAMRICD, developing scientific strategy as well as directing research and early development efforts. The incumbent will manage USAMRICD's functional science divisions to ensure business processes are being followed and that the divisions are effective in delivering value to the Institute. The Director will translate the scientific goals of the Commander into research activities by overseeing the execution of USAMRICD's project portfolio; reviewing proposed project plans; ensuring the transition of technology and candidate products to advanced developers; recommend scientific priorities to the Commander; recommend the prioritization of the USAMRICD project portfolio; support the development of USAMRICD's s scientific strategy; develop and execute an annual research plan in line with the Institutes' scientific strategy; ensure USAMRICD's scientific expertise through the incorporation of state-of-the-art technologies and the recruitment of a premier workforce; scan the biodefense field for promising technology; incorporate and further develop promising enabling technology and products; ensure USAMRICD attracts, trains, and retains a workforce with the necessary scientific skills; coordinate the activities of USAMRICD's science functions to establish seamless workflow; identify and resolve cross-functional and cross-disciplinary conflicts and develop and implement policies and procedures for the management of USAMRICD's research programs.
SERIES: 1301

Work involves skill, knowledge, and ability to provide effective scientific leadership, personnel management, and the acquisition and allocation of human and material resources for a department that is involved in the virology, viral pathogenesis, vaccine concept exploration, immunology, nonclinical testing, and transition to human testing of viral vaccines. Ability to assure that vaccine research, vaccine approaches and telemetry systems/services are of high quality, appropriate in direction, and of proper emphasis in accordance with mission requirements. Skill in developing program content, marketing/reporting, establishing research and development agreements with business or academic collaborators, and representing/defending programs at agency, national and international levels. Ability to function as a coordinator or scientific advisor for strategic plans, technology objectives, and vaccine steering committees.
SERIES: 0401, 0403 & 1320

Bio-risk management is the effective management of risks posed by working with infectious agents and toxins in laboratories; it includes a range of practices and procedures to ensure the biosecurity, biosafety, and biocontainment of those infectious agents and toxins. Biorisk management includes the full spectrum of safety and security measures for laboratories, from standard operating procedures to physical measures to individual practices in the laboratory and enterprise (DoD).
SERIES: 0601

Serves as the Bio-Risk Manager responsible for (1) Integrating disciplines of biosafety and biosecurity to be complete and complementary programs, (2) all bio-risk management functions for which the entity is responsible pursuant to regulation; (3) Bio-risk management planning, coordination, and oversight; and (4) Liaison with DoD and other Federal Agencies regarding bio-risk management of BSAT RDT&E. Develops, plans, coordinates, and oversees all aspects of bio-risk management vital to BSAT RDT&E programs and other materials derived from BSAT. Work involves establishing, implementing, managing, and maintaining oversight of the DoD Biological Defense Program's BSAT and BSAT derivative bio-risk management programs. Provides written guidance (regulations, policies, SOPs, etc.) that incorporate DoD, CDC/APHIS, and consensus standards into bio-risk management programs, and coordinates with supporting and supported entities. Requires knowledge of microbiology and familiarity with other disciplines such as principles of emergency management, principles of biosafety, risk management, and biosecurity policy, procedures, techniques, equipment, and methods. Develops/implements management databases tracking critical fields of BSAT and BSAT derivatives. Must be proficient in service risk management, personnel management, internal control program, and systems security management of DoD BSAT and BSAT derivatives, evaluates BSAT inventory audits, monitors BSAT inventory databases for accuracy and trends in BSAT usage as well as the personnel reliability programs. Evaluates DoD security programs on-site and through reports, both DoD and CDC/APHIS; tabulates security metrics from DoD RDTE facilities to identify incident trends and ensure proactive measures are instituted to prevent re-occurrence of deficiencies and BSAT-related incidents. In coordination with DoD, incumbent will participate at interagency regulatory meetings for BSAT.
SERIES: 0601

Work involves building and managing a portfolio of basic and applied research studies related to emerging infectious disease of importance to the US military mission, including but not limited to Middle East respiratory syndrome coronavirus, Ebola Virus, Zika Virus and effort in interactions with US government, other funders, sponsors and collaborating institutions. The incumbent will direct and manage the submission and continuing review of clinical research protocols with all applicable Institutional Review Boards (IRB) and regulatory bodies as well as the U.S. Food and Drug Administration (FDA). The incumbent will also be responsible for the writing and obtaining grant funding from US government agencies. Projects will include the development of countermeasures for emerging pathogens and surveillance for existing and undiscovered pathogens of public health importance in international areas where force health protection is a strategic priority to the US military and where WRAIR currently has existing research capabilities and collaborations, such as sub-Saharan Africa, Southeast Asia and the Middle East. Specifically, the incumbent will build and direct the efforts in development and execution of West African research capacity development. The incumbent will directly supervise and support clinical research conducted at US and international sites. The incumbent will also serve as the subject matter expert (and take on associated responsibilities) for the US military on emerging infectious disease topics as deemed necessary by the Military HIV Research Program (MHRP-Division of Retrovirology), WRAIR and the Medical Research and Materiel Command (MRMC). The incumbent will integrate MHRP members, MHRP network sites, USG collaborators and other collaborators into a cohesive team to meet mission objectives aligned with the emerging infectious disease threat effort at WRAIR.
SERIES: 0602

Work involves planning and implementing basic and applied research studies related to preventive, therapeutic development for HIV disease. Projects will include translational animal experiments, genetic analyses and epidemiologic studies. As either a principal investigator, associate investigator or consultant, the incumbent will also design, direct and manage clinical research protocols in accordance with the MHRP research plans to include preventative, therapeutic and observational cohort research. Additional tasks include preparing reports and scientific research papers delivering presentations pertaining to studies conducted. The incumbent will supervise the efforts of other MHRP staff on specific projects and protocols. The incumbent will also participate in network research activities in various roles to be assigned, extending from associate investigator to principal investigator. Liases with laboratory staff and basic research arm of the MHRP to support the HIV and non-HIV research efforts of the MHRP. The incumbent will guide site training, capacity development and research activities using resources within MHRP and US and international collaborators, as required accomplishing these goals.
SERIES: 0602

Work involves investigations in which the nature, scope, and emphasis of problems may vary due to the viruses or toxins under study, such as the development and application of assays for histologic localization of antigens/proteins, cellular populations, agent/host nucleic acid sequences, and host mediator constituents; development and application of assays for quantitation of antigens/proteins or specific nucleic acid sequences; and correlation of data with the clinicopathologic characteristics of the model being utilized. This involves biochemical techniques for demonstrating proteins (i.e. immunohistochemistry, immunoelectron-microscopy, analytical chemistry, Western blots, radioimmunoassay) and nucleic acid sequences (i.e., in situ hybridization, analytical slot blots, Northern and Southern gels and blots, filter hybridization) in fresh, fixed, and frozen tissue or specimens.
SERIES: 1320, 0601, 0602, 0701, 0644

Work includes serving as the primary instructor for the Field Identification of Biological Warfare Agents (FIBWA) programs for biological warfare (BW) agents using advanced diagnostics and detection methods. Duties include work in Biosafety Level 1 & 2 laboratories to develop and/or evaluate new laboratory procedures and reagents to support training program requirements. Responsibilities require coordination within the unit to ensure program responsibilities and between other government agencies to insure requests for training are scheduled and coordinated appropriately. Review and implement standing operating procedures (SOPs), project protocols, including those for support of accreditation processes, curriculum development and incorporating advancing technologies. Support training programs on site and in the field as required. Plan and execute complex training scenarios. This position requires a thorough, in-depth knowledge of molecular and immunoassay methods required to identify BW agents according to developed and ad hoc protocols. As well as a thorough knowledge of DoD concepts of BW agent diagnostic and detection programs and integration of those programs across other federal and state government agencies or departments to include CONUS and OCONUS deployment operations.
SERIES: 0404

Overseas the daily operation of classroom and teaching laboratory spaces. Specific responsibilities include, but are not limited to, procurement, inventory and stocking of supplies, calibration and maintenance of scientific equipment, training of support staff (including contractors and students), writing and maintaining SOPs, inventory and property documents and ensuring projects are performed in compliance with DoD/Army safety procedures, CLIP, GLP and other regulations that may be applicable. Scheduling work and training events, and advance planning for training opportunities.
SERIES: 0404

Performs laboratory assays and tests in support of diagnostic testing and of laboratory quality assurance programs in the Diagnostic Systems Division specifically the Special Pathogens Laboratory (SPL) and the National CDC Laboratory Response Network (LRN), in support of their patient care mission. Executes laboratory tests according to established procedures, standards of accuracy and turnaround time requirements. Prepares quality assurance and competency testing panels for both intramural and extramural laboratories. When applicable ensures laboratory operations are in compliance with Clinical Laboratory Improvement Program (CLIP), COLA, GLP, CDC/FDA and other regulatory and accrediting agency guidelines. Maintain training, quality assurance and competency requirements in accordance with accrediting agency guidelines.
SERIES: 0404

Serves as Civilian Deputy to the Science Director in providing strategic scientific leadership and vision to the Commander in the discovery, development, integration and transition of S&T knowledge and products focused on leading edge medical capabilities to deter and defend against current and emerging biological threat agents. Provides senior level technical information exchange with the Army, other services, OSD, the Military Health System, Federal agencies, National Laboratories, academic investigators and the international military and academic communities. Manage workforce strategic plans to attract, train, and retain a workforce with the necessary scientific skills; coordinate the activities within the laboratory to establish seamless workflow; identify and resolve cross-functional and cross-disciplinary conflicts and develop and recommend strategy to ensure the workforce skill sets remain current and relevant.
SERIES: 0401, 0403, 0601

Develops strategy, concepts, and plans for business innovation and strategic communication. Promotes and communicates business transformation, reform, re-design, innovation and culture change focused on continuous improvement and resource-informed application of resources. Work requires a high level of interaction with high level officials in Army and DoD and other external stakeholders in communicating major issues of laboratory business transformation interest.
SERIES: 0601

Directs the Business Office of the DOD biocontainment laboratory with oversight of the Office of Research and Technology Applications (ORTA), Business Plans, and Business Plans and Operations. The position requires knowledge of applicable DoD, Army, MEDCOM, and local regulations, policies, standards, procedures and rules. Incumbent must have the ability to analyze, interpret, and clarify data, solve generic to complex problems, by providing sound judgment and guidance. The position requires ability and skill in managing multiple and varied projects with differing timelines and independently advising IPT's, task groups, contractors, and consultants, both internal and external.
SERIES: 0601

The position requires skill, demonstrated expertise by innovations in science documented by publications, and ability to provide scientific leadership in each of the individual aspects of foundational science. Work involves contributing to, and development of, new research programs to investigate all aspects of systems biology including pathogenesis, immune responses, and therapeutic strategies for infections/exposures of military relevance and emerging threats. The complexity of the work requires directing multidisciplinary teams and having extensive collaborations with world-class experts. The candidate will have evidence of such collaborations among co-authors on their publications. Additional aspects of the work include: (a) addressing basic research questions to include the understanding and characterization of the infectious agent/toxin, synthetic biology, molecular biology, pathogenesis, pathology, immunological responses, and host/agent interactions; (b) maintaining a state-of-the-art viral and bacterial omics capability and bioinformatics knowledge; and (c) addressing fundamental mechanistic questions using state of the art technologies. Additional responsibilities include reporting results in scientific literature, presentations at national and international meetings, and preparation of command and agency briefings as requested.
SERIES: 0401, 0403

Directs the management and execution of complex medical research and development projects conducted to support priority missions such as biological defense and medical countermeasures. Responsible for managing the strategic research planning, programming, budgeting and reporting activities as well as working with DOD, FDA, and pharmaceutical industry in advancing biodefense product development. Developing and directing extramural research programs and in-house independent research programs, is required. Expert knowledge of biomedical research programs is critical.
SERIES: 0403, 0601

Work involves planning and executing basic and applied research directed at the discovery and transition to advanced development of drugs for the treatment and prevention of naturally occurring infectious diseases. Incumbent is a subject matter expert and provides expert advice in mechanisms of drug action, the design and synthesis of novel organic compounds, structural confirmation, development of methods for the analysis of drugs in complex biological milieus, isolation and structure elucidation of synthetic medicinals and biologics, biotransformation of drugs, molecular modeling, structure determination of target biological molecules, molecular biology, and drug-biomolecule interactions.
SERIES: 0403, 0601

The incumbent serves as Senior Microbiologist ensuring the facility's Select Agent Program is compliant with all DoD, Army, Federal, State, and activity regulations. May serve as CDC Alternate Responsible Official (ARO) and ensures that the facility's CDC registration, to include but not limited to eFSAP, and all BSAT-related activities comply are regulatory compliant for the acquisition, storage, use, transfer and destruction of BSAT. Responsible for the management of BSAT and direct the activity's BSAT inventory accountability program. Oversee BSAT animal studies and may serve as BSAT storage custodian. Provide full-spectrum BSAT management guidance and oversight of the DoD BSAT database and ensure that CDC-registered PIs and their staffs are appropriately trained to use the database. Conduct, develop, and manage BSAT-related research projects to support priority missions and search alternative technologies to enhance the biosecurity of BSAT and/or BSAT- related materials. May perform reviews of documents (manuscripts, proposals, reports, presentations, etc.) for Operations Security (OPSEC) and/or Dual Use Research of Concern (DURC). May serve as Certifying Official (CO) in the Biological Personnel Reliability Program (BPRP).
SERIES: 0403

Responsibility for both administrative and technical work in the management of linen, HAZMAT and regulated medical waste (RMW) programs. Performs inspections of RMW collection points throughout the facility and outlying buildings. Provides input to internal written policy regarding the storage, quality control and transfer of regulated medical waste. Work involves knowledge of regulatory requirements, special procedures, and preventive safety factors for the transportation or storage of hazardous materials. Management, plans, directs, controls, and coordinates warehouse operations. Requires extensive knowledge of Command Supply Discipline Program procedures and other applicable regulations.
SERIES: 2001

Deputy Director of the Research Program Office (RPO) that serves as a Command representative for outreach and collaboration negotiations with DoD and non-DoD funding partners. Discusses collaborator scientific research needs and analyzes Institute capability and capacity to meet collaborator requirements. Oversees the pre-proposal, full proposal, agreement generation and project execution business processes. Makes project and agreement approval recommendations to the Commander. Oversees project execution evaluation and tracking processes and communicates execution with leadership and funding sponsors. Uses scientific expertise, analytical and leadership experience to assess complex problems and create actionable solutions. Effectively communicates problems and potential solutions to leadership and funding sponsors to obtain understanding and decision.
SERIES: 0601

Conduct rigorous scientifically sound epidemiological research requiring knowledge and application of epidemiological methods and principles. Work independently as an investigator to develop and execute original epidemiological studies towards improving Warfighter performance. Perform advanced epidemiological analyses by determining applicability of study design, study data, and statistical approaches such multivariable linear and non-linear regression, mixed effects modeling, and survival analyses. Use Statistical Analysis Software (SAS), R, or other statistical software for data management and analysis. Support investigators in a collaborative role regarding appropriate study design, data analyses, and interpretation of research findings.
SERIES: 0601

Work with high-dimensional data in a large data repository of medical and administrative records on military personnel to extract relevant and meaningful information from secondary data sources. Technical programming and analytical skills for database management and data linkage required to combine and manipulate large observational datasets from multiple data sources in order to pre-process the data for epidemiological and statistical analyses. Integrate and summarize large-scale information into outputs to communicate analysis results to other investigators, organizations, and agencies.
SERIES: 0601

Provides research support for a comprehensive research program to investigate all aspects of the testing and evaluation of therapeutics for bacterial infections. Proficient in the performance of standard microbiology under BSL-2 and BSL-3 conditions. Expert in the maintenance of pathogenic bacteria inventory and the electronic records associated with the DoD BSAT Database. Involved in planning and executing studies requiring the safe culturing of pathogenic bacteria, determining in vitro minimum inhibitory concentrations (MIC) of antibiotics in accordance with Clinical and Laboratory Standards Institute (CLSI) guidelines, handling of laboratory animals (mice, rats, and rabbits) exposed to aerosolized bacteria via whole-body or nose-only exposures, preparation and administration of anti-infective compounds to animals under ABSL-3 conditions, and executing pharmacokinetics/pharmacodynamics studies in mice.
SERIES: 0403

Work involves defining, evaluating, developing and implementing a warfighter wearable health status monitoring system. A multi-disciplinary approach is needed to successfully accomplish this mission. Work entails defining warfighter acceptable human/sensor interfaces relying heavily on ergonomic best practices. Demonstrated experience is needed in ergonomics and information management in order to integrate sensor systems, models and algorithms in such a way as to predict cognitive state from sleep performance as well as thermal, hydration, and life sign states. Work requires the ability to take empirical data through various techniques - statistical, artificial intelligence, neural networks, fuzzy inference systems or machine induction - define and implement in standard programming languages (C++/Java) model algorithms useful in the understanding of warfighter state. Work requires the ability to plan, develop, implement, and conduct cognitive research. Research will include basic applied cognitive research as well as development of the WPSM system. Research will require skills in evaluating the effects of individual equipment, environment and operational stressors, and fatigue on Soldier's physical and cognitive performance. Skill required: Applied Psychology with ergonomics and computer interaction training, experience in clothing and individual equipment evaluations, experience in information management and system architecture, programming in C/C++/Java, experience in statistical and artificial intelligence analysis, and modeling techniques.
SERIES: 0180

Work requires in-depth knowledge and experience operating state-of-the-art electromagnetic interference/compatibility (EMI/EMC) test instrumentation and demonstrated experience testing medical devices for EMI in the laboratory and aboard U.S. Army MEDEVAC aircraft in accordance with MIL-STD. Position requires in-depth experience with writing EMI test plans for medical devices, staffing and writing technical reports, performing EMC risk assessment evaluation, and coordinating with external government and civilian agencies to perform EMI/EMC testing of medical systems.
SERIES: 0801

This position requires solid experience with operation and management of vibration, climatic, and altitude test systems. An in-depth understanding of the instrumentation used to measure acceleration, temperature, humidity, and pressure, and working knowledge of applicable MIL-STD test procedures are required. Experience with developing environmental and vibration test plans, executing and managing environmental and vibration testing activities, and evaluating performance of medical devices at extreme military environmental and vibration conditions is required.
SERIES: 0801

Serves as a research engineer within the Biotechnology HPC Software Application Institute (BHSAI). Formulates research projects, develops innovative approaches, designs and implements experimental protocols related to computational models. Develops and applies computational solutions to biomedical problems, involving signal processing of time-series physiological data, data mining, data-driven and physiological-based models, and artificial intelligence. Analyzes and models physiological data with relevance to, but not limited to, cognitive performance, heat stress, sleep disorders, and therapeutic interventions using MATLAB and associated toolboxes. Continuously surveys the scientific literature to generate novel ideas and advance projects and programs. Develops necessary new technologies and protocols. Collects, processes, and interprets experimental data and model outputs. Trains, and in some instances supervises, junior research scientists. Assists in the identification, development, and maintenance of collaborations with both internal and external research groups for development of new approaches to existing research problems. Prepares research proposals, progress reports, and manuscripts for submission to scientific journals. Performs Contract Officer's Representative duties on specific contracts or grants within their areas of expertise. Represents the Institute in meetings with program staff from the Activity and other DoD organizations. Prepares and presents technical briefings on Institute capabilities and accomplishments. Serves as Principal Investigator and executes research within their areas of expertise. Presents research methods and scientific concepts at appropriate scientific conferences. Ability to guide and execute interdisciplinary research bridging computational and experimental work in human physiology as it pertains to military medicine and an established record of cross-disciplinary publications in top-tier, peer-reviewed scientific journals.
SERIES: 0801

Product Transition for the development and sustainment of a transition plan to transition Virtual Health and Mobile Medical applications from Technology Based Development to Advanced Development Phase. Responsibilities include maintaining the necessary liaison and interface with research area directorates, integrated product team managers on the technology based side and the command to report program progress, managing a team of acquisition professionals in the planning, direction and coordination of program transfer into advanced development phase and advising the Command on the state of readiness of programs to be accepted by the Command for advanced development. Functions include employing appropriate communication with regulatory affairs leadership, Command, quality assurance, and external partners. Develop plans and programs for achieving oversight requirements.
SERIES: 0601

Work involves the application of scientific and mathematical principles to the design and implementation of research projects as a supporting member of one or more research teams. Requires a broad background in physics, mathematics, engineering, and modeling, and particularly in the application of computer techniques to accomplish research projects and resolve related problems. Requires knowledge of numerical methods, specifically experience with statistical, probabilistic, and/or optimization techniques preferred.
SERIES: 0801

Work involves scripting and programming for file management, parametric analyses, and post-processing data files. Requires knowledge and experience writing scripts in scripting languages, such as Perl, in environment shells, such as bash, and mathematical programs, such as Matlab. Requires knowledge and experience writing code in at least one programming language, such as Fortran, C++, and Visual Basic. Ability to develop windows GUIs is useful, but ability to develop batch analysis code is essential.
SERIES: 0801

Knowledge of limitations and capabilities of Windows and Linux OS and Windows/Linux secure interfaces are required. Prior experience working with Unix/Linux required so that a computational Linux, or Beowulf, cluster can be managed with minimum training. Requires experience using Linux PCs and PC clusters for biomechanics computational model simulations, either as single CPU or multi-CPU processes; experience managing a Linux cluster preferred. Basic networking experience required.
SERIES: 0801

As the Senior Scientific Advisor and Civilian Deputy Director for the Combat Casualty Care Research Program (CCCRP), use independent judgment to manage - across all portfolios - the Research, Development, Technology & Evaluation (RDT&E)/Science & Technology (S&T) investments in military trauma, which may include Traumatic Brain Injury (TBI), prolonged care, en route care, Tactical Combat Casualty Care (TCCC), hemorrhage, blood and blood products, shock, coagulopathy, airway management, burn, composite and extremity trauma, polytrauma and/or multi-organ failure. Encourage, identify, invite, evaluate, and recommend militarily-relevant medical research aimed at reducing morbidity and mortality from military trauma. Using Federal acquisition principles and experience, guide, lead and supervise portfolio managers in the Planning, Programming, Budgeting, and Execution (PPBE) process for Defense Health Program (DHP) and Army research in militarily-relevant S&T medical research in combat casualty care. As a well-established subject matter expert in military trauma, serve as a government-wide consultant and closely advise the Director and the Principal Assistant for Research and Technology on all aspects of military trauma research. Ensure the translation knowledge and materiel products in military trauma through the DoD acquisition and FDA regulatory processes to Advanced Development or to clinical practice in coordination with the Joint Trauma System. Lead, mentor, and provide senior trauma expertise and guidance to subordinates in the scientific and programmatic review of proposed and on-going research in military-relevant trauma. Present to senior leadership, industry and at conferences on needs of the Warfighter related to military trauma to encourage relevant research from extramural performers and partners. Communicate the current state of research and program needs to the U.S. Congress, U.S. Army, the Department of Defense Health Affairs, the public and other stakeholders through executive summaries, reports and briefings. Oversee, guide, and develop integrated technology roadmaps across portfolios and other program area directorates to ensure close alignment of program objectives against guidance and DoD operational requirements. Maintain close engagement and communication with senior military trauma stakeholders (Service liaisons, operational users, combat developers, researchers and research institutions, advanced development, regulatory experts, policy makers, Defense Health Agency, and national leaders). Develop program technical performance, cost and schedule data reporting requirements and their application to assessments of overall program status including current and strategic requirements. Monitor CCCRP program progress in terms of cost, schedule, performance, and risk. Author and contribute to scientific articles and the production of acquisition documents, reports, briefings, and documentation required by the Defense Acquisition System and DoD guidance. Lead DoD committees focused on research program gap analysis, program evaluation, vision setting and grant review. Provide military-relevance and guidance on senior governance panels for congressionally-directed medical research. Report to the Director and directly mentor and supervise Department of Army Civilians and contractors within the CCCRP. Work requires excellent interpersonal and written communication skills, leadership and management training and experience, and the ability to work effectively in a team environment.
SERIES: 0601

Work involves a comprehensive research program with objectives in the Environmental Extreme Capability area. Directs a multidiscipline program that requires extensive knowledge in: conducting human research to sustain and enhance military performance (physical and cognitive) capabilities and minimize medical problems associated with military operations at the environmental extremes of heat, cold, and high terrestrial altitude; conducting basic research (animal, tissue, molecular) to identify and elucidate the etiology and pathophysiological mechanisms of heat, cold and altitude induced injuries / illnesses; and supporting Health Hazard Assessments regarding thermal and hypoxic stress.
SERIES: 0413

As a Portfolio Manager for Neurotrauma and Traumatic Brain Injury, manage the Combat Casualty Care Research Program (CCCRP) Research, Development, Technology & Evaluation (RDT&E)/Science & Technology (S&T) investments in Traumatic Brain Injury (TBI) and related neurotrauma-trauma sciences. Encourage, identify, invite, evaluate, and recommend militarily-relevant medical research aimed at reducing morbidity and mortality from Neurotrauma. Using independent judgment, lead the S&T research effort to close critical gaps in knowledge and technology to diagnosis, manage, and treat TBI and related sequelae from point of injury through recovery. Using Federal acquisition principles and experience, lead the Planning, Programming, Budgeting, and Execution (PPBE) process for research in militarily-relevant S&T medical research in neurotrauma. Translate and transition knowledge and materiel products in neurotrauma through the DoD acquisition and FDA regulatory processes to Advanced Development. Chair and lead the interagency and inter-Service Neurotrauma working group for CCCRP in support of the Joint Program Committee on Combat Casualty Care (JPC-6). As an expert in the neurological sciences, serve as a government-wide consultant and advise the CCCRP Director on all aspects of Neurotrauma and the neurotrauma portfolio investments, including leading and/or participating in acquisition integrated product teams (IPT) and related committees. Lead the S&T Neurotrauma responsibilities for the National Response Action Plan (NRAP) for TBI, PTSD, and Suicide. Using independent judgment, scientifically and programmatically review proposed and on-going research in military-relevant neurotrauma and recommend follow-on actions. Present to senior leadership, industry and at conferences on needs of the Warfighter related to Neurotrauma to encourage relevant research from extramural performers and partners. Develop technology roadmaps and ensure close alignment of program objectives against guidance and requirements. Maintain close engagement and communication with key neurotrauma stakeholders (Service liaisons, operational users, combat developers, researchers and research institutions, advanced development, regulatory experts, policy makers, Defense Health Agency, and national leaders). Monitor program progress in terms of cost, schedule, performance, and risk. Regularly update the CCCRP Director and senior leadership regarding program progress and issues. Author and contribute to the production of acquisition documents, reports, briefings, and documentation required by the Defense Acquisition System and DoD guidance. Work requires excellent interpersonal and written communication skills, and the ability to work effectively in a team environment.
SERIES: 0601

Work involves developing toxicity sensors that provide rapid response to a broad range of toxic industrial chemicals in water and can be incorporated into an ESB system. Toxicity sensors may include whole organisms, cells, or enzyme-based systems. Research requires knowledge of aquatic organism culture and use, cell culture techniques, and other specialized laboratory techniques such as operating automated aquatic biomonitoring systems and water quality monitors. Additional responsibilities include data analysis and interpretation as well as planning, execution, documentation, presentation and management of research projects.
SERIES: 0401

Serves as the Director of the Office of Research Protections, consisting of the Human Research Protections Office (HRPO), Institutional Review Board Office (IRBO) and Animal Care and Use Review Office (ACURO). Serves as the Director, HRPO, and Headquarters Human Protections Administrator. Responsible for oversight of the activity's Human Research Protections Program, a broad, coordinated program of regulatory compliance for the activity's conducted and supported human research. Serves as a recognized senior-level authority and adviser in the field of human subjects protection and regulatory compliance. Ensures that the Organization Institutional Review Board operates in full regulatory compliance and that HRPO actions accelerate investigator's pursuit of Headquarters-level administrative approval. Ensures that DoD supported human research receives timely review of proposal and protocol submissions and protocol life cycle actions to ensure compliance with all applicable human subjects protection laws, regulations, policies, procedures, and guidelines. Possesses expert knowledge of current regulations and guidelines related to the protection of human subjects in research, and applies knowledge of these regulations and general ethical principles during the review of assigned projects. Provides comprehensive, timely, professional quality written reviews of research protocols that delineate deficiencies and areas of non-compliance. Formulates and recommends unique solutions to complex problems that would help bring protocols into human subjects protection regulatory compliance. Composes complex correspondence to explain and interpret DOD, Army, and Organization's policies and procedures and other human subjects protection regulations and guidelines. Contributes to the development of policies, procedures, guidelines, standard operating procedures and work instructions to ensure regulatory compliance, and formulates and recommends revisions. Must have familiarity with research regulations related to animal welfare in research. Fosters regulatory compliance through education and training of key personnel. Develops, coordinates and conducts innovative education and training programs designed to foster human subjects protection regulatory compliance targeted at personnel in key leadership and/or research roles.
SERIES: 0601

Work involves research directed toward examining the impact of fatigue, workload, and environmental stressors as they relate to Soldier performance. Tasks include identifying and defining Soldier-related stressors, proposing methods to reduce these stressors, and developing scientific techniques to test these hypotheses. The ability to design experiments to measure and predict Soldier performance under conditions likely to degrade mission effectiveness is essential. Conducting studies employing objective, performance measures, objective and subjective mental alertness evaluations, computerized cognitive function evaluations, and physiological indices to identify biomedical mechanisms which may impact Soldier effectiveness in operationally relevant scenarios are required. This position requires exercising responsibility for the process of original research protocol development, initiation, data gathering, analysis, and eventual publication in both government technical reports and refereed civilian journal formats. Ability to author and co-author technical reports, technical memos, letter reports, and open literature publications containing heretofore unknown scientific findings thereby expanding the science base of knowledge in the relevant areas of expertise.
SERIES: 0180

Deputy Director and Principal Assistant to the Director, MOMRP. Works with the Director in all aspects of Planning, Programming and Budgeting in the Environmental Health, Injury Prevention, Physiological Health, and Psychological Health Research Portfolios within the MOMRP. With the Director and Military Deputy Director, provides programmatic guidance and execution oversight of the Army funded portion of the Military Operational Medicine Research Program performed by Army Laboratories. As a senior staff advisor to the Director, provides program management support to laboratory research, clinical research and research support personnel. Provides direct, first line supervisory duties of MOMRP civilian staff. In addition oversees the development of goals and objectives for the Defense Health Program (DHP) funded portion of the MOMRP performed by DoD Laboratories and extramural performers. Works with Service stakeholders and external partners (e.g., The National Institutes of Health and The Department of Veterans Affairs) to develop research programs and collaborations that produce products that meet the needs of Service members and Families. Assists with milestone decisions and coordinates both knowledge and technology transition agreements. Provides the Director with accurate and timely assessments of project cost, schedule and performance metrics, in support of integrated, proactive program management. Coordinates with internal and external partners to transition both materiel and knowledge products through the Acquisition Lifecycle from concept development through Engineering and Manufacturing Development.
SERIES: 0601

Responsibilities include intricate oversight and coordination of a diverse spectrum of partnership efforts with both Department of Defense and other government agencies as well as personal interaction with potential new and existing partners. This involves complex daily coordination, collaboration, and communication on strategic levels with external organizations such as Congressional Affairs Contact Office, Assistant Secretary of Defense for Health Affairs, Defense Health Agency, and other Department of Defense services and organizations. The incumbent participates in executive level interagency and intergovernmental meetings and represents the organization where critical decisions are discussed and formulated.
SERIES: 0601

The Director of Science position involves the directing, planning, and execution of world-class scientific research programs. The programs represent the fusion of medicine and technology. The Director will guide the development of research that leverages technology to advance military medical care delivery in the operational theater. The Director will act as a focal point for scientific activities at Telemedicine and Advanced Technology Research Center (TATRC), developing scientific strategy as well as directing research and early development efforts. The incumbent will manage TATRC's functional science centers to ensure business processes are being followed and that the divisions are effective in delivering value to the organization. The Science Director will translate the scientific goals of the Director into research activities by overseeing the execution of TATRC's project portfolio; reviewing proposed project plans; ensuring the transition of technology and candidate products to advanced developers; recommending scientific priorities to the Director; supporting the development of TATRC's scientific strategy; developing and executing an annual research plan in line with TATRC's scientific strategy; ensure TATRC's scientific expertise through the incorporation of state-of-the-art technologies and the recruitment of a premier workforce; scan the medical technology field for promising technology; incorporate and further develop promising enabling technology and products; ensure TATRC attracts, trains, and retains a workforce with the necessary scientific skills; coordinate the activities of TATRC's science functions to establish seamless workflow; identify and resolve cross-functional and cross-disciplinary conflicts and develop and implement policies and procedures for the management of TATRC's research programs.
SERIES: 0601

Directs the implementation of an independent research program that requires the design and conduct of animal research studies to address the impact of environmental stress (heat, cold, and/or high altitude) on thermoregulation, circulating biomarkers and organ injury using rodent models. Assessing physiological responses to extreme heat and identifying novel interventions to optimize and sustain performance that address Army capability gaps. Additional duties include providing expert guidance and consultation in the field of study, writing of high-quality publications, oral presentation at national and international scientific conferences, submission of grant applications in environmental physiology and related areas that are specific to rodent adaptation and maladaptations to environmental stress. Technical skills required include subject matter expertise with animal models, protein biochemistry, gene expression and histology.
SERIES: 0413

Responsible for applying Program Management skills to program cost, schedule and performance; along with the planning, programming, budgeting, and execution of funded research program emphasizing delivery of medical autonomous and robotic knowledge, technology and research. As an expert to the Medical Simulation and Information Sciences Research Program (MSISRP) Director, they will provide expert guidance to the program area coordination and lead the laboratory research, clinical research, and research personnel with programmatic and strategic approaches, and ensures adherence to research policies and procedures. Duties include monitoring medical autonomous and robotics program and reporting progress and deliverables through reports, monitoring program compliance with applicable regulations pertaining to research activities, coordinating review and approval of research protocols, coordinating budget, procurement requirements to conduct research operations. Responsibilities include initiating, implementing and maintaining appropriate databases to track, correlate and integrate program efforts, budget and deliverables for tasks, demonstrate accomplishment of programmatic goals and manage resources. Expert development of policy changes in response to changes in appropriations and allocations alteration. Will lead programmatic reviews and evaluate research efforts in medical, robotics, and autonomy fields to identify potential challenges and ensures that research provides practical and specific solutions to identified Defense Medical Research and Development requirements. Formulates program requirements, activities, and resources needed to complete these items. Ensures the use of resources is consistent with laws, regulations, and policies; and guards' against waste, fraud, and misuse. Governs various factors to ensure that high quality, affordable, supportable, and effective medical systems are delivered to the Warfighter and the Military Health System as quickly as possible for technical advancements. Planning, organizing, monitoring, overseeing, and/or performing activities that relate to the design, development, planning and modification of medical autonomy and robotics research programs. Demonstrates competence in medical, autonomy, and robotics concepts along with an overview of technology and/or system development, within the Defense Acquisition process. Development of overall program goals for S&T funds by leading collaborative efforts to gather knowledge of scientists, physician researchers, engineers, and technical experts. Expertly manages providing funds to intramural S&T performers, and research efforts with extramural organizations including universities, industry, and Federal Government organizations.
SERIES: 0601

Work involves design and conduct of clinical research studies in the area of military medical relevance. Work involves protocol development, management of regulatory affairs, and quality assurance support for product development efforts involving Phase I and II human trials conducted according to current Good Clinical Practices to demonstrate safety and efficacy of candidate investigational medical countermeasures or retrospective clinical studies. Serves as subject matter expert in support of the research conducted within the work element. Knowledge and skills include both theoretical and practical knowledge of clinical trial design, Food and Drug Administration (FDA) clinical research regulations, laboratory practice, and manufacturing regulations and guidelines. Tasks include the following: (1) developing and reviewing clinical research protocols (i.e., experimental design, managing responses to scientific review committees/institutional review boards/ FDA, data management, and data analysis); (2) reviewing case report form and informed consent compliance; (3) reviewing submissions to the FDA for regulatory compliance and quality; (4) serving as liaison between satellite trial sites and the Institute; and (5) educating other investigators regarding regulatory requirements. Submits articles for publication in peer reviewed journals and/or presents research at national conferences (abstract, short topic, poster, or presentation). Prepares research proposal package(s) that support the research needs of the Army and the Department of Defense (DOD) and submits them for Army, DOD, or extramural funding. Provides medical advice and input to research efforts as requested, advising the Institute leadership and investigators regarding medical risks to HRV in the development and execution of research.
SERIES: 0601

Work involves research directed toward examining the ability to detect and assess correlational and causal relationships in the environment, with particular focus on perceptions of determinate and indeterminate data, as they relate to warfighter performance. Tasks include identifying stressors which may impair performance and develop measures to improve and predict future performance given these conditions. Conducting studies related to cognitive errors such as illusory correlations and covariation bias, causal analysis, probabilistically valid inferences from single observations, undefined correlational data, inferences from samples when univariate characteristics of the population are known, and the strength and direction of causal and correlational relationships. Developing theoretical hypotheses of covariation assessment based on Bayesian principles and experimental evaluation of these hypotheses through valid and reliable scientific techniques and statistical simulation. This position requires exercising full responsibility for the process of original research protocol development, initiation, data gathering, analysis, and eventual publication in both government technical reports and refereed civilian journal formats. Ability to author and co-author technical reports, technical memos, letter reports, and open literature publications containing heretofore unknown scientific findings thereby expanding the science base of knowledge in the relevant areas of expertise.
SERIES: 0180

Work involves functioning as a primary investigator conducting independent research in the areas of noise hazards, noise-induced hearing loss, speech intelligibility, hearing protective devices and clinical research in the areas of audiology, vestibular research, and traumatic brain injury. Position requires skills and knowledge of scientific methods and investigation techniques, experimental design, statistics, audiology, and acoustics. Ability to perform complete audiometric evaluation of experimental subjects (pure tone, noise band, and speech audiometry, middle ear analysis, otoacoustic emissions) and set up and conduct hearing research from which information can be gained relevant to voice communication in noisy environments in normal and hearing-impaired listeners and to occupational hearing conservation strategies. Work involves serving as a subject matter expert for the Army in the areas of audiology, acoustics, hearing protection and prevention, and vestibular research. Certificate of Clinical Competence in Audiology (CCC-A) is required.
SERIES: 0665

Work involves epidemiological research to quantitatively assess the neurological effects of military-relevant environmental exposures (such as jet fuel and permethrin) and evaluate specific assessment protocols. Data management and analytic emphasis will include multiple file-type integration and linkage procedures and repeated measures, mixed models, multivariate regression, and case series analyses for specific environmental and public health projects. Performs advanced epidemiological and biostatistical analysis and data management and cleansing in both the Statistical Analysis System (SAS) and Statistical Package for the Social Sciences (SPSS) statistical packages.
SERIES: 0601

Work involves theoretical, computational or experimental investigations into ballistic and blast effects on humans. Expertise, knowledge and skills include computational, structural and solid mechanics, biomechanics, continuum mechanics, experimental penetration mechanics, and numerical and analytical methods and techniques.
SERIES: 0858

Work involves knowledge of Army policies and regulations, administrative and financial functions pertaining to research execution and support services to include: Planning, Programming, Budgeting, Execution System (PPBES), experimental design, statistical methods, scientific analysis, military and civilian personnel; resource management, logistics; information management; facilities management; central laboratory support; safety; veterinary services; marketing, technical transfer and public affairs; and research quality assurance for the laboratory.
SERIES: 0413

Incumbent provides biophysical research to include modeling individual human responses to thermal work strain in training and operational environments. The position supports several ongoing protocols to include developing heat strain decision aid for the Ranger Training Brigade. This position assists in the WPSM (war fighter physiological status monitoring) research and development effort and associated modeling efforts related to the WPSM effort. Requires experience in the validation and examination of biomedical models that support the warfighter. Requires the ability to create or use specific computer languages such as C, C**, Java, and ACCESS and experience in statistical computer programs such as SPSS, STATA, and SAS.
SERIES: 1520

Conducts and coordinates research studies on the physiological aspects of military performance and human performance in extreme environmental conditions. Lines of research include but are not limited to identifying biomarkers of bone health, muscular injury and adaptation, occupational performance, physical training programs and hormonal adaptation (IGF-I, growth hormone), hydration and performance, hormonal markers of altitude acclimation, and human energy metabolism. Manage laboratories conducting immunoassays, phlebotomy, and general lab chemistry. Leads research study teams to ensure successful protocol execution. Requires proficiency in a wide variety of laboratory skills including, but not limited to phlebotomy and indwelling catheters, enzyme-linked immunosorbant assay, radioimmunoassay, Luminex (Multiplexing), osmolality, hematology, and automated general chemistry analyzers. Serves as lab manager in coordinating all ongoing protocol lab work and overseeing junior laboratory technicians on immunoassay analysis, phlebotomies, and other laboratory procedures including radioimmunoassay. Provides logistic support on all ongoing research projects, ensuring laboratory credentials, and trains junior lab staff members.
SERIES: 0413

Incumbent conducts nutritional research to expand knowledge in military operational health. Incumbent plans, organizes, and conducts research programs in nutrition, foods, dietary supplements, food ingredients and nutrition delivery systems, evaluating and utilizing appropriate methodology and tools to carry out investigations, to include research involving human subjects. Studies and analyzes recent scientific discoveries in nutrition for application in current research, for development health policy recommendations to sustain military health, fitness and performance, and to guide future research. Communicates findings through written reports, publications, oral briefings, and lectures.
SERIES: 0630

Work involves conduct of research pertaining to tactical exercise and physical task performance and applying technological metrics pertaining to human kinesiology. Assessing and detailing the key modifiable factors impacting injury, physical demands of individual Soldier tasks and required tactical capabilities so as to improve efficiency and capacity of physical task performance and avoid injury are required. Applying data collection metrics and procedures to evaluate human physical performance and assess bone and muscle functioning to optimize task performance is critical. Additional responsibilities involve understanding of technologies key for the assessment of musculoskeletal performance and presentation of research results.
SERIES: 0601, 0413

Work involves functioning as researcher in the design, conduct, and analysis of human kinesiology and exercise science research. Technical skills and knowledge are required in the areas of scientific methods and investigation techniques, project-, team- and data- coordination and management pertaining to military performance and reduction of musculoskeletal injury. The position requires focus on the assessment and optimization Soldier physical demands and occupational and operational performance and reduction in performance decrements. Research work includes screening for and evaluation of the performance factors that impact returning to combat effectiveness following musculoskeletal injury. Responsibilities include the ability to synthesize results to provide models or prediction strategies that lead to effective injury prevention, intervention strategies, and human performance, optimization, and enhancement.
SERIES: 0601, 0413

Research neuropsychologist with background in clinical assessment, diagnosis and treatment of diverse neurologic and psychiatric disorders such as Traumatic Brain Injury (TBI) and Post Traumatic Stress Disorder (PTSD). Research expertise in the areas of brain injury, stress and fatigue, as well as occupational and environmental neurotoxicologic exposure. Experience and expertise in the design and conduct of both laboratory and field-based study designs, using traditional and novel measures of central nervous system structure and function, including multimodal magnetic resonance neuroimaging, examiner-administered and computerized neurocognitive assessment measures, and neurophysiological assessment (e.g., postural stability/balance, eye tracking methods, EEG, fNIRS) within military and veteran populations.
SERIES: 0180

Conducts applied human performance research as it relates to a better understanding of the biomedical and physiological requirements associated with the successful completion of critical military physical tasks in male and female Soldiers. Must have the ability to analyze the strength, power, endurance and coordination needed to accomplish critical physical tasks. Develops research protocols to test, assess and monitor physical performance during Army Basic and Advanced training. Must have demonstrated understanding of periodization theory of designing physical training programs that optimize performance and mitigate the risk of musculoskeletal injury. Incumbent will rely upon expertise in isokinetic, isotonic and isometric strength testing, neuromuscular measurement through electromyography, and other unique tests that assess fatigue under extreme conditions. Incumbent must demonstrate proficiency in exercise physiology measures that include: body composition, aerobic capacity, and muscular force and power. Must be experienced and familiar with ethical conduct of human research procedures and research regulatory policies.
SERIES: 0413

Serves as the Director of the DoD Blast Injury Research Coordination Office (BIRCO). Applies technical, management and leadership skills while executing the coordination responsibilities of the DoD Executive Agent (EA) for Medical Research for Prevention, Mitigation, and Treatment of Blast Injuries which are mandated and codified in Public Law 109-163, "National Defense Authorization Act for Fiscal Year 2006," and DoD Directive 6025.21E, "Medical Research for Prevention, Mitigation, and Treatment of Blast Injuries," July 5, 2006. Leads a multidisciplinary staff comprising military, civilian, and contract support personnel. Establishes annual priorities and a supporting budget to fully execute the BIRCO's EA support mission. Keeps senior leaders apprised of key blast injury issues and corresponding BIRCO activities through formal and informal verbal and written communications. Establishes and maintains effective working relationships with DoD medical, operational, test and evaluation, and materiel development stakeholders to identify blast injury challenges, and to coordinate relevant, collaborative blast injury research that enables the development and delivery of timely and effective blast injury prevention, mitigation, treatment, and rehabilitation solutions for Service members. Establishes and chairs multi-disciplinary, multi-organizational, and multi-national work groups, task groups, and expert panels that address specific blast injury issues and research topics. Represents the EA in DoD medical science and technology planning and review activities to ensure that blast injury issues are adequately addressed. Establishes and oversees innovative processes that engage stakeholders from DoD, other Federal agencies, academia, industry, and allied nations in collaborative efforts to identify blast injury knowledge gaps and to recommend research efforts and policy initiatives to close the gaps and advance the science. Establishes and oversees innovative methods and vehicles for sharing research data and comprehensive information about the DoD's blast injury research efforts with stakeholders.
SERIES: 0601

Responsibilities include overseeing and leading a team of FDA regulatory submissions, document control, finance, business, administrative, regulated systems, and safety personnel. Candidate must have extensive direct experience related to business administration, budgeting, and finance in a regulatory environment and have a working knowledge of FDA eCTD submissions, electronic records, and safety reporting requirements. Candidate must possess the knowledge and skills necessary to oversee and guide eCTD submissions of a variety of documents to include, but not limited to, Investigational New Drug applications, New Drug Applications, Biologic License Applications and device applications. Skills required include demonstrated comprehensive knowledge and application of International Conference on Harmonisation (ICH) and FDA requirements for both eCTD and Common Technical Documents.
SERIES: 0601

Work involves the skill, knowledge, and ability to design and manage DNA microarray ("genomic") and protein mass spectrometric ("proteomic") research projects using mammals, fish, nematodes and cultured cells. The work requires: Recent experience and proficiency in DNA microarray ("genomics") and protein mass spectrometric analysis ("proteomics"). Experience with DNA microarrays must include familiarity with methods for data preprocessing, quality control, and data reduction for Agilent and Affymetrix microarrays, and experience with designing whole genome microarrays. Proficiency in the analysis of protein mass spectrometric data using the Waters ProteinLynx Global Server platform. Proficiency in using common software packages for high content data analysis such as Partek Pro Genomics Suite. Experience with extracting biological pathway information from high content data sets using pathway analysis tools such as Ingenuity Pathway Analysis and GeneGo Metacore. Familiarity with on-line databases for gene, transcript, and protein data relevant to the genomics and proteomics of mammalian, teleost, and nematode experimental models. Proficiency with the Perl scripting language.
SERIES: 0401

Assists to ensure compliance by researchers with federal regulations for the protection of human subjects participating in research. This position assists in the administration and coordination of the day to day operations of the USAMRDC Institutional Review Board (IRB). Supports the IRB Office leadership, the IRB Chair, and other IRB Office staff in meeting preparation. Works closely with IRB Office/IRB Chair, and IRB Office staff to provide administrative support in the review and processing of new and ongoing research submissions. Provides timely and accurate guidance to investigators and/or research support staff on preparation and submission of protocol submissions. Organizes, coordinates and attends monthly meetings of the IRB; including scheduling, building agendas, taking meeting minutes that document regulatory findings as required by regulatory agencies to assure institutional compliance in the protection of human subjects. Distributes protocol materials, regulatory and policy background, and any corresponding guidance documents to all IRB members for review following IRB Office procedures. Supports the IRB Office staff by communicating with Investigators and/or research support staff, in a timely manner, about committee decisions, requested corrections/changes/additional information, continuing review solicitations, and other communications as necessary. Distributes guidance documents to Investigators and/or research support staff on institutional policies/guidelines and federal regulations governing the protection of human subjects in research. Updates membership rosters, assurance documentation renewals, as well as membership records. Updates and maintains database records and electronic submission management system records in accordance with IRB Office procedures and regulatory requirements. Assists with editorial review, revisions, implementation and maintenance of IRB forms, meeting minutes and all necessary records according to appropriate regulatory agencies compliance requirements; and works with IRB Office leadership to continuously expand upon the body of knowledge and ability to apply the federal, state, local, and institutional regulations governing human research protection program policies to ensure regulatory compliance and the robust protection of human subjects.
SERIES: 0601

Serves as Chief, Medical Modeling, Simulation, Innovation and Visualization Center (MMSIV) at TATRC. Responsible for supervising, managing, directing, and overseeing fundamental and advanced technology research and development (R&D) programs associated with effectiveness and learning methods and simulation and training technologies, characterized by their breadth, complexity, and importance to fundamental research and advanced technology development. Research thrusts include adaptive tutoring, training effectiveness, distributed learning, artificial intelligence methods, virtual/mixed and augmented reality, virtual humans, live simulation technology, medical simulation, embedded training, and advances in computer/network information technology. Specific duties include: (1) Plan, prioritize, and direct a comprehensive effectiveness and learning methods and simulation and training technologies fundamental and advanced technology R&D program to achieve significant advances in medical training and mission effectiveness; (2) Ensure consideration of militarily-relevant environments and missions to produce high-payoff achievements in medical learning, retention, and transfer of knowledge and skills from the training environment to the operational environment; (3) Through linkages, collaboration, and leveraging with other services, other government agencies, industry, academia, and international partners, identify research findings and methods, models, and technology that can lead to enhanced effectiveness and learning methods and/or simulation and training technologies; (4) Attract world-class talent (e.g., in-house, post-doctoral, and guest researchers) who can execute the fundamental and advanced technology R&D program for the Army; (5) In conjunction with the Research, Development, and Engineering Centers, the Army Centers of Excellence, and other organizations and agencies, identify appropriate opportunities for demonstrating effectiveness and learning methods and/or simulation and training technologies; (6) Develop objective, quantitative metrics for assessing the impact of technology, doctrine, procedures, and training on Soldier training and, ultimately, mission effectiveness; (7) Translate research findings into performance-based design standards for use in the Army's requirements definition process and materiel acquisition process.
SERIES: 0858, 0801

Duties include designing and implementing an experimental human physiology research program to determine nutritional needs of modern Warfighters by investigating biochemical, cellular and molecular metabolic responses to exercise, nutritional manipulation, and environmental extremes. Requires use of biochemical and nutritional knowledge to plan and conduct human and laboratory animal experiments to elucidate candidate metabolic mechanisms suitable for exploitation by nutritional interventions to sustain and enhance optimal Warfighter biological function, health and performance. Requires experience writing research proposals and grant applications, publishing research findings in peer-reviewed scientific publications, and presenting research findings at international scientific conference, academic seminars and symposia. Requires skill using experimental human and laboratory animal models in research, design of research diets, kinetic assessments of human metabolism, and biochemical and molecular biological lab techniques for analyzing tissue metabolites.
SERIES: 0413

Serves as a Senior Technical Expert in training and simulation technology and is responsible for the conduct of fundamental research and advanced technology development to achieve advances in Soldier performance, and in medical care through technology integration and, ultimately, mission effectiveness. The incumbent will use an extensive knowledge of effectiveness and learning methods and simulation and training technologies to conduct research, establish new areas of research, identify barriers, establish priorities, provide redirection when critical problems arise, and recommend appropriate levels of effort in training and simulation fields consistent with the Army's needs. The Division Chief will identify ongoing commercial/civilian training and mission effectiveness research, which can be of use to the military and will identify unique military needs that require specific research. Interact with scientist and engineers within the DoD agencies including Program Executive Offices (PEOs), Program Managers (PMs), Research Development and Engineering Command (RDEC), Service Schools, the Battle Labs, and Naval and Air Force labs. Incumbent is also expected to interact with scientists and engineers in industry and academia, and to participate in agreements such as Technology Transfer Control Plans (TTCPs) and Memorandums Of Understanding (MOUs). Manages and oversees work force which includes scientists on Intergovernmental Personnel Act (IPA) mobility assignments and student scientists. Oversees work of contract support staff. Position requires in-depth knowledge of medical training, medical simulation product development and at least a National Registry of Emergency Medical Technicians (NREMT) paramedic level understanding of field medical care.
SERIES: 0858, 0801

Conducts basic science research in skeletal muscle physiology as it relates to muscle anabolism and injury. Develop research protocols in cells, animals, and humans to identify and validate targets for promoting muscle quality and anabolism, preventing muscle injuries, and promoting accelerated recovery from injuries. Requires proficiency in experimental design, research protocol development, animal surgical procedures (such as in vivo muscle performance assessment, euthanasia, and tissue processing), muscle and biochemical assessments of skeletal muscle adaptation (such as quantitative and myonuclei morphology, RNA/DNA/protein isolations, and polymerase chain reaction-PCR), and human performance assessments (such as VO2max testing, dual X-ray absorptiometry, and blood collection and processing). Additional responsibilities include training junior investigators and technicians and coordinating and collaborating with military and academic research partners.
SERIES: 0413

Work involves designing and directing research programs to determine nutritional needs of Warfighters during recovery from sustained dietary inadequacy, heavy physical work and activity, injury and infection. Research will require using state of the science technology for assessing dietary intake, physiological and metabolic responses to operational stress and associated health disorders, and development and testing of dietary strategies to enhance resilience and recovery. Requires use of nutritional, dietetic and physiological knowledge to generate hypotheses, plan and direct human laboratory experiments, field studies and trials. Requires demonstrated experience leading scientific research teams, writing research proposals and funding applications, publishing research findings in peer-reviewed scientific publications, and presenting research findings at international scientific conference, academic seminars and symposia. Requires skill using experimental human models in research, design of research diets, assessments of human dietary intake, techniques for measuring physiological and metabolic responses during exercise and dietary restriction, and biological lab techniques for analyzing physiological function. Requires experience and knowledge of human use research safety and regulatory compliance issues.
SERIES: 0630

Responsibilities include overseeing and leading a team of FDA regulatory submissions, document control and medical writing personnel. Candidate must have extensive direct experience related to submission of regulatory documents to the U.S Food and Drug Administration (FDA). Establishes internal standard operating procedures and an electronic Common Technical Document (eCTD) training program, and serves as the activity's eCTD Subject Matter Expert. Candidate must have extensive experience in utilizing FDA regulated electronic regulatory technology (including eCTD publishing software and FDA 21 Code of Federal Regulations CFR) part 11 electronic document management systems) and possess the knowledge and skills necessary to oversee and guide eCTD submissions of a variety of documents to include, but not limited to, Investigational New Drug applications, New Drug Applications, Biologic License Applications and device applications. Skills required include demonstrated comprehensive knowledge and application of International Conference on Harmonisation (ICH) and FDA requirements for both eCTD and Common Technical Documents. Candidate must possess comprehensive knowledge of regulatory document writing related to eCTD submissions and application of FDA Title 21 Code of Federal Regulations clinical research, regulatory compliance, document control and quality review of submissions to FDA relating to FDA regulated medical product development.
SERIES: 0601

Serves as a senior regulatory affairs advisor and Subject Matter Expert to The Surgeon General's (TSG) Sponsors Representative to the Federal Drug Administration (FDA), to the Commanding General (CG) of the U.S. Army Medical Research and Development Command (USAMRDC), and to the USAMRDC Principal Assistant for Acquisition. Provides input to establish regulatory strategies and processes to integrate regulatory support into the product development life-cycle from the discovery/pre-clinical stage to licensure, approval or cleared. Provides consultative support for non-TSG sponsored products using USAMRDC resources. Maintains necessary liaison and interfaces with USAMRDC activities as well as other government agencies, laboratories, industry, and contractors to remain cognizant of the product development effort and to apprise interested parties of the status of development and other requirements. Develops, implements, manages and provides oversight for the USAMRDC Quality Program. Advice the CG, USAMRDC staff and subordinate commands on quality planning, compliance and improvement for research and acquisition activities to include FDA-regulated and non-regulated development, basic research and other business processes. Demonstrates extensive knowledge and application of FDA clinical research, laboratory practice, and manufacturing regulations and guidelines, as well as comprehensive knowledge and application of Title 21 Code of Federal Regulations (CFR) and International Conference on Harmonization (ICH) guidelines.
SERIES: 0601

Manages and implements Safety and Occupational Health programs required for a large high containment medical research facility to ensure compliance with Federal, State and local laws and regulations. The primary objective of this work is the elimination or minimization of human injury and property and productivity losses, caused by harmful contact incidents, through the design of effective management policies, programs, or practices. Safety and occupational health management work requires application of the knowledge of: (1) the principles, standards, and techniques of safety and occupational health management; and (2) pertinent elements of engineering, physical science, ergonomics, psychology, industrial hygiene, physiology, sociology, and other scientific and technological fields, that contribute to the achievement of comprehensive safety and occupational health objectives. Individual will be responsible for the management of Safety, Biological Safety, Radiation Protection programs. Plans, directs, manages, assigns and implements Safety and Occupational Health Programs, that may include and is not limited to: Safety and Occupational health Training, Mishap reporting, Safety related investigations, respiratory protection, Hearing Conservation, Noise Abatement, Sight Conservation, Personal Protective equipment, Non-ionizing and ionizing radiation. Ergonomics, Confined space entry program, Blood borne pathogens, Occupational Reproductive hazards, Indoor Air quality, safety and occupational awards program, Visitor Safety and Fire Safety. Coordinates with the Installation and higher headquarters. Provides oversight of the Safety and health programs in administrative areas, facilities and logistics operations, animal care areas and in the research laboratory setting. Develop, formulate, establish, coordinate and issue policy and guidance for all safety-related efforts of the Commander's mission.
SERIES: 0018

Provides Good Laboratory Practices (GLP) guidance and strategic recommendations to Medical Countermeasures Test and Evaluation efforts throughout the Institute. Serves as a technical advisor on GLP matters to the Institute's Test Facility Management and GLP study teams. Incumbent oversees a team of regulatory professionals to provide the necessary technical elements for compliance with GLPs including study conduct, analytical method validation, animal model and challenge agent characterization, test/control article handling, test system integrity and archival processes. Assures the successful conduct of GLP-compliant test and evaluation studies for candidate medical products intended to provide medical countermeasures against biodefense agents. Incumbent is responsible for assessing and assuring the readiness and adequacy of GLP spaces, support services, processes and equipment prior to GLP study approval and initiation. Provides supervision and mentoring to a team of Study Directors, providing expert scientific and compliance oversight, including detailed review of reports, protocols and other documents that are critical to a GLP Medical Countermeasure Test and Evaluation effort. Provides on-going education to product teams and Institute personnel.
SERIES: 1320, 0401, 0403

Work involves evaluating program areas of occupational health, and biological, chemical and industrial safety associated with medical research involving biological agents, and other potential hazards. Represents the activity for all environmental health and safety matters.
SERIES: 0018

Provides management and analysis expertise for medical modeling, simulation and training research portfolio. Serves as the Contracting Officer Representative or Grants Officer representative for projects within this research domain. Serves as a primary representative during the grant negotiations, advising and assisting the Contract Officer in administering the awards and coordinating program management decisions. Establishes and facilitates collaborative research efforts within the DOD, academia and industry. Develops Inter-Service Support Agreements, Memorandum of Agreements and Memorandum of Understandings necessary to support both extramural and intramural research efforts. Assists in the development of program announcements which address research opportunities to meet programmatic goals and objectives within the medical modeling and simulation portfolio. Coordinates and promotes Science, Technology, and Engineering and Mathematics initiatives.
SERIES: 0601

Serves as a senior technical advisor for the medical modeling and simulation research program. Provides executive level management, programmatic direction and scientific and technical support for this diverse research portfolio. Responsible for planning, directing and developing medical simulation and modeling programs which result in products that improve the training of medical professionals. Utilizes expertise in mechanical engineering, software and hardware design, systems integration, and a solid understanding of the clinical aspects of field medical care to shape research program initiatives in concert with a multidisciplinary team of clinicians, academic experts and consumers to deliver products that meet critical research needs. Serves as the technical expert and manager of projects in the portfolio ensuring they are clinically valid, militarily relevant, technically sound, and the cost-schedule-deliverable targets are achieved. A key component of the position is to identify technical gaps in strategic plans and develop technical and programmatic solutions. Serves as the Contracting Officer Representative or Grants Officer Representative for medical research across a wide range of modeling or simulation initiatives. Position requires an in-depth knowledge of mechanical engineering, medical training, medical simulation product development and at least a National Registry of Emergency Medical Technicians (NREMT) paramedic level understanding of field medical care.
SERIES: 0830

Serves as the nursing technical advisor while providing management and analysis expertise for research initiatives in the Health Information Technology Research Program. Provides executive level management, programmatic direction and scientific support for this diverse research portfolio. Responsible for executing, directing and developing health information technology research which result in products that support the Military Health System. Plans, organizes, staffs, develops, coordinates, budgets, and reports on operations and processes affecting assigned projects, with specific details in cost, schedule and performance, using Earned Value Management where appropriate, and other sound project management principles espoused in the Project Management Institute Project Management Body of Knowledge (PMBOK), and the DOD 5000 Acquisition regulations. Utilizes expertise in health care delivery to shape research program initiatives in concert with a multidisciplinary team of clinicians, academic experts and consumers to produce products that meet critical research needs. Will be a Department of Defense representative at information technology standards organizations such as Health Level Seven, Organization for Advancement of Structured Information Standards and Office of the National Coordinator. Serves as the technical expert and manager of projects in the portfolio to ensure they are clinically valid, militarily relevant, technically sound, and the cost-schedule-deliverable targets are achieved. A key component of the position is to identify technical gaps in strategic plans and recommend technical and programmatic solutions. Serves as the Contracting Officer Representative or Grants Officer Representative for medical research across a wide range of health information technology initiatives. Position requires a in-depth knowledge of health care delivery within the Military Health System and expertise managing and directing health information technology research protocols.
SERIES: 0610

Serves as the Director, Telemedicine and Advanced Technology Research Center-South and is the program coordinator for electronic and mobile health research initiatives. Conceptualizes, designs, plans, manages and coordinates research efforts in electronic and mobile health as well as other areas involving advanced medical technology. Coordinates research initiatives in medical education and training using distance learning modalities. Directs and supervises the DHIC workforce. Is a subject matter expert in telehealth programs and serves as the Contracting Officer Representative or Grants Officer Representative for research initiatives across a wide range of telehealth research initiatives. Serves as the technical representative during grant negotiations, advising and assisting the Contract Officer in administering awards and coordinating program management decisions. Develops comprehensive research program announcements and conducts a review of research proposals determining the quality of the research, the applicability to the programmatic goals, military relevance while evaluating the ethical and regulatory requirements for human subject protection. Participates on national committees to assist in setting standards for electronic health to ensure military ehealth programs are compatible with commercial technology and practices. Authors and manages Small Business Innovative Research topics to promote research that fulfills a significant need within the telehealth portfolio. Position requires an in-depth knowledge of telehealth technologies, wireless communication technologies and wireless business practices for patient management and medical education and training.
SERIES: 601

Serves as the Deputy Director, Biotechnology High Performance Computing Software Applications Institute (BHSAI). Manages the day-to-day operation of the BHSAI providing scientific leadership and guidance to more than 35 scientists performing research in the areas of bioinformatics, biochemistry, biotechnology, high performance computing, computational chemistry and biology, molecular and cellular biology biomedical engineering, and systems biology. Prepares and presents programmatic reviews of the Institute's research program for review panels across the Department of Defense (DoD). Serves as Principal Investigator to execute research in computational drug design, vaccine development, and systems biology. Manages the development of computational-intensive software applications related to identification of genomic and proteomic biomarkers, computational prediction of protein structure and functions, and bimolecular network modeling and simulation. Conceives and writes proposals to multiple sponsors across the DoD and other government agencies. Writes research results and submits manuscripts to peer-reviewed journals and conference publications. Serves as the Contracting Officer Representative or Grants Officer Representative for research initiatives across a wide range of scientific domains. Serves as the technical representative during grant negotiations, advising and assisting the Contract Officer in administering awards and coordinating program management decisions. Position requires a Doctor of Philosophy degree in chemistry, theoretical or physical sciences, demonstrated leadership in guiding interdisciplinary research teams, proven track record of attaining new funded projects, demonstrated experience in managing day-to-day operations in research organizations with similar size and scope as the BHSAI, and substantial expertise in high performance computing applications, including applications in systems biology, computational chemistry, and drug/vaccine development, with an established record of cross-disciplinary publications in top-tier, peer-reviewed journals.
SERIES: 1320

Work involves knowledge of regulatory requirements, special procedures, and preventive safety factors for the transportation or storage of hazardous materials.
SERIES: 0018

Works directly with the MMSIV division Chief to operationalize and execute projects within the lab provides organizational and supervisory continuity in the absence of the division Chief. Develop and execute strategic scientific research and development plans for integration and application of those convergent technology areas to medical diagnosis, treatment, evacuation, and enroute care systems. Assigned as the Principle Investigator for research projects. Collaborate and communicate with industry, government, and academic partners to translate capability gaps, capability needs, and operational requirements into technical specifications for research and development solicitations and program announcements intended to exploit emerging technology enablers to meet requirements and fill gaps. Assigned as the Contraction Officer Representative for SBIR/STTR research projects. Develop research topics and contract statements of work, review scientific proposals, prioritized research resource allocation, and monitor contract performance for MMSIV projects. Maintain and disseminate scientific awareness of emerging technologies in areas of, medical modeling and simulation, visualization and human performance, combat health support telemedicine, medical informatics and tactical communications systems. Coordinates decisions regarding programs, funding, and priorities, and decisions with staff officers with the Medical Modeling Simulation, Informatics and Visualization Research division Chief. Synchronizes with division chief for administrative task to include requests for information, SITREPS, and project deliverables. Acquisition Workflow: Verifies purchase requests and forwards them up for approval. Assists the division chief with budgeting and funding.
SERIES: 0801

Support the MMSIV Chief in the planning and technical execution of simulation activities and other MMSIV projects, including the integration of systems, prototypes, networks and data. Gathers requirements and oversees technical configuration of systems to collect quantitative and qualitative data for measurement of human and system performance. Oversees completion of technical reports from simulation activities for internal and external customers and ensures that reports conform to technical and quality standards.
SERIES: 0801

Work involves management of military and civilian staff involved in providing statistical subject matter expertise and support to the agency. Work involves knowledge and experience of Army policies and regulations, administrative and financial functions pertaining to research execution and support services to include: Planning, Programming, Budgeting, Execution System (PPBES), experimental design, statistical methods, scientific analysis, military and civilian personnel; resource management, logistics; information management; facilities management; safety.
SERIES: 0602

Maintain and disseminate scientific awareness of emerging technologies in areas of artificial intelligence, medical robotics, unmanned systems, combat health support telemedicine, medical informatics and tactical communications systems. Develop and execute strategic scientific research and development plans for integration and application of those convergent technology areas to medical diagnosis, treatment, evacuation, and en-route care systems. Coordinate with Combat Developers to translate war-fighter and Defense Health Program capability gaps, capability needs and operational requirements into technical specifications for research and development solicitations and program announcements intended to exploit emerging technology enablers to meet requirements and fill gaps. Oversee and conduct scientific research, system development and convergent technology integration. Provide guidance and technical advice on communications, architecture and integration issues involving software and hardware development for medical products. Develop research topics and contract statements of work, review scientific proposals, prioritized research resource allocation, and monitor contract performance for medical unmanned systems, robotics, combat health support telemedicine and medical informatics projects. Conduct scientific, technical and operational literature reviews.
SERIES: 0601

The incumbent leads planning, development, and direction of major programs involving the collection, integration, analysis and modeling of large data sources in support of complex research and analytical studies of military health challenges and operational tasks and/or decisions related to robotic, autonomy or artificial intelligence programs, and initiatives. Anticipates and develops strategic plans to address major problems and future needs, seeks root causes, and develops practical courses of action and timely solutions. Identifies the methods, processes, algorithms, tools, and systems to extract and interpret findings from varied structured and unstructured data sets related to data science lifecycle. Contributes to the development of algorithms and/or tools to support data manipulation and processing as well as the use of data visualization techniques to articulate findings. Leads in applying professional knowledge of computer science and mathematical and statistical theories, techniques, and methods to gather, analyze, design and construct new processes for modeling, interpreting, and/or reporting quantitative information, trends, relationships and correlations among or within data sets. Develops feasible data architecture recommendations for new and emerging models, analysis tools, and projects. Overall responsible for preparing and presenting data science briefings and reports, and makes presentations regarding the progress and/or results of projects/studies to higher level Army and DoD organizations. Provides expert consultation to heads of major organizations, high-ranking government official, and key stakeholders within and outside the federal government. Trains, educates, and mentors others in the data science team on modern analytical solutions to Army's enterprise tasks.
SERIES: 0601

Serves as Deputy, Medical Modeling, Simulation, Information and Visualization Functional Team (MMSIV) at TATRC. Responsible for managing, directing, and overseeing fundamental and advanced technology research and development (R&D) programs associated with effectiveness and learning methods and simulation and training technologies, characterized by their breadth, complexity, and importance to fundamental research and advanced technology development. Works with the MMSIV functional lead in all aspects of planning, programming, and budgeting of the MMSIV Functional Team. As a senior staff advisor to the MMSIV Chief, provide program management support to laboratory and clinical research, and research support personnel. In addition, oversees the development of goals and objectives for funded TATRC efforts performed by both intramural and extramural performers. Provides the MMSIV Functional Team lead with accurate and timely assessments of project cost, schedule, and performance metrics, in support of integrated, proactive program management. Serves as a Principal Investigator or Co-Investigator on organizational research projects, and maintains appropriate research credentials to perform these duties, as required. Conducts scientific, technical, and operational literature reviews. Report to the Medical Modeling, Simulation, Information and Visualization Functional Team Lead and provides organizational continuity in the absence of the Chief. Coordinates decisions regarding programs, funding, and priorities, and decisions with staff officers within the Medical Modeling, Simulation, Information and Visualization Functional Team.
SERIES: 0601

Supervises key elements of a complex system of HQ Human Research Protection Office compliance oversight for USAMRMC conducted and/or supported human research. Serves as a HQ-level senior-level subject matter expert, authority and adviser in the field of human subjects protection and regulatory compliance. Possesses expert knowledge of current federal regulations and guidelines related to the protection of human subjects in research, and expertly applies knowledge of these regulations and general ethical principles to the supervision of staff reviews of assigned projects. Formulates and recommends unique solutions to complex human research protection regulatory challenges. Composes detailed correspondence to explain and interpret DOD, Army, and USAMRMC policies and procedures and other human subjects protection regulations and guidelines. Ensures that USAMRMC supported OCONUS research complies with host nation regulatory requirements. Develops policies, procedures, guidelines, standard operating procedures and work instructions to ensure efficient and effective HRPO regulatory oversight and actively manages processes to meet standards. Fosters regulatory compliance and human subjects protection through education and training of key personnel.
SERIES: 0601

Advises the Center for Military Psychiatry and Neurosciences on the management, supervision, and coordination of all facets of research on deployment-related mental health training, resilience, and early interventions at the WRAIR. In addition to providing scientific oversight, is responsible for providing leadership, technical direction, and advice in all aspects of Medical Research and Materiel Command's Psychological Health Research Program Area in the Military Operational Medicine Research Program. In this capacity, is the lead for developing a systematic and comprehensive program of research to be implemented by a team of researchers at the WRAIR focused on identifying effective early intervention techniques in deployment-related psychological health research. Assists other researchers in developing and executing protocols on deployment-related psychological health. In this regard, must understand the entire research execution process from human use approval to how one gains research approval from commanders within military units. Experience gaining research approval from senior military officers is required. Must mentor other research professionals in how to successfully execute scientific studies. Provides consultation to outside agencies (e.g., MRMC, CSF2, OTSG, and TRADOC) as requested.
SERIES: 0180

Work involves developing, implementing, and directing original research to reduce the health and occupational impact of mental disorders and enhance psychological resiliency among military personnel, both as a principal investigator and as part of a collaborative team. This position requires proficiency in research study design, clinical trials, survey methodology, human use protocol development, coordination, management of resources/ budgets, study execution, analysis, publication, and presentation of research findings. Recognized expertise in publishing in peer-reviewed journals, and ability to represent the research program at national level meetings and to senior military leaders. Additional tasks require good interpersonal skills, ability to mentor co-investigators, and ability to serve as manager of study team, providing supervision to various staff members involved in the research effort. Maintains licensure in clinical psychology.
SERIES: 0180

Incumbent is responsible for ensuring good laboratory practice (GLP) records resulting from research are managed and maintained in accordance with GLP and Army regulations as applicable. Records will be periodically reviewed and renamed as appropriate to ensure only GLP records are maintained in the data base. Incumbent will be responsible for creating an electronic, retrievable library located on a shared network. The e-library will have a records structure to ensure ease of accessibility of records. Because of the risk associated with managing boxes of hard copy records, incumbent will ensure the work environment is safe and all record boxes are accessible without compromising safety.
SERIES: 0403, 0401

Conducts applied human biomechanics research related to performance and musculoskeletal injury and the successful completion of military tasks. Focus includes assessment of Warfighter occupational and operational performance, reduction in performance decrements, and appropriate performance optimization and enhancement strategies. Functions as primary investigator with skills and knowledge in human biomechanics, physics, statistics, scientific methods and investigation techniques, and experimental design. Collects and processes human force and motion data. Leads and directs support personnel in assignment of work, setting of suspense, and evaluation of performance. Experienced and familiar with ethical conduct of human research procedures and research regulatory policies. Authors and co-authors technical reports, technical memos and scientific peer-reviewed publications. Develop tests and evaluations to assess the efficacy of field-based human performance monitoring equipment.
SERIES: 0830, 0858

Work involves training and supervising individuals on diagnostic proteomic and genomic platforms such as the matrix assisted laser desorption ionization time of flight mass spectroscopy (Bruker Biotyper), whole-genome mapping including the MAPSOLVER software program, and the Life Sciences Ion Torrent Personal Genome Machine. Work involves training and supervising individuals on Applied Maths Bionumerics version 7.1 or higher including the modules for integrating Biotyper, MAPSOLVER, and pulsed-field gel electrophoresis (PFGE) outputs. Work involves integrating Illumina MiSeq sequence data with PFGE data. Work involves validating and certifying PFGE and Bitoyper platforms for accreditation by the American College of Pathologists.
SERIES: 0403

Work involves the application of scientific and mathematical principles to the design and implementation of research projects and data analysis. Requires a broad background in physics, mathematics, engineering, and modeling, and particularly in the application of statistical and numerical analysis techniques, including survival analysis. Work involves formulated, developing, and conducting finite element, musculoskeletal modeling, and multi-body dynamic computational simulations of potentially injurious dynamic events involving humans and/or anthropomorphic testing devices (ATDs). Requires in-depth knowledge of limitations and capabilities of and experience with of industry standard software packages for computational model pre-processing, processing, and post-processing. Requires the ability to plan, direct, and execute research studies to produce knowledge products that recommend and specify solutions and guidance to address gaps for operational stakeholders.
SERIES: 0801

Incumbent performs specialized procedures for human and animal body composition measurements following controlled feeding trials, including use of peripheral quantitative computed tomography (pQCT) for the detection of bone and muscle changes in response to nutrition interventions and dual energy x-ray absorptiometry (DEXA) for both humans and animals for the detection of whole body tissue responses (including lean body mass, fat mass, and bone density) to both controlled feeding trials and military training. The incumbent will assess body composition (to include lean body and fat mass) using skinfold thickness measurements by skinfold calipers, as well as the Department of Defense circumference measurement procedures, to determine responses to nutrition and physical activity interventions.
SERIES: 0404

Incumbent performs specialized biochemical and molecular biology laboratory techniques for the analyses of animal and human tissue samples collected during diet and nutrition research experiments, to include detecting nutrient sensitive biomarkers using laboratory procedures such as Western blotting, RNA isolation, qPCR, ELISA, multiplex, and protein quantitation assays. Incumbent will also perform Kjeldahl reactions with animal tissue for the detection of bone minerals (to include iron and zinc), and human muscle subfraction analysis for the detection of proteins affected by diet. Incumbent will be responsible for general nutrition laboratory procedures including stereo, compound, and polarized light microscopy, gas chromatography-mass spectrometry, Fourier transform infrared spectroscopy, tissue culture, immunohistochemistry, nerve cell isolation, and laboratory animal handling, dissection, and post-mortem tissue harvesting.
SERIES: 0404

Work involves serving as subject matter expert and researcher in areas of tactile, auditory, and vestibular physiology to develop materiel countermeasures for operational issues including: improved targeting in noisy environments; enhanced spatial orientation in degraded visual environments; and improved balance for clinically compromised patients.
SERIES: 0602

Position requires skills, knowledge, and abilities to provide effective scientific management leadership for the Defense Health Program Military Operational Medicine Research Program. Tasks to be performed include analysis of requirements, development and execution of strategic and programmatic plans, implementation of leadership's programmatic strategies for any component from pre-Milestone "A" through Milestone "C", substantive participation in Integrated Product Teams or other committees, direct management of program resources, and defense of program content and structure in professional acquisition forums. Also required are skills and knowledge that comply with acquisition level I requirements (in accordance with DA and/or DOD policy). Work involves participating in the planning, coordinating, evaluation of, administration of, and reporting on various aspects of a complex operational medicine research program. Duties include responsibilities in the complete research oversight cycle from program announcement to project maturation and coordinating funding for intramural and extramural research programs. Knowledge and understanding of military operational medicine research programs are critical.
SERIES: 0401

The incumbent will develop, review, analyze and make recommendations to Leadership regarding all project management plans, including work breakdown structures, budgets, schedules, change orders, risk communication plans and risk mitigation solutions. Also, the incumbent will integrate programmatic linkages among major stakeholders and ensure all relevant projects have the appropriate level of project management support. The successful candidate will gain approval from stakeholders and senior leaders regarding product development activities, changes in the scope of the projects, provide analysis and adjust the product development strategy as required. The incumbent will perform fiscal portfolio analyses, monitor fiscal progress of research efforts, and assist in the development of comprehensive, integrated strategic approaches to solving military problems in the domain of military operational medicine. The staff member will develop, analyze and populate databases, develop appropriate and accurate reports and enhance data reporting such as through development of procedures and actual organization of consensus meetings and reports.
SERIES: 0401

Entails awareness and action with regard to the ethical questions that arise in the relationships among life sciences, biotechnology, medicine, politics, law, and philosophy. Serves as a recognized authority and adviser in the field of bioethics, and as an expert representative for human subjects in biomedical research, their protection, and how to apply regulatory requirements to the review of human subjects research protocols. Resolves major problems in gaining approval for the wide-ranging research of the laboratory from scientific review committees and numerous Institutional Review Boards (IRBs), intramural and extramural, domestic and international. Is current with regard to the literature of bioethics and with complex state/country laws, regulations, and guidelines that form the web of Army/DoD, federal and state governance of human subjects research. Must be current with and express the importance of Good Clinical Practices. Works closely with DoD Research Monitors, when applicable. Facilitates collection and analysis of information to improve understanding of risks to subjects and the institution's assurance to carry out human subjects research. Develops and enables improved tactics, techniques, and procedures/requirements, models/templates, etc. in order to prevent and/or mitigate research-related injuries, unanticipated problems involving subjects or others, and noncompliance.
SERIES: 0602

Advise investigators of applicable scientific information and regulations pertaining to human subject research, both orally and in writing. Provide guidance to investigators and IRB support staff to help resolve scientific, ethical and regulatory issues/challenges. Analyze and present protocols and other agenda items at Board meetings to facilitate informed decision making, and to set standards; serves as a role model in effective presentation and discussion for all Board members. Identify problems and issues, collect additional information or request corrections. Convey the Board's concerns with the research submission by composing written correspondence to investigators (and sponsors, when applicable). This may include requesting additional information and providing the rationale for required changes. Identify and assist in the resolution of problematic review items, through interaction with investigators and other IRB clients (Data Safety Monitoring Boards (DSMBs), monitors, regulatory specialists, sponsors, other IRBs, etc). Must be current with and express the importance of Good Clinical Practices.
SERIES: 0602

Works with investigators with regard to planning experimental research involving human subjects to determine the safety and efficacy of vaccines and drugs against a variety of infectious disease or biologic toxin agents of military importance. Ability to understand and provide bioethical input for Phase I & II (safety, dose finding) and Phase III (field) testing of these products and conduct research on the epidemiology of the disease in question in order to define the appropriate target population and the bases for measuring efficacy. This may also include the use of medical devices and/or off-label use of products. Regulatory oversight may include the FDA, the European Medicines Agency (EMA), or local authorities. Ability to understand and provide substantive input with regard to research on the pharmacokinetics and pharmacodynamics of selected drugs in human subjects. Skill in writing and revising clinical protocols for studies involving human subjects and providing expert consultation of infectious diseases of military importance. Advises on study design to ensure the project meets requirements of human subjects research regulations, policies and guidelines.
SERIES: 0602

Works with investigators in planning neurosciences research studies to improve prevention/treatment care options for soldiers exposed to head injury, operational stress, exposure to biological and chemical weapons, blast overpressure, sleep deficits, and hemorrhage. Understands and provides substantive input for human studies in the field, in hospital or clinic settings, and in controlled laboratory settings. This may also include the use of medical devices and/or off-label use of products. Advises on study design to ensure the project meets requirements of human subjects research regulations, policies and guidelines.
SERIES: 0602

Serves as the official Research Integrity Officer (RIO) in the Responsible Conduct of Research (RCR) Program in CONUS and OCONUS research activities. Responsible for assessing allegations of scientific misconduct and determining when such allegations warrant inquiries. Responsible for recommending reviewers and overseeing any inquiries and investigations, as mandated by federal agencies, and makes recommendations to the Commander, WRAIR (or designee) as to how to proceed. Develops and maintains RCR policies and procedures. Assists the WRAIR Science Director with the development of strategic plans and implementation of RCR initiatives. This will entail holding researchers accountable for the use of honest and verifiable methods in proposing, performing, and evaluating research, reporting research results with particular attention to adherence to rules, regulations guidelines, and following commonly accepted professional codes or norms.
SERIES: 602

Assures Animal Care and Use Program is in compliance with federal and DoD regulations and guidelines. Develops guidelines and policies for laboratory animal care activities, and assists in coordination of Animal Care and Use Committee responsibilities at the activity. Prepares and provides procedural guidance for protocols for research studies for initial submission, monitors and maintains the animal use protocols to assure compliance, maintains records of their progress, and provides investigators with appropriate documentation. Duties will also include the review of animal subjects research protocols, notification and review of reports for animal subjects research projects, in coordination with the protocol POCs.
SERIES: 0601

Serve as a reviewer for research protocols and their related documents involving animal subjects' protection and regulatory compliance for the activity and collaborative partners. Participate in the implementation of the activity's animal subjects' protection program, that deals with critical scientific and ethical issues. Is current with regard to the literature of bioethics and with the state laws, regulations, and guidelines that form the web of federal and state governance of animal subjects' research. Participates in the development of new research policies for the activity in order to keep it in line with the latest laws and regulations.
SERIES: 0601

Serves as the technical director for the TATRC Medical Modeling & Simulation (MM&S) program. The technical director will be responsible to develop and communicate a clear vision for the MM&S community of practice focusing on the validation of live tissue simulation tools. Establish a Provisional Joint Project Office for Medical Modeling and Simulation and TATRC's Simulator Validation Office. Responsible for concept of operations development, force structure, resource planning, the definition of roles, responsibilities, relationships, expectations, and deliverables. Facilitates integrated concept teams, integrated product teams, conferences and workshops, subject matter expert panels, in support of program's stated vision. Assess technology and industry trends to identify opportunities. Develop systematic process to identify promising technologies for transition to practice in the DOD or commercialization in the private sector. Serves as the Contracting Officer Representative or Grants Officer Representative for research initiatives across a broad area of MM&S projects managing all phases from proposal evaluation through project close-out. The technical director is the technical representative during contract or grant negotiations, advising and assisting the contract officer in administering awards and coordinating program management decisions. Develops the research goals and objectives and creates comprehensive program announcements related to this program. Coordinates the efforts of a multidisciplinary team of researchers, clinicians, academic experts and consumers to execute and manage research in this domain. Reviews research proposals to determine the quality of the research, the applicability to the programmatic goals, and the military relevance of the initiative while evaluating the ethical and regulatory requirements for human subject protections. Serves as the MedSim point of contact to facilitate MedSim team participation in national conferences. Authors and manages Small Business Innovative Research topics to promote research that fulfills a significant need within the portfolio. This position requires a broad situational awareness of current, emerging, and enabling technologies in the areas of medical modeling & simulation.
SERIES: 0343

The Cell Culture Laboratory Production Manager provides oversight, leadership and direction of laboratory activities related to the production and maintenance of cell lines for use in scientific and regulated studies. The Production Manager is knowledgeable and proficient in the processes of cell maintenance from cryopreservation to the production and distribution of cell preparations and monoclonal antibodies to be used in various biological assays. The Production Manager identifies, addresses, and implements Cell Culture projects and processes to enhance laboratory activities. The Production Manager assures appropriate coverage of the production schedule and compliance activities requirements. Serves as a document review authority. Oversees cell line qualification activities, and assures detailed, accurate records pertinent to cell culture laboratory processes, equipment and reagents, are kept. The production Manager assists in inventory control for both cell line stocks and laboratory reagents and supplies.
SERIES: 0403

Using an interdisciplinary approach collaborates with program partners to facilitate the accurate and relevant collection, analysis, and integration of injury data within the operational context of combat events, accidents and mishaps to improve our understanding of vulnerabilities to threats and enable the development of improved tactics, techniques, and procedures (TTP's), requirements, materiel solutions, models, etc. in order to prevent and mitigate injuries all in accordance with the guidelines of the Health Insurance Portability and Accountability Act (HIPAA) and other appropriate personally identifiable information regulations and directives to ensure patient confidentiality. Work involves identifying individual casualties from traumatic events, accidents and mishaps and retrieve stored medical data from computerized databases using standard information science methods; coordinating with the other medical community partners to gather data and information on specific injures for both Wounded in Action (WIA), Killed in Action (KIA), as well as peacetime trauma casualties. Interprets, and extracts injury data from medical records and data bases for analysis. Identifies conflicting data and information within various reports and data sets and collaborates with staff to resolve any issues; identifies and implements ways to eliminate or reduce significant bottlenecks and barriers to performance and responsiveness; Conducts rigorous data analysis within the Joint Trauma System (JTS). Knowledge of source data and recognition of erroneous data are required in order to ensure accuracy of output. Utilizes DCIPS, TMDS, and other databases to gather data and identify casualties. Work involves such activities as: 1) Ability to medically interpret clinician entries in the electronic health records of fallen warriors and translate those entries into data entries in the program database that populate reports and/or files providing management with the necessary information to make decisions. 2) Read, interpret, and extract injury data from medical records and data bases for analysis by the program analysts; provide professional medical expertise and integrate medical data and causes of injury for the program analysts, 3) Determining data needs by interaction with investigators to identify precise requirements. Interaction will be in the form of written correspondence, telephone, email, and personal interaction, 4) Planning, directing and evaluating collection activities, 5) Cleaning processed data for validity, 6) Summarizing and presenting data to investigator.
SERIES: 0610

Provide an advanced level of specialized nursing knowledge in the arena of trauma and critical care as well as information technology. Reviews comprehensive data relating to trauma patients by abstracting all trajectories of care, verify and update all information, compile and enter data into the Department of Defense Trauma Registry (DoDTR) in a timely manner, perform coding of injuries, procedures, and causes of injuries using standard medical record references, specifically ICD-9 and ICD-10 codes, assign diagnoses AIS and ICD-9/ICD-10 codes, and complete ISS and other trauma severity calculations. Provides clinical and technical expertise, report and query development, data management, statistical analysis and results interpretation/reporting for a variety of internal and external projects. Creation and utilization of mainframe databases for the identification appropriate report capabilities, data management analysis, analysis planning, and statistical analysis of data reported. Develops complex reports, prepares policy and SOPs and recommendations for improvement to the DoDTR system and data. Maintains and analyzes large data sets from sites around the world. Update and Maintain DoDTR Data Dictionary, User's Manual, Data Elements Data Base and other business tools as required by the Branch Chief and leadership. Conduct analytical reviews of databases, applications, and legacy government systems to facilitate potential data sharing. Oversee, assess, and report DoDTR user work-flow processes. Ensure fair and equal assignment of workload for DAB personnel. Document, report and troubleshoot reports of DoDTR application problems. Research and explore potential reasons for problems and corrective actions for software. Create and execute thorough testing plan for all aspects of DoDTR system; implement testing, report to leadership and vendor on results. Coordinate AIS 2005 military version updates and ICD-9, 10 updates in DEDB as well as in DoDTR. Coordinate, test, train, implement, and resolve DoDTR application modifications resulting from evolving theater trauma system requirements and system change requests. Facilitate information technology requirements (IT) as functional proponent to include, but not limited to refining the IT processes with government elements such as PASBA, USAMITC, satellite sites, ISR, NHRC, OAFME, USAF, and other government entities. Identify potential areas of vulnerability and risk with the DoDTR. Develops and implements internal audits, external audits, assessment programs and corresponding corrective actions, preventive actions, process improvement programs, and reporting to leadership. Oversees validation activities of systems and processes. Collects, analyzes, and integrates accurate and relevant injury data within the operational context of the DoDTR. Create and develop complex customized reports for operational units as well as central repository. Identify data cleaning priorities and monitor data quality. Directs data cleaning projects, reports, and data trends. Report results to leadership and trends and actions for data quality. Directs trainers and Data Quality Managers. Evaluate requests for changes, additions and deletions to the trauma registry data elements and pick-lists. Create and maintain DoDTR accounts and account database. Directs inter-rater reliability quality assurance reviews, trend reporting, focused audits, and targeted data cleaning. Identifies training needs of the DoDTR, Trauma Nurse Coordinators, and JTS staff. Design and implement custom databases for functional needs of the Data Acquisition Branch. Performs audits, inspections, staff assistance, analyzing and investigation of adverse trends in data quality and ensuring corrective actions, and developing, managing, and executing surveillance programs, providing oversight and assistance for data quality at all levels, delegating tasks, and overall management of DoDTR data and application.
SERIES: 0610

Functions as an independent and objective entity that reviews and evaluates work product within the organization. Develop plans to include, but not limited to, short term and annual Performance Improvement (PI) criteria and standards to monitor quality indicators and methods to evaluate success of related corrective actions. Implements Performance Improvement (PI) Plan; Identify trends, profiles and patterns and report to PI Division Director. Identify and initiate corrective actions to ensure data is accurate. Monitor and provide written reports on status and progress of trends and corrective actions. Provide reports of quality indicators on individual and group level on a monthly basis. Develops and implements internal audits, external audits, assessment programs and corresponding corrective actions, preventive actions, process improvement programs. Work involves ability to medically interpret clinician entries in the electronic health records and translate into data entry for the DoDTR. Performs audits, inspections, staff assistance, analyzing and investigation of adverse trends in data quality and ensuring corrective actions, and developing, managing, and executing surveillance programs, providing oversight and assistance for data quality at all levels, delegating tasks, and overall management of DoDTR data and application. Oversees validation activities of systems and processes across the continuum of care within the DoDTR. Directs and executes inter-rater reliability quality assurance reviews on all DoDTR users across the world. Identifies, directs and participates in targeted data cleaning projects to ensure highest level of quality data. Acts as principal trainer for all DoDTR users and other trainers and personnel participating in data cleaning projects to ensure consistency and standardization across the continuum of care.
SERIES: 0610

Work as an independent scientific investigator in the performance of Science and Technology (S&T) investigations, applying technical engineering, and technical scientific understanding to complex and dynamic visual sciences issues that can eventually be applied to the development of aviator performance standards. Expertise in the visual system's overall functional parameters governing visual fixation, pursuit eye movements, saccadic eye movements, phorias and tropias, as well as the shared functional capacity of the vestibular system's contribution to eye movement control, and physiology of the eye, (e.g. retina, cornea, extraocualar muscles). Knowledge of ocular and visual neuro-center anatomy, the nervous system's physical and functional cross-linkages, as well as the unique neuro-transmitter functions associated with the visual system.
SERIES: 0662

Knowledge and skill to serve as a subject matter expert on the areas of ocular anatomy, physiology, and the underlying energy-related enzymatic and metabolic cascades tied to the perception of visual input. Able to use ancillary ophthalmic devices in the imaging and analysis of ophthalmic tissue in the performance of basic, applied and advanced development RDT&E. Ability and skill in speaking as a recognized authority on all aspects of visual sciences research efforts affecting aviator health and aviator performance.
SERIES: 0662

Maintain and disseminate scientific awareness of emerging technologies in areas of artificial intelligence, medical robotics, unmanned systems, combat health support telemedicine, medical informatics and tactical communications systems. Develop and execute strategic scientific research and development plans for integration and application of those convergent technology areas to medical diagnosis, treatment, evacuation, and en-route care systems. Coordinate with Combat Developers to translate war-fighter and Defense Health Program capability gaps, capability needs and operational requirements into technical specifications for research and development solicitations and program announcements intended to exploit emerging technology enablers to meet requirements and fill gaps. Oversee and conduct scientific research, system development and convergent technology integration. Provide guidance and technical advice on communications, architecture and integration issues involving software and hardware development for medical products. Develop research topics and contract statements of work, review scientific proposals, prioritized research resource allocation, and monitor contract performance for medical unmanned systems, robotics, combat health support telemedicine and medical informatics projects. Conduct scientific, technical and operational literature reviews. Report to the Medical Intelligence Systems Research Program Manager and provides organizational and supervisory continuity in the absence of the Program Manager. Coordinates decisions regarding programs, funding, and priorities, and decisions with staff officers with the Medical Intelligence Systems Research Program Manager.
SERIES: 0601

As Director, Plans, Programs, Analysis & Evaluation Office, responsible for providing continuous, timely, accurate, and detailed planning and programmatic review and analysis of the USAMRMC's Research, Development, and Acquisition programs. Provides executive level review and analysis of medical research funding and program prioritization to provide input for the building the Program Objective Memorandum (POM). Review and analyze POM positions in the Program Optimization and Budget Evaluation System and their potential effect on the Command. Manages the preparation of Army and Defense Health Program Medical RDTE input to the Congressional Descriptive Summaries that accompany the President's Budget Estimates to Congress and which describe current accomplishments and future planned research in RDT&E programs. Integrates Congressional Special Interest projects, program manage the Small Business Technology Transfer and Small Business Innovation Research programs for the MRMC, oversee the 'Decision Gate' program, and develop policies and procedures for all these programs. Directs and provides executive level review of all Army Medical RDT&E input to key DOD and Army strategic planning documents associated with or which may affect, RDTE activities such as the Army Plan, The Army Campaign Plan, Army Strategic Planning Guidance, The Army Posture Statement, and the Army Science and Technology Master Plan. Coordination with MEDCOM, OTSG, ASA(ALT), OSD(HA), Congressional Liaisons, DA, and DOD required when both internal and external demands require rapid response to fluctuating program requirements and priorities to support a diverse and dynamic medical RDT&E environment. Provide the DHA Director of Research, Development, and Acquisition similar support (POM, RDA support, Congressional Inquiry, Small Business Technology Transfer and Small Business Innovation Research) as outlined in a support agreement with the DHA.
SERIES: 0340

Work involves the development of RDT&E programs, policies, assessments and impact analyses necessary to achieve efficiency and effectiveness of Command and/or Agency missions and assigned programs. Tasks include developing program and policy content (e.g., current and strategic goals and objectives, resourcing strategies), conducting program assessments, marketing/reporting /defending programs at Agency and national levels, and representing Command/Agency positions in DOD executive review forums. Skills and knowledge are required in theory and practice of program management; PPBE system; RDT&E processes; and program, science, and technology components.
SERIES: 0340

The position requires skill, demonstrated expertise (by publications), and ability to provide scientific leadership in each of the individual aspects of systems biology. Work involves the genomic analysis of pathogenic bacteria to identify genetic correlates of pathogenicity, virulence and antibiotic resistance. Requires understanding of the principles and methods for de novo assembly of next-generation sequencing data, genome annotation, detection of single nucleotide variants and genomic rearrangements, comparative genomics and phylogenetic analysis. Experience identifying protein motifs using programs such as HMMER and BLOCKS and evaluating the potential functional consequences of amino acid alterations is also required. Knowledge of public databases of gene and protein networks is desired. Experience processing, deconflicting, and adjudicating data from the major commercial automated microbial identification / antibiotic susceptibility testing platforms (BD Phoenix, bioMérieux VITEK 2, Siemens MicroScan) is required. Expertise in the management (relational databases, SQL) and analysis (parametric and nonparametric statistical tests, linear modeling, hierarchical clustering, and principal components analysis) of large, multidimensional datasets is essential. The position requires experience creating analytical pipelines using COTS, GOTS, open source and custom software. The ability to write code in scripting languages such as Perl, Python or Java and mathematical programs such as R/Bioconductor or Matlab is required. Additional responsibilities include preparing oral presentations, posters, memoranda and manuscripts that communicate the scientific work being conducted.
SERIES: 0403

Is an integrated team member supporting research conducted within their work area. Designs and executes research experiments. Prepares research proposal package(s) to support the research requirements of the Army and the Department of Defense (DOD). As an acquisition workforce member, obtains certification in Science and Technology Manager and participates as an active member of Integrated Product Team(s). Advances technology and submits articles for publication in peer reviewed journals and presents research at national conferences (abstract, short topic, poster, or presentation). Participates in internal training in their organization, which includes: relevant scientific and laboratory training in the research area assigned; assignment as associate or principal investigator to specific research projects; required regulatory training (e.g. Good Laboratory Practices); rotations through organizational elements supporting research, and participation in research or business meetings with funding partners and collaborators.
SERIES: 0601

Serve as the Principal Investigator, leading efforts to expand the current craniomaxillofacial bone restoration program in the development of therapeutic products that can be rapidly transitioned to the clinic for treating craniomaxillofacial battle injuries. Work involves the skill, knowledge and ability to design, formulate and carry out independent craniomaxillofacial bone healing research, including restoration and regeneration of craniomaxillofacial bone defects due to injuries. The position requires the incumbent to interact closely with other investigators and research scientists and staff within the unit to reduce the effects of life altering maxillofacial battle injuries and dental disease. Other work includes publishing findings in Army publications and peer reviewed journals; and writing research proposals for securing funding to support the proposed research. Additional duty involves the performance of supervisory functions constituting less than 25% of the position's time. Supervisory functions include authority to hire, direct, assign, evaluate, promote, reward, transfer, furlough, layoff, recall, suspend, discipline, or remove employees, to adjust their grievances, or to effectively recommend such action, if the exercise of the authority is not merely routine or clerical in nature but requires the consistent exercise of independent judgment.
SERIES: 0601

Work involves leadership and strategic planning of the Post-Traumatic Stress Disorder (PTSD) Research program within the Military Operational Medicine Research Program and Joint Program Committee 5 (Military Operational Medicine). The position involves identification of capability gaps through analysis of a variety of requirements documents and development of research gaps that are synthesized into overarching program goals. Planning, programming and budgeting for multi-year research studies and approval of research objectives and plans are critical elements of the work. Evaluation of research against the goals, objectives and plans and the assessment of the science being conducted are all essential aspects of the position. The technical areas of the work include oversight of research projects focused on prevention, diagnosis and treatment of PTSD.
SERIES: 0180

Work requires substantial subject matter expertise and involves interactions that include: collaboration with other Federal agencies that fund similar types of research, leadership and involvement on DoD and other Federal working groups, and representation of US Army Medical Research and Materiel Command and the Defense Health Agency in national and international forums. Tasks include coordination of responses from multiple Federal Departments to "Request for Information" from the White House and Congress as well as data calls from DoD and other Federal Departments. Represents the Army and Defense Health Agency (DHA) in multiple task forces, work groups and research review boards and provides critical feedback to facilitate solutions that best meet strategic requirements for the military.
SERIES: 0180

Serves as a recognized authority and senior level expert advisor to the Director, US Army Medical Research and Materiel Command (USAMRMC) Office of Research Protections (ORP) and the Director, ORP Institutional Review Board (IRB) Office in the field of human subjects protection and regulatory compliance. Assists in the administration of the HQ USAMRMC IRB. Accelerates investigators' pursuit of HQ USAMRMC IRB approval through timely review of research protocol submissions and protocol life cycle actions to assure compliance with all applicable human subjects protection laws, regulations, policies, procedures, and guidelines. Possesses and applies expert knowledge of current human subjects protection regulatory requirements and general ethical principles during the review of assigned projects as well as projects assigned to IRB Office staff members. Provides comprehensive, timely, professional quality written reviews of research protocols that delineate deficiencies and areas of non-compliance and reviews ORP IRB Office staff members' work products for same. Formulates and recommends unique solutions to complex problems that help bring protocols into human subjects protection regulatory compliance. Reviews and approves ORP IRB Office contract staff work products prior to their transmission to investigators or review by the HQ USAMRMC IRB Chair or convened IRB. Reviews projects submitted for determination of the applicability of the human subjects protection regulations and issues official determination memoranda for those protocols not requiring IRB review. Composes complex correspondence to explain and interpret Federal, DOD, Army, and USAMRMC human subjects protection regulations and guidelines. Develops institutional agreements for IRB review and memoranda of agreement with HQ USAMRMC IRB customers. Contributes to the development and updates of policies, procedures, guidelines, standard operating procedures, and work instructions to ensure regulatory compliance, and provides input to updates of Army and USAMRMC regulations and policies. Fosters regulatory compliance and human subjects protection through education and training of key personnel. Provides support for post-approval compliance monitoring on behalf of the HQ USAMRMC IRB, conducts detailed regulatory files reviews, and assists with preparation of after-action reports. Participates in the conduct of non-compliance investigations and random and for-cause compliance inspections. Serves as a Human Research Protections Official approval authority for headquarters-level administrative review.
SERIES: 0601

Planning, executing, and evaluating research related to mechanical and electrical engineering design, development, prototyping, testing and evaluation of robotic and autonomous systems and integrating them with general purpose robotic and unmanned systems. Conducts technology watch in robotic and autonomous systems engineering sciences and provides technical advice to program managers and executives. Develops robotics engineering research objectives, budgets and execution plans. Performs research contracting officer's representative management functions for extramural robotic and unmanned systems RDTE efforts.
SERIES: 0830

Position requires knowledge of Information Technology (IT) policies, standards, and procedures; knowledge of automated data processing equipment, communications, and other information systems, applications and management policies; knowledge of government policies, directives and other regulatory materials concerning procurement and IT acquisition. Serves as the budget coordinator. Receives draft operating budgets prepared by DCSIM functional components. Combines all subordinate budgets into the required format and submits the draft ODCSIM budget to supervisor for final approval. Maintains and monitors the IM/IT budget and cost schedule for all activity IT purchases. Work also involves acquisition of IT software and hardware through the use of an automated purchase request system to ensure all governmental contracts and purchasing requirements are in accordance with applicable regulations. Incumbent is responsible for initiating, processing and gaining approval of IT purchase requests from activity customers. Work involves inventory accounting and knowledge to maintain the integrity of the Army's accountable records. Incumbent will manage the use of a government credit card to make necessary IT purchases for both hardware and software, complete monthly reconciliation statements and assist other credit card holders with their monthly reconciliation. Manages IT service contracts for activity hardware and software support and ensures that suspense dates are met.
SERIES: 0301; 0342; 0560; 2210

Responsible for coordinating and facilitating research on combat-related injuries most relevant to the AMEDD. Ensures research products meet the highest standards of evidence and peer-review and that research knowledge involving military and veteran populations is disseminated in peer-reviewed journals and in a manner most relevant for informing health care practices and policies. Serves as an investigator and/or consultant on protocols focused on preventing and treating combat-related injuries among U.S. Soldiers. Leverages existing research efforts through collaborations with other organizations and mentorship of junior researchers, residents, and fellows. Incumbent operates independently, takes a proactive approach to integration management, and attends / holds meetings and conferences as appropriate. Evaluates study proposals for epidemiological design and impact and advises investigators in a consultant role on potential avenues for research based on available data, analytical capabilities, and previous work. Collaborates with investigators in the conduct of epidemiologic studies involving data from the JTTS/JTTR that are either intramural or extramural to the ISR. Acts as liaison for the activity with other laboratories that have specific epidemiologic focus. Incumbent will serve to establish requirements for data sharing and collaboration with those laboratories as defined by the activity's policy and protocol. Serves as an independent investigator to develop internal and/or external research questions in order to develop and execute study design for analysis in collaboration with a team of data and statistical resources that will produce reports and presentations from the activity and other available data sources. Research questions received from external sources become valid taskings once approved by the Command to be resourced. Work products will include study reports, opinions and recommendations. All work products are subject to the approval of the activity Commander, and review for Operational Security concerns in accordance with Service and Department of Defense policy.
SERIES: 0601

Occupational Health Nurse who will be responsible for managing, and coordinating an Occupational Health Program within the organization. Population served encompasses military, civilian, and contract personnel in a research facility. Provides professional advice and guidance to the organization regarding occupational health matters. Coordinates with the primary offices to include, but not limited to Occupational Health, Veterinary Services, Laboratory Support, Safety, Regulatory Compliance and Quality, and any other applicable offices in planning and scheduling an occupational health program. Participates in the formulation of decisions that affect policy for the provision of required occupational health services; revises and updates Occupational Health policy as needed. Assesses hazards involving zoonoses, biologic, chemical, and physical hazards (such as radiation and allergies) and selects safeguards appropriate to the risks. Conducts initial risk assessments for staff conducting animal experiments and staff members involved with animal care, adopts an appropriate immunization schedule, and schedules regular follow-up care. Identifies potential hazards intrinsic to animal care and use to include non-human primates. Reviews assigned duties and occupational exposure for potential hazards. Evaluates individuals with chronic diseases or disabilities that may be affected by their work assignment. Counsels and interviews employees, interprets medical and work histories and their relationship to present or potential health problems; evaluates test results and recommends duty limitations or change in job assignment. Keeps abreast of advances in all areas relative to the field of occupational medicine. Assist with plans, organizes, develops, and directs health educational efforts throughout organization. Participates in conducting classes, attends safety meetings and provides occupational health guidance, standards, and similar materials pertaining to health and safety within the organization. Participates in continuing medical education programs and in Quality Improvement activities at this organization and at other institutions to remain current in medical knowledge and practice. Participates in in-service training and informal training and teaching of military, Department of the Army Civilian and contract personnel.
SERIES: 0610

Work involves planning and performing research in hypothermia to identify safe brain cooling strategies to treat moderate to severe TBI, specifically minimally invasive selective brain cooling techniques. The primary threat would be moderate-severe TBI. Important skills include small animal surgery and TBI modeling specifically military relevant penetrating injury models and projectile concussive head injury models, the ability to use whole animal studies and methods to sustain core and brain temperatures independently and chronically in injured but physiologically stable subjects. Skills also include ability to measure cerebral blood flow, perfusion pressures, intracranial pressure, and cortical spreading depression in isolated TBIs and TBIs with polytrauma physiology; and conduct combination therapy isobolic protocols with drugs and cooling as required. Additional expertise in acute and delayed longitudinal outcome assessments including histopathology, immunocytochemistry, light and confocal microscopy, in vivo neurofunction and cognitive testing is required. Expertise in ultrasound technology preferably credential by ARDMS (the American Registry for Diagnostic Medical Sonography) is required. Additional responsibilities include reporting results in peer reviewed manuscripts, preparing technical reports and briefings, and presentations at scientific meeting.
SERIES: 0401, 0405, 0413

Work involves planning and performing research in stem cell neurobiology to identify regenerative strategies to treat TBI including neural stem cell therapies, stem cell and tissue engineering strategies and regenerative-based therapies consisting of neuroprotective and neurorestorative proteins. The primary threat would be moderate-severe TBI. Important skills include small animal surgery and rodent TBI modeling specifically in military relevant penetrating injury models and projectile concussive head injury models. Required expertise includes management of preclinical stem cell protocols, microdissection techniques, neural stem cell labeling, fluorescence activated cell sorting (FCAS), neural stem cell transplantation. Must be experienced in conducting in vivo treatment protocols using acute and chronic neurotransplantation/infusion techniques and applying modern technology to longitudinal neurofunctional testing and sophisticated quantitative analysis of brain neural and axonal integrity and confocal microscopy. Additional responsibilities include reporting results in peer reviewed manuscripts, preparing technical reports and briefings, and presentations at scientific meeting.
SERIES: 0401, 0405, 0413

The primary threat is mild, moderate and severe concussive head injury and penetrating brain injury. Work involves designing, implementing, and analyzing molecular neurobiology experiments to identify molecular biomarkers of adequate fidelity (i.e. sensitivity and specificity) for TBI. Expertise required to identify changes in gene expression, and protein and small molecule abundance profiles following TBI, specifically in models of military relevant penetrating and projectile concussive injuries. Work requires extensive practical and didactic knowledge in molecular neurobiology; data mining using a systems biology approach to identify novel pathways affected by brain injury or novel biomarker of brain injury. The position requires: expertise in small animal surgery skills preclinical rodent TBI models with the ability to dissect specific brain regions, to extract and analyze DNA/RNA, protein, and small molecules from brain tissue, the ability to collect and analyze proteins and small molecules in serum, plasma and CSF. Practical hands-on expertise is required in biochemistry and molecular biology techniques including: western blotting, ELISA, protein purification and chromatography, RNA isolation and purification, PCR, immunohistochemistry/immunofluorescence microscopy, HPLC including mass spectrometry, and biostatistics. Additional responsibilities include data mining, compilation and analysis, as well as reporting results in peer reviewed manuscripts, preparing technical reports and briefings, and presentations at scientific meeting.
SERIES: 0401, 0405, 0413

Work involves planning, designing, and performing programs of neurobehavioral research in animals to determine and model the underlying processes for militarily relevant traumatic stress and militarily relevant Post-Traumatic Stress Disorder toward the identification of preclinical candidate therapeutic compounds and other countermeasures. The position entails utilizing rodents, non-human primates, and other animal species to evaluate all aspects of behavioral performance including complex cognitive performance, motor and sensory function and underlying biochemical and pharmacological processes involved in traumatic stress. Demonstrated ability to perform preclinical efficacy and safety assessment of potential therapeutic compounds for use against traumatic stress is required. Additional responsibilities include reporting results through publications in the scientific literature, through presentations at scientific meetings, and in technical reports as well as providing official briefings as requested.
SERIES: 0180

Work involves planning and implementing basic and applied research studies associated to trauma, hemorrhage, and resuscitation using novel approaches such as intravital microscopy to seek solutions to important problems in this specialty area. Research concentrates in the study of the microcirculation and hemorrhage/resuscitation management. Work requires ability to oversee and conduct in vivo experiments utilizing anesthetized and awake animals, use fluorescence and phosphorescence microscopy, and micro-surgery techniques, as well as preparing reports and scientific research proposals and papers. Tasks also include work pertaining to inflammation, blood, and ischemia/reperfusion injury with special attention to the fields of microcirculation, oxygen transport, tissue, blood vessel and endothelial cell physiology. Development of new methodologies is required, as is analysis and interpretation of experimental data.
SERIES: 0413

Serves as the subject-matter expert and portfolio manager for medical imaging technology directly managing research efforts in Alzheimer's Disease and Traumatic Brain Injury. Serves as the Contracting Officer Representative or Grants Officer Representative for research initiatives across a wide range of imaging technologies, neuroscience, molecular diagnostics and molecular pathology. Serves as the technical representative during grant negotiations, advising and assisting the Contract Officer in administering awards and coordinating program management decisions. Develops comprehensive research program announcements and conducts a review of research proposals determining the quality of the research, the applicability to the programmatic goals, military relevance while evaluating the ethical and regulatory requirements for human subject protection. Authors and manages Small Business Innovative Research topics to promote research that fulfills a significant need within the portfolio. Position requires an in-depth knowledge for a broad spectrum of imaging modalities, emerging imaging technology capabilities, neurodegenerative diseases, neuroscience, and cognitive and psychological testing.
SERIES: 0601

Provides scientific, program management and DoD acquisition expertise to direct research and development activities for a complex program seeking effective pharmacotherapeutic agents for the treatment of Posttraumatic Stress Disorder (PTSD). Uses appropriate scientific and program management principles and standards to lead a multi-functional Integrated Product Team (IPT) supporting Food and Drug Administration (FDA) regulated multisite phase 2 and phase 3 clinical trials. Responsible for coordination of teams to complete all aspects of product development including: clinical trial design; preparation of clinical trial protocols and related documents; supervision of clinical trials; and preparation of Investigational New Drug (IND) Applications and New Drug Applications (NDA)/Supplemental New Drug Applications (SNDA). Directs and monitors the utilization of resources in developing, executing, and attaining program goals. Monitors program progress in terms of cost, schedule, performance and risk, and develops and implements risk mitigation solutions as needed. Builds and maintains constructive and respectful working relationships with colleagues, support personnel, collaborators and superiors. Regularly updates the Project Manager and senior leadership regarding program progress and issues. Authors and contributes to the production of acquisition documents, reports, briefings, and documentation required by the Defense Acquisition System and/or the USAMRMC. Work requires excellent interpersonal and written communication skills, and the ability to work effectively in a team environment.
SERIES: 0601

Individual will co-chair the Committee on Tactical Combat Casualty Care (COTCCC), which is a subpanel of the newly formed Trauma and Injury Subcommittee of the Defense Health Board. This committee is a permanent standing body of trauma care specialists, operational medicine practitioners, and Special Operations Forces Combat Medics and Corpsmen who serve to monitor advances in medicine pertinent or adaptable to battlefield trauma care, and to periodically issue updated battlefield trauma care guidelines to be published in the Prehospital Trauma Life Support Manual. There are voting members representing all four services, their respective Special Forces components, the Public Health Service, the American College of Surgeons Committee on Trauma, and the National Association of Emergency Medicine Technicians Committee on Pre-hospital Trauma Care. The employee will facilitate all functions of the committee including periodic meetings, medical specialty workshops, and associated travel and facilities arrangements. Must be thoroughly familiar with operational medicine planning and practice, and especially with Tactical Combat Casualty Care, and with methods of consensus development. Serves as a member of the Committee on TCCC; assists exercising control over COTCCC subcommittees; and ensures that the committee runs in accordance with an operating charter that will be approved by the COTCCC and the Commander, USAISR. Monitors professional medical literature for advances in trauma care, and must be skilled in the critique of articles published in peer-reviewed medical journals. Develops and maintains a continuously expanding database of such literature in support of the work of the COTCCC. Serves as liaison between the Committee and major DoD medical research laboratories, communicating the Committee's recommendations for future biomedical research topics. Individual may publish scientific articles or publications as a result of research and curriculum development in the area of Tactical Combat Casualty Care. Individual will be a resource for the Department of Defense on matters relating to TCCC, to include providing briefings to DoD leadership and conferences, as required, as will as attending conferences at which talks relating to this topic will be presented. These issues include, but are not limited to: issues currently before the COTCCC for consideration, new TCCC guidelines approved by the COTCCC, the administrative oversight of the COTCCC, TCCC research issues, and TCCC transition issues. This individual will be responsible for directing the efforts of the COTCCC as it assimilates input from a multitude of sources on both the success of the current TCCC guidelines on the battlefield and monitors emerging information and technology relating to battlefield trauma care that could be considered for inclusion in future TCCC guidelines.
SERIES: 0602

Responsibilities include the writing and editing of documents intended for submission to the Prehospital Trauma Life Support Manual in both paper and electronic submission format. The candidate must possess knowledge of advanced biomedical subjects in order to review and edit scientific and technical manuscripts prior to submission to ensure conclusions are properly drawn and presented logically and clearly from both scientific and editorial points of view. The candidate must possess the ability to rewrite major portions of manuscripts as necessary to assist authors in data presentation. Extensive experience in the writing and editing of technical or scientific reports, including clinical study reports, annual reports, master files, protocols, investigator's brochures, and standard operating procedures. In completing assignments, imposes proficiency in Microsoft Word and Visio and applies knowledge of technical editing in the biomedical sciences and editorial requirements imposed by the Department of the Army, Department of Defense, and biomedical journals. Experience with teaching is beneficial.
SERIES: 0602

Incumbent is the recognized authority and primary advisor/administrator to the Commander, in the area of training trauma care specialists, operational medicine practitioners, and Special Operations Forces Combat Medics and Corpsmen. Incumbent oversees the education and training of staff and committee members involved in the development of curricula and training materials. Incumbent studies and projects present and future activity needs and formulates alternative policies and ways of meeting these needs. The work involves (1) Gathering, compiling, analyzing and evaluating data; (2) Projecting needs and establishing goals; (3) Developing single or alternative plans, policies, programs, and recommendations and measures of their costs, benefits, and feasibility; and (4) Reevaluating progress to assure that plan objectives are realized in putting the plans into effect. This category includes missions, policy, and program planning.
SERIES: 0602

As a Product Manager in the Neurotrauma and Psychological Health Project Management Office (NPH PMO), manage the advanced development of a portfolio of knowledge product solutions to care for service members with Traumatic Brain Injury (TBI), Posttraumatic Stress Disorder (PTSD), and other neurotrauma and psychological heath related threats and conditions. Product Manager will assist Project Manager in the development of processes for incorporating knowledge products into the PMO portfolio. Product Manager uses appropriate scientific and program management principles and standards to lead working groups and multi-functional Integrated Product Teams (IPT) supporting advanced research efforts, including Food and Drug Administration (FDA) regulated multisite phase 2 and phase 3 clinical trials when applicable. Responsible for coordination of teams to complete all aspects of product development including: trial and protocol design, continuous market research; and supervision of research progress. Responsible for oversight of and lifecycle planning for efforts that will produce knowledge solutions, either as part of a materiel solution or as a standalone development effort. Product Manager will manage a portfolio of knowledge products and will ensure close alignment of stakeholders along each product's lifecycle from research and development to advanced development and implementation or fielding of the product or solution. Monitors program progress in terms of cost, schedule, performance, and risk, and develops and implements risk mitigation solutions as needed. Regularly updates the Project Manager and senior leadership regarding program progress and issues. Authors and contributes to the production of acquisition documents, reports, briefings, and documentation required by the Defense Acquisition System and/or the USAMRMC. Work requires excellent interpersonal and written communication skills, and the ability to work effectively in a team environment.
SERIES: 0601

Work involves preclinical development of neuroprotective, neurorestorative, and anti-seizure therapeutics using military-relevant rodent models of brain injury (TBI) including penetrating ballistic-like brain injury (PBBI) and mild closed concussive head injury. Requires expertise of in vivo pharmacology design and testing of monotherapy and combination therapy protocols using systemic drug administration and or alternative therapies including selective brain cooling. Requires knowledge and experience in isobolic design and analysis of drug combination pairs. Uses behavioral (neuromotor and cognitive) and histological (immunocytochemistry) parameters as well as molecular (gene and protein analysis, biomarker discovery), physiology (ICP, CBF, MAP, respiratory/pulse oxygen, brain temperature) and real-time electroencephalographic (EEG) outcome metrics to study the neuroprotection efficacy of drug combination therapies. Uses in vivo neurosurgical and vascular techniques on small animals, including electrode implantation and venous/arterial cannulation as well as the ability to monitor post-injury physiological parameters including blood pressure, heart rate, blood gas, intracranial pressure, and cerebral blood flow. Requires comprehensive technical experience and expertise in conducting dose-response studies of neuroprotective agents, anti-seizure drugs, and therapeutic hypothermia using selective brain cooling techniques. Requires knowledge and experience working with rules, laws, regulations, and processes pertaining to conduct of animal research in a government facility.
SERIES: 0401

Work involves specialization in histopathology, molecular biology, and biochemistry specific to military-relevant rodent models of traumatic brain injury (TBI) including penetrating ballistic-like brain injury (PBBI) and mild closed concussive head injury. Requires knowledge and expertise in designing sophisticated analyses to evaluate axonal sprouting, synaptogenesis, neurogenesis, neurotrophic factor expression, mitochondrial function and metabolic biochemical profile. Use histological (immunohistochemistry) parameters as well as molecular/biochemistry (protein analysis, ex vivo mitochondrial assay, metabolomic fingerprinting) outcome metrics to study TBI-related neuroplastic mechanisms. Requires experience and expertise in performing enzyme-linked immunosorbent assays (ELISA), ultra performance liquid chromatography (UPLC), mitochondrial respiration assay, immunoblotting, immunostaining, light microscopy and histopathology. Uses rodent acute and chronic neurobehavioral (motor and cognitive) outcome metrics. Additional required technical skills include small animal neurosurgery, vascular cannulation and necropsy skills, bio-specimen collections (i.e. brain tissue, CSF, serum, and plasma), and intracerebral microdialysis techniques. Requires specific experience working with rules, laws, regulations, and processes pertaining to conduct of animal research in a government facility.
SERIES: 0401

Serves as a pre-hospital Heath Care Combat Health Material Systems Analyst. Reviews Army, DoD, and Joint planning programs and material solutions to determine viability within the force structure. Assists with the development and testing of current and future AMEDD operational concepts in pre-hospital care in support of Army, Joint and Coalition warfare across the full spectrum of conflict. Supports AMEDD efforts in the Tactical Combat Casualty Care Program, including, but limited to the identification, development, coordination, and integration of medical and non-medical concepts, materiel solutions, requirements documents, studies, testing, independent evaluation plans and requirements, positions on priorities, and review of technical publications. Works with other agencies, including TRADOC, AMEDD Center & School, Special Operations Command, and The Program Executive Office (PEO) Soldier on combat casualty care issues. Directs, initiates, organizes, presents, and conducts conferences on material solutions and operational concept proposals. Collects and evaluates data related to point of injury and pre-hospital health care to determine viability of medical material solutions and procedures. Performs intensive systematic analysis of highly complex and unique problems associated with pre-hospital care.
SERIES: 0601

Provides on-site management for the Department of Defense Trauma Registry (DoDTR) Military Orthopaedic Trauma Registry (MOTR) Branch. Responsible for the following branch activities: regular progress reports, orientation, training, feedback on operations of the DoDTR MOTR databases and application; data quality, data analysis and data retrieval for special orthopaedic projects. Manage and coordinate the systematic collection, aggregation, coding, storage, retrieval, and reporting of demographic, incident, treatment, and outcome data for casualties during military operations. Review, and analyze medical and orthopaedic trauma statistical data in support of the DODTR MOTR program. Monitor results of the DoDTR MOTR Quality Management Plan, and take and document actions as necessary; execute, and monitor plans to improve processes and data quality. Provide monthly status reports on productivity, data quality, problems, etc in order to ensure efficient and effective DoDTR MOTR interface and performance. Communicate and coordinate with Patient Administration Systems and Biostatistics Activity (PASBA), United States Army Medical Information Technology (USAMITC), Joint Trauma System (JTS) and other United States Army Institute of Surgical Research (USAISR) entities, and any other external agency for processes, data sharing, and other related DoDTR MOTR procedures. Identify and coordinate necessary system change requests (i.e. data elements) through DoDTR Data Acquisition Branch (DAB) Chief and follow through until implementation and evaluation. Coordinate with all levels of care to ensure consistent and quality data for inpatient care, transport and outpatient follow-up. Identify inconsistencies or discrepancies in medical documentation and/or DoDTR MOTR data, and recommend processes or guidelines for resolution. Coordinate system requirements with JTS Information Technology (IT) Chief and other ISR IT personnel. Provide and coordinate support to special research requests, requirements, or other special projects for Director, Department of Orthopaedics and Research and the Director, JTS, USAISR. Coordinate internal/external training for DoDTR MOTR staff a. May be required to travel for other tasks directly related to the MOTR. Participate in inter-rater reliability quality assurance reviews. Create and maintain a module specific MOTR business rule database and user guide. Coordination with San Antonio Military Medical Center (SAMMC) Department of Orthopaedics and Rehabilitation (DOR) for access to outpatient follow-up appointment information. Participates in all aspects of orthopaedic registry module software development/update and use, including data entry, analysis, retrieval, and reporting. Additional responsibilities will be in implementation, evaluation and monitoring policies, processes and procedures for all Military Orthopaedic Trauma Registry Branch functions. Utilizes Theater Medical Data Store (TMDS), Armed Forces Health Longitudinal Technology Application - Theater (ALTHA -T), TRANSCOM Regulating and Command & Control Evacuation System (TRAC2ES) and other electronic data warehouses for patient data (WISPR, DEERS, CHCS, SIDR, SADR, etc.) to gather data and identify injury and treatment details. Serves as Contracting Officer Representative (COR), the advisor and representative of the Contracting Officer as described in the Defense Acquisition Regulation Supplement.
SERIES: 0610

Work involves planning and implementing basic and applied research studies related to trauma, hemorrhage, and resuscitation. Research concentrates on problems relevant to trauma management. Developing new methodologies is required, as is analyzing/interpreting results. Serve as Consultant Surgeon for Comprehensive Intensive Care Research (CICR), conduct research and development to deliver technology products (software and hardware systems) to the battlefield that improve combat casualty care.
SERIES: 0602

Provide full range of diagnostic and therapeutic procedures for patients with surgical conditions, primarily trauma and thermal injury, requiring the services of a General Surgeon. Participates in training of surgical residents, and contributes to clinical and basic research. Examines, establishes diagnoses, and performs surgery where appropriate for patients with surgical conditions.
SERIES: 0602

Work involves functioning as primary investigator with skills and knowledge in mechanics, injury biomechanics, pathophysiology physics, statistics, human safety engineering, scientific methods and investigation techniques, experimental design, instrumentation, program management, and the research, development, testing and evaluation process. Preparing documentation and justification for both monetary and supportive manpower resourcing is required. As a team leader, supervising and directing scientific and engineering technical personnel in assignment of work, setting of suspense, and evaluation of performance is essential. Authoring and co-authoring technical reports, technical memos, and open literature publications are also required. Additionally, implementing, sustaining, and reporting on internal management controls in area of operation are required.
SERIES: 0180, 0602

Biomechanics of Injury, provides professional medical expertise to support basic and applied biomechanics research projects including hands-on execution of research protocols, particularly with human cadaveric surrogates and medical injury data; development and maintenance of a biomechanical research database that links sensor exposure to injury data; data analysis and reviews analysis reports; coordination with partner laboratories and the project working group to ensure all medical expertise are met. Duties include participating as a member of biomedical multidisciplinary teams to identify and research health hazard risks, injury mechanisms, and correlate human responses to physical exposures. Extensive knowledge and experience in directing scientific biomedical research from the most basic to applied, product-oriented efforts are critical. Establishes and facilitates collaborative research efforts within the DOD, academia and industry to support injury biomechanics research. Develops Inter-Service Support Agreements, Memorandum of Agreements, and Memorandum of Understandings, and other documentation necessary to support both extramural and intramural research efforts.
SERIES: 0602

Serve as staff surgeon and intensivist at the US Army Burn Center, the only burn center for warfighters and other DoD beneficiaries, and civilians in the south Texas region. Serves as a DoD subject matter expert on burns and related injuries, contribute to the world literature on burn and trauma care. Mentor and train other surgeons, residents and fellows on burn care. Provide full range of diagnostic and therapeutic procedures for patients with surgical conditions, primarily trauma and thermal injury, requiring the services of a General Surgeon. Examines, establishes diagnoses, and performs surgery where appropriate for patients with surgical conditions. Responsible for maintaining accurate clinical records and receiving consultations and laboratory work of specific patients. Provides consultation services for members of the hospital staff. Assignments involve the full range of cases and problems in the specialty, including the very difficult where there is responsibility for recognizing rare and difficult-to-identify symptoms or signs, and responsibility for developing a full treatment regimen involving a knowledge of new techniques or the use of prolonged or complicated procedures or advanced and delicate skills. Cases are often critical and require immediate decisions or are complicated because patients fail to respond to previously-tried treatment regimens. Performs major surgical operations to include (but not limited to) (a) Endoscopy - Therapeutic broncohoscopy of secretions, choledochoscopy, diagnostic sigmoidoscopy and colonoscopy, (including biopsy), diagnostic esophagogastroscopy (including biopsy), laparoscopy, operative and diagnostic. (b) Head and Neck - Biopsy, partial or complete resection of lesions of the thyroid, parathyroid, salivary glands, face, scalp, external ear, soft tissues of the face and neck, and lymph node dissection. (c) Chest - Open and closed cardiac massage, pleural abrasion, closed tube thoracostomy, excision, partial or total mastectomies, radical node dissection of neck, axilla, or groin, (d) Abdomen - Repair of hernias, operations on the gastrointestinal tract, biliary tract, pancreas, spleen, liver, adrenals, rectum and anus, kidney, urethra, bladder, uterus, tubes and ovaries and extgernal genitalia. (e) Extremities - Operations on nerves, ganglia, muscles, tendons and management of simple fractures. (f) Intensive Care Management - Placement and interpretation of arterial, central venous and pulmonary artery lines and management of fluid and electrolyte problems including hyperalimentation. (g) Diagnostic procedures - Introduction of radiological contrast materials in conjunction with operative procedures or assessment of trauma (h) Use of mechanical, electrocautery for the excision, coagulation, vaporation and/or repair of tissue. Performs skin grafts. Utilizes advance laproscopic techniques. Contributes to clinical and basic research.
SERIES: 0602

Work involves directing the identification, development, establishment, management and execution of a complex medical research and development program conducted to support priority missions associated with combat casualty care and regenerative medicine. Responsibilities include managing major changes to the structure and content of research programs; exercising discretionary authority to approve the allocation and distribution of funds from all sources (Army approved budgets as well as grants for scientific research) in the organization and executes studies, program reports, and other staff work independently. Extensive knowledge and experience in directing scientific biomedical research from the most basic to applied, product-oriented efforts are critical.
SERIES: 0601

Applies expert scientific knowledge of blast injuries and senior-level experience in DoD medical research and development program structure and management processes to advise on the coordination of medical research on diverse blast injury topics. Develops the conceptual framework for DoD blast injury research stakeholder coordination processes that fulfill DoD Executive Agent (EA) responsibilities, and assists with process implementation and oversight. Serves as a subject matter expert on projects and processes relating to computational modeling of blast-related brain injury and DoD blast injury prevention standards. Provides senior scientist support and assists in the management of international collaborative research activities, including but not limited to activities sanctioned by the NATO Human Factors and Medicine Panel. Establishes and manages interdisciplinary working groups of program managers and researchers from diverse blast injury research and stakeholder communities, both within and outside of the DoD. Develops information products such as Executive Summaries, information papers, and briefings for senior DoD leaders. Develops and presents briefings on behalf of the DoD EA at meetings and other forums (classified and unclassified) at MEDCOM, DA, DoD, other Federal agencies, academia, and industry. Identifies opportunities and develops processes that foster collaboration and information sharing among blast injury research experts from DoD, other Federal agencies, academia, industry, and international allies to advance the state-of-the science in blast injury research and to fulfill EA responsibilities.
SERIES: 0601

Responsible for assisting in planning, programming, budgeting, and execution of funded research program emphasizing delivery of immediate and far-forward care for soldiers sustaining injuries on the battlefield. Provides program management support to the laboratory research, clinical research, and research support personnel. Distributes work to accommodate Program Manager's priorities and ensures adherence to research policies and procedures. Reviews and evaluates research program to identify potential problems for the Program Manager and ensures that research provides practical and specific solutions to identified Army requirements. Assists the Program Manager to formulate program requirements, activities, and resources needs. Ensures that use of resources is consistent with laws, regulations, and policies; and guards resources against waste, fraud, and misuse. Balances the many factors that influence research cost, schedule, and performance to ensure that high quality, affordable, supportable, and effective medical systems are delivered to the warfighter as quickly as possible. Incumbent plans, organizes, monitors, oversees, and/or performs activities that relate to the design, development, planning and modification of research programs. Demonstrates competence in concept and technology development and/or system development and demonstration within the Defense Acquisition Process. Experience in developing overall program goals for S&T funds; acquiring the services of scientists, physician researchers, engineers, and technical support personnel. Demonstrates research expertise providing funds to and oversight of in-house S&T performers, and institutionally funded research at outside organizations including universities, industry, and Federal Government organizations; and interfacing with technology customers, industry, and academia to expedite the transition of medical technology through advanced development and clinical trials. Duties include assisting in monitoring program and reporting progress and products through Balanced Score Card, Annual Research Progress Reports, In-House Laboratory Research Reports, and like reports, monitoring program compliance with applicable regulations pertaining to research activities, coordinating review and approval for research protocols, coordinating budget, procurement and manpower requirements to support research operations. Assists in initiating, implementing and maintaining appropriate databases to track, correlate and integrate program, budget and deliverables for STO/Task Area tasks, work units to demonstrate accomplishment of programmatic goals and manage resources. Manages the development of policy changes in response to changes in appropriations and allocations alteration.
SERIES: 0601

Work involves planning and implementing basic and applied research studies with a variety of in vitro models of trauma, hemorrhage, and resuscitation to seek solutions to important problems in this specialty area. Answering these research questions requires the ability to use flow and static models of coagulation, including the design, development, and implementation of new in vitro models such as flow monitoring systems. Research will include a focus on the study of protein-protein, protein-cell, and cell-cell interactions through a number of biochemistry and molecular biology techniques. Works requires a thorough knowledge of coagulation physiology, microcirculation, microfluidics, shear and variable flow rate effects, endothelial biology, and cell culture. Tasks also include development and/or modification methodologies and analysis, interpretation, and presentation of experimental data.
SERIES: 0601

Work involves serving as medical subject matter expert in health hazards of vibration and repeated impact environments, lethality assessment of blunt impacts, injury assessment of whole body acceleration, and injury patterns. Work requires knowledge and skillful application of operational medical and aviation experience, aviation operations, risk evaluation and reduction, research methods and practices on a variety of investigatory projects focused on the protection, safety, and risk reduction of the Army aviator or aircrew. Work involves general knowledge of vehicle injury patterns and personal protective equipment (PPE). Requires knowledge of Army accident investigation practices, procedures, techniques, legal limitations, Aviation Life Support Equipment design and function, and survival factors. Extensive experience in Army rotary-wing operations is applied to investigations. Ability to evaluate and recommend risk reduction measures. Ability to work with other agencies for data acquisition necessary for Division projects and mishap investigations. Must have the ability to assist a team through knowledge and application of leadership and team building skills and techniques such as group facilitation, coordination, coaching, problem solving, interpersonal communication, and integration of work processes and products. Writes, rewrites, edits a variety of technical and non-technical medical sciences material. Requires knowledge of medical sciences terminology, manuscript editing, and using word processing software.
SERIES: 0601

Work involves leadership and strategic planning of Injury Prevention Research within the Military Operational Medicine Research Program and Joint Program Committee 5 (Military Operational Medicine). The position involves identification of capability gaps through analysis of a variety of requirements documents and development of research approaches that are synthesized into overarching program goals to deliver solutions to Service members. Position will include planning, programming and budgeting for multi-year research studies and approval of research objectives and plans as critical elements of the work. Position will involve establishment of budget priorities for intramural and extramural investments for Service member health protection research initiatives. Evaluation of research against the goals, objectives and plans and the assessment of the science being conducted are all essential aspects of the position. The technical areas of the work include musculoskeletal, sensory and mild traumatic brain injury research topics for performance sustainment and health protection of service members across the deployment and life cycle.
SERIES: 0413

Responsible for comprehensive medical educational and staff development programs; integrating new employees into the unit; developing, planning, coordinating, implementing and evaluating the medical educational needs and skill levels of military, civilian and contracted personnel. Coordinate and conduct continuing educational programs for medical staff, including: orientation; preceptorship; on-the-job training; pre-deployment sustainment; Advanced Burn Life Support Provider and Instructor Courses; multidisciplinary continuing education programs; and moderation and unit based in-service education platforms. Serve as a Nurse Administrator and Planner for the U.S. Army Nurse Corps Continuing Health Education Program (ANC-CHEP). Develop criteria for continuing education programs based up current established guidelines set up by official accreditation organizations. Evaluate the effectiveness of the multi-disciplinary continuing educational programs.
SERIES: 0610

Ensure education and training programs are conducted in accordance with applicable service regulations, current standards of practice, and accredited guidelines for all staff. Assess new policies, procedures, and practices to determine whether educational programs should be developed to facilitate organizational change. Prepare, maintain and submit required records reports. Serve as an advisor, or a member of, various hospital committees and process action teams, as directed. Counsel professional and paraprofessional personnel regarding military and civilian medical education programs and opportunities. Assist, support, and instruct hospital staff and students in various educational experiences. Provide didactic instruction as needed. Maintain current knowledge of research in nursing and health care. Coordinate with professional and paraprofessional personnel within the organization who are directed to act as instructors for various continuing educational programs. Devise, implement, and maintain communication with the medical staff regarding the status of educational programs and staff participation. Participate in strategic planning and forecasting for medical staff and faculty development. Promote knowledge sharing, through networking with colleagues, in the civilian and military nursing communities. Comply with facility specific personnel and healthcare policies and directives.
SERIES: 0610

Assist principal investigators in the research program in the preparation, conduct and documentation of exempt and human subject research. Work with the Institutional Review Board, sponsors, unit personnel, and collaborators to coordinate the funding, execution and dissemination of research. Participate in the planning, design, regulatory approval and resource allocation decisions regarding research projects. Conduct research involving human subjects in accordance with Federal laws, rules and regulations. Collaborate with patients and other research participants to obtain informed consent for participation in studies. Deliver care and training as directed in research protocols and records clinical data to include use of computerized data acquisition systems. Review data to ensure accuracy, develops and uses record keeping systems to ensure data integrity and participates in the analysis of results. Report progress of research and participates in the ongoing review of research to ensure regulatory compliance, patient safety, scientific quality and progress. Prepare reports outlining research status for internal and external use. Assist in preparation and delivery of presentations and manuscripts regarding research results. Maintain current understanding of research applications and training staff to use novel software systems mobile devices. Complete mandatory military healthcare training requirements.
SERIES: 0610

Incumbent is responsible for nursing care assignment to various skill levels of professional and nonprofessional personnel. Assigns nursing staff to patient care duties based on patient condition and expertise of individual staff member. Monitors, evaluates and oversees staff performance to assure work is accomplished in a timely manner. Ensures staff makes legible, accurate and complete nursing entries in the patient chart. Ensures appropriate patient education occurs during the shift and that the appropriate responses to patient emergencies are made. Reviews physician's orders written and assists on clarification of orders, if necessary. Reviews and assists with the revision of nursing care plans, as needed. Ensures physicians are advised of significant changes in a patient's condition in a timely manner. Collaborates with physicians and other health care team members to assure optimal level of care is provided to all seriously ill patients on the unit. Approves short-term emergency or sick leave requested during the shift. Initiates call back of off-duty nurses and other personnel as required by unexpected emergencies. Ensures completion of documentation for quality assurance problems, unusual occurrences, on-the-job injuries, or staff performance issues. Assists with visits by distinguished visitors from all levels of the military and educational community. Provides comprehensive nursing care to patients in the Burn Center.
SERIES: 0610

Incumbent provides an advanced level of specialized nursing care to high acuity level, complex patients having numerous complicating conditions requiring a high level of technological interventions. Provides continuous patient observation, monitoring and reporting to prevent complications and restore the patient to health. Observations and monitoring includes interpretation of vital signs, and symptoms of deterioration in condition, and interpretation of normal and abnormal cardiac rhythms. Takes emergent corrective action with scope of practice and promptly notifies physician. In the absence of a physician, independently makes decisions and implements proper emergency measures after identifying and interpreting life-threaten conditions initiate's life-saving measures. Performs arterial punctures and troubleshoots respirator adjunctive therapy. Assists with intubation, insertion of arterial and venous catheters and chest tubes, in addition to other procedures. Inserts intravenous catheters, performs phlebotomy and arterial blood draws. Monitors intake and output of fluids and notifies physician when caloric and fluid replacements have changed. Assesses patient vital signs, level of consciousness and other neurological and circulatory responses. Administers and monitors the use of therapeutic agents (medications) in accordance with Nursing Service's policies and procedures, published resources and unit operating instructions and clinical Practice Guidelines (CPG). Uses specialized patient equipment such as respiratory equipment, intravenous infusion pumps, various suction apparatus, pleurovacs, cardiovascular monitors, defibrillators, transcutaneous and external pacing devices, thermoregulating equipment, burn grafting devices, and other equipment as required by the patient's condition.
SERIES: 0610

Serves as the Clinical Nurse OIC (CNOIC), overseeing the scope of practice and provision of nursing services within the clinic. Implements evidenced based nursing practice, policy enforcement, performance/quality improvement, utilization management, Joint Commission preparedness, National Committee for Quality Assurance (NCQA) preparedness, budget management, staff education and competency validation, direct patient care activities and other support activities within the scope of practice. Advises the senior leadership on nursing matters; reviews, recommends changes, and assists in the development of regulations, procedures, and other matters. Responsible for working with senior leaders to optimize unit performance, meet Healthcare Effectiveness Data and Information Set (HEDIS) measures, National Committee for Quality Assurance (NCQA) recognition, preventive health care measures, access to care and other organizational directed initiatives. Supports the commander's vision, organization mission, and organizational strategic themes for performance by aligning clinic initiatives and practices with Balanced Scorecard objectives. Adjusts operations to meet mission and resources; evaluates work performance and productivity; makes decisions on training needs and requests by nursing and ancillary staff; and handles ambulatory care nursing complaints and concerns as appropriate. As a Secretary of the Army Designee, the CNOIC is required to coordinate and maintain authorization for burn care for all non-DoD civilian patients (approximately 75% of the clinic patient population) under the Secretary of the Army Program for the activity.
SERIES: 0610

Serves as a board certified physician responsible for the examination, diagnosis and treatment of patients who are seen in the Burn Clinic, admitted to the inpatient burn center from the outpatient setting, and on the burn progressive care unit on a consultation basis. Exercises independent judgment in selection and performance of a full range of wound care diagnostic and therapeutic procedures as well as diagnostic procedures in the outpatient setting. Examines and assesses patients, provides medical oversight of a comprehensive rehabilitation program, evaluates radiographic and laboratory tests and prescribes appropriate treatment to include therapeutic services and modalities, medications, and durable medical equipment. Refers to appropriate specialty clinic when required for evaluation and/or treatment. Provides prescription renewal and telephone consultative services. Provides episodic care to acute and chronic patients and pain management with these patients, including referral to consultation clinics as necessary. Performs brief psychological screening. Participates in clinical performance improvement and research, and in the development and implementation of prospective and retrospective studies with the goal of presenting the results in appropriate forums. Reviews articles and contributes to publication at the request of or with the approval of staff members. Advises, teaches and provides consultation to other health care providers (nurse practitioners, physician assistants, therapists, medical students and residents). Serves as a member of a health care team comprised of other physicians, non-physician providers, and ancillary staff. Provides medical consultative services and chart reviews for quality assurance purposes. Attends burn center staff meetings, morbidity and mortality conferences, and other hospital, regional, and/or national meetings as directed.
SERIES: 0602

Work involves functioning as researcher in the design, conduct, and analysis of human physiology and exercise science research and evaluation. Technical skills and knowledge are required in the areas of scientific methods and investigation techniques, experimental design, instrumentation, project and data management, and the research, development, testing and evaluation process. Work will focus on the assessment, optimization, and enhancement of Soldier occupational and operational performance and a reduction in performance decrements. Research work will assess the physiological responses and medical outcomes to physically demanding occupational and operational requirements. Responsibilities include the ability to synthesize results into models or products that lead to effective injury prevention, intervention strategies, and human performance, optimization, and enhancement.
SERIES: 0601, 0413

Work involves functioning as a researcher in the design, conduct, and analysis of studies manipulating exercise and/or diet as an independent or dependent variable. The work will focus on the assessment of, and nutritional interventions to optimize or enhance Soldier operational performance, and improve Soldier health readiness. Technical skills and knowledge are required in the areas of exercise and nutritional science, scientific methods and investigation techniques, experimental design, instrumentation, project and data management, and the research, development, testing and evaluation process. Responsibilities will include exercise testing and/or strength and conditioning testing, counselling volunteers regarding study specific diet and exercise restrictions to assure adherence to study protocols, venipuncture and IV catheter placement, blood and other biological sample processing, body composition assessment, indirect calorimetry at rest and during exercise, and the use of biological sensor equipment for assessment of physiological state.
SERIES: 0601

Anesthetizes patients for a broad range of surgery extending from the simplest to the most complex of surgical procedures. Provides conscious sedation and interventional pain management of patients, progressive care unit, and post anesthetic care unit (PACU). Evaluates patient's physical and mental status with respect to anesthesia, consulting with the anesthesiologist, if necessary, to evaluate patient's condition and desired anesthetic course of action. Reviews type of anesthesia to be utilized with the patient, explains expected outcomes and possible anesthetic complications. Determines appropriate techniques, drugs, and equipment for use in the administration of anesthesia to all patients undergoing any and all forms of surgical and/or diagnostic procedures. Administers anesthesia by inhalation, endotracheal intubation, intravenous, epidural and subarachnoid block, axillary block, intravenous block, transtracheal and superior laryngeal block, local infiltration, and topical application. Induces anesthesia to proper levels and manages patient's anesthetic care throughout surgery. Determines need for and administers parenteral fluids, including blood, and plasma. Sets up intravenous solutions and maintains proper flow rate. Performs invasive monitoring techniques and interprets the information obtained through the use of these monitors. Administers vasoactive drugs as required. Observes the patient during surgery for signs to accomplish and maintain the proper stage of anesthesia and to prevent overdose. Adjusts the level of administration of anesthetic agents and adjunctive drugs and utilizes proper methods to support patient's respiratory, circulatory, and renal functions. Provides emergency airway management and progressive care unit (ward). Gives immediate postanesthetic care to patients for the extent of time required to provide patent airway, adequate fluid volume and urinary output, and freedom from possibility of shock or other adverse reactions during transport to and stay in the recovery room. In emergency situations, when a physician is not present or immediately available, initiates appropriate measures, to include resuscitative measures during cardiac or respiratory arrest. Assumes responsibility for care, sanitation and inspection to ensure proper functioning of all equipment used.
SERIES: 0610

Work involves planning and conducting research in the area of hemorrhage, circulatory shock, and trauma as they relate to both military and civilian issues. The ability to elucidate the biomedical and molecular mechanisms underlying the pathophysiological changes following hemorrhage and trauma and devise means to ameliorate them is essential. Additional tasks include developing new methods and adapting existing methods to solve research problems directed at understanding the cell and molecular biology of cell injury and repair. Overseeing and conducting research, such as preparing reports and scientific research papers pertaining to studies.
SERIES: 0601

Work involves protocol development, management of regulatory affairs, and quality assurance support for product development efforts involving Phase I and II human trials conducted according to current Good Clinical Practices to demonstrate safety and efficacy of candidate Investigational compounds, devices and materials. Knowledge and skills include both theoretical and practical knowledge of clinical trial design, Food and Drug Administration (FDA) clinical research regulations, laboratory practice, and manufacturing regulations and guidelines. Tasks include the following: (1) protocol development and review (i.e. experimental design, managing responses to scientific review committees/ institutional review boards/ FDA, data management, and data analysis); (2) case report form and informed consent compliance review; (5) compiling and formatting Annual Reports and Final Reports for IRB, and FDA; (3) reviewing submissions to the FDA for regulatory compliance and quality; (4) consultant to investigators for optimization of clinical trial design (5) assessing study feasibility and alignment to requirements; (6) contributing to presentations and manuscripts; and (7) educating other investigators regarding regulatory requirements.
SERIES: 0601

Oversees the day-to-day management and mentoring of staff within this research program, ensuring appropriate administrative support to investigators, cost effectiveness, and adherence to all applicable DoD regulations. Reviews, evaluates, and develops recommendations concerning the research operations, including policies and programs designed to improve program effectiveness. Maintains research records in accordance with applicable laws and regulations. Identifies and completes grant applications appropriate to the mission and the objectives of the organization. Ensures that funding through Foundations, Research Grant Societies, Government Research Agencies and/or Academic institutions are received, processed and administered. Serves as subject matter expert on research and protocol issues.
SERIES: 0633, 0631

Incumbent will design and develop novel biomedical instrumentation systems to support research protocols in critical care medical and performance physiology. Work entails using knowledge of electronic engineering, biomedical engineering, computer programming, feedback control theory, and microprocessors to produce biomedical instrumentation systems to measure physiological parameters of human subjects exposed to extreme environmental and clinical (e.g., severe central hypovolemia, physical exercise) conditions in laboratory and field situations. Skills operating lower body negative pressure (LBNP) and monitoring physiologic status of human subjects. Duties include developing data acquisition and physiologic monitoring systems, applying engineering theory to mathematical analysis of physiological responses and development of novel instrumentation to solve biomedical problems (e.g., advanced medical monitors, hemorrhage detection devices). This may involve validation and verification including Failure Modes and Effects Analysis (FMEA) and risk analysis.
SERIES: 0858

Incumbent will have skills in interfacing electronic data capture, data mining, data storage and data management systems. Skills in computer programming (MATLAB, Python, SPSS, FORTRAN, Mathematica, MS Office) and other database programming languages and software (e.g., OpenSim, Autolev). Skills in data analysis (machine learning, numerical analysis, modeling, simulation, statistics, optimization, surrogate response surfaces).
SERIES: 0858

Work involves planning and implementing basic and applied research studies related to severe burn trauma. Experience with a variety of in vitro and in vivo models of burn trauma, including conducting animal modeling of infections related to burn injury. Research concentrates on major research problems relevant to military and civilian acute burn injury and trauma. Tasks include reviewing and or conducting experiments pertaining to burn and trauma and wound repair. Additional tasks include developing new methodologies and analyzing and interpreting results.
SERIES: 0601

Work involves planning and conducting basic and applied cell and molecular research studies, with a special emphasis on cellular injury after burn injury. Developing new methods or adapting existing procedures as needed to solve research problems directed at understanding the molecular biology of cell injury and repair is required. This position involves overseeing and conducting research utilizing biomaterial development, knowledge and experience in drug delivery platforms, cell culture, and additional methods for the identification of cellular responses to burn injury.
SERIES: 0601

Serves as the subject matter expert (by Publications) and team leader in the field of Systems Biology. Provides oversight to pre-clinical and clinical efforts to meet scientific mission. Prepares and presents programmatic reviews of the Institute's research program for review panels across the Department of Defense (DoD). Serves as Principal Investigator to execute research in systems biology approaches to issues of military relevance and apply molecular and multidisciplinary tools to develop solutions to protect the health of soldiers. Demonstrated expertise and ability to provide scientific leadership systems biology approaches. Contributes to new research programs to investigate all aspects of systems biology including clinical, physiological, behavioral, and therapeutic strategies for issues of military relevance. Writes research results and submits manuscripts to peer-reviewed journals and conference publications. Serves as the Contracting Officer Representative or Grants Officer Representative for research initiatives across a wide range of scientific domains. Serves as the technical representative during grant negotiations, advising and assisting the Contract Officer in administering awards and coordinating program management decisions. Demonstrated leadership in guiding interdisciplinary research teams, proven track record of attaining new funded projects, and demonstrated experience in managing day-to-day operations.
SERIES: 0401

Complete burn in-patient and out-patient treatments appropriate for patient. Utilize clinically accepted measurement and evaluation tools, clinical observations, patient and staff interviews, and review of medical history. Utilize computer assisted technology for treatment and evaluation of patients, to include BTE Work Simulator and computerized upper and lower extremity diagnostic and treatment systems. Utilize observation and interaction, to make assessment of the burn patient's physical, developmental, social, spiritual, emotional and mental status; reports changes in signs and symptoms; coordinates with the multidisciplinary staff to modify the plan of care accordingly.
SERIES: 0631

Serves as the laboratory QA coordinator. Performs a variety of medical technology and administrative duties in support of the QA PROGRAM. Maintains current knowledge of all laboratory related accreditation and regulatory requirements and other applicable guidelines and directives published by higher command authority, the College of American Pathologists and DoD Clinical Laboratory Improvement Program (CLIP). Assists with preparation for laboratory inspections by periodically reviewing current operations to ensure that requirements are met. Assists in developing and implementing corrective actions when deficiencies are identified. Provides oversight of the laboratory's internal and external quality control programs. Assesses compliance with accreditation guidelines and good laboratory practices. Provides suggestions for corrective action when compliance with accreditation/regulatory requirements, trends/shifts, or out-of-control indicators are evident. Reviews inter and intra laboratory quality control data and evaluates the laboratory's performance. Performs or reviews statistical analysis of data and verifies that professionally accepted standards of accuracy and precision during analysis are maintained. Ensures deviations and appropriate responses/corrective actions are documented. Possesses in-depth knowledge of quality control systems, proficiency testing programs, and procedures for preventive maintenance, function verification checks and performance verification checks on analytical instrumentation and equipment sufficient to identify and ensure resolution of problems while ensuring compliance with applicable accreditation requirements.
SERIES: 0644

Establishes, organizes, administers, troubleshoots, facilitates, and maintains access to electronic content through specialized library tools and software such as link resolvers/OpenURL resolvers, A-Z lists, library electronic resource management systems (ERMs), and library electronic content management systems (ECMs). Administers and manages an authentication system, such as a proxy service or OpenAthens, and coordinates with vendors, authentication providers, and local Information Management to resolve access issues. Ensures compliance with copyright law and license agreements when providing information or access to information to staff. Develops and justifies annual budget and monitors expenditures of funds during fiscal year. Gathers, compiles, and maintains resource usage statistics for locally acquired resources to aid in yearly renewal decisions and in outreach efforts. Applies knowledge and ability to implement library resource contracts for services through FEDLINK to cover periodical subscriptions, monograph acquisition, database access, and training. Uses an Integrated Library System (ILS) to perform circulation duties, inventory management, and compile annual statistics. Applies general knowledge of cataloging rules and principles to perform copy cataloging duties.
SERIES: 1410

Responsible for the full scope of the medical library's operation, administration, and management and ensures that the library fulfills the mission. Work involves application of theories, principles, and techniques of library and information management in a biomedical research information center serving a research and clinical staff of military and non-military personnel. Develops and promotes programs and services that fill information needs of staff. Performs exhaustive literature searches for biomedical researchers to prevent duplication of research efforts or to meet the animal welfare requirements of research involving animals. Applies extensive expertise, knowledge, and skill in the search and manipulation of PubMed and other online biomedical database systems (medical, nursing, dental, & scientific) to produce literature searches on specialized biomedical subjects for research and clinical staff. Assists and instructs researchers with and on the organization of information sources through citation or bibliographic management software such as EndNote. Applies skill to locate requested unique information sources with incorrect or incomplete citation information. Provides interlibrary loan services through lending consortia such as DOCLINE or OCLC. Applies knowledge of copyright law and CONTU interlibrary loan guidelines to determine the best method of filling interlibrary loan requests. Develops collection development policies to guide in the management, evaluation, selection, determination of format, and withdrawal of information resources. Plans and conducts library orientations on resources and services and training sessions on biomedical information resources for staff. Advises staff on general copyright.
SERIES: 1410

Serve as principal investigator and scientific leader for research in biomedical engineering and wound repair of burn and soft tissue. Demonstrated a track record of being able to obtain funding for research. Demonstrated research and understanding of burn injury and development of wound treatments for the battlefield. Demonstrated a track record of understanding and managing intellectual property and obtaining patents. Coordinates with industrial, academic, and clinical partners in the disciplines of basic, translational, and clinical research. Skilled in establishing a research program in and soft tissue injury and prevention of infection. Serves as the source matter expert for a wide range of natural and synthetic biomaterials and their application in severe burn injury.
SERIES: 0601

Designs, develops, tests and evaluates problems relative to providing surgical and medical solutions for military requirements to protect and sustain the force. Applies advanced theories, concepts, principles and processes to further research in combat casualty care. As primary investigator: plans, develops, and writes formal protocols and submits them within designated deadlines for approval. Plans and coordinates budget, facility requirements, support functions (laboratory, pathology, etc) and manpower to ensure protocol advancement and completion. Provides mid-year review data and other follow-up information as needed on protocols to meet all guidelines and regulations. Provides direct and indirect support for critical care to research protocols. Leverages capabilities of staff to recruit new studies for assigned area of responsibility. Uses advanced nursing skills in the process of supporting research, thereby providing a value-added service to these protocols. Works directly with research staff to provide advanced nursing and critical care support. Composes, authors, and submits scientific articles for publication in peer-reviewed journals. Composes, develops and presents scientific data at national or military medical or scientific conferences. Develops formal and informal educational programs and projects to students, staff members, and nursing staff on topics related to specialty and provided services. Provides lecture support and serves to instruct, teach, and proctor educational programs and activities. Serves on committees and other intra-institute activities to support the mission.
SERIES: 0610

As a research nurse (clinical research coordinator) provides professional assistance to investigators in the combat casualty care research program in the preparation, conduct and documentation of human subject research. Works with the Institutional Review Board, sponsors and ISR personnel to coordinate the execution of research. Works within the trauma critical care unit, emergency department and burn center critical care/intermediate care units, operating room and outpatient care environment to conduct scientific investigations. Participates in the planning design, regulatory approval and resource allocation decisions regarding research projects. Requires knowledge of laws, rules and regulations regarding the conduct of research involving human subjects. Possesses the ability to work with patients to obtained informed consent for participation in studies. Delivers care as directed in research protocols (to include processing of laboratory specimens) and records clinical data to include use of computerized data acquisition systems. Reviews data to ensure accuracy, develops and uses record keeping systems to ensure data integrity and participates in the analysis of results. Reports progress of research and participates in the ongoing review of research to ensure regulatory compliance, patient safety, scientific quality and progress. Prepares reports for internal use, assists in preparation of reports and presentations for external use.
SERIES: 0610

Serves as senior nurse administrator and clinical analyst for the USAISR Burn Center. Analyzes clinical operations and business operations in order to apply objective, data-driven solution sets to: maximize value, as part of the Military Health System and Army modernization efforts; align with Army Futures Command and Defense Health Agency strategic objectives; comply with pertinent regulatory and higher headquarters policy/guidance; and ensure effective/efficient use and stewardship of resources. Provides products / reports directly to: ISR Commander, ISR Deputy Commander for Nursing, Burn Center Director, and Burn Center Executive Officer.
SERIES: 0610

Conducts analysis and develops analytical techniques for complex organizational problems that require higher headquarters support or intervention. Conducts business case studies for the ISR Burn Center, including inpatient (ICU/Step-down), outpatient, surgical, rehabilitative, and pulmonary sections. Analyzes the direct care delivered and supports the development of major ISR Command protocols, models, and overarching policies designed to enhance business operations. Delivers business case studies on the cost breakdown of patient care delivery, efficiency of services, tracking of direct care workload, and other operational aspects of patient care delivery. Provides alternatives and recommends courses of action to senior leaders after comprehensive analysis and study. Uses an interdisciplinary approach, collaborating with ISR partners to facilitate accurate and relevant business plans. Prepares detailed implementation plans for strategic and reorganization efforts. Oversees the accomplishment of long-term implementation plans. Coordinates execution of approved plans.
SERIES: 0610

Bridges the domains of nursing methods and quantitative analysis to the ISR's daily business and clinical operations. Utilizes databases such as Excel, Military Health System Mart (M2), DMHRSi, Access, Microsoft applications, and WMSNi. Also utilizes CHCS, AHLTA, Essentris, T Systems, and other local and regional databases to gather information. Interprets, extracts, and provides Burn center business data and information. Is familiar with hospital operations such as patient administration, medical records, intake, coding, billing cycles, and workload management.
SERIES: 0610

Identifies trends and problem areas. Utilizes lean methodologies coupled with critical thinking to identify root causes for non-compliant clinical and business operation objectives that have a negative impact on organizational administrative decisions. Works independently to review, update, and contribute input into local policy. Supports the development of plans of action for efficient resourcing and allocation from a medical standpoint. Serves as a senior advisor regarding process optimization, outcomes, assessments, and policy based on the Defense Health Agency and Army Medicine's transition to a system of health and in line with the mission as identified by the ISR Commander, MRDC, and Army Futures Command.
SERIES: 0610

Develops performance metrics and indicators that assist ISR leadership in decision-making and reporting. Works collaboratively with other administrative offices and clinical departments that have an impact on the Burn Center at local MTF level, MEDCOM, Market, and Regional level. When required, acts as a senior representative for the Burn Center on business matters and functional teams on a broad spectrum of complex projects that focus on optimization of MTF-wide patient care delivery. Is aware of policy and regulation and incorporates both into business plans. Acts as a senior business consultant for the burn center. Stays proficient by reviewing and applying appropriate literature.
SERIES: 0610

Serves as a Research Scientist. Formulates research projects, develops innovative approaches, designs and implements experimental protocols related to computational models. Develops and applies computational solutions to biomedical problems, involving signal processing of time-series physiological data, data mining, data-driven and physiological-based models, and artificial intelligence. Analyzes and models physiological data with relevance to trauma. Continuously surveys the scientific literature to generate novel ideas and advance projects and programs. Develops necessary new technologies and protocols. Collects, processes, and interprets experimental data and model outputs. Trains, and in some instances supervises, junior research scientists, fellows and interns. Assists in the identification, development, and maintenance of collaborations with both internal and external research groups for development of new approaches to existing research problems. Prepares research proposals, progress reports, and manuscripts for submission to scientific journals. Performs Contract Officer's Representative duties on specific contracts or grants within their areas of expertise. Represents the Institute in meetings with program staff from the U.S. Army Medical Research and Development Command (MRDC) and other DoD organizations. Prepares and presents technical briefings on Institute capabilities and accomplishments to DoD, Army, and MRDC staff. Serves as Principal Investigator and executes research within their areas of expertise. Presents research methods and scientific concepts at appropriate scientific conferences. Position requires demonstrated ability to guide and execute interdisciplinary research bridging computational and experimental work in human physiology as it pertains to military medicine and an established record of cross-disciplinary publications in top-tier, peer-reviewed scientific journals.
SERIES: 0401

Oversees this clinical research program, ensuring appropriate administrative support to investigators, cost effectiveness, and adherence to all applicable DoD regulations. Reviews, evaluates, and develops recommendations concerning the research operations, including policies and programs designed to improve program effectiveness. Maintains research records in accordance with applicable laws and regulations. Identifies and completes grant applications appropriate to the mission and the objectives of the organization. Ensures that funding through Foundations, Research Grant Societies, Government Research Agencies and/or Academic institutions are received, processed and administered. Applies the principles, theories, and practices of rehabilitation science and biomechanics to design methodologically sound studies, write protocols, conduct appropriate data analysis, and prepare manuscripts to present study findings. The nature of the research focuses on specialized aspects of burn rehabilitation to improve or enhance industry standards and evaluate the effectiveness of treatment strategies that enhance return to full function/return to duty. These problems require considerable understanding of cutaneokinematics and interpretation of limitations required for the analysis of rehabilitation strategies that maximize function which can be used by medical professionals involved in the treatment of burns injuries. The performance of these duties requires a professional expertise in the broad areas of normal and abnormal motor, sensory, cognitive, psychological and social skills and abilities expected at various stages of healing; common disabilities or incapacities associated with neurological, orthopedic, and general medical conditions that can impair function; and a working knowledge of protocol development and statistics. Experience with treating patients with traumatic and burn injuries is desired.
SERIES: 0633

Performs work in conjunction with the investigation of brain health and performance of military personnel, including the areas of brain injury, stress and fatigue, cognitive performance, and occupational and environmental neurotoxicologic exposure. Hands on experience in the use and scoring of cognitive tests, psychological assessments, and behavioral measures (e.g., eye tracking, motor function tests), as well as knowledge of or experience with functional brain (e.g., electroencephalography, magnetic resonance spectroscopy) and physiological measures (e.g., heart rate variability, electrodermal activity) is required. Work involves coordination of extramural and intramural research projects, to include study preparation and schedule management and training of staff in study-related SOPs. Contributes to research design and methods, data collection in accordance with established protocols, establishment and maintenance of data files, statistical analysis, and preparation Provides editorial support for document preparation and presentations. Maintain inventory and ordering of supplies, calibration and maintenance of scientific equipment, and contract management as needed.
SERIES: 0180

Applies expert scientific knowledge of infectious disease and senior-level experience in DoD medical research and development program structure and management processes to advise on the coordination of medical research on diverse infectious disease topics. Develops the conceptual framework for DoD infectious disease research stakeholder coordination processes that fulfill DoD Executive Agent (EA) responsibilities, and assists with process implementation and oversight. Serves as a subject matter expert on projects and processes relating to infectious disease research and medical countermeasure development for biological threats. Provides senior scientist support and assists in the management of international collaborative research activities, including but not limited to activities of the World Health Organization. Establishes and manages interdisciplinary working groups of program managers and researchers from diverse infectious disease research and stakeholder communities, both within and outside of the DoD. Develops information products such as Executive Summaries, information papers, and briefings for senior DoD leaders. Develops and presents briefings on behalf of the DoD EA at meetings and other forums (classified and unclassified) at MEDCOM, DA, DoD, other Federal agencies, academia, and industry. Identifies opportunities and develops processes that foster collaboration and information sharing among infectious disease research experts from DoD, other Federal agencies, academia, industry, and international allies to advance the state-of-the science in infectious disease research and medical countermeasure development and to fulfill EA responsibilities.
SERIES: 0601

Serves in the Burn Operating Room as a member of the surgical team. Participates with surgeon in planning procedures; initiates preparation for surgeon-directed procedure; assists the physician throughout the procedure. Transports patients. Ensures that the operating surgeons are notified of the procedure status, the current patient condition, and other vital information that may affect the procedure. Prepares and organizes the operating room and is responsible for keeping it functioning smoothly. Performs all setup of equipment and medication needed for procedure being performed. Checks instruments/equipment for completeness and proper functioning. Performs basic maintenance of equipment as needed and/or sends to designated repair center. Conducts quality control checks; performs corrective actions as needed. Sterilizes instruments after each use. Ensures the patient stays in the proper position. Requires knowledge and ability to apply basic life support (BLS) techniques and skill to initiate life-saving measures. Ensures that the Operating Rooms have adequate supplies for all procedures performed and orders supplies as needed. Assists in setting up a sterile field, prepping and draping the patient, and providing items needed for the procedure.
SERIES: 0649

As an expert in the nursing care of burn patients, serves as a resource person with whom other experienced nurses and other health care providers consult when particularly difficult problems in the care of burn patients arise. Serves as a role model to experienced nurses as well as those who are not fully trained. Provides guidance and leadership to other professional nurses, and oversees the work of paraprofessional personnel. Provides orientation and on-the-job training for such personnel. Is a preceptor for newly assigned nurses. Conducts in-service lectures and provides formal and informal training. Leads patient care conferences. Participates in the development of standards of care and in the establishment of quality assurance goals for the unit.
SERIES: 0610

Work involves the development and administration of human cadaver use programs, policies, assessments and review and oversight necessary to achieve efficiency and effectiveness of Command and/or Agency missions and assigned programs. Tasks include developing program and policy content, review and approval of cadaver use activities, conducting assessments of human cadaver programs, and coordinating required reporting.
SERIES: 0601

As a SME, coordinate with Joint Trauma System for development of burn care Clinical Practice Guidelines. Facilitate and maintain oversight of orientation; preceptorship; and on-the-job training for clinical rotators from all military healthcare programs, civilian healthcare programs, and pre-deployment training. Maintain status as (sole) American Burn Association National Faculty (or equivalent), including maintaining organizational membership, to facilitate and teach Advanced Burn Life Support Provider and Instructor Courses (or equivalent) across the DHA and civilian partners within the local region; maintain ability to travel to conduct necessary burn education training for mission readiness. Primarily responsible for class coordination. Serve as the only Burn Center Nurse Administrator and Planner for the U.S. Army Nurse Corps Continuing Health Education Program (ANC-CHEP); manage Burn Center multidisciplinary continuing education programs, trainings, and administration of continuing education hours. Coordinate and conduct continuing educational programs for healthcare personnel. Develop criteria for continuing education programs based up current established guidelines set up by official accreditation organizations. Evaluate the effectiveness of the multi-disciplinary continuing educational programs.
SERIES: 0610

As an expert in the nursing care of burn patients, serves as a role model and resource person to experienced burn nurses as well as those who are not fully trained, using knowledge of an extensive range of professional nursing theories, principles, and procedures; knowledge of interrelations of body systems and disease process; knowledge of emergency and resuscitative measures; knowledge of pathologic conditions associated with a variety of medical conditions; and skill to interact with patients and family members. Provides guidance and leadership to other nurses. Provides orientation and on job training (OJT) to nurses, providers, and other paraprofessionals that are rotating through the Burn Center for clinical training. Teaches burn patient care to other healthcare professionals at all levels of development, across the DHA, facilitating Individual Critical Tasks are met.
SERIES: 0610

Work includes the skill, knowledge and ability to operate a highly complex and sophisticated clinical pathology laboratory that provides support to numerous and varied research protocols. Researches, tests, and evaluates clinical pathology laboratory procedures, equipment, and supplies necessary to provide clinical pathology services to biomedical researchers in the following areas of medical science: hematology, clinical chemistry, and microbiology. Responsibilities require detailed understanding of and performance evaluation of both routine and specialized hematologic and biochemical analysis of bodily fluids from a number of different laboratory animal species. Assists biomedical researchers by solving complex technical questions regarding appropriate methods for biological specimen analysis. Ensures the following regarding laboratory data: is captured in a timely manner; is presented in an appropriate form; procedures, accuracy, quality standards are met. Conducts routine and necessary quality control measures for hematology, clinical chemistry, and microbiological equipment. Reviews and implements standard operating procedures (SOPs) for hematology, clinical chemistry, and microbiology. Monitors the maintenance and operation of numerous pieces of highly sophisticated and expensive hematologic and clinical chemistry analyzers. Monitors and maintains an extensive inventory of laboratory supplies and reagents required to provide a diverse spectrum of testing capabilities within the laboratory.
SERIES: 403

The incumbent of this position is responsible for planning, coordinating, integrating and managing complex scientific research projects in support of medical countermeasures test and evaluation for biological defense. Incumbent will interface/coordinate with Department of Defense, industry, and other government agency partners, and integrate the various institute functional areas required to move products through advanced development. Incumbent develops and manages budgets, schedules and business plans to meet project objectives. This position requires strong organizational and managerial skills and requires knowledge and experience in a technical field related to biodefense medical countermeasure development. Incumbent will have a strong working knowledge of Good Laboratory Practice (GLP) and the US Food and Drug Administration (FDA) regulatory process, including the FDA Animal Rule.
SERIES: 0340, 0401, 0403, 0301

Serves as the Biosurety Program Officer for an Army biocontainment research laboratory/institute. Incumbent will manage the day-to-day operations of the Institute's Biosurety Program. Provides oversight of the Biological Accident Incident Response Assistance (BAIRA) Program and the Biological Personnel Reliability Program (BPRP) to ensure these programs receive the necessary emphasis and resources. Responsible for coordinating Surety Board's meetings and development and implementation of Institute surety policies and written procedures for implementation of technical safety standards, codes, and safety requirements for a wide variety of operations and activities, including a comprehensive biological safety and surety program. Responsible for scheduling, planning, conducting, reporting, and all follow-up actions of onsite evaluations, and for responding to all inspections and audits by higher headquarters and Federal agencies. The incumbent will compile onsite inspection findings, and present them to the Commander and to the Biosafety and Surety Boards. With the help of the Institute Biosafety and Surety Boards, plans for and/or conducts special assignments, which typically involve technical or complex safety problems having high visibility and interest by headquarters, or the general public, or which involve application of new policies and procedures. Conducts training on surety and biosecurity programs. Incumbent will be proficient in surety program regulatory compliance.
SERIES: 0403, 0401, 0301

Develops, implements, and manages a comprehensive didactic and hands-on Biosafety Level-4 (BSL-4) training program for multidisciplinary research and support personnel working in high containment and non-containment laboratories. Develops annual training plan, coordinates training schedule, prepares training materials, and provides training. Develops and updates training program with input from subject matter experts in relevant scientific, research support, facilities/engineering, and regulatory disciplines. Plans, acquires, and manages training equipment, supplies and other resources for the BSL-4 simulation laboratory. Assesses the training requirements of all individuals working in high containment and determines their proficiency and competency to work under high containment conditions. Incumbent will maintain training documents and records in accordance with all applicable regulations, policies, and SOPs. Incumbent will assist Suite Supervisors of containment laboratories and Safety Division personnel in conducting inspections in high containment laboratories. Incumbent will serve as a BSL-4 Mentor and Escort for institute personnel and inspectors from various agencies.
SERIES: 0404

Work involves establishing, implementing, managing, and maintaining the command-wide Biological and Chemical Defense Surety Program, and the Environmental Protections Program for the US Army Medical Research and Materiel Command (USAMRMC). As an element of the USAMRMC HQ, the incumbent will oversee the Command-wide Biological and Chemical Surety Programs, and oversee the existing Command-wide Environmental Protection Program. In this capacity, the incumbent will coordinate with the USAMRMC Research, Development, Test and Evaluation (RDTE) laboratories that work with or store designated biological etiologic and chemical defense agents. The incumbent will also coordinate with the USAMRMC HQ and all USAMRMC subordinate commands regarding their Environmental Protection Programs. Requires knowledge primarily of biology with familiarity of other sciences such as chemistry. Incumbent must also be familiar with regulatory compliance, Army risk management, physical security, facilities design/construction, inventory management, internal control program, safety and occupational health management and environmental protection. Responsible for enhancing operational missions and personnel safety, occupational health, security and accountability, and ensuring establishment/implementation of personnel reliability programs at biological and chemical defense RDTE facilities that work with designated chemical and biological etiologic agents. Must be proficient in surety program regulatory compliance areas to evaluate subordinate command programs that work with designated biological etiologic and chemical defense agents. Must be proficient in safety and occupational health and environmental protection program regulatory compliance areas to evaluate headquarters and subordinate command programs. Incumbent will represent the USAMRMC and, as directed, OTSG/MEDCOM, at DA and DOD levels to establish regulatory guidance for the Chemical and Biological Surety Programs, Safety and Environmental Protection Programs.
SERIES: 0401, 0028

The incumbent serves as the activity's expert scientific advisor and technical spokesperson for synchronization of effort for all elements of biological security and biorisk management. The incumbent advises the Commander on internal and external factors that impact on biological security and bio-risk management; develops new concepts, policies, and procedures that are directly related to biosecurity and bio-risk management programs involving physical security, personnel security, operational security, information security, biological personnel reliability, biological select agents and toxins (BSAT) accountability, and emergency response to optimize BSAT management. Serves as expert BSAT Manager for bio-risk management, facilities management, and garrison support activities. Is the authoritative expert regarding BSAT operations for reporting to County, State, and Federal entities; demonstrates a high degree of judgment to ensure the activity is compliant with all Department of Defense, Army, Federal, State, and International regulations and laws that govern BSAT management; ensures that activity principal investigators are adequately resourced and knowledgeable to be fully compliant with all applicable regulations and laws that govern BSAT management; directs studies to further characterize and/or validate BSAT status for agents and toxins stored in the activity; establishes best practices for the management and accountability of BSAT. Is the Responsible Official (RO) for the activity's CDC BSAT registration and, as such, ensures that local policies and procedures for the handling, use, storage and transfer of BSAT comply with the regulatory requirements of 42 CFR 73, 9 CFR 121, AR 50-1, and local policies and procedures.
SERIES: 0401

Work involves specialized knowledge of antibiotic resistance and the multiple genetic mutations and horizontal gene transfer events associated with its dissemination. Microbiology research, laboratory methodology and microbial genomics research, including high-throughput whole genome sequencing, genome assembly and annotation, plasmid assembly and annotation, and comparative genomics methodology. Familiarity with mobile genetic elements associated with microbial genomes.
SERIES: 0403

Work involves leading short and long read next generation sequencing platforms, including Illumina, Pacific Biosciences, and Oxford Nanopore. Functional task include library preparation methods for next generation sequencing, including multiplex adapter design, mate-pair libraries, and large insert libraries for long read single molecule sequencing. Also required is experience with liquid handling laboratory automation and its application to high-throughput whole genome sequencing. Duties require familiarity with data formats produced by different sequencing platforms and how to store, manage, and filter next gen sequence data from various platforms.
SERIES: 0403

This position requires skill with the Linux computing environment: operating system installation and maintenance, command line software installation, software utilization for next gen sequence data analysis, and software integration into data processing pipelines. The complexity of the work requires extensive experience with the analysis of next generation sequence data, including read trimming, genome assembly, data/assembly quality determination, genome annotation, and data storage. Additional aspects of the work include (a) familiarity with producing finished sequences of whole bacterial chromosomes and plasmids (b) Experience with the design and implementation of high-throughput bioinformatics pipelines for genome assembly and genome/strain comparison, including pipeline design, testing and troubleshooting, and integration into a production scale laboratory workflow (c) specialty knowledge of genomic features associated with antibiotic resistance, including gene detection and annotation, mutation detection, and mobile element detection and classification. This position requires familiarity with genome databases and public data repositories such as GenBank and those storing data for: MLST profiles, resistance genes, insertion sequences, plasmid types, prophage, etc. Duties require experience with comparative genomic methods to assess loss or gain of sequence segments between genomes, detect mobile DNA events, and evaluate sequence similarity between genomes at the level of individual single nucleotide polymorphisms (SNP) and small insertion/deletion events (INDEL). Additional responsibilities include familiarity with SNP/INDEL filtering, detection of recombination events between genomes and experience with large genomic data set analysis of hundreds to thousands of bacterial genomes and associated techniques including high-throughput SNP detection pipelines, core genome MLST (cgMLST), and whole genome MLST (wgMLST) methodologies.
SERIES: 0403

Requires knowledge of supply operations, equipment management, and program requirements. Requires ability to perform supply management support and control functions that include: requisitioning, receiving, inspecting, storing, issuing, and disposing of supplies and equipment. Assists in solving logistical issues and coordinates the delivery of supplies and equipment. Skills in filing and recording receipt and issue documentation. Assists in the performance of maintaining supply and accountability for customer property held within the organization.
SERIES: 0346

Work involves the development of RDT&E and DTRA JSTO programs, policies, assessments and impact analyses necessary to achieve efficiency and effectiveness of Command and/or Agency missions and assigned programs. Tasks include developing program and policy content (e.g., current and strategic goals and objectives, resourcing strategies), conducting program assessments, marketing/reporting /defending programs at Agency, national and international levels, and representing Command/Agency positions in DOD executive review forums. Skills and knowledge are required in theory and practice of program management; PPBES; RDT&E and DTRA JSTO processes; and program, science, and technology components.
SERIES: 0601

Work involves the assessment, establishment, execution, and nurturing of strategic partnerships in support of medical chemical defense and training programs to assist and support Command mission goals and objectives as they relate to current and future military concepts. This includes, but is not limited to coordination and synchronization of efforts with the medical materiel and combat developers and logisticians, Army and DOD medical research facilities and other related federal agencies, university, and industry program efforts. Duties include oversight and coordination of a spectrum of partnership efforts as well as personal interaction with potential new and existing partners. Other duties include oversight of development and negotiation of interagency agreements, memoranda of agreement, and understanding to support strategic partnerships.
SERIES: 0601

Work involves executing supervised research related to application of biomedical engineering technologies to intelligent robotic and autonomous systems for combat casualty care, operational medicine, and force health protection. Responsibilities include supporting biomedical engineering research studies; and design, prototype, integrate, test and evaluation of intelligent closed loop biomedical systems and devices intended for military medical applications. Position requires ability to perform supervised technical analyses, programming, integration, testing, evaluation, and documentation of biomedical systems which incorporate artificial intelligence, machine learning, with emerging physiological monitoring sensor technologies; ability to apply skills in scientific tools and systems engineering processes, including mathematical modeling and programming languages, such as MATLAB, C++, Python, and R, and model based systems engineering tools to design and development of diagnosis, monitoring, and treatment systems for combat casualty care settings.
SERIES: 0858

Serves as Research Engineer within the Biotechnology HPC Software Application Institute (BHSAI). Work involves planning, executing, and evaluating research related to the application of biomedical engineering technologies to cognitive performance, heat stress, sleep disorders, and therapeutic interventions. Responsibilities include applying engineering theory to mathematical analysis of physiological responses generated from novel instrumentation including wearable devices, such as smartwatches and wearable electrocardiogram devices, to solve biomedical problems; developing innovative solutions and conducting biomedical engineering research studies; design and implementation of experimental protocols involving signal processing of time-series physiological data, data mining, data-driven and physiological-based models, and artificial intelligence; ability to apply systems engineering principles to design and develop systems for improved diagnosis, monitoring, and treatment of disease or injury; and skills in scientific tools and processes, including mathematical modeling and programming languages, such as MATLAB, C++, Python, and R, and model based systems engineering methods.
SERIES: 0858

Work involves designing and implementing a basic and applied research program to investigate the physiological mechanisms regulating illness and performance decrements at low oxygen, high carbon dioxide and thermal stress environments. Work requires skill in establishing new acclimatization protocols or using existing human or cellular experimental models and physiological laboratory techniques that are appropriate to study the impact of combinations of environmental stress on metabolic energy expenditure, endocrine responses, and molecular changes in the blood. Responsibilities include conducting environmental chamber and field studies on human volunteers, development of military guidance/doctrine related to high terrestrial altitude or subterranean environments, acclimatization/training programs, pharmacological/nutraceutical interventions, and specialized clothing/equipment to minimize physical and cognitive strain, reduce environmental illness and optimize and sustain performance during military operations.
SERIES: 0413

Work involves overseeing biomedical modeling research and model development/verification in the interface area of biophysics and engineering related to human physiological responses to environmental extremes. Management of personnel investigating approaches to improve health readiness, performance and survivability in environmental extremes and the associated research programming is required.
SERIES: 0413

Serves as recognized authority for Defense Health Agency Clinical Laboratory Improvement Program requirements and associated accrediting body requirements. Work involves development, oversite, certification and transition of the DoD high complexity clinical laboratory for evaluation of human samples for chemical agent exposure and result placement into a medical record. Responsible for quality assurance, compliance and auditing processes as well as human subjects protections. Additional tasks include protocol and funding proposal development, collaborating with internal and external customers, engaging with national, government and international bodies on program oversite and compliance.
SERIES: 0601

Serves as the Chemical Surety Officer, managing day-to-day operations of the Institute's Chemical Surety Program. Provides oversight of the Institute/APG Chemical Agent Facilities Response and Assistance (CIMRA) program, the USAMRICD Chemical Personnel Reliability Program, and the USAMRICD Controlled Substance Program. Plan, direct, and execute all USAMRICD CIMRA exercises; responsible for coordinating and leading APG Surety Working Group meetings. Responsible for comprehensive Institute environmental and chemical surety programs to include writing program policies and procedures and ensuring enforcement of APG, MRDC, AFC, HQDA, and DoD surety and environmental policies. In addition, responsible for oversight of the USAMRICD environmental program ensuring compliance with Maryland Department of the Environment regulations as well as Environmental Protection Agency regulations. Also serves as the chemical surety POC for all inquiries regarding the program by MRDC, AFC, HQDA, and the DoD, serving on review panels for updating Army Regulations (ARs), Department of the Army Pamphlets (DA Pams) and other regulations as requested by proponent organizations. Oversee the implementation of guidelines developed by our higher Commands, and initiate and write procedures for the implementation of chemical surety, environmental, and controlled substances standards, procedures, policies.
SERIES: 0301

Acts as the focal point for surety matters. Provides oversight of all quarterly Chemical Accident or Incident Response and Assistance (CAIRA) exercises. Plan, lead, direct, and execute all of our CAIRA exercises. Oversee the implementation of guidelines developed by our higher commands, Initiate and write procedures for implementation of chemical surety standards.
SERIES: 0301

Work involves planning and implementing basic and applied research studies related to severe burn trauma. Experience with a variety of in vitro and in vivo models of burn trauma, including conducting animal modeling of infections related to burn injury. Research concentrates on major research problems relevant to military and civilian acute burn injury and trauma. Tasks include reviewing and or conducting experiments pertaining to burn and trauma and wound repair. Additional tasks include developing new methodologies and analyzing and interpreting results.
SERIES: 0601

Serves as the Biorisk (BSAT biological safety and biological security) and Chemical Surety Specialist for the USAMRDC reporting to the Command Select Agents and Environmental Compliance Office (SAECO) Manager. Provides planning and direction to assure an active and dynamic select agent program. Coordinates with mission elements and host installation staff on all select agent program matters to assure a proactive program is in place. Provides technical and administrative support for USAMRDC subordinate activities with select agent programs to ensure requirements are met and that required records are current and accurate. Works independently, initiating work assignments as a result of meetings, changing regulations, and/or self-identified requirements in conjunction with the SAECO. Makes recommendations for change; and implements decisions for effecting such changes. This position advises the SAECO, Commanders and senior mission directors on matters involving select agent operations and compliance. Serves as the alternate SAECO. Reviews and analyzes proposed Department of Defense (DoD) and Headquarters (HQ) Department of Army (DA) policies and directives pertaining to select agents determining applicability and assurance. Lead coordinator for assuring compliance with all Biorisk and Chemical Surety reporting. Serves on both DoD, HQDA and AFC surety working groups.
SERIES: 0401

Incumbent performs specialized procedures for human body composition measurements following controlled feeding trials and military training, including use of peripheral quantitative computed tomography (pQCT) for the detection of bone and muscle changes in response to nutrition interventions and dual energy x-ray absorptiometry (DEXA) for the detection of whole body tissue responses (including lean mass, fat mass, and bone density). The incumbent will assess body composition (to include lean body and fat mass) using skinfold thickness measurements by skinfold calipers, as well as the Department of Defense circumference measurement procedures, to determine responses to nutrition and physical activity interventions.
SERIES: 0630

Incumbent designs and prepares diets for controlled feeding studies in a metabolic kitchen, including assuring diets are intervention and placebo matched for randomized, placebo-controlled trials. They will also coordinate the production of the nutrition intervention for studies requiring a unique food product or capsule. Incumbent will quantify nutrient intake utilizing 24 hour recall, 3-day diet record, and food frequency questionnaires. The incumbent will provide study specific diet recommendations to study volunteers to assure adherence to study protocols and assess dietary intake using Food Processor, Statistical Package for Social Sciences (SPSS), and SigmaPlot. The incumbent will coordinate blood processing supplies and procedures to assess nutritional biomarkers in response to military training and dietary intervention.
SERIES: 0630

Work involves leadership and strategic planning of Psychological Health Research programs within the Military Operational Medicine Research Program and Joint Program Committee 5 (Military Operational Medicine). The position involves identification of capability gaps through analysis of a variety of requirements documents and development of research gaps that are synthesized into overarching program goals. Planning, programming and budgeting for multi-year research studies and approval of research objectives and plans are critical elements of the work. Evaluation of research against the goals, objectives and plans and the assessment of the science being conducted are all essential aspects of the position. The technical areas of the work include psychological health topics such as resilience, suicide prevention, substance abuse prevention, post-traumatic stress disorder diagnosis and treatment, prevention of the workplace violence/aggression and studies of the issues faced by families of deployed service members.
SERIES: 0180

Work requires substantial subject matter expertise and involves interactions that include: collaboration with other Federal agencies that fund similar types of research, leadership and involvement on DoD and other Federal working groups, and representation of US Army Medical Research and Materiel Command and the Defense Health Agency (DHA) in national and international forums. Tasks include coordination of responses from multiple Federal Departments to "Request for Information" from the White House and Congress as well as data calls from DoD and other Federal Departments. Represents the Army and DHA in multiple task forces, work groups and research review boards and provides critical feedback to facilitate solutions that best meet strategic requirements for the military.
SERIES: 0180

Provides scientific, project management and DoD acquisition expertise to direct product development and research activities for a complex program seeking effective pharmacotherapeutic agents for the treatment of Posttraumatic Stress Disorder (PTSD). Uses appropriate scientific and program management principles and standards to lead a multi-functional Integrated Product Team (IPT) supporting Food and Drug Administration (FDA)- regulated and/or non-FDA-regulated multisite phase 2 and phase 3 clinical research efforts. Responsible for coordination of individuals assigned to matrixed teams and working groups to complete all aspects of product development including: DoD acquisition and product management documents that comply with governing federal acquisition and professional program management principals; clinical trial design; preparation of clinical trial protocols and related documents; supervision and management of clinical trials; and preparation of Investigational New Drug (IND) Applications and New Drug Applications (NDA)/Supplemental New Drug Applications (SNDA). Directs and monitors the utilization of resources in developing, executing, and attaining program goals. Monitors program progress in terms of cost, schedule, performance and risk, and develops and implements risk mitigation solutions as needed. Develops realistic program budgets. Builds and maintains constructive and respectful working relationships with colleagues, support personnel, collaborators and superiors within and outside of the agency (other federal agencies, academia, and industry). Develop briefings, information papers, and other documents to regularly update the Project Manager and senior leadership regarding program progress and issues. Author or co-author and contributes to the production of acquisition documents, reports, briefings, and documentation required by the Defense Acquisition System and/or the USAMRMC Decision Gate process. Work requires excellent interpersonal, written and oral/presentation communication skills, and the ability to work effectively in a matrixed team environment.
SERIES: 0601

Work involves the management and execution of a medical research, development, testing and evaluation program or a subpart of a program to include technical content and/or cost, schedule, and performance. Work includes analysis of functional requirements, development and/or execution of technical execution plans, development of program strategies for any program component from Materiel Development Decision through Milestone C; substantive participation as a leader of Integrated Product Teams; direct management of program resources, schedules, and budgets; and defend of program content and structure in professional acquisition forums. Skills and knowledge are required that comply with acquisition Program Management Level I, II or III (in accordance with DODD 5000.1, DODI 5000.58.1, and/or other DA and/or DOD policies) depending on the job responsibility description.
SERIES: 0601

Serves as the Director, Environmental Health Program (EHP), U.S. Army Center for Environmental Health Research. Manages the day-to-day operation of the EHP providing scientific leadership and guidance to more than 13 scientists performing research in the areas of toxicology, molecular biology, bioinformatics, biochemistry, biotechnology, biomedical engineering, and systems biology. Provides oversight to both aquatic and rodent experimentation to meet scientific mission. Prepares and presents programmatic reviews of the Institute's research program for review panels across the Department of Defense (DoD). Serves as Principal Investigator to execute research in aquatic and rodent toxicology, predictive toxicology, and systems biology. Manages the development of capabilities related to identification of genomic and proteomic biomarkers, extensive knowledge in using systems approaches to solve complex problems related to toxicology and other environmental exposures relevant to Service members. Conceives and writes proposals to multiple sponsors across the DoD and other government agencies. Writes research results and submits manuscripts to peer-reviewed journals and conference publications. Serves as the Contracting Officer Representative or Grants Officer Representative for research initiatives across a wide range of scientific domains. Serves as the technical representative during grant negotiations, advising and assisting the Contract Officer in administering awards and coordinating program management decisions. Position requires the candidate to successful identify military relevant problems related to environmental exposures and identify their solutions.
SERIES: 0601, 0401

Demonstrated expertise and ability to provide scientific leadership in each of the individual aspects of molecular and systems biology. Work involves contributing to and development of new research programs to investigate all aspects of systems biology including physiological, host responses, and therapeutic strategies for infections/exposures of military relevance. The complexity of the work requires extensive research collaboration and publication co-authorship with world-class experts. Additional aspects of the work include (a) evaluation of the molecular biology and systems biology approaches applied to illnesses of military relevance, (b) experience and publications illustrating skill for research in metabolomics and integration with physiological characteristics, (c) experience using animal models and applying state of the art technologies; (d) bioinformatics and data mining analyses of host responses to illness or exposures (to pathogens).
SERIES: 0401

Demonstrated expertise in developing specialized techniques for analyte preparation. Skill and experience for use of next-generation sequencing (NGS), capability and experience with DNA methylation using microarrays, branched chain PCR, and qPCR (experience with multiple platforms is essential). The position requires extensive experience and demonstrated capability in using bioinformatics tools for analysis of large datasets, such as from global multi-omic studies and extracting key features, regulatory networks and integrating them with clinical aspects and identification of host correlates of infection to pathogens of military importance. The position may require working with hazardous materials and animals. Appropriate clearance status for use of select agents in BioSafety Level 2 (BSL-2) is critical. Knowledge and skills for implementation of a completely electronic format of planning, collecting, and storage of laboratory data using Laboratory Information Management System (LIMS) is critical. Responsibilities also include reporting results in scientific literature, presentations at national and international meetings, and preparation of command and agency briefings.
SERIES: 0401

Work involves regulatory affairs and quality assurance support for advanced and early 'tech base' medical device and diagnostic product development efforts involving Food and Drug Administration (FDA) regulated activities. These include, but are not limited to, nonclinical (preclinical) studies/testing, clinical studies conducted according to current Good Clinical Practices (cGCP) to demonstrate safety and efficacy of candidate investigational medical device and In Vitro Diagnostics (IVD) products; and manufacturing and testing of medical device and IVD products performed according to current Good Manufacturing Practices (cGMP)/Quality System Regulation (QSR). Skills required include thorough understanding of premarket and post-market requirements for medical devices to ensure development plans are consistent with FDA regulations required to meet FDA approval/clearance. Knowledge and application of medical device classification process; concepts of Significant Risk (SR) and Non-significant Risk (NSR) device studies; Investigation Device Exemption (IDE); and medical device submission process for 510(k) and Premarket Approval (PMA). Responsibilities include: regulatory review of medical device submissions to FDA (e.g., Pre-Submissions, IDE, 510(k), PMA, pre-Emergency Use Authorization and Emergency Use Authorization requests); protocol reviews with case report form and informed consent compliance review; regulatory compliance and quality review of submissions to FDA relating to product development and approval; coordination of regulatory activities within internal and external product development teams; medical device determinations; interfacing with FDA (formal meetings, responses to requests for information, email and telephone communications. Ability to provide technical representation for regulatory affairs support contracting; regulatory affairs standard operating procedures, policy, and guidance document development; and education of researchers regarding regulatory requirements.
SERIES: 0601

Work involves managing and executing tissue injury research and development program directed at the transition from early development to advanced development of drugs, biologics, and devices to restore form, fit, function, and appearance to wounded service members. Serves as consultant for the planning and organizing of research involving human subjects to define outcome criteria, determine the safety and efficacy, and implementation strategy of military importance. Provides medical physician expert consultation in Phase I & II (safety, dose finding) and Phase III (efficacy and field) testing of these products and research on the epidemiology of the condition in question in order to define the appropriate target population and the basis for measuring efficacy. Plays a consultation role in preclinical development of experimental procedures, drugs, biologics, and devices designed to answer specific questions about safety, immunogenicity, or efficacy of technologies. Responsibilities include integrating cost, schedule and performance targets with program design and outcomes; continually maintaining awareness of trauma patterns for U.S. troops; managing changes to the structure and content of research programs; exercising effective coordination of research, development, and implementation activities among government, academia, industry and international health organizations. Develops communication materials including briefs, and communicates effectively verbally and in writing with others; works independently, exhibits knowledge and experience in directing scientific research and developing strategic plans for the organization.
SERIES: 0602

Work involves directing the identification, development, establishment, management and execution of a complex medical research and development program conducted to support priority missions associated with combat casualty care. Responsibilities include managing major changes to the structure and content of research programs; exercising discretionary authority to approve the allocation and distribution of funds from all sources (Army approved budgets as well as grants for scientific research) in the organization and executes studies, program reports, and other staff work independently.
SERIES: 0601

Work involves assisting the technology transfer function for a federal laboratory IAW 15 USC 3710a and associated laws and regulations. Duties include disseminating information on laboratory products, processes and services to state and local governments and private industry; providing technical assistance in response to requests from state and local officials and private industry; and consulting with scientists and engineers working in government, academic and industrial research centers on emerging and advanced state technology. The position requires knowledge of Chapter 63, Title 15 of the U.S. Code Annotated and related rules and regulations concerning technology transfer and requires ability to negotiate and execute technology transfer contracts and agreements.
SERIES: 0601

Work involves planning, development, establishment, management and execution of complex medical research and development projects conducted to support priority missions such as combat casualty care. Responsibilities include coordinating extramural research projects and directing in-house independent research projects to develop medical devices. Broad theoretical knowledge or hands-on experience in such disciplines as microbiology, immunology, molecular biology, and physiology in performing different aspects of research projects, and extensive knowledge and experience in directing and executing scientific biomedical research from the most basic to applied, product-oriented efforts are critical.
SERIES: 0601

Work involves design, evaluation, and implementation (or re-implementation) of novel polymers and coatings for both storage of blood products and development of related functional tests. Research will rely on the use of a wide range of biochemical analysis techniques to evaluate functional parameters including, but not limited to, cellular adhesion to material, gas exchange, and viability/functionality of stored products. Work requires knowledge of human blood and blood products, current blood banking practices, coagulation, polymer chemistry, biocompatibility, surface functionalization, and cell-surface interactions. Tasks will include designing and executing experiments followed by interpreting and reporting data orally and in writing. Reviews grant/contract proposals in areas of expertise as requested. Serves as COR as requested.
SERIES: 0601

Work involves using a variety of microscopy techniques in the pursuit of solutions to important problems in the realm of blood coagulation and blood product research. Work requires experience in the use of light microscopy and transmission/fluorescence spectroscopy, incorporating models of circulatory flow, coagulation, thrombosis, and wound healing; confocal microscopy for mechanistic molecular biology of these processes; and electron microscopy for analysis of the physical properties of clots. Advanced knowledge of engineering and optics is required to design and develop unique configurations and optical systems to address evolving analytical requirements and drive innovation in this field. Tasks will include designing, executing, and interpreting experiments and written/oral reporting.
SERIES: 0601

The Senior Scientist provides technical and programmatic representation on behalf of the laboratory to the US Army Medical Research and Development Command (USAMRDC) Principal Assistant for Research and Technology (PART) and the Principal Assistant for Acquisition (PAA) and their subordinate program planning staffs. The Senior Scientist is called on by the PART and the PAA to assist and advise on key strategic and policy decisions that impact significantly on the execution of the medical research mission, and is a primary advisor to the Laboratory Commander on alignment of the Laboratory's competencies and capabilities to Department of Defense (DOD), Army, and USAMRDC strategic guidance and program directives. The Senior Scientist also serves as a senior level representative on behalf of the laboratory and USAMRDC in Department of Defense, Interagency and International forums.
SERIES: 0601, 0401

The Research Director position involves the directing, planning, and execution of world-class scientific research programs. The Director will act as a focal point for scientific activities at USAISR, developing scientific strategy as well as directing research and early development efforts. The incumbent will manage USAISR's Research Directorate to ensure business processes are being followed and that the Task Areas are effective in delivering value to the Institute. The Director will translate the scientific goals of the Commander into research activities by overseeing the execution of USAISR's project portfolio; reviewing proposed project plans; ensuring the transition of technology and candidate products to advanced developers; recommend scientific priorities to the Commander; recommend the prioritization of the USAISR project portfolio; support the development of USAISR's s scientific strategy; develop and execute an annual research plan in line with the Institutes' scientific strategy; ensure USAISR's scientific expertise through the incorporation of state-of-the-art technologies and the recruitment of a premier workforce; scan the combat casualty care and trauma field for promising technology; incorporate and further develop promising enabling technology and products; ensure USAISR attracts, trains, and retains a workforce with the necessary scientific skills; coordinate the activities of USAISR's science functions to establish seamless workflow; identify and resolve cross-functional and cross-disciplinary conflicts and develop and implement policies and procedures for the management of USAISR's research programs.
SERIES: 0601

Manage a team of scientists that provide Food and Drug Administration (FDA)-regulated manufacturing and nonclinical scientific and technical support for the development of medical products (biologics, drugs, devices) with potential use for the warfighter. Responsible for and demonstrated experience in ensuring that manufacturing and nonclinical regulatory obligations, per Code of Federal Regulations (CFR) and International Conference on Harmonization (ICH) guidance, are fulfilled for FDA-regulated product development activities. Demonstrated experience in providing scientific guidance with regards to nonclinical and Good Laboratory Practices (GLP) studies; validations for assays and bioanalytical testing; manufacturing process validation; Good Manufacturing Practice (GMP)/Quality Systems Regulation (QSR) product manufacturing and testing methods and records review, stability testing, storage, and accountability for FDA-regulated medical products. Serve as liaison with partners and integrated product development teams (IPTs) to provide advice and recommendations on regulatory compliance, manufacturing and nonclinical development plans, and management and oversight of contract manufacturing, storage and testing activities. Assists with writing/reviewing of Modules 2, 3 and 4 of electronic Common Technical Document (eCTD) Investigational New Drug (IND) submissions. Conducts manufacturing, testing, and clinical research laboratory site visits and reports on compliance of GLP/GMP/QSR activities, documents, and facilities; generates and provides metrics, and status reports required by management. Must have the ability to assist a team through knowledge and application of leadership and team building skills and techniques such as group facilitation, coordination, coaching, problem solving, interpersonal communication, and integration of work processes and products. Required to direct and motivate activities, provide training and mentoring of staff, establish and update processes and policies, manage budgets, staffing and other resources within the branch, and outputs to produce a smooth-running operation.
SERIES: 0601

Provides scientific, program management and DoD acquisition expertise to direct research and development activities for a complex program seeking effective drugs, biologics, devices or combinations for the treatment of tissue and sensory injury. Uses appropriate scientific and program management principles and standards to lead a multi-functional Integrated Product Team (IPT) supporting Food and Drug Administration (FDA) regulated multisite phase 2 and phase 3 clinical trials. Chairs and/or serves as a substantive participant in Integrated Product Teams (IPT). Responsible for coordination of teams to complete all aspects of product development including: clinical trial design and management; manufacturing development and qualifications; appropriate testing criteria and test development; and preparation of FDA marketing applications. Directs and monitors the utilization of resources in developing, executing, and attaining program goals. Monitors program progress in terms of cost, schedule, performance and risk, and develops and implements risk mitigation solutions as needed. Builds and maintains constructive and respectful working relationships with colleagues, support personnel, collaborators and superiors. Regularly updates the Project Manager and senior leadership regarding program progress and issues. Authors and contributes to the production of acquisition documents, reports, briefings, and documentation required by the Defense Acquisition System and/or the USAMRMC. Work requires excellent interpersonal and written communication skills, and the ability to work effectively in a team environment.
SERIES: 0601

Incumbent designs diet and/or exercise protocols for studies imparting nutrition and/or exercise as an independent or dependent variable. Incumbent will quantify energy intake and energy expenditure utilizing multi-day food and activity records, 24 hour recall, and indirect calorimetry. The incumbent has obtained certification in exercise testing and/or strength and conditioning from a nationally-recognized organization. The incumbent will perform, and interpret data from, indirect calorimetry at rest and during submaximal and maximal aerobic exercise. The incumbent will counsel volunteers regarding study specific diet and exercise restrictions to assure adherence to study protocols. The incumbent will assess total daily energy intake and expenditure using excel, Statistical Package for Social Sciences (SPSS), and SigmaPlot. The incumbent will collect blood via venipucture and IV catheter placements, and coordinate blood processing supplies and procedures, to assess physiological biomarkers in response to military training and exercise and/or dietary intervention. The incumbent will search and interpret current literature related to nutrition and performance.
SERIES: 0413

Provides consultant services to a wide variety of health care professionals at the USAISR Burn Center to facilitate and ensure continuity of care, treatment and follow-up of patients with psychiatric, behavioral, and emotional problems. Serves in a teaching capacity to provide formal and informal education to patients, families and staff, individually and in groups. Works closely with other members of the total treatment team in the formulation of the multi-disciplinary treatment plan for patients. Determines and recommends appropriate referrals. Screens new patients for psychiatric issues, takes histories, performs health screening, orders diagnostic tests and laboratory studies and interprets data obtained from the results. Provides comprehensive care for patients based upon the multi-disciplinary treatment plan and the mental, emotional and physical needs of the patient and provides assessment of acute and non-acute clinical problems and toxicity's as they relate to a patient's psychiatric condition. Documents assessments and recommendations on consultation forms, nursing notes, progress notes and other forms as appropriate. Maintains records and caseload documentation as required. Functions as therapist, co-therapist and/or participant in group sessions with patients. Prescribes medications according to accepted standards of psychiatric practice that is preferentially evidenced based. Through therapeutic relationships, directly assists patients and families to cope with illness, stress, depression, loss, grief and other psychological problems. Utilizes various modalities of care, i.e. therapeutic use of individual and group counseling, crisis intervention and medication management. Records all medical histories, findings, diagnoses, plans referrals, consultations, medications prescribed, and any other pertinent data in the systematic manner required by applicable regulations and policies. Initiates and submits records and reports as required.
SERIES: 0610

Responsible for the inpatient clinical pharmacy functions of the USAISR Burn Center. Serves as the primary pharmacist practitioner for the burn center team providing a full scope of healthcare services for patients with burn and trauma injuries. Provides therapeutic consultation to evaluate, recommend, or modify medication therapy in patients with complex medical problems or difficult to manage pain and disease states. Utilizes expertise in special compounding to further enhance patient outcomes. Provides patient education/counseling services including medication reconciliation and discharge counseling to enhance compliance and reduce the occurrence of medication related problems. Competently manages problems in the progressive care ward or intensive care unit setting. Examines and conducts thorough evaluations of patients utilizing laboratory and clinical findings to appropriately treat or refer patients to the appropriate specialty. Obtains a health history and performs medications reconciliation from family/guardian and records findings. Initiates and participates in research projects related to pharmaceutical care. Requests special screening tests and laboratory tests and uses the results in developing and revising the pharmaceutical care plan.
SERIES: 0660

Provides highly specialized intervention services to burn/trauma patients in the USAISR Burn Center. Assesses, plans, develops, implements, and evaluates services for patients and their families, including case management, family health counseling, education, role modeling, client/family advocacy, and consultation. Serves as a utilization manager in assisting with the preauthorization, denials, appeals and DD Form 2569. Assist in scheduling outpatient procedures and surgeries after preauthorization. Assists with paperwork including but not limited to Short Term Disability, FMLA and non-FMLA Sick Leave Workers Compensation, Social Security Disability, Medicaid, Food Stamps and Duty Status.
SERIES: 0610

Collaborates with military and civilian agencies to ensure continuity of care. Serves as liaison and expert consultant to medical, installation, and community agencies for matters concerning services for burn patients. Develops an intervention plan for identified patients working with the appropriate case manager, health care professionals, or other agencies when required. Work with these individuals to assess the impact of services on the individual, family unit, or installation. Continuously assesses and responds to changing needs of patients based on deployment cycles or critical events. Serve as a sponsor and contact person for MTF entry. Provides community referrals to a variety of resources.
SERIES: 0610

Provides nutrition care for Wounded Warriors and others with burn, trauma, or disabilities that impact nutritional status. Serves as a registered dietitian (RD) as part of an interdisciplinary treatment team composed of physicians, physician assistants, nurses, and other allied health professionals. Determines optimal medical nutrition therapy utilizing a four-step nutrition care process: (1) nutrition assessment; (2) nutrition diagnosis; (3) nutrition intervention; and (4) nutrition monitoring and evaluation. Evidence-based nutrition practice guidelines assist the RD and patient in making decisions about nutrition care and the treatment plan. Assesses health and nutrition history to include present condition, past medical and surgical history, laboratory values, medication and supplement use, activity level, typical eating patterns, cultural background, psychosocial issues that impact on nutritional status, and other conditions. Performs anthropometric measurements as needed to assess nutritional status. Incorporates various patient-centered counseling and education techniques such as motivational interviewing and cognitive behavioral therapy to enhance understanding and compliance of diet modifications. Instructs patients on use of electronic or print food and activity diaries to improve compliance and monitoring of diet modification. Manages patient care through evidence-based treatment plans to include follow-up routine telephonic monitoring, secure messaging, and web-based care. Monitors patient compliance through metric indicators such as waist circumference, lipid abnormalities and iron levels. Contacts patients for follow-up care and diet counseling. Actively participates in the performance improvement program. Identifies areas for improvement in patient care, establishes objectives for improvement and reports on the progress of attaining objectives. Completes and reports ongoing performance improvement indicators such as metrics, patient satisfaction and peer review. Maintains and compiles data for potential future educational projects, studies, and research.
SERIES: 0630

Serves as senior manager for integration and coordination of all executive-level functions, operations, and activities involved in providing support for execution of the Command's research and technology program. Leads activities supporting oversight and management for development of medical S&T investment strategies to enable responsive and comprehensive planning, programming, budgeting, and sustaining of a broad-based biomedical R&D program; ensuring responsive focus on warfighter medically related information and materiel needs; preventing technological surprise and ensuring a viable S&T infrastructure to support those needs and concepts. Performs ongoing evaluation of program strategies, policies, and performance, including medically unique regulatory compliance, conducts independent reviews of subprogram and competency areas, and recommends the need for refocus, redirection, and/or adjustment of programs and infrastructure.
SERIES: 0601

Work involves serving as medical subject matter expert in health hazards of vibration and repeated impact environments, lethality assessment of blunt impacts, injury assessment of whole body acceleration, and injury patterns. Work requires knowledge and skillful application of operational medical and aviation experience, aviation operations, risk evaluation and reduction, research methods and practices on a variety of investigatory projects focused on the protection, safety, and risk reduction of the Army aviator or aircrew. Work involves general knowledge of vehicle injury patterns and personal protective equipment (PPE). Requires knowledge of Army accident investigation practices, procedures, techniques, legal limitations, Aviation Life Support Equipment design and function, and survival factors. Extensive experience in rotary-wing operations is applied to investigations. Ability to evaluate and recommend risk reduction measures. Ability to work with other agencies for data acquisition necessary for Division projects and mishap investigations. Must have the ability to assist a team through knowledge and application of leadership and team building skills and techniques such as group facilitation, coordination, coaching, problem solving, interpersonal communication, and integration of work processes and products. Writes, rewrites, edits a variety of technical and non-technical medical sciences material. Requires knowledge of medical sciences terminology, manuscript editing, and using word processing software.
SERIES: 0602

Work involves functioning as a primary scientific investigator based on graduate level visual sciences training. The position requires knowledge and skill to serve as subject matter expert in the fields of physiological optics, visual sciences, ocular anatomy and biochemistry, visual sensation, perception, equipment, and environment. (Such emphasis should be concentrated in theories of corneal structure, biochemistry, and physiology.) Tasks include exercising full responsibility for the process of original research protocol development, initiation, data gathering, analysis, and eventual publication in both government technical reports and refereed civilian journal formats.
SERIES: 0601

Work involves being a research team leader, supervising and directing scientific and engineering technical personnel in the assignment of work, setting suspense, establishing performance standards, and evaluating performance. Additional tasks include conducting independent vision-related research associated with night vision, protective masks, and ophthalmic devices to include assessments of visual acuity, resolution, field of view, absolute and relative scotopic sensitivity, and methods to improve those aspects of visual function. Expertise in corneal structure, biochemistry, and physiology research is essential. Additional responsibilities include preparing documentation and justification for monetary and supportive manpower resources and the additional implementation, sustainment, and reporting on internal management controls in area of operation. Ability and skill in speaking as an authority on research efforts affecting visual performance.
SERIES: 0601

Serve as principal investigator for research in skeletal muscle and bone health, in particular as it applies to soldier occupational performance. Work involves designing and conducting applied human research studies in the fields of skeletal muscle and bone physiology and physical performance utilizing biochemical and bone and muscle imaging techniques. Develops biochemical strategies and identifies biomarkers to detect and mitigate decrements in musculoskeletal and bone health and performance. Coordinates and collaborates with industrial, academic, and clinical partners in the disciplines of basic, translational, and clinical research. Additional responsibilities include the ability to synthesize results into models or products that lead to effective injury intervention strategies. Incumbent is experienced and capable of training junior investigators and technicians in the specialized procedures for human body composition measurements, including use of peripheral quantitative computed tomography (pQCT) for the detection of bone and muscle changes and dual energy x-ray absorptiometry (DEXA) for the detection of whole body tissue responses (including lean mass, fat mass, and bone density).
SERIES: 0413

Work involves functioning as primary investigator through designing, conducting, and analyzing applied human research and evaluation studies in the fields of kinesiology, physiology, and physical performance. Skills and knowledge required in biomechanics, statistics, human factors, scientific methods and investigation techniques, experimental design, instrumentation, project management, and the research, development, testing and evaluation process. Work will focus on the assessment and enhancement of Soldier occupational and operational performance and a reduction in performance decrements due to physical loading (e.g., head-supported devices, whole body acceleration or impact) and motion (e.g., human response to external stimuli or human-controlled motion). Conducts research studies to assess the physiological responses and medical outcomes to physically demanding occupational and operational requirements. Develops biomechanical strategies, identifies biomarkers to detect, and identifies existing or potential risks to mitigate decrements in physical capability. Develops and performs health hazard assessments (HHAs) and recommends risk mitigation strategies, which can include innovative physical training programs, occupational and operational loading limitations, and changes to PPE, vehicles, and SOPs to sustain or enhance performance. Additional responsibilities include the ability to synthesize results into models or products that lead to effective injury prevention and intervention strategies. Authoring and co-authoring technical reports, technical memos, and open literature publications are also required.
SERIES: 0601

Fully shares the duties with Branch Chief of providing leadership and management in planning, implementing, and coordinating all of the scientific research, analytical, educational, and programmatic activities of the Branch. Leadership focused on responsibility for managing programmatic, strategic, and administrative activities of the Military Psychiatry Branch as a full assistant to the Branch Chief. Lead with the Branch Chief in setting short- and long-term scientific priorities and goals for the Branch. Must be able to lead in carrying out all functions of the Military Psychiatry Branch in Branch Chief's absence. Must exercise decisions with wide latitude and independent judgment, largely operating on a day-to-day basis in an independent manner. Must exercise skill in directing and effectively managing the work of a complex organizational unit. Directs the work, with the Branch Chief, of DB II and III-level Research Psychologists as well as serve as a (primary) rater for uniformed personnel within the Branch. Ability to manage major changes to the structure and content of research programs; exercise discretionary authority in approving the allocation and distribution of funds from all sources in the organization; and skill in executing studies, program reports, and other staff work. Is able to function on special task forces and committees that develop new programs, evaluate various proposals, lay out long-range plans, evaluate highly controversial issues, or investigate critical difficulties, failures and obstacles in important and extensive programs. Can act as a consultant on all branch-related research to other specialists in the field and address national professional organizations and technical symposia.
SERIES: 0180

Provides professional assistance to investigators in the sleep research program with the preparation, conduction and documentation of human subject research. Works with the Institutional Review Board (IRB), research personnel and sponsors to implement approved human use protocols, adhering to Standard Operating Procedures, Study Specific Procedures and Work Instructions. Participates in the planning, design, regulatory approval and resource allocation decisions regarding research projects. Requires knowledge of laws, rules and regulations regarding the conduct of research involving human subjects. Ensures compliance with pertinent FDA regulations, rules and policies regarding the collection, recording, storage and archiving of all study related data. Documents adverse events and protocol deviations. Possesses the ability to work with study volunteers to obtain informed consent for participation in studies. Conducts sleep studies as directed in research protocols (to include processing of laboratory specimens), and records clinical data (to include use of computerized data acquisition systems). Maintains source documents and regulatory files for human use protocols. Reviews data to ensure accuracy, develops and uses record keeping systems to ensure data integrity, and participates in the analysis of results. Reports progress of research and participates in the ongoing review of research to ensure regulatory compliance, patient safety, scientific quality and progress. Coordinates scheduling for projects at multiple institutions. Completes Continuing Review Reports and amendments. Initiates protocols and monitors reviews for submission to the IRB. Assists in preparation of reports and presentations for external use. Possesses a bachelor's degree and appropriate certifications as a Clinical Research Coordinator. Maintains Basic Life Support Certification. Possesses five or more years of experience in a research environment. Complies with training requirements required in the military research environment.
SERIES: 0403

Work involves specialized knowledge and experience needed to conduct regulated laboratory studies. Laboratory activities require compliance with, and a working knowledge of, Food and Drug Administration (FDA) requirements for Good Laboratory Practices (cGLP), Good Manufacturing Practices (cGMP), and/or Good Clinical Practices (cGCP). Compliance may be required with regulations for clinical laboratory activities (Clinical Laboratory Improvement Act; CLIA88). In addition, activities require working knowledge of compliance with regulatory requirements for electronic records and electronic signatures. Responsibilities include coordination, interaction and communication with Regulatory Affairs, the Internal Review Board, the Human Subjects Protection Board (HSPB) quality assurance support, independent monitoring organizations, and pharmaceutical sponsor personnel. Possesses knowledge of, and ability to apply, current FDA clinical study research. Knowledge and experience in analytical method optimization and validation is highly desirable. Additional tasks include developing, preparing and reviewing SOP's for the accuracy of test results, planning a master schedule for all protocol procedures, researching and preparing reports and communications for active and future protocols, educating research scientists regarding regulatory practices and requirements, and developing local procedures and policies for FDA-regulated activities.
SERIES: 0403

Provides support in the execution of research protocols and subsequent analyses of data. Specific responsibilities include (but are not limited to) supply inventory and purchasing of supplies using the Government Purchase Card, calibration and maintenance of scientific equipment (to include maintaining the Datatron Monitoring System and training staff in its use), study preparation, training of contractors and other research personnel in study-related SOPs, management of study schedules, scoring of study data (e.g., sleep/EEG scoring), data collection in accordance with established protocols, and establishment and maintenance of data files.
SERIES: 0403

Coordinates with staff to facilitate recruitment of potential volunteers IAW individual protocols, and works with multiple colleges and universities to post recruitment flyers. Recruits and screens potential volunteers for human research protocols, briefs and obtains subject consent on all phases of protocol, administers neurobehavioral tests on research subjects, and ensures that all records are maintained IAW FDA rules, regulations and policies. Develops and maintains the schedule for use of the sleep laboratory facilities so as to optimize efficient conduct of multiple concurrent studies, and the optimal use of human and material resources.
SERIES: 0403

Coordinates the efforts of the Cooperative Biological Engagement Program (CBEP) at WRAIR in regards to the human surveillance and epidemiology aspects of the program. Serves as a deputy to the WRAIR-CBEP Program Manager. Leads operational, research, training and travel for the human surveillance and epidemiology elements for the Department of Health Systems. Assists WRAIR-CBEP program manager in the development of budgetary requirements for CBEP program. Assists with the development of personnel requirements for CBEP program. Travels not less than 8 weeks per year to OCONUS CBEP countries. Attends meetings with DTRA and other CBEP collaborators as required. Presents required and requested data to DTRA senior management. Collaborates with other CBEP partners (e.g. CDC, universities, etc.) as needed to accomplish the Department of Health Systems mission. Meets weekly with CBEP program manager regarding the status of the CBEP program at WRAIR. Requires at least five years of experience with infectious diseases surveillance. Experience with public health systems in former Soviet Union countries desirable. Requires specific knowledge in infectious diseases, infectious disease epidemiology, biostatistics, research development, surveillance systems, and public health.
SERIES: 0601

Incumbent serves as a hypobaric chamber crew chief responsible for conducting human and animal studies and equipment tests in simulated high altitude conditions. Specific responsibilities include, but are not limited to: preparing and maintaining hypobaric chamber operation instructions and equipment in accordance with applicable safety standards, implementing and maintaining a training program for hypobaric chamber operators, providing investigators with technical expertise for planning and conducting research studies in the hypobaric chamber, conducting a preventative maintenance program, coordinating maintenance and calibration requirements with appropriate agencies and contractors, recommending equipment upgrades and scheduling hypobaric chamber operators to support chamber operations. Experience operating a human-rated hypobaric chamber is a critical component of this position.
SERIES: 0640

Incumbent conducts specialized warfighter cognitive performance research to expand knowledge in service member performance under simulated combat conditions using the Engagement Skills Trainer (EST). Incumbent is responsible for EST preparation, operation, calibration, data collection, data downloads, and data analysis and contributes to writing study reports. Incumbent provides operation and safety instruction to test volunteers and outfits volunteers with bio monitors and calibrated weapons. Incumbent provides investigators with technical expertise for planning and conducting research studies in the EST and schedules marksmanship training, testing, and preventative maintenance.
SERIES: 0640

The position requires skill, demonstrated expertise (by publications), and ability to provide scientific leadership in each of the individual aspects of NextSeq and PacBio sequencing. Work involves the genomic analysis of pathogenic bacteria to identify genetic correlates of pathogenicity, virulence and antibiotic resistance. Requires understanding of the principles and methods for de novo assembly of next-generation sequencing data, genome annotation, detection of single nucleotide variants and genomic rearrangements, comparative genomics and phylogenetic analysis. This is a uniquely specialized position that requires a specific combination of clinical microbiology, epidemiology, and advanced molecular techniques including next-generation Illumina and single molecule real time sequencing. At a minimum, the skill set for this position requires): 1) Comprehensive experience running an advanced molecular DNA sequencing laboratory, to include real-time PCR and next generation sequencing capabilities; 2) Experience coordinating activities between laboratory and bioinformatics personnel to ensure efficient work flow; 3) Proven track record in the development and implementation of new projects; 4) Full knowledge and familiarity working with all bacteria involved in hospital and community -acquired infections, to include Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus; 5) Proven track record of publications in high-quality journals on the aforementioned bacterial species; 6) Experience, designing, implementing, and troubleshooting clinical molecular diagnostic systems such as multi-plexed real-time PCR; 7) Full knowledge and expertise of multiple, next generation sequencing platforms including the Ion Torrent, the Illumina MiSeq and NextSeq, and the Pac Bio RS II; 8) Experience in troubleshooting technical challenges and problems with real-time PCR and next generation sequencing; 9) Knowledge of public databases of gene and protein networks; 10) Knowledge of, and experience working in, a clinical microbiology laboratory; 11) ability to coordinate and supervise the collection of bacterial isolates from hospital microbiology laboratories; 12) experience processing, deconflicting, and adjudicating data from the major commercial automated microbial identification /antibiotic susceptibility testing platforms (BD Phoenix, BioMerieux VITEK 2, Siemens MicroScan); 13) Experience co-coordinating activities and research with military hospitals located in CONUS and OCONUS; 14) Experience liaising with medical and infection-control personnel in the U.S. Military healthcare system ) Additional responsibilities include liaising with external government and academic agencies such as NIH, NCBI, Public Health England, Institute Pasteur, and the CDC to optimize and enhance surveillance for antibiotic resistant bacteria.
SERIES: 0403

Serves as a Research Scientist III within the Biotechnology HPC Software Application Institute (BHSAI). Manages the day-to-day operation of the Computational Immunology group. Leads the development and execution of multiple computational immunology and vaccine research projects, formulates experimental hypotheses, develops innovative approaches, and designs and implements experimental protocols related to computational models. Uses the scientific literature to examine cross-disciplinary research areas for developing new projects and programs. Develops necessary new technologies and protocols, assesses the strengths and weaknesses of the projects and their progress. Collects, processes, and interprets experimental data and model outputs. Supervises and develops research scientists. Initiates, develops, and maintains collaborations with scientists, computational staff, and external research groups for research projects and development of new approaches to existing research problems. Prepares programmatic reviews, research proposals, progress reports, and manuscripts for submission to scientific journals. Actively participates in appropriate scientific conferences. Represents the Institute in meetings with program staff from the U.S. Army Medical Research and Materiel Command (MRMC), Defense Threat Reduction Agency (DTRA), and other DoD organizations. Prepares and presents technical briefings on Institute capabilities and accomplishments to DoD, Army, and MRMC staff. Serves as Principal Investigator and executes research within his/her areas of expertise. Performs Contract Officer's Representative duties on specific contracts or grants within his/her areas of expertise. Presents the Institute's research in abstracts, posters, and presentations at national and international science meetings. Position requires a Doctor of Philosophy in the biophysical or other quantitative theoretical biomedical sciences, demonstrated ability to guide and execute interdisciplinary research bridging computational and experimental work, with special emphasis on malaria and dengue fever research, experience in high-performance computing applications, including applications in immunology, computational chemistry/biology, and drug/vaccine development, and an established record of cross-disciplinary publications in top-tier, peer-reviewed scientific journals.
SERIES: 0401

Serves as a regulatory affairs advisor and Subject Matter Expert to The Surgeon General's (TSG) Sponsors Representative to the FDA, to the Commanding General of the US Army Medical Research and Materiel Command (USAMRMC), to the USAMRMC Milestone Decision Authority, to the USAMRMC Principal Assistant for Acquisition, and to the Commander of the US Army Medical Materiel Development Activity (USAMMDA). Serves as an interface between the Directors of the USAMMDA Division of Regulated Activity and Compliance and the Clinical Services Support Divisions and the TSG Sponsor's Representative to the FDA. Provides input to establish regulatory strategies and processes to integrate regulatory support into the product development life-cycle from the discovery/pre-clinical stage to licensure, approval or cleared. Responds to requests for TSG-sponsored IND products from Department of State, Defense, Homeland Security, Health and Human Services, and other interested parties. Provides consultative support for non-TSG sponsored products using USAMRMC resources. Maintains necessary liaison and interfaces with USAMRMC activities; as well as, other government agencies, laboratories, industry, and contractors to remain cognizant of the product development effort and to apprise interested parties of the status of development and other requirements. Demonstrates knowledge and application of FDA clinical research, laboratory practice, and manufacturing regulations and guidelines; as well as, knowledge and application of Title 21 Code of Federal Regulations (CFR) and International Conference on Harmonization (ICH) guidelines.
SERIES: 0601

Provide leadership and management in planning, implementing, and coordinating all of the scientific research, analytical, educational, and programmatic activities of the Branch. Exercise full responsibility for managing programmatic, strategic, and administrative activities of the Brain Trauma Neuroprotection and Neurorestoration Branch. Lead by setting short- and long-term scientific priorities and goals for the Branch. Demonstrate the ability to make decisions with wide latitude and independent judgment, largely operating on a day-to-day basis in an independent manner. Exercise skill in directing and effectively managing the work of a complex organizational unit. Establish guidelines for subordinates (including subordinate supervisors or team leaders). Serve as a Rater for civilian and military personnel within the Branch. Direct the overall accomplishment of program areas by making necessary adjustments, modifications, and revisions to meet objectives, and include authority to approve or disapprove requests for leave. Exercise discretionary authority in approving the allocation and distribution of funds from all sources in the organization. Function on special task forces and committees that develop new programs, evaluate various proposals, lay out long-range plans, evaluate highly controversial issues, or investigate critical difficulties, failures and obstacles in important and extensive programs. May act as a consultant on all branch-related research to other specialists in the field and address national professional organizations and technical symposia.
SERIES: 0401

Incumbent will serve as Regulatory Coordinator and single point of responsibility to assure Good Laboratory Practice (GLP) readiness of all Biosafety Level 4 (BSL-4) containment laboratories supporting the conduct of non-clinical studies in agreement with (IAW) 21 CFR Part 58. Individual will coordinate with key stakeholders, correct deficiencies, and ensure that all BSL-4 containment laboratories are continually maintained in compliance with GLP regulations. Therefore, incumbent will be required to maintain an in depth understanding of all relevant standard operating procedures (SOPs) and guidelines pertinent to maintaining the BSL-4 laboratory space and associated equipment. The individual will interact regularly with the quality assurance unit to request, host, and respond to facility audits, inspection of equipment maintenance procedures, corrective and preventative action plans (CAPA), and to document and report deviations related to equipment maintenance. The employee will remain aware of all studies to be conducted in the BSL-4 containment laboratories and proactively identify all aspects of laboratory readiness required for successful GLP study completion. This includes, but is not limited to, equipment validation and maintenance, clinical analyzer readiness, environmental monitoring systems, and equipment notebooks. Employee will proactively engage with validation engineers and other appropriate study team members to identify equipment validation needs prior to study initiation. Additionally, employee will interact with all key stakeholders in the research and support divisions to assure appropriate scheduling, documentation, and timely performance of GLP equipment maintenance. At study completion, the individual will be responsible for ensuring that all equipment maintenance and environmental monitoring system records are archived IAW the study protocol and applicable SOPs. Assist with logistics, planning, and execution of animal studies for the division. Tasks will include but are not limited to signing up for room or hood space, preparing NHP cages for telemetry, ordering and maintaining supplies, performing quality checks on data, data entry, preparation of study forms, preparation of study specific databases, preparation of sample collection tubes, maintaining inventory of samples and preparation of study binders. The employee will maintain up to date GLP training IAW SOPs.
SERIES: 0404

Serves as the expert Subject Matter Consultant (SMC) for drug therapy and pharmacy service issues and as technical advisor for related components in the Burn Center. Monitors and manages care for patients as they move through the system to ensure cost-effective care. Responsible for providing health care, assisting patient care providers with the development and oversight of long-range innovative programs relating to delivery of pharmacy services, and assisting the staff in developing, planning, and implementing patient care support programs. Uses extensive and intensive knowledge and experience with drugs and other pharmaceuticals available, their nature, action, and interaction, provides authoritative instructions, advice, and assistance in prescribing and dispensing officials in the Burn center on effectiveness, suitability, hazards, and other aspects of their use. Provides input concerning items to be stocked based on their effectiveness, economy, and appropriateness for their intended use. Serves on a variety of boards, committees, and other bodies and provides authoritative input on all pharmacy related matters. Identifies situations in which the physician should be consulted immediately.
SERIES: 0660

Serves as a consultant on cases involving multiple, serious, or life--threatening conditions with conflicting drug requirements, serious drug reactions or interactions, or other factors not receptive to standard or more common specialized approaches. Collaborates with specialists in other subspecialties on cases with complex and multifaceted problems. Follows through on all patients to ensure effective comprehensive medical service. Develops, with physicians, pharmacotherapeutics regimens for especially difficult or complex cases. Monitors progress and response to the regimen, modifying dosages or methods as necessary.
SERIES: 0660

Designs and conducts studies intended to evaluate particular drugs, their effectiveness and suitability, or to study the reaction of diseases, patients, and conditions to drug based treatment. Reviews and recommends pharmacy aspects of all protocols and investigative studies. Reviews proposed study protocols before Institutional Review Board (IRB) consideration. Negotiates and establishes mechanisms acceptable to the IRB, and investigator to receive, store, prepare, label, dispense, and account for investigational drugs; to assure continuous supply of such drugs for the duration of the study; and to properly dispose of supplies remaining after the study is closed. This may involve the use of the investigator's technicians, clinical nurse coordinators, and /or pharmacy staff or equipment in special manufacturing or repackaging operations. Supports research operations by reviewing protocols for randomization, scientific method, and protection of human subjects. Will collaborate with designing and conducting research and communicating results through publication.
SERIES: 0660

Work involves expert review of animal programs conducting DOD sponsored or conducted animal research and medical training. Review animal program support documents for the purpose of evaluating program quality and regulatory compliance. Conduct compliance inspections and site visits to perform in depth evaluation of IACUC function and performance, record keeping, and institutional support for animal care and use program. Provide professional and courteous verbal briefings to Commanders and Institutional Officials regarding inspection results, limiting results to significant or repetitive issues and concerns. Prepare written reports of inspections, including clear and concise descriptions of all findings and concerns.
SERIES: 1801

Work involves improving the organizational development, effectiveness and expansion of specific research, development and acquisition (RDA) programs, as well as overall program development and management, including DHP and Army advanced development programs. Work involves the development, review, analysis and recommendations to leadership regarding project management plans, including work breakdown structures, budgets, schedules, change orders, risk communication plans and risk mitigation solutions. Scientific background to support knowledge of research and development programs.
SERIES: 0601